{"entity": "researcher", "timestamp": "2026-08-22T07:49:12.277Z", "family": "Schembri", "given": "Luke S", "initials": "LS", "orcid": "0000-0001-5588-1077", "affiliations": ["Department of Medicinal Chemistry, Uppsala University, SE-75123 Uppsala, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/a58aaafb4b1f411fac8203a2213c398f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/a58aaafb4b1f411fac8203a2213c398f"}}, "publications": [{"entity": "publication", "iuid": "606c029c07de4107896beac5055fd3b0", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/606c029c07de4107896beac5055fd3b0.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/606c029c07de4107896beac5055fd3b0"}}, "title": "Region-Specific and Age-Dependent Multitarget Effects of Acetylcholinesterase Inhibitor Tacrine on Comprehensive Neurotransmitter Systems.", "authors": [{"family": "Fridjonsdottir", "given": "Elva", "initials": "E"}, {"family": "Vallianatou", "given": "Theodosia", "initials": "T", "orcid": "0000-0002-1477-7756", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4374524ab2c14bd9ae46f904144dea63.json"}}, {"family": "Mantas", "given": "Ioannis", "initials": "I"}, {"family": "Shariatgorji", "given": "Reza", "initials": "R", "orcid": "0000-0001-9484-0921", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/76faa76e9dc445a3bbb1f470e9d33a23.json"}}, {"family": "Nilsson", "given": "Anna", "initials": "A"}, {"family": "Schembri", "given": "Luke S", "initials": "LS", "orcid": "0000-0001-5588-1077", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a58aaafb4b1f411fac8203a2213c398f.json"}}, {"family": "Odell", "given": "Luke R", "initials": "LR", "orcid": "0000-0001-7658-5103", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/49395660c6af4fce9ad0f7f8fc793744.json"}}, {"family": "Svenningsson", "given": "Per", "initials": "P"}, {"family": "Andr\u00e9n", "given": "Per E", "initials": "PE", "orcid": "0000-0002-4062-7743", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f1dd27e8b238475383983480e10099f6.json"}}], "type": "journal article", "published": "2022-01-21", "journal": {"title": "ACS chemical biology", "issn": "1554-8937", "volume": "17", "issue": "1", "pages": "147-158", "issn-l": "1554-8929"}, "abstract": "Regional brain distribution and metabolism of neurotransmitters and their response to drug treatment are fundamentally important for understanding the central effects of neuroactive substances. We used matrix-assisted laser desorption/ionization mass spectrometry imaging in combination with multivariate analysis to visualize in anatomical detail metabolic effects of aging and tacrine-mediated acetylcholinesterase inhibition on comprehensive neurotransmitter systems in multiple mouse brain regions of 12-week-old and 14-month-old mice. We detected age-related increases in 3,4-dihydroxyphenylacetaldehyde and histamine, indicating oxidative stress and aging deficits in astrocytes. Tacrine had a significant impact on the metabolism of neurotransmitters in both age groups; predominantly, there was an increased norepinephrine turnover throughout the brain and decreased 3-methoxy tyramine, a marker for dopamine release, in the striatum. The striatal levels of histamine were only elevated after tacrine administration in the older animals. Our results demonstrated that tacrine is a multitarget and region-specific neuroactive agent, inducing age-specific responses. Although well-studied, the complete mechanisms of the action of tacrine are not fully understood, and the current findings reveal features that may help explain its treatment-related effectiveness and central side effects.", "doi": "10.1021/acschembio.1c00803", "pmid": "34932310", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8787750"}], "notes": [], "created": "2026-08-21T11:35:23.371Z", "modified": "2026-08-21T11:35:23.484Z"}]}