{"entity": "researcher", "timestamp": "2026-08-22T06:58:06.293Z", "family": "Hu", "given": "Kejia", "initials": "K", "orcid": "0000-0001-6680-8107", "affiliations": ["Unit of Integrative Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/a3db50670ad8437f92e155073db5d667.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/a3db50670ad8437f92e155073db5d667"}}, "publications": [{"entity": "publication", "iuid": "bf7742a629e94fa2bc314fa79f7a3262", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/bf7742a629e94fa2bc314fa79f7a3262.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/bf7742a629e94fa2bc314fa79f7a3262"}}, "title": "Use of Antibiotics and Risk of Psychiatric Disorders in Newly Diagnosed Cancer Patients: A Population-Based Cohort Study in Sweden.", "authors": [{"family": "Hu", "given": "Kejia", "initials": "K", "orcid": "0000-0001-6680-8107", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a3db50670ad8437f92e155073db5d667.json"}}, {"family": "Smedby", "given": "Karin E", "initials": "KE"}, {"family": "Sj\u00f6lander", "given": "Arvid", "initials": "A"}, {"family": "Montgomery", "given": "Scott", "initials": "S", "orcid": "0000-0001-6328-5494", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/558159f8c8934d25b30effc337433350.json"}}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur", "initials": "U", "orcid": "0000-0001-5382-946X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/16dcb423ea4947bc9bfaf3cd91a7e769.json"}}, {"family": "Engstrand", "given": "Lars", "initials": "L", "orcid": "0000-0002-7713-2373", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/02d8684df81e42169e613de803446fbf.json"}}, {"family": "Fang", "given": "Fang", "initials": "F", "orcid": "0000-0002-3310-6456", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c65cfa2c711f41428a39a9cdac12b2db.json"}}, {"family": "Fall", "given": "Katja", "initials": "K", "orcid": "0000-0002-3649-2639", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/71681e4b08b94f4392ef89dba1eca16e.json"}}], "type": "journal article", "published": "2022-03-01", "journal": {"title": "Cancer Epidemiol Biomarkers Prev", "issn": "1538-7755", "volume": "31", "issue": "3", "pages": "528-535", "issn-l": null}, "abstract": "Antibiotic-induced dysbiosis is associated with an increased risk of depression and anxiety in the general population. A diagnosis of cancer is associated with an immediately and dramatically elevated risk of psychiatric disorders, but the potential influence of prediagnostic antibiotic-induced dysbiosis is unknown.\n\nBased on a national cohort of cancer patients in Sweden, we included 309,419 patients who were diagnosed with a first primary malignancy between July 2006 and December 2013. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) of first-onset psychosis, depression, anxiety, or stress-related disorders during the first year after cancer diagnosis for antibiotic use during the year before cancer diagnosis.\n\nCompared with no antibiotic use, use of antibiotics was associated with a higher rate of the aforementioned psychiatric disorders (HR, 1.23; 95% CI, 1.16-1.30) after adjustment for sociodemographic factors, comorbidity, potential indications for antibiotics, and cancer stage and type. The magnitude of the association was higher for broad-spectrum antibiotics (HR, 1.27; 95% CI, 1.18-1.37), higher doses (HR, 1.32; 95% CI, 1.22-1.44), more frequent use (HR, 1.33; 95% CI, 1.21-1.46), and recent use (HR, 1.26; 95% CI, 1.17-1.35).\n\nUse of antibiotics, especially of broad-spectrum type, of high dose and frequency, with recent use, was associated with an aggravated risk of psychiatric disorders, compared with no antibiotic use.\n\nA better understanding of the microbiota-gut-brain axis may open up a wide avenue for the prevention and treatment of psychiatric disorders in cancer patients.", "doi": "10.1158/1055-9965.EPI-21-1095", "pmid": "35027429", "labels": [], "xrefs": [{"db": "pii", "key": "1055-9965.EPI-21-1095"}], "notes": [], "created": "2026-08-21T12:29:01.816Z", "modified": "2026-08-21T12:29:02.009Z"}]}