{"entity": "researcher", "timestamp": "2026-06-07T19:54:11.324Z", "family": "Carl\u00e9n", "given": "Marie", "initials": "M", "orcid": "0000-0003-1658-1631", "affiliations": ["Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden. marie.carlen@ki.se.", "Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden. marie.carlen@ki.se."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/a5bb1bfff3214cca8753a75f5a251b93.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/a5bb1bfff3214cca8753a75f5a251b93"}}, "publications": [{"entity": "publication", "iuid": "a8fa7a7e41e14c9f868233e3b29ce60c", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/a8fa7a7e41e14c9f868233e3b29ce60c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/a8fa7a7e41e14c9f868233e3b29ce60c"}}, "title": "Esr1+ hypothalamic-habenula neurons shape aversive states.", "authors": [{"family": "Calvigioni", "given": "Daniela", "initials": "D"}, {"family": "Fuzik", "given": "Janos", "initials": "J", "orcid": "0000-0002-5408-4882", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb41e780c4244ded84b6c6740d971efa.json"}}, {"family": "Le Merre", "given": "Pierre", "initials": "P", "orcid": "0000-0003-4205-7411", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3ebebeabbd3a4bc89ea05d00cc47013a.json"}}, {"family": "Slashcheva", "given": "Marina", "initials": "M"}, {"family": "Jung", "given": "Felix", "initials": "F", "orcid": "0000-0002-7565-977X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/482ed1ec940c4b09aaf24e71403ac324.json"}}, {"family": "Ortiz", "given": "Cantin", "initials": "C"}, {"family": "Lentini", "given": "Antonio", "initials": "A", "orcid": "0000-0003-1239-5495", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c5042d3005814ad0a2d1eaeee5d2de3b.json"}}, {"family": "Csillag", "given": "Veronika", "initials": "V"}, {"family": "Graziano", "given": "Marta", "initials": "M"}, {"family": "Nikolakopoulou", "given": "Ifigeneia", "initials": "I"}, {"family": "Weglage", "given": "Moritz", "initials": "M", "orcid": "0000-0002-9173-7459", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f0e6c7066d05464aa7270b87f9a08f51.json"}}, {"family": "Lazaridis", "given": "Iakovos", "initials": "I", "orcid": "0000-0002-4578-2347", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a5db088903a0452181c145009d6eace8.json"}}, {"family": "Kim", "given": "Hoseok", "initials": "H"}, {"family": "Lenzi", "given": "Irene", "initials": "I", "orcid": "0000-0002-9229-7301", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9ce77429076541e98927c8000ff1d2ae.json"}}, {"family": "Park", "given": "Hyunsoo", "initials": "H", "orcid": "0000-0001-5754-9617", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/216293b628d44f22a52c691d888adfd3.json"}}, {"family": "Reinius", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0002-7021-5248", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a7c1abacc8d446bf8855254246b8d899.json"}}, {"family": "Carl\u00e9n", "given": "Marie", "initials": "M", "orcid": "0000-0003-1658-1631", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a5bb1bfff3214cca8753a75f5a251b93.json"}}, {"family": "Meletis", "given": "Konstantinos", "initials": "K", "orcid": "0000-0001-5665-4781", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/314d93feac4048799b81ca9cb04fc078.json"}}], "type": "journal article", "published": "2023-07-00", "journal": {"title": "Nat. Neurosci.", "issn": "1546-1726", "volume": "26", "issue": "7", "pages": "1245-1255", "issn-l": "1097-6256"}, "abstract": "Excitatory projections from the lateral hypothalamic area (LHA) to the lateral habenula (LHb) drive aversive responses. We used patch-sequencing (Patch-seq) guided multimodal classification to define the structural and functional heterogeneity of the LHA-LHb pathway. Our classification identified six glutamatergic neuron types with unique electrophysiological properties, molecular profiles and projection patterns. We found that genetically defined LHA-LHb neurons signal distinct aspects of emotional or naturalistic behaviors, such as estrogen receptor 1-expressing (Esr1+) LHA-LHb neurons induce aversion, whereas neuropeptide Y-expressing (Npy+) LHA-LHb neurons control rearing behavior. Repeated optogenetic drive of Esr1+ LHA-LHb neurons induces a behaviorally persistent aversive state, and large-scale recordings showed a region-specific neural representation of the aversive signals in the prelimbic region of the prefrontal cortex. We further found that exposure to unpredictable mild shocks induced a sex-specific sensitivity to develop a stress state in female mice, which was associated with a specific shift in the intrinsic properties of bursting-type Esr1+ LHA-LHb neurons. In summary, we describe the diversity of LHA-LHb neuron types and provide evidence for the role of Esr1+ neurons in aversion and sexually dimorphic stress sensitivity.", "doi": "10.1038/s41593-023-01367-8", "pmid": "37349481", "labels": {"Antonio Lentini": null, "DDLS Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC10322719"}, {"db": "pii", "key": "10.1038/s41593-023-01367-8"}], "notes": [], "created": "2025-03-28T07:09:46.854Z", "modified": "2025-03-28T07:09:47.130Z"}, {"entity": "publication", "iuid": "3fb34aa25ef941b8ab69d0b2a4f89a83", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/3fb34aa25ef941b8ab69d0b2a4f89a83.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/3fb34aa25ef941b8ab69d0b2a4f89a83"}}, "title": "A whole-brain atlas of monosynaptic input targeting four different cell types in the medial prefrontal cortex of the mouse.", "authors": [{"family": "\u00c4hrlund-Richter", "given": "Sofie", "initials": "S", "orcid": "0000-0002-7845-7831", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fe6a6174a14c425bac84b597cf420a0f.json"}}, {"family": "Xuan", "given": "Yang", "initials": "Y", "orcid": "0000-0003-0497-7137", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ae7a8f41efb949c187488f6dc0f505ae.json"}}, {"family": "van Lunteren", "given": "Josina Anna", "initials": "JA"}, {"family": "Kim", "given": "Hoseok", "initials": "H"}, {"family": "Ortiz", "given": "Cantin", "initials": "C", "orcid": "0000-0001-9564-0059", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d0cfad4461f843c4b1671515cfc6beac.json"}}, {"family": "Pollak Dorocic", "given": "Iskra", "initials": "I", "orcid": "0000-0002-6391-5377", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/36e47528fef34ecb9e8e195844ebc94e.json"}}, {"family": "Meletis", "given": "Konstantinos", "initials": "K", "orcid": "0000-0001-5665-4781", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/314d93feac4048799b81ca9cb04fc078.json"}}, {"family": "Carl\u00e9n", "given": "Marie", "initials": "M", "orcid": "0000-0003-1658-1631", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a5bb1bfff3214cca8753a75f5a251b93.json"}}], "type": "journal article", "published": "2019-04-00", "journal": {"title": "Nat. Neurosci.", "issn": "1546-1726", "volume": "22", "issue": "4", "pages": "657-668", "issn-l": "1097-6256"}, "abstract": "The local and long-range connectivity of cortical neurons are considered instrumental to the functional repertoire of the cortical region in which they reside. In cortical networks, distinct cell types build local circuit structures enabling computational operations. Computations in the medial prefrontal cortex (mPFC) are thought to be central to cognitive operation, including decision-making and memory. We used a retrograde trans-synaptic rabies virus system to generate brain-wide maps of the input to excitatory neurons as well as three inhibitory interneuron subtypes in the mPFC. On the global scale the input patterns were found to be mainly cell type independent, with quantitative differences in key brain regions, including the basal forebrain. Mapping of the local mPFC network revealed high connectivity between the different subtypes of interneurons. The connectivity mapping gives insight into the information that the mPFC processes and the structural architecture underlying the mPFC's unique functions.", "doi": "10.1038/s41593-019-0354-y", "pmid": "30886408", "labels": {"Iskra Pollak Dorocic": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41593-019-0354-y"}], "notes": [], "created": "2021-12-13T14:32:49.142Z", "modified": "2022-11-07T11:32:58.000Z"}]}