{"entity": "researcher", "timestamp": "2026-08-22T08:31:11.062Z", "family": "Sj\u00f6wall", "given": "Christopher", "initials": "C", "orcid": "0000-0003-0900-2048", "affiliations": ["Department of Clinical and Experimental Medicine, Rheumatology/Division of Neuro and Inflammation Sciences, Link\u00f6ping University, 581 83, Link\u00f6ping, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/a9fcc24622ec440bac6996072cceea0e.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/a9fcc24622ec440bac6996072cceea0e"}}, "publications": [{"entity": "publication", "iuid": "7fdaf83387f347b4beea8fc27c202ef7", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/7fdaf83387f347b4beea8fc27c202ef7.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/7fdaf83387f347b4beea8fc27c202ef7"}}, "title": "Quick Systemic Lupus Activity Questionnaire (Q-SLAQ): a simplified version of SLAQ for patient-reported disease activity.", "authors": [{"family": "Svenungsson", "given": "Elisabet", "initials": "E", "orcid": "0000-0003-3396-3244", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2c44ebd4f33e46a1862877bce94be05b.json"}}, {"family": "Gunnarsson", "given": "Iva", "initials": "I", "orcid": "0000-0002-4514-7706", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fad22fbcc212423b9bc9539482d723e8.json"}}, {"family": "Illescas-B\u00e4ckelin", "given": "Vera", "initials": "V"}, {"family": "Trysberg", "given": "Estelle", "initials": "E"}, {"family": "J\u00f6nsen", "given": "Andreas", "initials": "A", "orcid": "0000-0002-4418-5786", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1bb7503e46d04e648d95e03e58a4b465.json"}}, {"family": "Leonard", "given": "Dag", "initials": "D"}, {"family": "Sj\u00f6wall", "given": "Christopher", "initials": "C", "orcid": "0000-0003-0900-2048", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a9fcc24622ec440bac6996072cceea0e.json"}}, {"family": "Pettersson", "given": "Susanne", "initials": "S", "orcid": "0000-0001-7432-2756", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/49b93682e1a4420ba9249f467e35b729.json"}}], "type": "journal article", "published": "2021-05-00", "journal": {"title": "Lupus Sci Med", "issn": "2053-8790", "volume": "8", "issue": "1", "issn-l": null}, "abstract": "Most indices of disease activity in SLE combine physicians' assessments and laboratory tests. However, there is also a need to capture patients' perspectives of disease activity. Consequently, we need new, preferably quick and easy instruments to collect this information, which can be very useful for online consultations and registry purposes. We compared patients' assessments of SLE disease impact/activity, as reported by a shorter version of the Quick Systemic Lupus Activity Questionnaire (Q-SLAQ), with physicians' assessments using SLE Activity Measure (SLAM) and SLE Disease Activity Index (SLEDAI-2K) and with the original Systemic Lupus Activity Questionnaire (SLAQ).\n\nPatients with SLE (n=115), with a disease duration of 15 years (IQR 17), completed the Q-SLAQ prior to physicians' assessments by SLAM and SLEDAI-2K. A second set of patients (n=85) with similar characteristics filled out Q-SLAQ and SLAQ. Spearman's \u03c1 correlations were explored between patients' total Q-SLAQ and subscales (Symptom Score, Patient's Global Disease Activity) and physicians' SLAM and SLEDAI-2K, with and without laboratory items (SLAM-nolab and SLEDAI-2K-nolab) and SLAQ. Corresponding items in Q-SLAQ and SLAM were compared.\n\nCorrelations between patients' and physicians' assessments were higher for SLAM-nolab (total Q-SLAQ, \u03c1=0.71; Symptom Score, \u03c1=0.67; and Patient's Global Disease Activity, \u03c1=0.68) than for the original SLAM (total Q-SLAQ, \u03c1=0.53; Symptom Score, \u03c1=0.50; and Patient's Global Disease Activity, \u03c1=0.53). Regarding specific symptoms, fatigue (\u03c1=0.72) and alopecia (\u03c1=0.71) correlated best, while pulmonary/respiratory symptoms correlated least (\u03c1=0.19, p=0.039). Physicians assessment with SLEDAI-2K-nolab correlated weakly with patients' assessments (total Q-SLAQ, \u03c1=0.30; Symptom Score, \u03c1=0.30; and Patient's Global Disease Activity, \u03c1=0.36). Bivariate correlations between Q-SLAQ and SLAQ were good (\u03c1=0.82-0.96).\n\nQ-SLAQ and the original SLAQ performed equally well, demonstrating that the shorter Q-SLAQ can safely be used to monitor patients' perception of disease impact/activity. We also noted an intriguing discrepancy between physicians' and patients' evaluations of pulmonary/respiratory symptoms, which requires further investigations.", "doi": "10.1136/lupus-2020-000471", "pmid": "33972457", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8112425"}, {"db": "pii", "key": "8/1/e000471"}], "notes": [], "created": "2026-08-21T12:27:33.947Z", "modified": "2026-08-21T12:27:34.175Z"}, {"entity": "publication", "iuid": "6a9f77fa28684d3abf0118aa1d269abc", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/6a9f77fa28684d3abf0118aa1d269abc.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/6a9f77fa28684d3abf0118aa1d269abc"}}, "title": "Contributions of de novo variants to systemic lupus erythematosus.", "authors": [{"family": "Alml\u00f6f", "given": "Jonas Carlsson", "initials": "JC"}, {"family": "Nystedt", "given": "Sara", "initials": "S"}, {"family": "Mechtidou", "given": "Aikaterini", "initials": "A"}, {"family": "Leonard", "given": "Dag", "initials": "D"}, {"family": "Eloranta", "given": "Maija-Leena", "initials": "ML"}, {"family": "Grosso", "given": "Giorgia", "initials": "G"}, {"family": "Sj\u00f6wall", "given": "Christopher", "initials": "C", "orcid": "0000-0003-0900-2048", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a9fcc24622ec440bac6996072cceea0e.json"}}, {"family": "Bengtsson", "given": "Anders A", "initials": "AA"}, {"family": "J\u00f6nsen", "given": "Andreas", "initials": "A"}, {"family": "Gunnarsson", "given": "Iva", "initials": "I"}, {"family": "Svenungsson", "given": "Elisabet", "initials": "E"}, {"family": "R\u00f6nnblom", "given": "Lars", "initials": "L", "orcid": "0000-0001-9403-6503", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5f7ec7a7befd44cc988091ba0858d3c0.json"}}, {"family": "Sandling", "given": "Johanna K", "initials": "JK", "orcid": "0000-0003-1382-2321", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c5bbdb0cf40c48198ea04ede2fb33377.json"}}, {"family": "Syv\u00e4nen", "given": "Ann-Christine", "initials": "AC"}], "type": "journal article", "published": "2021-01-00", "journal": {"title": "Eur. J. Hum. Genet.", "issn": "1476-5438", "volume": "29", "issue": "1", "pages": "184-193", "issn-l": "1018-4813"}, "abstract": "By performing whole-genome sequencing in a Swedish cohort of 71 parent-offspring trios, in which the child in each family is affected by systemic lupus erythematosus (SLE, OMIM 152700), we investigated the contribution of de novo variants to risk of SLE. We found de novo single nucleotide variants (SNVs) to be significantly enriched in gene promoters in SLE patients compared with healthy controls at a level corresponding to 26 de novo promoter SNVs more in each patient than expected. We identified 12 de novo SNVs in promoter regions of genes that have been previously implicated in SLE, or that have functions that could be of relevance to SLE. Furthermore, we detected three missense de novo SNVs, five de novo insertion-deletions, and three de novo structural variants with potential to affect the expression of genes that are relevant for SLE. Based on enrichment analysis, disease-affecting de novo SNVs are expected to occur in one-third of SLE patients. This study shows that de novo variants in promoters commonly contribute to the genetic risk of SLE. The fact that de novo SNVs in SLE were enriched to promoter regions highlights the importance of using whole-genome sequencing for identification of de novo variants.", "doi": "10.1038/s41431-020-0698-5", "pmid": "32724065", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7852530"}, {"db": "pii", "key": "10.1038/s41431-020-0698-5"}], "notes": [], "created": "2026-08-21T11:47:58.766Z", "modified": "2026-08-21T11:47:58.955Z"}, {"entity": "publication", "iuid": "6538516184c34387bbd73b670be1f443", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/6538516184c34387bbd73b670be1f443.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/6538516184c34387bbd73b670be1f443"}}, "title": "NCF1-339 polymorphism is associated with altered formation of neutrophil extracellular traps, high serum interferon activity and antiphospholipid syndrome in systemic lupus erythematosus.", "authors": [{"family": "Linge", "given": "Petrus", "initials": "P", "orcid": "0000-0001-8906-2715", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c83a8ed6a2ac4711b0465b6dfbcabcc9.json"}}, {"family": "Arve", "given": "Sabine", "initials": "S", "orcid": "0000-0002-3347-5550", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5d063b42c4af42efbba4afb26b9a9fd3.json"}}, {"family": "Olsson", "given": "Lina M", "initials": "LM"}, {"family": "Leonard", "given": "Dag", "initials": "D"}, {"family": "Sj\u00f6wall", "given": "Christopher", "initials": "C", "orcid": "0000-0003-0900-2048", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a9fcc24622ec440bac6996072cceea0e.json"}}, {"family": "Frodlund", "given": "Martina", "initials": "M"}, {"family": "Gunnarsson", "given": "Iva", "initials": "I"}, {"family": "Svenungsson", "given": "Elisabet", "initials": "E", "orcid": "0000-0003-3396-3244", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2c44ebd4f33e46a1862877bce94be05b.json"}}, {"family": "Tyd\u00e9n", "given": "Helena", "initials": "H"}, {"family": "J\u00f6nsen", "given": "Andreas", "initials": "A"}, {"family": "Kahn", "given": "Robin", "initials": "R", "orcid": "0000-0002-3167-1179", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/17ecdb4f26a648ba9ee080bb72a86c82.json"}}, {"family": "Johansson", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "R\u00f6nnblom", "given": "Lars", "initials": "L"}, {"family": "Holmdahl", "given": "Rikard", "initials": "R", "orcid": "0000-0002-4969-2576", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/aef6264212044f46a28c24d5fc147438.json"}}, {"family": "Bengtsson", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2020-02-00", "journal": {"title": "Ann. Rheum. Dis.", "issn": "1468-2060", "volume": "79", "issue": "2", "pages": "254-261", "issn-l": "0003-4967"}, "abstract": "\u200bOBJECTIVES: A single nucleotide polymorphism in the NCF1 gene (NCF1-339, rs201802880), encoding NADPH oxidase type II subunit NCF1/p47phox, reducing production of reactive oxygen species (ROS) is strongly associated with the development of systemic lupus erythematosus (SLE). This study aimed at characterising NCF1-339 effects on neutrophil extracellular trap (NET) formation, type I interferon activity and antibody profile in patients with SLE. \u200bMETHODS: Neutrophil NET-release pathways (n=31), serum interferon (n=141) and finally antibody profiles (n=305) were investigated in SLE subjects from Lund, genotyped for NCF1-339. Then, 1087 SLE subjects from the rheumatology departments of four Swedish SLE centres, genotyped for NCF1-339, were clinically characterised to validate these findings. \u200bRESULTS: Compared with patients with normal-ROS NCF1-339 genotypes, neutrophils from patients with SLE with low-ROS NCF1-339 genotypes displayed impaired NET formation (p<0.01) and increased dependence on mitochondrial ROS (p<0.05). Low-ROS patients also had increased frequency of high serum interferon activity (80% vs 21.4%, p<0.05) and positivity for anti-\u03b22 glycoprotein I (p<0.01) and anticardiolipin antibodies (p<0.05) but were not associated with other antibodies. We confirmed an over-representation of having any antiphospholipid antibody, OR 1.40 (95% CI 1.01 to 1.95), anti-\u03b22 glycoprotein I, OR 1.82 (95% CI 1.02 to 3.24) and the antiphospholipid syndrome (APS), OR 1.74 (95% CI 1.19 to 2.55) in all four cohorts (n=1087). \u200bCONCLUSIONS: The NCF1-339 SNP mediated decreased NADPH oxidase function, is associated with high interferon activity and impaired formation of NETs in SLE, allowing dependence on mitochondrial ROS. Unexpectedly, we revealed a striking connection between the ROS deficient NCF1-339 genotypes and the presence of phospholipid antibodies and APS.", "doi": "10.1136/annrheumdis-2019-215820", "pmid": "31704719", "labels": [], "xrefs": [{"db": "pii", "key": "S0003-4967(24)01509-7"}], "notes": [], "created": "2026-08-21T12:25:45.018Z", "modified": "2026-08-21T12:25:45.336Z"}, {"entity": "publication", "iuid": "191800c9d869443d9998693fbc3506f9", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/191800c9d869443d9998693fbc3506f9.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/191800c9d869443d9998693fbc3506f9"}}, "title": "The majority of Swedish systemic lupus erythematosus patients are still affected by irreversible organ impairment: factors related to damage accrual in two regional cohorts.", "authors": [{"family": "Frodlund", "given": "M", "initials": "M", "orcid": "0000-0001-7522-5069", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9c2a2a76eb194d7aa2a9fe54690318d0.json"}}, {"family": "Reid", "given": "S", "initials": "S"}, {"family": "Wetter\u00f6", "given": "J", "initials": "J", "orcid": "0000-0002-6916-5490", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b0b6222e1f124564a5a5a0ec7d63a571.json"}}, {"family": "Dahlstr\u00f6m", "given": "\u00d6", "initials": "\u00d6"}, {"family": "Sj\u00f6wall", "given": "C", "initials": "C", "orcid": "0000-0003-0900-2048", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a9fcc24622ec440bac6996072cceea0e.json"}}, {"family": "Leonard", "given": "D", "initials": "D"}], "type": "journal article", "published": "2019-09-00", "journal": {"title": "Lupus", "issn": "1477-0962", "volume": "28", "issue": "10", "pages": "1261-1272", "issn-l": "0961-2033"}, "abstract": "Although the survival of patients with systemic lupus erythematosus (SLE) has improved, irreversible organ damage remains a critical concern. We aimed to characterize damage accrual and its clinical associations and causes of death in Swedish patients.\n\nAccumulation of damage was evaluated in 543 consecutively recruited and well-characterized cases during 1998-2017. The Systemic Lupus International Collaborating Clinics (SLICC)/American College of Rheumatology damage index (SDI) was used to estimate damage.\n\nOrgan damage (SDI \u2265 1) was observed in 59%, and extensive damage (SDI \u2265 3) in 25% of cases. SDI \u2265 1 was significantly associated with higher age at onset, SLE duration, the number of fulfilled SLICC criteria, neurologic disorder, antiphospholipid antibody syndrome (APS), hypertension, hyperlipidemia, depression and secondary Sj\u00f6gren's syndrome (SS). In addition, SDI \u2265 3 was associated with serositis, renal and haematological disorders and interstitial lung disease. A multiple regression model identified not only well-known risk factors like APS, antihypertensives and corticosteroids, but pericarditis, haemolytic anaemia, lymphopenia and myositis as being linked to SDI. Malignancy, infection and cardiovascular disease were the leading causes of death.\n\nAfter a mean SLE duration of 17 years, the majority of today's Swedish SLE patients have accrued damage. We confirm previous observations and report some novel findings regarding disease phenotypes and damage accrual.", "doi": "10.1177/0961203319860198", "pmid": "31296137", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6710616"}], "notes": [], "created": "2026-08-21T12:32:03.646Z", "modified": "2026-08-21T12:32:03.786Z"}]}