{"entity": "researcher", "timestamp": "2026-09-27T17:06:55.513Z", "family": "J\u00e4rver", "given": "Peter", "initials": "P", "orcid": "0000-0001-9643-5874", "affiliations": ["Department of Molecular Biosciences, Wenner-Gren Institute, Stockholm University, 106 91, Stockholm, Sweden. peter.jarver@su.se."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/a219e589c5e0473caa67e217cdabe872.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/a219e589c5e0473caa67e217cdabe872"}}, "publications": [{"entity": "publication", "iuid": "e3a163cfcb6f4b64b10abca39a384d96", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/e3a163cfcb6f4b64b10abca39a384d96.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/e3a163cfcb6f4b64b10abca39a384d96"}}, "title": "Single-Stranded Nucleic Acids Regulate TLR3/4/7 Activation through Interference with Clathrin-Mediated Endocytosis.", "authors": [{"family": "J\u00e4rver", "given": "Peter", "initials": "P", "orcid": "0000-0001-9643-5874", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a219e589c5e0473caa67e217cdabe872.json"}}, {"family": "Dondalska", "given": "Aleksandra", "initials": "A"}, {"family": "Poux", "given": "Candice", "initials": "C"}, {"family": "Sandberg", "given": "AnnSofi", "initials": "A"}, {"family": "Bergenstr\u00e5hle", "given": "Joseph", "initials": "J"}, {"family": "Sk\u00f6ld", "given": "Annette E", "initials": "AE"}, {"family": "Dereuddre-Bosquet", "given": "Nathalie", "initials": "N"}, {"family": "Martinon", "given": "Fr\u00e9deric", "initials": "F"}, {"family": "P\u00e5lsson", "given": "Sandra", "initials": "S"}, {"family": "Zaghloul", "given": "Eman", "initials": "E"}, {"family": "Brodin", "given": "David", "initials": "D"}, {"family": "Sander", "given": "Birgitta", "initials": "B"}, {"family": "Lennox", "given": "Kim A", "initials": "KA"}, {"family": "Behlke", "given": "Mark A", "initials": "MA"}, {"family": "El-Andaloussi", "given": "Samir", "initials": "S"}, {"family": "Lehti\u00f6", "given": "Janne", "initials": "J", "orcid": "0000-0002-8100-9562", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/561efcf32e2648c8a10fee692fc4e908.json"}}, {"family": "Lundeberg", "given": "Joakim", "initials": "J", "orcid": "0000-0003-4313-1601", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d9fa47767cd14ef2b9528c8b998cf095.json"}}, {"family": "LeGrand", "given": "Roger", "initials": "R"}, {"family": "Spetz", "given": "Anna-Lena", "initials": "AL", "orcid": "0000-0003-3964-9512", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7cffbfcc2e734c71bd9bc9d4a186ba5e.json"}}], "type": "journal article", "published": "2018-10-26", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "8", "issue": "1", "pages": "15841", "issn-l": "2045-2322"}, "abstract": "Recognition of nucleic acids by endosomal Toll-like receptors (TLR) is essential to combat pathogens, but requires strict control to limit inflammatory responses. The mechanisms governing this tight regulation are unclear. We found that single-stranded oligonucleotides (ssON) inhibit endocytic pathways used by cargo destined for TLR3/4/7 signaling endosomes. Both ssDNA and ssRNA conferred the endocytic inhibition, it was concentration dependent, and required a certain ssON length. The ssON-mediated inhibition modulated signaling downstream of TLRs that localized within the affected endosomal pathway. We further show that injection of ssON dampens dsRNA-mediated inflammatory responses in the skin of non-human primates. These studies reveal a regulatory role for extracellular ssON in the endocytic uptake of TLR ligands and provide a mechanistic explanation of their immunomodulation. The identified ssON-mediated interference of endocytosis (SOMIE) is a regulatory process that temporarily dampens TLR3/4/7 signaling, thereby averting excessive immune responses.", "doi": "10.1038/s41598-018-33960-4", "pmid": "30367171", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6203749"}, {"db": "pii", "key": "10.1038/s41598-018-33960-4"}], "notes": [], "created": "2026-09-23T11:52:02.462Z", "modified": "2026-09-23T11:52:02.600Z"}]}