{"entity": "researcher", "timestamp": "2026-09-24T00:35:33.470Z", "family": "Mangelsdorf", "given": "David J", "initials": "DJ", "orcid": "0000-0002-4355-0796", "affiliations": ["Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390; gunter.schumann@kcl.ac.uk davo.mango@utsouthwestern.edu p.elliott@imperial.ac.uk.", "Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/a8c0b8d4363a45ca8500cdd6a8872344.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/a8c0b8d4363a45ca8500cdd6a8872344"}}, "publications": [{"entity": "publication", "iuid": "da2a397ecd4e419eb6bd0843ae0bcbb4", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/da2a397ecd4e419eb6bd0843ae0bcbb4.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/da2a397ecd4e419eb6bd0843ae0bcbb4"}}, "title": "KLB is associated with alcohol drinking, and its gene product \u03b2-Klotho is necessary for FGF21 regulation of alcohol preference.", "authors": [{"family": "Schumann", "given": "Gunter", "initials": "G"}, {"family": "Liu", "given": "Chunyu", "initials": "C"}, {"family": "O'Reilly", "given": "Paul", "initials": "P"}, {"family": "Gao", "given": "He", "initials": "H"}, {"family": "Song", "given": "Parkyong", "initials": "P"}, {"family": "Xu", "given": "Bing", "initials": "B"}, {"family": "Ruggeri", "given": "Barbara", "initials": "B"}, {"family": "Amin", "given": "Najaf", "initials": "N"}, {"family": "Jia", "given": "Tianye", "initials": "T"}, {"family": "Preis", "given": "Sarah", "initials": "S"}, {"family": "Segura Lepe", "given": "Marcelo", "initials": "M"}, {"family": "Akira", "given": "Shizuo", "initials": "S"}, {"family": "Barbieri", "given": "Caterina", "initials": "C"}, 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"initials": "A"}, {"family": "Penninx", "given": "Brenda", "initials": "B"}, {"family": "Pirastu", "given": "Nicola", "initials": "N"}, {"family": "Psaty", "given": "Bruce", "initials": "B"}, {"family": "Raitakari", "given": "Olli", "initials": "O"}, {"family": "Ridker", "given": "Paul", "initials": "P"}, {"family": "Rose", "given": "Richard", "initials": "R"}, {"family": "Rotter", "given": "Jerome I", "initials": "JI"}, {"family": "Samani", "given": "Nilesh J", "initials": "NJ"}, {"family": "Schmidt", "given": "Helena", "initials": "H"}, {"family": "Spector", "given": "Tim D", "initials": "TD"}, {"family": "Stott", "given": "David", "initials": "D"}, {"family": "Strachan", "given": "David", "initials": "D"}, {"family": "Tzoulaki", "given": "Ioanna", "initials": "I"}, {"family": "van der Harst", "given": "Pim", "initials": "P"}, {"family": "van Duijn", "given": "Cornelia M", "initials": "CM"}, {"family": "Marques-Vidal", "given": "Pedro", "initials": "P"}, {"family": "Vollenweider", "given": "Peter", "initials": "P"}, {"family": "Wareham", "given": "Nicholas J", "initials": "NJ"}, {"family": "Whitfield", "given": "John B", "initials": "JB"}, {"family": "Wilson", "given": "James", "initials": "J"}, {"family": "Wolffenbuttel", "given": "Bruce", "initials": "B"}, {"family": "Bakalkin", "given": "Georgy", "initials": "G"}, {"family": "Evangelou", "given": "Evangelos", "initials": "E"}, {"family": "Liu", "given": "Yun", "initials": "Y"}, {"family": "Rice", "given": "Kenneth M", "initials": "KM"}, {"family": "Desrivi\u00e8res", "given": "Sylvane", "initials": "S"}, {"family": "Kliewer", "given": "Steven A", "initials": "SA"}, {"family": "Mangelsdorf", "given": "David J", "initials": "DJ", "orcid": "0000-0002-4355-0796", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a8c0b8d4363a45ca8500cdd6a8872344.json"}}, {"family": "M\u00fcller", "given": "Christian P", "initials": "CP"}, {"family": "Levy", "given": "Daniel", "initials": "D"}, {"family": "Elliott", "given": "Paul", "initials": "P"}], "type": "journal article", "published": "2016-12-13", "journal": {"title": "Proc. Natl. Acad. Sci. U.S.A.", "issn": "1091-6490", "volume": "113", "issue": "50", "pages": "14372-14377", "issn-l": "0027-8424"}, "abstract": "Excessive alcohol consumption is a major public health problem worldwide. Although drinking habits are known to be inherited, few genes have been identified that are robustly linked to alcohol drinking. We conducted a genome-wide association metaanalysis and replication study among >105,000 individuals of European ancestry and identified \u03b2-Klotho (KLB) as a locus associated with alcohol consumption (rs11940694; P = 9.2 \u00d7 10-12). \u03b2-Klotho is an obligate coreceptor for the hormone FGF21, which is secreted from the liver and implicated in macronutrient preference in humans. We show that brain-specific \u03b2-Klotho KO mice have an increased alcohol preference and that FGF21 inhibits alcohol drinking by acting on the brain. These data suggest that a liver-brain endocrine axis may play an important role in the regulation of alcohol drinking behavior and provide a unique pharmacologic target for reducing alcohol consumption.", "doi": "10.1073/pnas.1611243113", "pmid": "27911795", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC5167198"}, {"db": "pii", "key": "1611243113"}], "notes": [], "created": "2018-12-05T09:33:49.840Z", "modified": "2026-09-23T06:40:45.645Z"}]}