{"entity": "researcher", "timestamp": "2026-09-28T05:29:39.675Z", "family": "Jin", "given": "Chunsheng", "initials": "C", "orcid": "0000-0002-0229-102X", "affiliations": ["Proteomics Core Facility at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/a101a608bfd24b54856d1ca422a0ffcf.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/a101a608bfd24b54856d1ca422a0ffcf"}}, "publications": [{"entity": "publication", "iuid": "87bdd77d961c40c98787a4417cff8e6d", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/87bdd77d961c40c98787a4417cff8e6d.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/87bdd77d961c40c98787a4417cff8e6d"}}, "title": "Seal milk oligosaccharides rival human milk complexity and exhibit functional dynamics during lactation.", "authors": [{"family": "Jin", "given": "Chunsheng", "initials": "C", "orcid": "0000-0002-0229-102X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a101a608bfd24b54856d1ca422a0ffcf.json"}}, {"family": "Lundstr\u00f8m", "given": "Jon", "initials": "J", "orcid": "0000-0003-2733-7124", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/143dd0ab2b034524ab081ebd3e4d4e84.json"}}, {"family": "Cori", "given": "Carmen R", "initials": "CR"}, {"family": "Guu", "given": "Shih-Yun", "initials": "SY"}, {"family": "Bennett", "given": "Alexander R", "initials": "AR", "orcid": "0000-0003-4869-9132", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/72c3e68726ee4b1c94df835a395d1db0.json"}}, {"family": "Dannborg", "given": "Mirjam", "initials": "M"}, {"family": "Pomeroy", "given": "Patrick P", "initials": "PP", "orcid": "0000-0003-1603-5630", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/491ac57fc5c243868da12506f51f4cc4.json"}}, {"family": "Kennedy", "given": "Malcolm W", "initials": "MW", "orcid": "0000-0002-0970-5264", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c1f6e32c4c8b483499b760358f1614fd.json"}}, {"family": "Bengtsson-Palme", "given": "Johan", "initials": "J", "orcid": "0000-0002-6528-3158", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4c666068e9d34939b0252a627007cec7.json"}}, {"family": "Hevey", "given": "Rachel", "initials": "R", "orcid": "0000-0002-2649-3427", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1eb0458f8032456db2515a98ebb1603e.json"}}, {"family": "Khoo", "given": "Kay-Hooi", "initials": "KH"}, {"family": "Bojar", "given": "Daniel", "initials": "D", "orcid": "0000-0002-3008-7851", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e478a4f31d694706a63d5d71e02ecf1c.json"}}], "type": "journal article", "published": "2025-11-25", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "16", "issue": "1", "pages": "10067", "issn-l": "2041-1723"}, "abstract": "Milk oligosaccharides are crucial for neonatal development and health in mammals. Yet most milk research focuses on humans, or on domesticated mammals that are poor in milk oligosaccharide complexity. Here, we perform an exhaustive mass spectrometry-driven structural characterization of milk oligosaccharides in a wild mammal, female Atlantic grey seals (Halichoerus grypus), throughout their lactation period. Characterizing and quantifying 332 milk oligosaccharides, including 166 unreported structures, we reveal seals to rival human milk in complexity. We report seal free oligosaccharides to reach up to 28 monosaccharides in size. Paired glycomics and metabolomics time course analysis establishes a concerted regulatory process reshaping the seal milk glycome throughout lactation, similar to human milk. Functional analysis of the structures we here characterized reveals anti-biofilm effects and immunomodulatory functions of seal milk oligosaccharides. Our findings challenge long-held assumptions about milk complexity of non-human mammals and enable insights into the functional relevance of complex carbohydrates in milk.", "doi": "10.1038/s41467-025-66075-2", "pmid": "41290693", "labels": {"DDLS Fellow": ""}, "xrefs": [{"db": "pmc", "key": "PMC12647773"}, {"db": "pii", "key": "10.1038/s41467-025-66075-2"}], "notes": [], "created": "2026-09-23T11:36:00.656Z", "modified": "2026-09-23T11:36:00.914Z"}, {"entity": "publication", "iuid": "f3ba37fee1514362b3dfe942ae230410", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f3ba37fee1514362b3dfe942ae230410.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f3ba37fee1514362b3dfe942ae230410"}}, "title": "Metabolic reprogramming and membrane glycan remodeling as potential drivers of zebrafish heart regeneration.", "authors": [{"family": "Spelat", "given": "Renza", "initials": "R", "orcid": "0000-0001-5794-8976", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a75758dfbb60443bb0321351827d27fb.json"}}, {"family": "Ferro", "given": "Federico", "initials": "F", "orcid": "0000-0002-6023-8227", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ad5d7f730e874aa381810f9425928345.json"}}, {"family": "Contessotto", "given": "Paolo", "initials": "P"}, {"family": "Aljaabary", "given": "Amal", "initials": "A", "orcid": "0000-0003-0361-166X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca41b354baf94470bb02a684b57fff55.json"}}, {"family": "Martin-Salda\u00f1a", "given": "Sergio", "initials": "S", "orcid": "0000-0002-9506-8483", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e8e9dde0abce4eeaa8a0a556e3d895b4.json"}}, {"family": "Jin", "given": "Chunsheng", "initials": "C", "orcid": "0000-0002-0229-102X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a101a608bfd24b54856d1ca422a0ffcf.json"}}, {"family": "Karlsson", "given": "Niclas G", "initials": "NG", "orcid": "0000-0002-3045-2628", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1c08a75b6d56459bbd00e8e3fe8004bf.json"}}, {"family": "Grealy", "given": "Maura", "initials": "M"}, {"family": "Hilscher", "given": "Markus M", "initials": "MM", "orcid": "0000-0001-7782-0830", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ec435b1759284c98aa17c7dfd11c3617.json"}}, {"family": "Magni", "given": "Fulvio", "initials": "F"}, {"family": "Chinello", "given": "Clizia", "initials": "C"}, {"family": "Kilcoyne", "given": "Michelle", "initials": "M", "orcid": "0000-0002-8870-1308", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/efa8bcd7e34541209600e3a554cf5765.json"}}, {"family": "Pandit", "given": "Abhay", "initials": "A", "orcid": "0000-0002-6292-4933", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ee7eede49c3c4a6493ffc0d2d7a7c3df.json"}}], "type": "journal article", "published": "2022-12-13", "journal": {"title": "Commun Biol", "issn": "2399-3642", "volume": "5", "issue": "1", "pages": "1365", "issn-l": "2399-3642"}, "abstract": "The ability of the zebrafish heart to regenerate following injury makes it a valuable model to deduce why this capability in mammals is limited to early neonatal stages. Although metabolic reprogramming and glycosylation remodeling have emerged as key aspects in many biological processes, how they may trigger a cardiac regenerative response in zebrafish is still a crucial question. Here, by using an up-to-date panel of transcriptomic, proteomic and glycomic approaches, we identify a metabolic switch from mitochondrial oxidative phosphorylation to glycolysis associated with membrane glycosylation remodeling during heart regeneration. Importantly, we establish the N- and O-linked glycan structural repertoire of the regenerating zebrafish heart, and link alterations in both sialylation and high mannose structures across the phases of regeneration. Our results show that metabolic reprogramming and glycan structural remodeling are potential drivers of tissue regeneration after cardiac injury, providing the biological rationale to develop novel therapeutics to elicit heart regeneration in mammals.", "doi": "10.1038/s42003-022-04328-2", "pmid": "36509839", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9744865"}, {"db": "pii", "key": "10.1038/s42003-022-04328-2"}], "notes": [], "created": "2026-09-23T11:57:10.884Z", "modified": "2026-09-23T11:57:11.188Z"}]}