{"entity": "researcher", "timestamp": "2026-08-20T20:58:11.324Z", "family": "Pettersson", "given": "Mats", "initials": "M", "orcid": "0000-0002-7372-9076", "affiliations": ["Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, 751 23 Uppsala, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/a2310759fe6e4fd0b4a48ba9c35d3f84.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/a2310759fe6e4fd0b4a48ba9c35d3f84"}}, "publications": [{"entity": "publication", "iuid": "a63e338efe4e4d7d97442b54940b4869", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/a63e338efe4e4d7d97442b54940b4869.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/a63e338efe4e4d7d97442b54940b4869"}}, "title": "Genetic Stock Identification Reveals Mismatches Between Management Areas and Population Genetic Structure in a Migratory Pelagic Fish.", "authors": [{"family": "Seljestad", "given": "Gaute Wilhelmsen", "initials": "GW", "orcid": "0000-0003-2169-5027", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/68f5292dc62241b5ba9a2eb47e9f679f.json"}}, {"family": "Quintela", "given": "Mar\u00eda", "initials": "M", "orcid": "0000-0003-4762-2192", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/39d6ef990bbe4f909c8c1783319c0c6a.json"}}, {"family": "Bekkevold", "given": "Dorte", "initials": "D", "orcid": "0000-0002-5297-032X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6012c2efbca34901bc4807c35d2278eb.json"}}, {"family": "Pampoulie", "given": "Christophe", "initials": "C", "orcid": "0000-0001-6425-9060", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8acb1c3fd81d48cfb2fc56f22987b2ca.json"}}, {"family": "Farrell", "given": "Edward D", "initials": "ED"}, {"family": "Kvamme", "given": "Cecilie", "initials": "C"}, {"family": "Slotte", "given": "Aril", "initials": "A", "orcid": "0000-0001-9401-4929", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/08658440c9cb43028893bbd8fc3588cb.json"}}, {"family": "Dahle", "given": "Geir", "initials": "G", "orcid": "0000-0002-6070-8073", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d430a27712314e0fa285408c49ca4250.json"}}, {"family": "S\u00f8rvik", "given": "Anne Grete", "initials": "AG"}, {"family": "Pettersson", "given": "Mats E", "initials": "ME", "orcid": "0000-0002-7372-9076", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a2310759fe6e4fd0b4a48ba9c35d3f84.json"}}, {"family": "Andersson", "given": "Leif", "initials": "L", "orcid": "0000-0002-4085-6968", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7c8202937eda401fa0d07f583589359d.json"}}, {"family": "Folkvord", "given": "Arild", "initials": "A", "orcid": "0000-0002-4763-0590", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fbb41f66be234742877f11ba8c2f49ec.json"}}, {"family": "Glover", "given": "Kevin A", "initials": "KA", "orcid": "0000-0002-1006-170X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e8fb8213ad9f42f29b9163f4c66702a5.json"}}, {"family": "Berg", "given": "Florian", "initials": "F", "orcid": "0000-0003-1543-8112", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1c27bfa1ca2d4089809f81d2eb8d2714.json"}}], "type": "journal article", "published": "2024-10-00", "journal": {"title": "Evol Appl", "issn": "1752-4571", "volume": "17", "issue": "10", "pages": "e70030", "issn-l": "1752-4571"}, "abstract": "Sustainable fisheries management is important for the continued harvest of the world's marine resources, especially as they are increasingly challenged by a range of climatic and anthropogenic factors. One of the pillars of sustainable fisheries management is the accurate identification of the biological units, i.e., populations. Here, we developed and implemented a genetic baseline for Atlantic herring harvested in the Norwegian offshore fisheries to investigate the validity of the current management boundaries. This was achieved by genotyping > 15,000 herring from the northern European seas, including samples of all the known populations in the region, with a panel of population-informative SNPs mined from existing genomic resources. The final genetic baseline consisted of ~1000 herring from 12 genetically distinct populations. We thereafter used the baseline to investigate mixed catches from the North and Norwegian Seas, revealing that each management area consisted of multiple populations, as previously suspected. However, substantial numbers (up to 50% or more within a sample) of herring were found outside of their expected management areas, e.g., North Sea autumn-spawning herring north of 62\u00b0 N (average = 19.2%), Norwegian spring-spawning herring south of 62\u00b0 N (average = 13.5%), and western Baltic spring-spawning herring outside their assumed distribution area in the North Sea (average = 20.0%). Based upon these extensive observations, we conclude that the assessment and management areas currently in place for herring in this region need adjustments to reflect the populations present. Furthermore, we suggest that for migratory species, such as herring, a paradigm shift from using static geographic stock boundaries towards spatial dynamic boundaries is needed to meet the requirements of future sustainable management regimes.", "doi": "10.1111/eva.70030", "pmid": "39464230", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11502719"}, {"db": "pii", "key": "EVA70030"}, {"db": "Dryad", "key": "10.5061/dryad.rfj6q57kb"}], "notes": [], "created": "2026-08-20T11:17:48.286Z", "modified": "2026-08-20T11:17:48.665Z"}, {"entity": "publication", "iuid": "e4b5e53f62164562bd425e639c28f442", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/e4b5e53f62164562bd425e639c28f442.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/e4b5e53f62164562bd425e639c28f442"}}, "title": "Limited parallelism in genetic adaptation to brackish water bodies in European sprat and Atlantic herring", "authors": [{"family": "Pettersson", "given": "Mats E", "initials": "ME", "orcid": "0000-0002-7372-9076", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a2310759fe6e4fd0b4a48ba9c35d3f84.json"}}, {"family": "Quintela", "given": "Maria", "initials": "M"}, {"family": "Besnier", "given": "Francois", "initials": "F"}, {"family": "Deng", "given": "Qiaoling", "initials": "Q"}, {"family": "Berg", "given": "Florian", "initials": "F"}, {"family": "Kvamme", "given": "Cecilie", "initials": "C"}, {"family": "Bekkevold", "given": "Dorte", "initials": "D"}, {"family": "Mosbech", "given": "Mai Britt", "initials": "MB"}, {"family": "Bunikis", "given": "Ignas", "initials": "I"}, {"family": "Lille-Langoey", "given": "Roger", "initials": "R"}, {"family": "Leonori", "given": "Iole", "initials": "I"}, {"family": "Wallberg", "given": "Andreas", "initials": "A"}, {"family": "Glover", "given": "Kevin A", "initials": "KA"}, {"family": "Andersson", "given": "Leif", "initials": "L", "orcid": "0000-0002-4085-6968", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7c8202937eda401fa0d07f583589359d.json"}}], "type": "posted-content", "published": "2024-02-18", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2024.02.16.580647", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:52:18.263Z", "modified": "2026-08-20T10:52:18.336Z"}, {"entity": "publication", "iuid": "423e19a9f50f4ce787723017cade475a", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/423e19a9f50f4ce787723017cade475a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/423e19a9f50f4ce787723017cade475a"}}, "title": "Using evolutionary constraint to define novel candidate driver genes in medulloblastoma.", "authors": [{"family": "Roy", "given": "Ananya", "initials": "A"}, {"family": "Sakthikumar", "given": "Sharadha", "initials": "S"}, {"family": "Kozyrev", "given": "Sergey V", "initials": "SV"}, {"family": "Nordin", "given": "Jessika", "initials": "J", "orcid": "0000-0002-8414-2190", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a285875862f24b6fa0b378550da371fa.json"}}, {"family": "Pensch", "given": "Raphaela", "initials": "R", "orcid": "0000-0002-0313-8369", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca3190f9abf5474fae557aa4c8bbea3d.json"}}, {"family": "M\u00e4kel\u00e4inen", "given": "Suvi", "initials": "S"}, {"family": "Pettersson", "given": "Mats", "initials": "M", "orcid": "0000-0002-7372-9076", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a2310759fe6e4fd0b4a48ba9c35d3f84.json"}}, {"family": "Zoonomia Consortium", "given": "", "initials": ""}, {"family": "Karlsson", "given": "Elinor K", "initials": "EK", "orcid": "0000-0002-4343-3776", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/81b5c82fcb904394b6a6b1d811863fa0.json"}}, {"family": "Lindblad-Toh", "given": "Kerstin", "initials": "K", "orcid": "0000-0001-8338-0253", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/612a779b69494f1ca9b6c5f1d84fd711.json"}}, {"family": "Forsberg-Nilsson", "given": "Karin", "initials": "K"}], "type": "journal article", "published": "2023-08-15", "journal": {"title": "Proc. Natl. Acad. Sci. U.S.A.", "issn": "1091-6490", "volume": "120", "issue": "33", "pages": "e2300984120", "issn-l": "0027-8424"}, "abstract": "Current knowledge of cancer genomics remains biased against noncoding mutations. To systematically search for regulatory noncoding mutations, we assessed mutations in conserved positions in the genome under the assumption that these are more likely to be functional than mutations in positions with low conservation. To this end, we use whole-genome sequencing data from the International Cancer Genome Consortium and combined it with evolutionary constraint inferred from 240 mammals, to identify genes enriched in noncoding constraint mutations (NCCMs), mutations likely to be regulatory in nature. We compare medulloblastoma (MB), which is malignant, to pilocytic astrocytoma (PA), a primarily benign tumor, and find highly different NCCM frequencies between the two, in agreement with the fact that malignant cancers tend to have more mutations. In PA, a high NCCM frequency only affects the BRAF locus, which is the most commonly mutated gene in PA. In contrast, in MB, >500 genes have high levels of NCCMs. Intriguingly, several loci with NCCMs in MB are associated with different ages of onset, such as the HOXB cluster in young MB patients. In adult patients, NCCMs occurred in, e.g., the WASF-2/AHDC1/FGR locus. One of these NCCMs led to increased expression of the SRC kinase FGR and augmented responsiveness of MB cells to dasatinib, a SRC kinase inhibitor. Our analysis thus points to different molecular pathways in different patient groups. These newly identified putative candidate driver mutations may aid in patient stratification in MB and could be valuable for future selection of personalized treatment options.", "doi": "10.1073/pnas.2300984120", "pmid": "37549291", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10438395"}], "notes": [], "created": "2026-08-20T09:31:26.073Z", "modified": "2026-08-20T09:31:26.234Z"}, {"entity": "publication", "iuid": "1449285faa9c454cbcdca3bf6a07e530", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/1449285faa9c454cbcdca3bf6a07e530.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/1449285faa9c454cbcdca3bf6a07e530"}}, "title": "Using evolutionary constraint to define novel candidate driver genes in medulloblastoma", "authors": [{"family": "Roy", "given": "Ananya", "initials": "A"}, {"family": "Sakthikumar", "given": "Sharadha", "initials": "S"}, {"family": "Kozyrev", "given": "Sergey V", "initials": "SV"}, {"family": "Nordin", "given": "Jessika", "initials": "J"}, {"family": "Pensch", "given": "Raphaela", "initials": "R"}, {"family": "Pettersson", "given": "Mats", "initials": "M", "orcid": "0000-0002-7372-9076", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a2310759fe6e4fd0b4a48ba9c35d3f84.json"}}, {"family": "Karlsson", "given": "Elinor", "initials": "E"}, {"family": "Lindblad-Toh", "given": "Kerstin", "initials": "K"}, {"family": "Forsberg-Nilsson", "given": "Karin", "initials": "K"}], "type": "posted-content", "published": "2022-11-03", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2022.11.02.514465", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:42:02.290Z", "modified": "2026-08-20T10:42:02.344Z"}, {"entity": "publication", "iuid": "9e3a7147a8744a5b87ac0edab53481b6", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/9e3a7147a8744a5b87ac0edab53481b6.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/9e3a7147a8744a5b87ac0edab53481b6"}}, "title": "Spatiotemporal variations in retrovirus-host interactions among Darwin\u2019s finches", "authors": [{"family": "Hill", "given": "Jason", "initials": "J", "orcid": "0000-0002-0151-8931", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6a24b7bc510949189e95f46c3bb64135.json"}}, {"family": "Lillie", "given": "Mette", "initials": "M", "orcid": "0000-0001-8714-0812", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/22653aa83dc64e2b97cf97ab9e3ea8dc.json"}}, {"family": "Pettersson", "given": "Mats E", "initials": "ME", "orcid": "0000-0002-7372-9076", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a2310759fe6e4fd0b4a48ba9c35d3f84.json"}}, {"family": "Rubin", "given": "Carl Johan", "initials": "CJ", "orcid": "0000-0001-8238-5052", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cc83e7c8e44145778f170d3ac49c52a6.json"}}, {"family": "Grant", "given": "B Rosemary", "initials": "BR"}, {"family": "Grant", "given": "Peter R", "initials": "PR"}, {"family": "Andersson", "given": "Leif", "initials": "L", "orcid": "0000-0002-4085-6968", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7c8202937eda401fa0d07f583589359d.json"}}, {"family": "Jern", "given": "Patric", "initials": "P", "orcid": "0000-0003-3393-5825", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3fbbdf5987064ce7954279ccbc3857fb.json"}}], "type": "posted-content", "published": "2022-03-26", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2022.03.25.485756", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:10:32.801Z", "modified": "2026-08-20T10:10:32.956Z"}, {"entity": "publication", "iuid": "72c4a0eb776d4ee4a3bc42ce2e203553", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/72c4a0eb776d4ee4a3bc42ce2e203553.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/72c4a0eb776d4ee4a3bc42ce2e203553"}}, "title": "A chromosome-level assembly of the Atlantic herring \u2013 detection of a supergene and other signals of selection", "authors": [{"family": "Pettersson", "given": "Mats E", "initials": "ME", "orcid": "0000-0002-7372-9076", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a2310759fe6e4fd0b4a48ba9c35d3f84.json"}}, {"family": "Rochus", "given": "Christina M", "initials": "CM"}, {"family": "Han", "given": "Fan", "initials": "F"}, {"family": "Chen", "given": "Junfeng", "initials": "J"}, {"family": "Hill", "given": "Jason", "initials": "J"}, {"family": "Wallerman", "given": "Ola", "initials": "O"}, {"family": "Fan", "given": "Guangyi", "initials": "G"}, {"family": "Hong", "given": "Xiaoning", "initials": "X"}, {"family": "Xu", "given": "Qiwu", "initials": "Q"}, {"family": "Zhang", "given": "He", "initials": "H"}, {"family": "Liu", "given": "Shanshan", "initials": "S"}, {"family": "Liu", "given": "Xin", "initials": "X"}, {"family": "Haggerty", "given": "Leanne", "initials": "L"}, {"family": "Hunt", "given": "Toby", "initials": "T"}, {"family": "Martin", "given": "Fergal J", "initials": "FJ"}, {"family": "Flicek", "given": "Paul", "initials": "P"}, {"family": "Bunikis", "given": "Ignas", "initials": "I"}, {"family": "Folkvord", "given": "Arild", "initials": "A"}, {"family": "Andersson", "given": "Leif", "initials": "L"}], "type": "posted-content", "published": "2019-06-11", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/668384", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T11:14:00.648Z", "modified": "2026-08-20T11:14:00.693Z"}]}