{"entity": "researcher", "timestamp": "2026-08-26T22:47:36.430Z", "family": "Labadie", "given": "Julia D", "initials": "JD", "orcid": "0000-0002-9942-7797", "affiliations": ["Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. jdlabadie@gmail.com.", "Department of Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA. jdlabadie@gmail.com."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/aa19f0b061dc4b86b345b3f2190ca9d9.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/aa19f0b061dc4b86b345b3f2190ca9d9"}}, "publications": [{"entity": "publication", "iuid": "d1b6495508b146bdaa4a0a28518c777d", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/d1b6495508b146bdaa4a0a28518c777d.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/d1b6495508b146bdaa4a0a28518c777d"}}, "title": "Genome-wide association analysis of canine T zone lymphoma identifies link to hypothyroidism and a shared association with mast-cell tumors.", "authors": [{"family": "Labadie", "given": "Julia D", "initials": "JD", "orcid": "0000-0002-9942-7797", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/aa19f0b061dc4b86b345b3f2190ca9d9.json"}}, {"family": "Elvers", "given": "Ingegerd", "initials": "I"}, {"family": "Feigelson", "given": "Heather Spencer", "initials": "HS"}, {"family": "Magzamen", "given": "Sheryl", "initials": "S"}, {"family": "Yoshimoto", "given": "Janna", "initials": "J"}, {"family": "Dossey", "given": "Jeremy", "initials": "J"}, {"family": "Burnett", "given": "Robert", "initials": "R"}, {"family": "Avery", "given": "Anne C", "initials": "AC"}], "type": "journal article", "published": "2020-07-06", "journal": {"title": "BMC Genomics", "issn": "1471-2164", "volume": "21", "issue": "1", "pages": "464", "issn-l": "1471-2164"}, "abstract": "T zone lymphoma (TZL), a histologic variant of peripheral T cell lymphoma, represents about 12% of all canine lymphomas. Golden Retrievers appear predisposed, representing over 40% of TZL cases. Prior research found that asymptomatic aged Golden Retrievers frequently have populations of T zone-like cells (phenotypically identical to TZL) of undetermined significance (TZUS), potentially representing a pre-clinical state. These findings suggest a genetic risk factor for this disease and caused us to investigate potential genes of interest using a genome-wide association study of privately-owned U.S. Golden Retrievers.\n\nDogs were categorized as TZL (n = 95), TZUS (n = 142), or control (n = 101) using flow cytometry and genotyped using the Illumina CanineHD BeadChip. Using a mixed linear model adjusting for population stratification, we found association with genome-wide significance in regions on chromosomes 8 and 14. The chromosome 14 peak included four SNPs (Odds Ratio = 1.18-1.19, p = .3 \u00d7 10- 5-5.1 \u00d7 10- 5) near three hyaluronidase genes (SPAM1, HYAL4, and HYALP1). Targeted resequencing of this region using a custom sequence capture array identified missense mutations in all three genes; the variant in SPAM1 was predicted to be damaging. These mutations were also associated with risk for mast cell tumors among Golden Retrievers in an unrelated study. The chromosome 8 peak contained 7 SNPs (Odds Ratio = 1.24-1.42, p = 2.7 \u00d7 10- 7-7.5 \u00d7 10- 5) near genes involved in thyroid hormone regulation (DIO2 and TSHR). A prior study from our laboratory found hypothyroidism is inversely associated with TZL risk. No coding mutations were found with targeted resequencing but identified variants may play a regulatory role for all or some of the genes.\n\nThe pathogenesis of canine TZL may be related to hyaluronan breakdown and subsequent production of pro-inflammatory and pro-oncogenic byproducts. The association on chromosome 8 may indicate thyroid hormone is involved in TZL development, consistent with findings from a previous study evaluating epidemiologic risk factors for TZL. Future work is needed to elucidate these mechanisms.", "doi": "10.1186/s12864-020-06872-9", "pmid": "32631225", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7339439"}, {"db": "pii", "key": "10.1186/s12864-020-06872-9"}], "notes": [], "created": "2026-08-21T12:38:05.440Z", "modified": "2026-08-21T12:38:05.525Z"}]}