{"entity": "researcher", "timestamp": "2026-09-29T16:41:13.393Z", "family": "Teppo", "given": "Susanna", "initials": "S", "orcid": "0000-0003-2569-8030", "affiliations": ["Tampere Center for Child Health Research, University of Tampere and Tampere University Hospital, 33520 Tampere, Finland."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/a04e4fd18502412eaa64661935e338b2.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/a04e4fd18502412eaa64661935e338b2"}}, "publications": [{"entity": "publication", "iuid": "c4018645d84948d78280d5bc77f69325", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/c4018645d84948d78280d5bc77f69325.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/c4018645d84948d78280d5bc77f69325"}}, "title": "Genome-wide repression of eRNA and target gene loci by the ETV6-RUNX1 fusion in acute leukemia.", "authors": [{"family": "Teppo", "given": "Susanna", "initials": "S", "orcid": "0000-0003-2569-8030", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a04e4fd18502412eaa64661935e338b2.json"}}, {"family": "Laukkanen", "given": "Saara", "initials": "S"}, {"family": "Liuksiala", "given": "Thomas", "initials": "T"}, {"family": "Nordlund", "given": "Jessica", "initials": "J"}, {"family": "Oittinen", "given": "Mikko", "initials": "M"}, {"family": "Teittinen", "given": "Kaisa", "initials": "K"}, {"family": "Gr\u00f6nroos", "given": "Toni", "initials": "T"}, {"family": "St-Onge", "given": "Pascal", "initials": "P"}, {"family": "Sinnett", "given": "Daniel", "initials": "D"}, {"family": "Syv\u00e4nen", "given": "Ann-Christine", "initials": "AC"}, {"family": "Nykter", "given": "Matti", "initials": "M"}, {"family": "Viiri", "given": "Keijo", "initials": "K"}, {"family": "Hein\u00e4niemi", "given": "Merja", "initials": "M", "orcid": "0000-0001-6190-3439", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/46bc89dc6780459b8957c8c5f56b1b16.json"}}, {"family": "Lohi", "given": "Olli", "initials": "O", "orcid": "0000-0001-9195-0797", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fc11c521950f4c6b8a9588893b2d5190.json"}}], "type": "journal article", "published": "2016-11-00", "journal": {"title": "Genome Res", "issn": "1549-5469", "volume": "26", "issue": "11", "pages": "1468-1477", "issn-l": "1088-9051"}, "abstract": "Approximately 20%-25% of childhood acute lymphoblastic leukemias carry the ETV6-RUNX1 (E/R) fusion gene, a fusion of two central hematopoietic transcription factors, ETV6 (TEL) and RUNX1 (AML1). Despite its prevalence, the exact genomic targets of E/R have remained elusive. We evaluated gene loci and enhancers targeted by E/R genome-wide in precursor B acute leukemia cells using global run-on sequencing (GRO-seq). We show that expression of the E/R fusion leads to widespread repression of RUNX1 motif-containing enhancers at its target gene loci. Moreover, multiple super-enhancers from the CD19+/CD20+-lineage were repressed, implicating a role in impediment of lineage commitment. In effect, the expression of several genes involved in B cell signaling and adhesion was down-regulated, and the repression depended on the wild-type DNA-binding Runt domain of RUNX1. We also identified a number of E/R-regulated annotated and de novo noncoding genes. The results provide a comprehensive genome-wide mapping between E/R-regulated key regulatory elements and genes in precursor B cell leukemia that disrupt normal B lymphopoiesis.", "doi": "10.1101/gr.193649.115", "pmid": "27620872", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC5088590"}, {"db": "pii", "key": "gr.193649.115"}, {"db": "medline", "key": "9509184"}], "notes": [], "created": "2018-12-05T10:23:15.488Z", "modified": "2026-09-23T13:43:25.097Z"}]}