{"entity": "researcher", "timestamp": "2026-09-23T22:17:38.711Z", "family": "Kasper", "given": "Maria", "initials": "M", "orcid": "0000-0002-6117-2717", "affiliations": ["Department of Cell and Molecular Biology, Karolinska Institutet, 171 77, Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/a6accbbc62ab4b9eb2949d7c5d98c146.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/a6accbbc62ab4b9eb2949d7c5d98c146"}}, "publications": [{"entity": "publication", "iuid": "55a7b0bf4cb94d799662cb79f0cbfe84", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/55a7b0bf4cb94d799662cb79f0cbfe84.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/55a7b0bf4cb94d799662cb79f0cbfe84"}}, "title": "ARF suppression by MYC but not MYCN confers increased malignancy of aggressive pediatric brain tumors.", "authors": [{"family": "Mainwaring", "given": "Oliver J", "initials": "OJ", "orcid": "0000-0002-7973-9849", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/29515b9bedc74325aa50a0da62cd299a.json"}}, {"family": "Weishaupt", "given": "Holger", "initials": "H"}, {"family": "Zhao", "given": "Miao", "initials": "M", "orcid": "0000-0002-4895-1177", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/75b5d6dc5cde46b8aca859fb961bf1de.json"}}, {"family": "Ros\u00e9n", "given": "Gabriela", "initials": "G"}, {"family": "Borgenvik", "given": "Anna", "initials": "A"}, {"family": "Breinschmid", "given": "Laura", "initials": "L"}, {"family": "Verbaan", "given": "Annemieke D", "initials": "AD"}, {"family": "Richardson", "given": "Stacey", "initials": "S"}, {"family": "Thompson", "given": "Dean", "initials": "D"}, {"family": "Clifford", "given": "Steven C", "initials": "SC"}, {"family": "Hill", "given": "Rebecca M", "initials": "RM"}, {"family": "Annusver", "given": "Karl", "initials": "K", "orcid": "0000-0002-9515-7216", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/225d6f2d28a04cb1b47923316914bf0d.json"}}, {"family": "Sundstr\u00f6m", "given": "Anders", "initials": "A"}, {"family": "Holmberg", "given": "Karl O", "initials": "KO"}, {"family": "Kasper", "given": "Maria", "initials": "M", "orcid": "0000-0002-6117-2717", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a6accbbc62ab4b9eb2949d7c5d98c146.json"}}, {"family": "Hutter", "given": "Sonja", "initials": "S"}, {"family": "Swartling", "given": "Fredrik J", "initials": "FJ", "orcid": "0000-0002-8460-4367", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2e673fa8c86348fb8c1a2ae34ba7ba9a.json"}}], "type": "journal article", "published": "2023-03-03", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "14", "issue": "1", "pages": "1221", "issn-l": "2041-1723"}, "abstract": "Medulloblastoma, the most common malignant pediatric brain tumor, often harbors MYC amplifications. Compared to high-grade gliomas, MYC-amplified medulloblastomas often show increased photoreceptor activity and arise in the presence of a functional ARF/p53 suppressor pathway. Here, we generate an immunocompetent transgenic mouse model with regulatable MYC that develop clonal tumors that molecularly resemble photoreceptor-positive Group 3 medulloblastoma. Compared to MYCN-expressing brain tumors driven from the same promoter, pronounced ARF silencing is present in our MYC-expressing model and in human medulloblastoma. While partial Arf suppression causes increased malignancy in MYCN-expressing tumors, complete Arf depletion promotes photoreceptor-negative high-grade glioma formation. Computational models and clinical data further identify drugs targeting MYC-driven tumors with a suppressed but functional ARF pathway. We show that the HSP90 inhibitor, Onalespib, significantly targets MYC-driven but not MYCN-driven tumors in an ARF-dependent manner. The treatment increases cell death in synergy with cisplatin and demonstrates potential for targeting MYC-driven medulloblastoma.", "doi": "10.1038/s41467-023-36847-9", "pmid": "36869047", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9984535"}, {"db": "pii", "key": "10.1038/s41467-023-36847-9"}], "notes": [], "created": "2026-09-23T11:04:01.417Z", "modified": "2026-09-23T11:04:01.582Z"}, {"entity": "publication", "iuid": "9a12ebf1533741eda4c842bb3d25a6b0", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/9a12ebf1533741eda4c842bb3d25a6b0.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/9a12ebf1533741eda4c842bb3d25a6b0"}}, "title": "Molecular and spatial design of early skin development", "authors": [{"family": "Jacob", "given": "Tina", "initials": "T", "orcid": "0000-0002-7180-2698", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3b6f9f4167664fe08306f0d4473c3cb7.json"}}, {"family": "Annusver", "given": "Karl", "initials": "K", "orcid": "0000-0002-9515-7216", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/225d6f2d28a04cb1b47923316914bf0d.json"}}, {"family": "Czarnewski", "given": "Paulo", "initials": "P", "orcid": "0000-0001-8150-4021", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/501677a1262c438aa4077b205bb39a72.json"}}, {"family": "Dalessandri", "given": "Tim", "initials": "T", "orcid": "0000-0001-5690-295X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d1449df22ee24f2cbdb95148ed6f4a4f.json"}}, {"family": "Kastriti", "given": "Maria Eleni", "initials": "ME", "orcid": "0000-0002-0563-7399", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9eb7a38e5c5c43efa5deccc7c3a89698.json"}}, {"family": "Levron", "given": "Chiara Levra", "initials": "CL", "orcid": "0000-0003-1057-9792", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d1df5de0b0b34bfcb15f590c6c8b49d7.json"}}, {"family": "Mikkola", "given": "Marja L", "initials": "ML", "orcid": "0000-0002-9890-3835", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/eeeb12bfbfc047fe8928927e07574044.json"}}, {"family": "Rendl", "given": "Michael", "initials": "M", "orcid": "0000-0001-6326-620X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/66b1b1cc9fa349e990cdc37812588b15.json"}}, {"family": "Lichtenberger", "given": "Beate M", "initials": "BM", "orcid": "0000-0001-6882-0257", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/18ffad5ebeea43b7b713f8e8040e26b0.json"}}, {"family": "Donati", "given": "Giacomo", "initials": "G", "orcid": "0000-0002-0370-8288", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6f97a22e2d1b4b1da285e9749c8e635d.json"}}, {"family": "Bj\u00f6rklund", "given": "\u00c5sa", "initials": "\u00c5", "orcid": "0000-0003-2224-7090", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1cfd05eeb19640eea44f996699f998f0.json"}}, {"family": "Kasper", "given": "Maria", "initials": "M", "orcid": "0000-0002-6117-2717", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a6accbbc62ab4b9eb2949d7c5d98c146.json"}}], "type": "posted-content", "published": "2022-12-29", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2022.12.28.522081", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-09-23T14:21:16.960Z", "modified": "2026-09-23T14:21:17.347Z"}]}