{"entity": "researcher", "timestamp": "2026-08-20T21:45:07.886Z", "family": "Heckman", "given": "Caroline A", "initials": "CA", "orcid": "0000-0002-4324-8706", "affiliations": ["iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Helsinki, Finland.", "Institute for Molecular Medicine Finland -FIMM, Helsinki Institute for Life Sciences -HiLIFE, University of Helsinki, Helsinki, Finland."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/a0490f5eb61a4d92a44815d03de84af4.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/a0490f5eb61a4d92a44815d03de84af4"}}, "publications": [{"entity": "publication", "iuid": "a2d4d6d4a5c5405aa4e890d419216721", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/a2d4d6d4a5c5405aa4e890d419216721.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/a2d4d6d4a5c5405aa4e890d419216721"}}, "title": "Distinct molecular profiles and shared drug vulnerabilities in pancreatic metastases of renal cell carcinoma.", "authors": [{"family": "Roos-Mattila", "given": "Matilda", "initials": "M", "orcid": "0000-0002-2834-3211", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f9dd8feca623400d8e0c17b2725b6dc7.json"}}, {"family": "Kallio", "given": "Pauliina", "initials": "P", "orcid": "0000-0001-6374-6203", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/341466e88f824af587e257b73582d6dd.json"}}, {"family": "Luck", "given": "Tamara J", "initials": "TJ"}, {"family": "Polso", "given": "Minttu", "initials": "M"}, {"family": "Kumari", "given": "Romika", "initials": "R"}, {"family": "Mikkonen", "given": "Piia", "initials": "P"}, {"family": "V\u00e4lim\u00e4ki", "given": "Katja", "initials": "K", "orcid": "0000-0001-9117-7589", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6e4948127dec4455803fa8c74fefbde5.json"}}, {"family": "Malmstedt", "given": "Minna", "initials": "M"}, {"family": "Ellonen", "given": "Pekka", "initials": "P"}, {"family": "Pellinen", "given": "Teijo", "initials": "T", "orcid": "0000-0001-9652-7373", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8e73595c0cc64a68a59cd95772784859.json"}}, {"family": "Heckman", "given": "Caroline A", "initials": "CA", "orcid": "0000-0002-4324-8706", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a0490f5eb61a4d92a44815d03de84af4.json"}}, {"family": "Mustonen", "given": "Harri", "initials": "H", "orcid": "0000-0001-5632-6796", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f009308cd84542ae8c384fbfe87501d2.json"}}, {"family": "Puolakkainen", "given": "Pauli A", "initials": "PA"}, {"family": "Alitalo", "given": "Kari", "initials": "K", "orcid": "0000-0002-7331-0902", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d9a1a31264694e4fba6026b293655ff0.json"}}, {"family": "Kallioniemi", "given": "Olli", "initials": "O", "orcid": "0000-0002-3231-0332", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cb8605b07c884323afe4e1f2da37a031.json"}}, {"family": "Mirtti", "given": "Tuomas", "initials": "T", "orcid": "0000-0003-0455-9891", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c1963bc5086f4b45b9a48cb60115d578.json"}}, {"family": "Rannikko", "given": "Antti S", "initials": "AS"}, {"family": "Pieti\u00e4inen", "given": "Vilja M", "initials": "VM", "orcid": "0000-0003-3125-2406", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6d24125e51334b94bce4ef70fed1e585.json"}}, {"family": "Sepp\u00e4nen", "given": "Hanna E", "initials": "HE"}], "type": "journal article", "published": "2024-10-20", "journal": {"title": "Commun Biol", "issn": "2399-3642", "volume": "7", "issue": "1", "pages": "1355", "issn-l": "2399-3642"}, "abstract": "Clear-cell renal cell carcinoma (ccRCC) is the most common origin of pancreatic metastases (PM). Distinct genomic aberrations, favorable prognosis, and clinical observations on high angiogenesis, and succeeding tyrosine kinase inhibitor (TKI) sensitivity have been reported in PM-ccRCC. However, no functional or single-cell studies have been conducted thus far. We recruited five PM-ccRCC patients and investigated the genomic, single-cell transcriptomic, and drug sensitivity profiles of their patient-derived cells (PDCs). The PM depicted both expected and novel genomic alterations. Further, the transcriptomics differed from both primary and metastatic ccRCC, with upregulations of the PI3K/mTOR and - supporting the clinical observations - angiogenesis pathways. Data integration at pathway level showed that transcriptomics explained drug sensitivities the best. Accordingly, PM-ccRCC PDCs shared sensitivity to many PI3K/mTOR inhibitors. Altogether, we show distinct genomic and transcriptomic signatures in PM-ccRCC, highlight the superiority of transcriptomics in interpreting drug sensitivities, and encourage the use of TKIs and PI3K/mTOR inhibitors in PM-ccRCC.", "doi": "10.1038/s42003-024-07004-9", "pmid": "39427059", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11490566"}, {"db": "pii", "key": "10.1038/s42003-024-07004-9"}], "notes": [], "created": "2026-08-20T09:25:17.594Z", "modified": "2026-08-20T09:25:17.901Z"}, {"entity": "publication", "iuid": "b4c37168301940ce9efedc7b49904d36", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b4c37168301940ce9efedc7b49904d36.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b4c37168301940ce9efedc7b49904d36"}}, "title": "Implementing a Functional Precision Medicine Tumor Board for Acute Myeloid Leukemia.", "authors": [{"family": "Malani", "given": "Disha", "initials": "D"}, {"family": "Kumar", "given": "Ashwini", "initials": "A"}, {"family": "Br\u00fcck", "given": "Oscar", "initials": "O"}, {"family": "Kontro", "given": "Mika", "initials": "M", "orcid": "0000-0001-6353-0664", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0661dd63c7df44d79aa7c50a309c55db.json"}}, {"family": "Yadav", "given": "Bhagwan", "initials": "B", "orcid": "0000-0002-3502-9335", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0f979e77a9854141b2077a3d10164d08.json"}}, {"family": "Helles\u00f8y", "given": "Monica", "initials": "M", "orcid": "0000-0002-0115-7427", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/65449b403fe24b85b0b1956e899ee9b8.json"}}, {"family": "Kuusanm\u00e4ki", "given": "Heikki", "initials": "H"}, {"family": "Dufva", "given": "Olli", "initials": "O"}, {"family": "Kankainen", "given": "Matti", "initials": "M"}, {"family": "Eldfors", "given": "Samuli", "initials": "S", "orcid": "0000-0001-5056-4750", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/84b0e10b975c44fc88a5997ca1ee09b7.json"}}, {"family": "Potdar", "given": "Swapnil", "initials": "S", "orcid": "0000-0002-2778-6918", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8e17191dcbef4dc7917d15792cfe5d6e.json"}}, {"family": "Saarela", "given": "Jani", "initials": "J", "orcid": "0000-0001-7306-7175", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8ba79c74ec3c489ab321465d195c0844.json"}}, {"family": "Turunen", "given": "Laura", "initials": "L", "orcid": "0000-0003-0274-4794", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/35779e69fefa43cdb2d13c9e7fd05df7.json"}}, {"family": "Parsons", "given": "Alun", "initials": "A"}, {"family": "V\u00e4strik", "given": "Imre", "initials": "I", "orcid": "0000-0001-6658-9311", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5cb6a5a735404b78823b54059bf0990c.json"}}, {"family": "Kivinen", "given": "Katja", "initials": "K"}, {"family": "Saarela", "given": "Janna", "initials": "J", "orcid": "0000-0002-0853-6219", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/80f36bfb769b400fadd19daa0f80565c.json"}}, {"family": "R\u00e4ty", "given": "Riikka", "initials": "R"}, {"family": "Lehto", "given": "Minna", "initials": "M"}, {"family": "Wolf", "given": "Maija", "initials": "M"}, {"family": "Gjertsen", "given": "Bjorn Tore", "initials": "BT"}, {"family": "Mustjoki", "given": "Satu", "initials": "S", "orcid": "0000-0002-0816-8241", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/77ae8c3136924c22b8f56b35a24fc507.json"}}, {"family": "Aittokallio", "given": "Tero", "initials": "T", "orcid": "0000-0002-0886-9769", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/433e429e6a5b49818cf54f5fc102fff7.json"}}, {"family": "Wennerberg", "given": "Krister", "initials": "K", "orcid": "0000-0002-1352-4220", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/40883b183a28459a9b7b515312c8c44c.json"}}, {"family": "Heckman", "given": "Caroline A", "initials": "CA", "orcid": "0000-0002-4324-8706", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a0490f5eb61a4d92a44815d03de84af4.json"}}, {"family": "Kallioniemi", "given": "Olli", "initials": "O"}, {"family": "Porkka", "given": "Kimmo", "initials": "K"}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "Cancer Discov", "issn": "2159-8290", "volume": "12", "issue": "2", "pages": "388-401", "issn-l": "2159-8274"}, "abstract": "We generated ex vivo drug-response and multiomics profiling data for a prospective series of 252 samples from 186 patients with acute myeloid leukemia (AML). A functional precision medicine tumor board (FPMTB) integrated clinical, molecular, and functional data for application in clinical treatment decisions. Actionable drugs were found for 97% of patients with AML, and the recommendations were clinically implemented in 37 relapsed or refractory patients. We report a 59% objective response rate for the individually tailored therapies, including 13 complete responses, as well as bridging five patients with AML to allogeneic hematopoietic stem cell transplantation. Data integration across all cases enabled the identification of drug response biomarkers, such as the association of IL15 overexpression with resistance to FLT3 inhibitors. Integration of molecular profiling and large-scale drug response data across many patients will enable continuous improvement of the FPMTB recommendations, providing a paradigm for individualized implementation of functional precision cancer medicine. SIGNIFICANCE: Oncogenomics data can guide clinical treatment decisions, but often such data are neither actionable nor predictive. Functional ex vivo drug testing contributes significant additional, clinically actionable therapeutic insights for individual patients with AML. Such data can be generated in four days, enabling rapid translation through FPMTB.See related commentary by Letai, p. 290.This article is highlighted in the In This Issue feature, p. 275.", "doi": "10.1158/2159-8290.CD-21-0410", "pmid": "34789538", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9762335"}, {"db": "pii", "key": "2159-8290.CD-21-0410"}], "notes": [], "created": "2026-08-20T12:14:31.294Z", "modified": "2026-08-20T12:14:31.705Z"}]}