{"entity": "researcher", "timestamp": "2026-10-10T11:11:58.626Z", "family": "Cao", "given": "Yin", "initials": "Y", "orcid": "0000-0001-9835-7662", "affiliations": ["Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St Louis, MO.", "Alvin J. Siteman Cancer Center, Washington University School of Medicine, St Louis, MO."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/a34eb276a5514342adb104aa5df642c9.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/a34eb276a5514342adb104aa5df642c9"}}, "publications": [{"entity": "publication", "iuid": "4c01528e8841434099155d393ffd4cc3", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/4c01528e8841434099155d393ffd4cc3.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/4c01528e8841434099155d393ffd4cc3"}}, "title": "Ultraprocessed Food Consumption and Risk of Early-Onset Colorectal Cancer Precursors Among Women", "authors": [{"family": "Wang", "given": "Chen", "initials": "C", "orcid": "0000-0003-3936-4023", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cfac9dfcdfc04a88b002ffe4ee8a5bb4.json"}}, {"family": "Du", "given": "Mengxi", "initials": "M"}, {"family": "Kim", "given": "Hanseul", "initials": "H"}, {"family": "Nguyen", "given": "Long H", "initials": "LH"}, {"family": "Wang", "given": "Qiao Li", "initials": "QL", "orcid": "0000-0003-4152-7821", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/357edb3116b64ad5aa929dcb7d07a1be.json"}}, {"family": "Drew", "given": "David A", "initials": "DA"}, {"family": "Leeming", "given": "Emily R", "initials": "ER"}, {"family": "Khandpur", "given": "Neha", "initials": "N"}, {"family": "Sun", "given": "Qi", "initials": "Q", "orcid": "0000-0002-8480-1563", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4a65407257ac4518ac5cb19317ee3b32.json"}}, {"family": "Zong", "given": "Xiaoyu", "initials": "X", "orcid": "0000-0001-5646-710X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f1250f735b6b4cd2a6873a9208e862a8.json"}}, {"family": "Gweon", "given": "Tae Geun", "initials": "TG"}, {"family": "Ogino", "given": "Shuji", "initials": "S"}, {"family": "Ng", "given": "Kimmie", "initials": "K", "orcid": "0000-0003-0631-1494", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/00bc0d97cfc44e9398c9bf1db5783402.json"}}, {"family": "Berry", "given": "Sarah", "initials": "S"}, {"family": "Giovannucci", "given": "Edward L", "initials": "EL", "orcid": "0000-0002-6123-0219", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4958abe8f85b417cae3009a782e9f69d.json"}}, {"family": "Song", "given": "Mingyang", "initials": "M"}, {"family": "Cao", "given": "Yin", "initials": "Y", "orcid": "0000-0001-9835-7662", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a34eb276a5514342adb104aa5df642c9.json"}}, {"family": "Chan", "given": "Andrew T", "initials": "AT"}], "type": "journal-article", "published": "2026-01-01", "journal": {"title": "JAMA Oncol", "issn": "2374-2445", "issn-l": null, "volume": "12", "issue": "1", "pages": "49"}, "abstract": "Early-onset colorectal cancer (EOCRC) (diagnosed age <50 years) incidence is increasing globally, in parallel with increased consumption of ultraprocessed foods (UPFs). The role of UPFs in early-onset colorectal neoplasia remains underexplored.\n\nTo evaluate the association between UPF consumption and risk of EOCRC precursors.\n\nThis prospective cohort study included participants of the Nurses' Health Study II, an ongoing US prospective cohort of female registered nurses established in 1989. Participants were followed up from June 1, 1991, through June 1, 2015. Data were analyzed from October 2024 to July 2025. UPF intake, derived from food-frequency questionnaires administered every 4 years and classified using the Nova system, was modeled as quintiles of energy-adjusted servings per day. Of the nurses enrolled, those who had completed the baseline 1991 food-frequency questionnaire, undergone at least 1 lower endoscopy before age 50 years after baseline, had no history of cancer (except for nonmelanoma skin cancer) before endoscopy, and no colorectal polyp or inflammatory bowel disease were included.\n\nIncidence of EOCRC precursors, including conventional adenomas and serrated lesions, confirmed via medical records and pathology reports. Multivariable logistic regression models with generalized estimating equations for clustered data were used to estimate adjusted odds ratios (AORs) and 95% CIs, accounting for known and putative risk factors.\n\nAmong 29 105 female participants (mean [SD] age, 45.2 [4.5] years) over 24 years of follow-up, 1189 cases were documented of early-onset conventional adenomas and 1598 serrated lesions. UPFs provided 34.8% of total daily calories (median, 5.7 [IQR, 4.5-7.4] servings per day). Participants with higher UPF intake had an increased risk of early-onset conventional adenomas (highest vs lowest intake: AOR, 1.45; 95% CI, 1.19-1.77; overall P < .001) but not serrated lesions (AOR, 1.04; 95% CI, 0.89-1.22; P = .48 for trend). Findings were consistent after further adjustment for body mass index, type 2 diabetes, dietary factors (fiber, folate, calcium, and vitamin D), and Alternative Healthy Eating Index-2010 score.\n\nIn this study, higher UPF intake was associated with increased risk of early-onset colorectal conventional adenomas. These data highlight the important role of UPFs in early-onset colorectal tumorigenesis and support improving dietary quality as a strategy to mitigate the increasing burden of EOCRC.", "doi": "10.1001/jamaoncol.2025.4777", "pmid": "41231486", "labels": {"DDLS Fellow": null, "Qiaoli Wang": null}, "xrefs": [{"db": "pmc", "key": "PMC12616530"}, {"db": "pii", "key": "2841354"}], "notes": [], "created": "2025-11-28T12:26:13.403Z", "modified": "2026-07-12T12:43:02.057Z"}, {"entity": "publication", "iuid": "a43536e195f64a35a033e6e8d4d2e0a4", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/a43536e195f64a35a033e6e8d4d2e0a4.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/a43536e195f64a35a033e6e8d4d2e0a4"}}, "title": "Germline genetic variation impacts clonal hematopoiesis landscape and progression to malignancy.", "authors": [{"family": "Liu", "given": "Jie", "initials": "J", "orcid": "0000-0001-6365-1888", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ddad30666cdd405aa37bb60d42f29348.json"}}, {"family": "Tran", "given": "Duc", "initials": "D", "orcid": "0000-0003-2918-8601", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f911948879504edd8870280ef9293a1c.json"}}, {"family": "Xue", "given": "Liying", "initials": "L"}, {"family": "Wiley", "given": "Brian J", "initials": "BJ"}, {"family": "Vlasschaert", "given": "Caitlyn", "initials": "C"}, {"family": "Watson", "given": "Caroline J", "initials": "CJ", "orcid": "0000-0002-8351-268X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c61f7e01d88b48f29b0909570d2eec97.json"}}, {"family": "MacGregor", "given": "Hamish A J", "initials": "HAJ"}, {"family": "Zong", "given": "Xiaoyu", "initials": "X"}, {"family": "Chan", "given": "Irenaeus C C", "initials": "ICC"}, {"family": "Das", "given": "Indraniel", "initials": "I"}, {"family": "Uddin", "given": "Md Mesbah", "initials": "MM", "orcid": "0000-0003-1846-0411", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/42f1ac7010c34ba997a3fd9e56c6a56a.json"}}, {"family": "Niroula", "given": "Abhishek", "initials": "A", "orcid": "0000-0002-5904-0635", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/05df7afc7a494ba5af8a378e5ffa53f0.json"}}, {"family": "Griffin", "given": "Gabriel", "initials": "G", "orcid": "0000-0002-4042-6757", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f6153204e19d4660b640dc4467605973.json"}}, {"family": "Ebert", "given": "Benjamin L", "initials": "BL", "orcid": "0000-0003-0197-5451", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/56e4f1c53a4348e2b0ceb44a38850a17.json"}}, {"family": "Mack", "given": "Taralynn", "initials": "T", "orcid": "0000-0003-1043-2950", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b126c40c737b4b06a8702801ee227b04.json"}}, {"family": "Pershad", "given": "Yash", "initials": "Y", "orcid": "0000-0002-2282-1403", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ba3556fc94884dee9cc2bb4a79415631.json"}}, {"family": "Sharber", "given": "Brian", "initials": "B", "orcid": "0009-0005-9598-8211", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cbee42b03e8943e4b6ea4e5690b8dca0.json"}}, {"family": "Berger", "given": "Michael", "initials": "M", "orcid": "0000-0003-3882-5000", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/38cae43288b94d39a9261c1790cb51ea.json"}}, {"family": "Zehir", "given": "Ahmet", "initials": "A", "orcid": "0000-0001-5406-4104", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a0c0313e93434df3bdf14217e4b5aea2.json"}}, {"family": "Ptashkin", "given": "Ryan", "initials": "R"}, {"family": "Levine", "given": "Ross L", "initials": "RL", "orcid": "0000-0002-7884-1905", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/db32b99e8427494c93dbce3366801c54.json"}}, {"family": "Papaemmanuil", "given": "Elli", "initials": "E", "orcid": "0000-0003-1709-8983", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6ea61c4aa9324a398fffe747c0e7824d.json"}}, {"family": "Joseph", "given": "Vijai", "initials": "V", "orcid": "0000-0002-7933-151X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a056e9c694a14da8a883ac07a4c039c9.json"}}, {"family": "Gao", "given": "Teng", "initials": "T", "orcid": "0000-0002-0196-689X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/553d7ec1abd34703bb7145d35b484c29.json"}}, {"family": "Kemel", "given": "Yelena", "initials": "Y", "orcid": "0000-0002-5042-5651", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0cea60ee959b44c19549b815cb31a1eb.json"}}, {"family": "Mandelker", "given": "Diana", "initials": "D", "orcid": "0000-0003-4154-0567", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/03937c44ffc94ba79aa713ea4b93c6ee.json"}}, {"family": "Stopsack", "given": "Konrad H", "initials": "KH", "orcid": "0000-0002-0722-1311", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/120f5a25b7254b7f834cc9cebfa6c0d3.json"}}, {"family": "Pharoah", "given": "Paul D P", "initials": "PDP", "orcid": "0000-0001-8494-732X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/723de78b315e47bcb52e2c89a2d3918a.json"}}, {"family": "Mukherjee", "given": "Semanti", "initials": "S"}, {"family": "Ding", "given": "Li", "initials": "L", "orcid": "0000-0003-1517-2975", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/148794e8a0a84be98b9c47b5d1fa8b27.json"}}, {"family": "Cao", "given": "Yin", "initials": "Y", "orcid": "0000-0001-9835-7662", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a34eb276a5514342adb104aa5df642c9.json"}}, {"family": "Walter", "given": "Matthew J", "initials": "MJ", "orcid": "0000-0002-7753-1091", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/055099b1d98c4b43bf1163a4553c1f34.json"}}, {"family": "Blundell", "given": "Jamie R", "initials": "JR"}, {"family": "Chatterjee", "given": "Nilanjan", "initials": "N", "orcid": "0000-0002-9060-008X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4ec346fd556e40bda203b75825b4324b.json"}}, {"family": "Offit", "given": "Kenneth", "initials": "K"}, {"family": "Godley", "given": "Lucy A", "initials": "LA", "orcid": "0000-0003-1914-9158", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3364441e62b7475086fea2db834a3760.json"}}, {"family": "Link", "given": "Daniel C", "initials": "DC", "orcid": "0000-0002-3170-7581", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/48661b793e284fd480d5d070a0b9a7e5.json"}}, {"family": "Stadler", "given": "Zsofia K", "initials": "ZK", "orcid": "0000-0002-6985-2864", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/726b7892e14b40ba8a6569a9de8a39b1.json"}}, {"family": "Bick", "given": "Alexander G", "initials": "AG"}, {"family": "Natarajan", "given": "Pradeep", "initials": "P"}, {"family": "Bolton", "given": "Kelly L", "initials": "KL", "orcid": "0000-0001-6584-3357", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/74eb7c71cebc4e8c888ff2b7426b4438.json"}}], "type": "journal article", "published": "2025-08-00", "journal": {"title": "Nat. Genet.", "issn": "1546-1718", "volume": "57", "issue": "8", "pages": "1872-1880", "issn-l": "1061-4036"}, "abstract": "With age, clonal expansions occur pervasively across normal tissues yet only in rare instances lead to cancer, despite being driven by well-established cancer drivers. Characterization of the factors that influence clonal progression is needed to inform interventional approaches. Germline genetic variation influences cancer risk and shapes tumor mutational profile, but its influence on the mutational landscape of normal tissues is not well known. Here we studied the impact of germline genetic variation on clonal hematopoiesis (CH) in 731,835 individuals. We identified 22 new CH-predisposition genes, most of which predispose to CH driven by specific mutational events. CH-predisposition genes contribute to unique somatic landscapes, reflecting the influence of germline genetic backdrop on gene-specific CH fitness. Correspondingly, somatic-germline interactions influence the risk of CH progression to hematologic malignancies. These results demonstrate that germline genetic variation influences somatic evolution in the blood, findings that likely extend to other tissues.", "doi": "10.1038/s41588-025-02250-x", "pmid": "40664769", "labels": {"DDLS Fellow": "", "Abhishek Niroula": ""}, "xrefs": [{"db": "pmc", "key": "PMC12339400"}, {"db": "pii", "key": "10.1038/s41588-025-02250-x"}], "notes": [], "created": "2025-11-17T15:51:13.415Z", "modified": "2026-09-23T09:07:46.350Z"}, {"entity": "publication", "iuid": "367da52594d24257b0893c583572611c", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/367da52594d24257b0893c583572611c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/367da52594d24257b0893c583572611c"}}, "title": "Clonal Hematopoiesis and Risk of Incident Lung Cancer.", "authors": [{"family": "Tian", "given": "Ruiyi", "initials": "R", "orcid": "0000-0001-5024-6832", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1a2cc8a38bbe41649a441405def87345.json"}}, {"family": "Wiley", "given": "Brian", "initials": "B"}, {"family": "Liu", "given": "Jie", "initials": "J", "orcid": "0000-0001-6365-1888", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ddad30666cdd405aa37bb60d42f29348.json"}}, {"family": "Zong", "given": "Xiaoyu", "initials": "X", "orcid": "0000-0001-5646-710X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f1250f735b6b4cd2a6873a9208e862a8.json"}}, {"family": "Truong", "given": "Buu", "initials": "B", "orcid": "0000-0003-0043-0812", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/24e9ec70c1f74fdfa182de3d7d9e21fa.json"}}, {"family": "Zhao", "given": "Stephanie", "initials": "S", "orcid": "0000-0001-6637-1486", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e8551483c0f5406b864d2353e8978add.json"}}, {"family": "Uddin", "given": "Md Mesbah", "initials": "MM", "orcid": "0000-0003-1846-0411", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/42f1ac7010c34ba997a3fd9e56c6a56a.json"}}, {"family": "Niroula", "given": "Abhishek", "initials": "A", "orcid": "0000-0002-5904-0635", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/05df7afc7a494ba5af8a378e5ffa53f0.json"}}, {"family": "Miller", "given": "Christopher A", "initials": "CA", "orcid": "0000-0003-4266-6700", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/80d153aa89554327b42354faae946064.json"}}, {"family": "Mukherjee", "given": "Semanti", "initials": "S", "orcid": "0000-0002-1843-9359", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7fe7a9badb944aa5998031b33a6d43cc.json"}}, {"family": "Heiden", "given": "Brendan T", "initials": "BT", "orcid": "0000-0002-0116-7377", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9fa032b03f8b4b9cab62d43a2d4fc7ac.json"}}, {"family": "Luo", "given": "Jingqin", "initials": "J", "orcid": "0000-0003-2759-3072", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/767ef98656bb42149d14aebb4618059e.json"}}, {"family": "Puri", "given": "Varun", "initials": "V"}, {"family": "Kozower", "given": "Benjamin D", "initials": "BD"}, {"family": "Walter", "given": "Matthew J", "initials": "MJ", "orcid": "0000-0002-7753-1091", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/055099b1d98c4b43bf1163a4553c1f34.json"}}, {"family": "Ding", "given": "Li", "initials": "L"}, {"family": "Link", "given": "Daniel C", "initials": "DC"}, {"family": "Amos", "given": "Christopher I", "initials": "CI", "orcid": "0000-0002-8540-7023", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dc5439b0cf4b4619a56d6d361fc12210.json"}}, {"family": "Ebert", "given": "Benjamin L", "initials": "BL", "orcid": "0000-0003-0197-5451", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/56e4f1c53a4348e2b0ceb44a38850a17.json"}}, {"family": "Govindan", "given": "Ramaswamy", "initials": "R", "orcid": "0000-0002-6964-9612", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f0d884b2cbfb41af8df1101ba9d7f7d0.json"}}, {"family": "Natarajan", "given": "Pradeep", "initials": "P", "orcid": "0000-0001-8402-7435", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fe8bd48c61c047cd8e61c35d9e9ac650.json"}}, {"family": "Bolton", "given": "Kelly L", "initials": "KL", "orcid": "0000-0001-6584-3357", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/74eb7c71cebc4e8c888ff2b7426b4438.json"}}, {"family": "Cao", "given": "Yin", "initials": "Y", "orcid": "0000-0001-9835-7662", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a34eb276a5514342adb104aa5df642c9.json"}}], "type": "journal article", "published": "2023-03-01", "journal": {"title": "J Clin Oncol", "issn": "1527-7755", "volume": "41", "issue": "7", "pages": "1423-1433", "issn-l": "0732-183X"}, "abstract": "To prospectively examine the association between clonal hematopoiesis (CH) and subsequent risk of lung cancer.\n\nAmong 200,629 UK Biobank (UKBB) participants with whole-exome sequencing, CH was identified in a nested case-control study of 832 incident lung cancer cases and 3,951 controls (2006-2019) matched on age and year at blood draw, sex, race, and smoking status. A similar nested case-control study (141 cases/652 controls) was conducted among 27,975 participants with whole-exome sequencing in the Mass General Brigham Biobank (MGBB, 2010-2021). In parallel, we compared CH frequency in published data from 5,003 patients with solid tumor (2,279 lung cancer) who had pretreatment blood sequencing performed through Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets.\n\nIn UKBB, the presence of CH was associated with increased risk of lung cancer (cases: 12.5% v controls: 8.7%; multivariable-adjusted odds ratio [OR], 1.36; 95% CI, 1.06 to 1.74). The association remained robust after excluding participants with chronic obstructive pulmonary disease. No significant interactions with known risk factors, including polygenic risk score and C-reactive protein, were identified. In MGBB, we observed similar enrichment of CH in lung cancer (cases: 15.6% v controls: 12.7%). The meta-analyzed OR (95% CI) of UKBB and MGBB was 1.35 (1.08 to 1.68) for CH overall and 1.61 (1.19 to 2.18) for variant allele frequencies \u2265 10%. In Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets, CH with a variant allele frequency \u2265 10% was enriched in pretreatment lung cancer compared with other tumors after adjusting for age, sex, and smoking (OR for lung v breast cancer: 1.61; 95% CI, 1.03 to 2.53).\n\nIndependent of known risk factors, CH is associated with increased risk of lung cancer.", "doi": "10.1200/JCO.22.00857", "pmid": "36480766", "labels": {"Abhishek Niroula": null, "DDLS Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC9995101"}], "notes": [], "created": "2023-11-20T11:36:22.458Z", "modified": "2023-11-20T11:36:23.254Z"}, {"entity": "publication", "iuid": "1b5959ae2a0048a2963b6e9fbb0d3a1e", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/1b5959ae2a0048a2963b6e9fbb0d3a1e.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/1b5959ae2a0048a2963b6e9fbb0d3a1e"}}, "title": "Sugar-sweetened beverage and sugar consumption and colorectal cancer incidence and mortality according to anatomic subsite.", "authors": [{"family": "Yuan", "given": "Chen", "initials": "C", "orcid": "0000-0002-0708-9648", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cd3904c835394e0d89bba633a0b74c54.json"}}, {"family": "Joh", "given": "Hee-Kyung", "initials": "HK"}, {"family": "Wang", "given": "Qiao-Li", "initials": "QL"}, {"family": "Zhang", "given": "Yin", "initials": "Y"}, {"family": "Smith-Warner", "given": "Stephanie A", "initials": "SA", "orcid": "0000-0003-3462-8608", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/caa1fd8a54d7407aa1f6f9eb33f45383.json"}}, {"family": "Wang", "given": "Molin", "initials": "M"}, {"family": "Song", "given": "Mingyang", "initials": "M", "orcid": "0000-0002-4780-4642", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/92720682df6c466997c4ae4fb4419c56.json"}}, {"family": "Cao", "given": "Yin", "initials": "Y", "orcid": "0000-0001-9835-7662", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a34eb276a5514342adb104aa5df642c9.json"}}, {"family": "Zhang", "given": "Xuehong", "initials": "X"}, {"family": "Zoltick", "given": "Emilie S", "initials": "ES"}, {"family": "Hur", "given": "Jinhee", "initials": "J", "orcid": "0000-0003-0968-208X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/51ce46416a8f4ab0bc5ca87fc9fa11bd.json"}}, {"family": "Chan", "given": "Andrew T", "initials": "AT"}, {"family": "Meyerhardt", "given": "Jeffrey A", "initials": "JA", "orcid": "0000-0002-1120-0898", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1be03d64e6674271953b194ddaac4f29.json"}}, {"family": "Ogino", "given": "Shuji", "initials": "S"}, {"family": "Ng", "given": "Kimmie", "initials": "K", "orcid": "0000-0003-0631-1494", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/00bc0d97cfc44e9398c9bf1db5783402.json"}}, {"family": "Giovannucci", "given": "Edward L", "initials": "EL"}, {"family": "Wu", "given": "Kana", "initials": "K"}], "type": "journal article", "published": "2022-06-07", "journal": {"title": "Am. J. Clin. Nutr.", "issn": "1938-3207", "volume": "115", "issue": "6", "pages": "1481-1489", "issn-l": "0002-9165"}, "abstract": "Recent preclinical research strongly suggests that dietary sugars can enhance colorectal tumorigenesis by direct action, particularly in the proximal colon that unabsorbed fructose reaches.\n\nWe aimed to examine long-term consumption of sugar-sweetened beverages (SSBs) and total fructose in relation to incidence and mortality of colorectal cancer (CRC) by anatomic subsite.\n\nWe followed 121,111 participants from 2 prospective US cohort studies, the Nurses' Health Study (1984-2014) and Health Professionals Follow-Up Study (1986-2014), for incident CRC and related death. Cox proportional hazards regression was used to compute HRs and 95% CIs.\n\nDuring follow-up, we documented 2733 incident cases of CRC with a known anatomic location, of whom 901 died from CRC. Positive associations of SSB and total fructose intakes with cancer incidence and mortality were observed in the proximal colon but not in the distal colon or rectum (Pheterogeneity \u2264 0.03). SSB consumption was associated with a statistically significant increase in the incidence of proximal colon cancer (HR per 1-serving/d increment: 1.18; 95% CI: 1.03, 1.34; Ptrend = 0.02) and a more pronounced elevation in the mortality of proximal colon cancer (HR: 1.39; 95% CI: 1.13, 1.72; Ptrend = 0.002). Similarly, total fructose intake was associated with increased incidence and mortality of proximal colon cancer (HRs per 25-g/d increment: 1.18; 95% CI: 1.03, 1.35; and 1.42; 95% CI: 1.12, 1.79, respectively). Moreover, SSB and total fructose intakes during the most recent 10 y, rather than those from a more distant period, were associated with increased incidence of proximal colon cancer.\n\nSSB and total fructose consumption were associated with increased incidence and mortality of proximal colon cancer, particularly during later stages of tumorigenesis.", "doi": "10.1093/ajcn/nqac040", "pmid": "35470384", "labels": {"DDLS Fellow": null, "Qiaoli Wang": null}, "xrefs": [{"db": "pmc", "key": "PMC9170474"}, {"db": "pii", "key": "S0002-9165(22)00274-X"}], "notes": [], "created": "2025-11-27T18:53:37.269Z", "modified": "2025-11-27T18:53:37.448Z"}]}