{"entity": "researcher", "timestamp": "2026-08-20T21:44:18.782Z", "family": "Schelzig", "given": "Korbinian", "initials": "K", "orcid": "0009-0001-3791-0716", "affiliations": ["Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/a5ffa105eeea4750a28fd7b1f4b3e4de.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/a5ffa105eeea4750a28fd7b1f4b3e4de"}}, "publications": [{"entity": "publication", "iuid": "05055972eaff415c8f51b09d91d400fd", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/05055972eaff415c8f51b09d91d400fd.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/05055972eaff415c8f51b09d91d400fd"}}, "title": "The one-carbon metabolic enzyme MTHFD2 promotes resection and homologous recombination after ionizing radiation.", "authors": [{"family": "Marttila", "given": "Petra", "initials": "P", "orcid": "0000-0002-0115-8067", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4ed95784f80a45d9abb072fbb74fc225.json"}}, {"family": "Bonagas", "given": "Nadilly", "initials": "N"}, {"family": "Chalkiadaki", "given": "Christina", "initials": "C"}, {"family": "Stigsdotter", "given": "Hannah", "initials": "H"}, {"family": "Schelzig", "given": "Korbinian", "initials": "K", "orcid": "0009-0001-3791-0716", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a5ffa105eeea4750a28fd7b1f4b3e4de.json"}}, {"family": "Shen", "given": "Jianyu", "initials": "J"}, {"family": "Farhat", "given": "Crystal M", "initials": "CM"}, {"family": "Hondema", "given": "Amber", "initials": "A"}, {"family": "Albers", "given": "Julian", "initials": "J"}, {"family": "Wiita", "given": "Elis\u00e9e", "initials": "E"}, {"family": "Rasti", "given": "Azita", "initials": "A"}, {"family": "Warpman Berglund", "given": "Ulrika", "initials": "U"}, {"family": "Slipicevic", "given": "Ana", "initials": "A"}, {"family": "Mortusewicz", "given": "Oliver", "initials": "O", "orcid": "0000-0002-4290-4994", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6f546fe8f2c54824b942f7f88976e3bd.json"}}, {"family": "Helleday", "given": "Thomas", "initials": "T", "orcid": "0000-0002-7384-092X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/385586c159494955a9a72c3381e3ad47.json"}}], "type": "journal article", "published": "2024-09-00", "journal": {"title": "Mol Oncol", "issn": "1878-0261", "volume": "18", "issue": "9", "pages": "2179-2195", "issn-l": "1574-7891"}, "abstract": "The one-carbon metabolism enzyme bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 (MTHFD2) is among the most overexpressed proteins across tumors and is widely recognized as a promising anticancer target. While MTHFD2 is mainly described as a mitochondrial protein, a new nuclear function is emerging. Here, we observe that nuclear MTHFD2 protein levels and association with chromatin increase following ionizing radiation (IR) in an ataxia telangiectasia mutated (ATM)- and DNA-dependent protein kinase (DNA-PK)-dependent manner. Furthermore, repair of IR-induced DNA double-strand breaks (DSBs) is delayed upon MTHFD2 knockdown, suggesting a role for MTHFD2 in DSB repair. In support of this, we observe impaired recruitment of replication protein A (RPA), reduced resection, decreased IR-induced DNA repair protein RAD51 homolog 1 (RAD51) levels and impaired homologous recombination (HR) activity in MTHFD2-depleted cells following IR. In conclusion, we identify a key role for MTHFD2 in HR repair and describe an interdependency between MTHFD2 and HR proficiency that could potentially be exploited for cancer therapy.", "doi": "10.1002/1878-0261.13645", "pmid": "38533616", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11467796"}], "notes": [], "created": "2026-08-20T06:26:58.460Z", "modified": "2026-08-20T06:26:58.641Z"}]}