{"entity": "researcher", "timestamp": "2026-05-12T22:35:07.379Z", "family": "M\u00fcller-Hauser", "given": "Anna A", "initials": "AA", "orcid": "0000-0002-8031-2404", "affiliations": [], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/aa6eb65b570d4b6390871b05b6c824a6.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/aa6eb65b570d4b6390871b05b6c824a6"}}, "publications": [{"entity": "publication", "iuid": "f661e59ccc0c4711b5934ab6937dff43", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f661e59ccc0c4711b5934ab6937dff43.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f661e59ccc0c4711b5934ab6937dff43"}}, "title": "Intercrypt sentinel macrophages tune antibacterial NF-\u03baB responses in gut epithelial cells via TNF.", "authors": [{"family": "Hausmann", "given": "Annika", "initials": "A", "orcid": "0000-0001-8852-3444", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e0048a8661d44d5e929f1724cded7b39.json"}}, {"family": "Felmy", "given": "Boas", "initials": "B", "orcid": "0000-0002-9464-707X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6a2640ba7f7d431082ca196c9126664f.json"}}, {"family": "Kunz", "given": "Leo", "initials": "L", "orcid": "0000-0001-7332-3343", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/aa0495bb149440a3927920dbac7386a6.json"}}, {"family": "Kroon", "given": "Sanne", "initials": "S", "orcid": "0000-0002-5722-0763", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4ee4762c9bf94dd0a583281a4963cc35.json"}}, {"family": "Berthold", "given": "Doroth\u00e9e Lisa", "initials": "DL", "orcid": "0000-0002-9045-6348", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/53d7074e1b6947e28bf9a5cf47cf1b64.json"}}, {"family": "Ganz", "given": "Giverny", "initials": "G", "orcid": "0000-0003-1222-3781", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5a96e1234ca54a479945692585a6f196.json"}}, {"family": "Sandu", "given": "Ioana", "initials": "I", "orcid": "0000-0003-4696-0683", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a76cb953e62e486fab96331fc735232f.json"}}, {"family": "Nakamura", "given": "Toshihiro", "initials": "T", "orcid": "0000-0001-5051-4323", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7f99facb23c64d5a9080385014e90f8e.json"}}, {"family": "Zangger", "given": "Nathan S\u00e9bastien", "initials": "NS", "orcid": "0000-0003-1130-1899", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/71b7116da6bd4ecaa534c9dfa0f0a761.json"}}, {"family": "Zhang", "given": "Yang", "initials": "Y", "orcid": "0000-0002-1763-6908", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7eb6794ef4be4579bb908fa4809a57b6.json"}}, {"family": "Dolowschiak", "given": "Tamas", "initials": "T", "orcid": "0000-0002-2031-9399", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6f1af24e9d6b4d92aa8dc0f72cfcf278.json"}}, {"family": "Fattinger", "given": "Stefan Alexander", "initials": "SA", "orcid": "0000-0003-4899-4414", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2a3891756a0e46b7be8494556da9254f.json"}}, {"family": "Furter", "given": "Markus", "initials": "M", "orcid": "0000-0003-4073-2268", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/51f09daa062347adb84d145a0128c608.json"}}, {"family": "M\u00fcller-Hauser", "given": "Anna Angelika", "initials": "AA", "orcid": "0000-0002-8031-2404", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/aa6eb65b570d4b6390871b05b6c824a6.json"}}, {"family": "Barthel", "given": "Manja", "initials": "M", "orcid": "0000-0001-6771-7661", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/adc1778ad09f4333abd2f45a29c113c1.json"}}, {"family": "Vlantis", "given": "Katerina", "initials": "K", "orcid": "0000-0002-7347-1589", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3739c46c24554582bd241f3cb16e1994.json"}}, {"family": "Wachsmuth", "given": "Laurens", "initials": "L", "orcid": "0000-0003-1701-9384", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4de7546893064de3af973373e7832d9e.json"}}, {"family": "Kisielow", "given": "Jan", "initials": "J", "orcid": "0000-0002-4482-5202", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/92846935bd80461886c261239645ff3f.json"}}, {"family": "Tortola", "given": "Luigi", "initials": "L", "orcid": "0000-0002-4335-412X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a7a1b0cfe81748839e5a02a9bd20745e.json"}}, {"family": "Heide", "given": "Danijela", "initials": "D", "orcid": "0000-0002-5670-7457", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6acd61a91f92460fa5e6e213d89eb201.json"}}, {"family": "Heikenw\u00e4lder", "given": "Mathias", "initials": "M", "orcid": "0000-0002-3135-2274", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5aeb664a4bb84c97862a3780a695a8e0.json"}}, {"family": "Oxenius", "given": "Annette", "initials": "A", "orcid": "0000-0002-2079-2354", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0a6c6eb9dca64e02b8ddbb63a1da33b5.json"}}, {"family": "Kopf", "given": "Manfred", "initials": "M", "orcid": "0000-0002-0628-7140", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0e378992386f4993a167c04aa529cf6f.json"}}, {"family": "Schroeder", "given": "Timm", "initials": "T", "orcid": "0000-0001-9320-0252", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/97c9fe7a450a4280837c4cd727cad137.json"}}, {"family": "Pasparakis", "given": "Manolis", "initials": "M", "orcid": "0000-0002-9870-0966", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a31f3861513f43e29c1ab07d465ddfcb.json"}}, {"family": "Sellin", "given": "Mikael Erik", "initials": "ME", "orcid": "0000-0002-8355-0803", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/559c18ec87d64318a0afc6267ea879e2.json"}}, {"family": "Hardt", "given": "Wolf-Dietrich", "initials": "WD", "orcid": "0000-0002-9892-6420", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1049556a73b84d258e26a84382fe5870.json"}}], "type": "journal article", "published": "2021-11-01", "journal": {"title": "J. Exp. Med.", "issn": "1540-9538", "volume": "218", "issue": "11", "issn-l": "0022-1007"}, "abstract": "Intestinal epithelial cell (IEC) NF-\u03baB signaling regulates the balance between mucosal homeostasis and inflammation. It is not fully understood which signals tune this balance and how bacterial exposure elicits the process. Pure LPS induces epithelial NF-\u03baB activation in vivo. However, we found that in mice, IECs do not respond directly to LPS. Instead, tissue-resident lamina propria intercrypt macrophages sense LPS via TLR4 and rapidly secrete TNF to elicit epithelial NF-\u03baB signaling in their immediate neighborhood. This response pattern is relevant also during oral enteropathogen infection. The macrophage-TNF-IEC axis avoids responses to luminal microbiota LPS but enables crypt- or tissue-scale epithelial NF-\u03baB responses in proportion to the microbial threat. Thereby, intercrypt macrophages fulfill important sentinel functions as first responders to Gram-negative microbes breaching the epithelial barrier. The tunability of this crypt response allows the induction of defense mechanisms at an appropriate scale according to the localization and intensity of microbial triggers.", "doi": "10.1084/jem.20210862", "pmid": "34529751", "labels": {"Mikael Sellin": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "212646"}, {"db": "pmc", "key": "PMC8480669"}], "notes": [], "created": "2021-12-05T09:46:45.613Z", "modified": "2022-11-04T11:32:12.368Z"}, {"entity": "publication", "iuid": "f229e19e6b83494a81fb7d790ab88618", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f229e19e6b83494a81fb7d790ab88618.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f229e19e6b83494a81fb7d790ab88618"}}, "title": "Salmonella Typhimurium discreet-invasion of the murine gut absorptive epithelium.", "authors": [{"family": "Fattinger", "given": "Stefan A", "initials": "SA"}, {"family": "B\u00f6ck", "given": "Desir\u00e9e", "initials": "D", "orcid": "0000-0001-8142-0629", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b1ba5760859a4340a83fca45b4e92d57.json"}}, {"family": "Di Martino", "given": "Maria Letizia", "initials": "ML", "orcid": "0000-0002-9491-4000", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ccaa06e9e2d441589299b7e33ee55034.json"}}, {"family": "Deuring", "given": "Sabrina", "initials": "S"}, {"family": "Samperio Ventayol", "given": "Pilar", "initials": "P", "orcid": "0000-0002-3726-7871", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e7647686922142a8b8bd8629142445fc.json"}}, {"family": "Ek", "given": "Viktor", "initials": "V", "orcid": "0000-0002-5039-8163", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a80b49fa9bd9407a8b806355e89ca201.json"}}, {"family": "Furter", "given": "Markus", "initials": "M", "orcid": "0000-0003-4073-2268", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/51f09daa062347adb84d145a0128c608.json"}}, {"family": "Kreibich", "given": "Saskia", "initials": "S"}, {"family": "Bosia", "given": "Francesco", "initials": "F", "orcid": "0000-0001-6021-7672", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e85e92f19bc14b3095cf38a05c639343.json"}}, {"family": "M\u00fcller-Hauser", "given": "Anna A", "initials": "AA", "orcid": "0000-0002-8031-2404", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/aa6eb65b570d4b6390871b05b6c824a6.json"}}, {"family": "Nguyen", "given": "Bidong D", "initials": "BD"}, {"family": "Rohde", "given": "Manfred", "initials": "M"}, {"family": "Pilhofer", "given": "Martin", "initials": "M", "orcid": "0000-0002-3649-3340", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5c78a3970a954249aa16c9e824813e0d.json"}}, {"family": "Hardt", "given": "Wolf-Dietrich", "initials": "WD", "orcid": "0000-0002-9892-6420", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1049556a73b84d258e26a84382fe5870.json"}}, {"family": "Sellin", "given": "Mikael E", "initials": "ME", "orcid": "0000-0002-8355-0803", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/559c18ec87d64318a0afc6267ea879e2.json"}}], "type": "journal article", "published": "2020-05-00", "journal": {"title": "PLoS Pathog", "issn": "1553-7374", "issn-l": "1553-7366", "volume": "16", "issue": "5", "pages": "e1008503"}, "abstract": "Salmonella enterica serovar Typhimurium (S.Tm) infections of cultured cell lines have given rise to the ruffle model for epithelial cell invasion. According to this model, the Type-Three-Secretion-System-1 (TTSS-1) effectors SopB, SopE and SopE2 drive an explosive actin nucleation cascade, resulting in large lamellipodia- and filopodia-containing ruffles and cooperative S.Tm uptake. However, cell line experiments poorly recapitulate many of the cell and tissue features encountered in the host's gut mucosa. Here, we employed bacterial genetics and multiple imaging modalities to compare S.Tm invasion of cultured epithelial cell lines and the gut absorptive epithelium in vivo in mice. In contrast to the prevailing ruffle-model, we find that absorptive epithelial cell entry in the mouse gut occurs through \"discreet-invasion\". This distinct entry mode requires the conserved TTSS-1 effector SipA, involves modest elongation of local microvilli in the absence of expansive ruffles, and does not favor cooperative invasion. Discreet-invasion preferentially targets apicolateral hot spots at cell-cell junctions and shows strong dependence on local cell neighborhood. This proof-of-principle evidence challenges the current model for how S.Tm can enter gut absorptive epithelial cells in their intact in vivo context.", "doi": "10.1371/journal.ppat.1008503", "pmid": "32365138", "labels": {"Mikael Sellin": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "PPATHOGENS-D-20-00095"}, {"db": "pmc", "key": "PMC7224572"}], "notes": [], "created": "2020-11-24T14:44:13.211Z", "modified": "2022-11-04T11:32:15.048Z"}]}