{"entity": "researcher", "timestamp": "2026-09-24T20:34:27.305Z", "family": "Leidel", "given": "Sebastian A", "initials": "SA", "orcid": "0000-0002-0523-6325", "affiliations": ["Max Planck Institute for Molecular Biomedicine, M\u00fcnster, Germany.", "Cells-in-Motion Cluster of Excellence, University of M\u00fcnster, M\u00fcnster, Germany.", "Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/a783a69dc3164efbb16cffa8db91e241.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/a783a69dc3164efbb16cffa8db91e241"}}, "publications": [{"entity": "publication", "iuid": "24238b8a934a49d58f14b161f0d6d727", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/24238b8a934a49d58f14b161f0d6d727.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/24238b8a934a49d58f14b161f0d6d727"}}, "title": "Translational offsetting as a mode of estrogen receptor \u03b1-dependent regulation of gene expression.", "authors": [{"family": "Lorent", "given": "Julie", "initials": "J"}, {"family": "Kusnadi", "given": "Eric P", "initials": "EP"}, {"family": "van Hoef", "given": "Vincent", "initials": "V"}, {"family": "Rebello", "given": "Richard J", "initials": "RJ"}, {"family": "Leibovitch", "given": "Matthew", "initials": "M"}, {"family": "Ristau", "given": "Johannes", "initials": "J"}, {"family": "Chen", "given": "Shan", "initials": "S"}, {"family": "Lawrence", "given": "Mitchell G", "initials": "MG"}, {"family": "Szkop", "given": "Krzysztof J", "initials": "KJ"}, {"family": "Samreen", "given": "Baila", "initials": "B"}, {"family": "Balanathan", "given": "Preetika", "initials": "P"}, {"family": "Rapino", "given": "Francesca", "initials": "F"}, {"family": "Close", "given": "Pierre", "initials": "P"}, {"family": "Bukczynska", "given": "Patricia", "initials": "P"}, {"family": "Scharmann", "given": "Karin", "initials": "K"}, {"family": "Takizawa", "given": "Itsuhiro", "initials": "I"}, {"family": "Risbridger", "given": "Gail P", "initials": "GP"}, {"family": "Selth", "given": "Luke A", "initials": "LA"}, {"family": "Leidel", "given": "Sebastian A", "initials": "SA", "orcid": "0000-0002-0523-6325", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a783a69dc3164efbb16cffa8db91e241.json"}}, {"family": "Lin", "given": "Qishan", "initials": "Q"}, {"family": "Topisirovic", "given": "Ivan", "initials": "I", "orcid": "0000-0002-5510-9762", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1bca1813f34c4864940ac6593044a9cc.json"}}, {"family": "Larsson", "given": "Ola", "initials": "O", "orcid": "0000-0003-1412-1308", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3f81c6cbbe564d38bc78d1af5153d804.json"}}, {"family": "Furic", "given": "Luc", "initials": "L", "orcid": "0000-0002-1893-9812", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6d3fff390b43428392318962213bb59b.json"}}], "type": "journal article", "published": "2019-12-02", "journal": {"title": "EMBO J.", "issn": "1460-2075", "volume": "38", "issue": "23", "pages": "e101323", "issn-l": "0261-4189"}, "abstract": "Estrogen receptor alpha (ER\u03b1) activity is associated with increased cancer cell proliferation. Studies aiming to understand the impact of ER\u03b1 on cancer-associated phenotypes have largely been limited to its transcriptional activity. Herein, we demonstrate that ER\u03b1 coordinates its transcriptional output with selective modulation of mRNA translation. Importantly, translational perturbations caused by depletion of ER\u03b1 largely manifest as \"translational offsetting\" of the transcriptome, whereby amounts of translated mRNAs and corresponding protein levels are maintained constant despite changes in mRNA abundance. Transcripts whose levels, but not polysome association, are reduced following ER\u03b1 depletion lack features which limit translation efficiency including structured 5'UTRs and miRNA target sites. In contrast, mRNAs induced upon ER\u03b1 depletion whose polysome association remains unaltered are enriched in codons requiring U34-modified tRNAs for efficient decoding. Consistently, ER\u03b1 regulates levels of U34-modifying enzymes and thereby controls levels of U34-modified tRNAs. These findings unravel a hitherto unprecedented mechanism of ER\u03b1-dependent orchestration of transcriptional and translational programs that may be a pervasive mechanism of proteome maintenance in hormone-dependent cancers.", "doi": "10.15252/embj.2018101323", "pmid": "31556460", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6885737"}, {"db": "GEO", "key": "GSE120917"}, {"db": "GEO", "key": "GSE107590"}, {"db": "GEO", "key": "GSE117569"}, {"db": "GEO", "key": "GSE35428"}, {"db": "GEO", "key": "GSE104399"}, {"db": "GEO", "key": "GSE72249"}], "notes": [], "created": "2026-09-23T09:24:59.418Z", "modified": "2026-09-23T09:24:59.542Z"}]}