{"entity": "researcher", "timestamp": "2026-08-20T20:54:22.782Z", "family": "Dulewicz", "given": "Maciej", "initials": "M", "orcid": "0000-0002-7149-017X", "affiliations": ["Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/9ed234121de64d68a933a30e3f059099.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/9ed234121de64d68a933a30e3f059099"}}, "publications": [{"entity": "publication", "iuid": "ffc6bb28896f4bf3a807f710db44b029", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ffc6bb28896f4bf3a807f710db44b029.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ffc6bb28896f4bf3a807f710db44b029"}}, "title": "Clinical Validation of Novel Immunoassays for Plasma Phosphorylated Tau 217, 212, 181, 231, and Brain-Derived Tau Across the Biochemical Spectrum of Alzheimer's Disease.", "authors": [{"family": "Dulewicz", "given": "Maciej", "initials": "M", "orcid": "0000-0002-7149-017X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9ed234121de64d68a933a30e3f059099.json"}}, {"family": "Kac", "given": "Przemys\u0142aw Rados\u0142aw", "initials": "PR"}, {"family": "Ortiz", "given": "Fernando Gonzalez", "initials": "FG"}, {"family": "Karikari", "given": "Thomas K", "initials": "TK"}, {"family": "Kulczy\u0144ska-Przybik", "given": "Agnieszka", "initials": "A"}, {"family": "Mroczko", "given": "Barbara", "initials": "B"}, {"family": "Turton", "given": "Michael", "initials": "M"}, {"family": "Harrison", "given": "Peter", "initials": "P"}, {"family": "Maler", "given": "Manuel", "initials": "M"}, {"family": "Oberstein", "given": "Timo", "initials": "T"}, {"family": "Kornhuber", "given": "Johannes", "initials": "J"}, {"family": "Hanrieder", "given": "J\u00f6rg", "initials": "J"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H", "orcid": "0000-0003-3930-4354", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/18365a2ea4ec4ca2baeb657cd1c8bd8f.json"}}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Lewczuk", "given": "Piotr", "initials": "P"}], "type": "journal article", "published": "2025-12-00", "journal": {"title": "J. Neurochem.", "issn": "1471-4159", "volume": "169", "issue": "12", "pages": "e70313", "issn-l": "0022-3042"}, "abstract": "Plasma biomarkers have emerged as promising less invasive alternatives for Alzheimer's disease (AD) detection. However, the diagnostic performance of phosphorylated tau (p-tau) isoforms remains incompletely validated. In a cohort of 160 patients from a memory clinic, plasma levels of p-tau217, p-tau212, p-tau181, p-tau231, and BD-tau were measured using Single Molecule Array (Simoa) in-house assays, alongside NFL and GFAP. Subjects were classified using the Erlangen Score into Controls (n = 53), neurochemically possible AD (n = 27), and probable AD (n = 80). Plasma concentrations of all p-tau isoforms were significantly elevated in both Possible AD and Probable AD groups compared to Controls (p < 0.001). Notably, p-tau217 exhibited the highest diagnostic accuracy (AUC = 0.954) and correlated with CSF classical biomarkers. A positive result for p-tau217 increases the probability of AD almost fivefold. Plasma p-tau217 reflects AD neurochemical changes and has high negative predictive value, supporting its use as a screening tool. However, moderate PPV suggests the need for confirmatory testing to ensure an accurate diagnosis.", "doi": "10.1111/jnc.70313", "pmid": "41321279", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12666730"}], "notes": [], "created": "2026-08-20T11:18:17.380Z", "modified": "2026-08-20T11:18:17.468Z"}, {"entity": "publication", "iuid": "e5364452cb3440d49d8852f68eb246d2", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/e5364452cb3440d49d8852f68eb246d2.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/e5364452cb3440d49d8852f68eb246d2"}}, "title": "Associations between Microglia and Astrocytic Proteins and Tau Biomarkers across the Continuum of Alzheimer's Disease.", "authors": [{"family": "Doroszkiewicz", "given": "Julia", "initials": "J"}, {"family": "Kulczy\u0144ska-Przybik", "given": "Agnieszka", "initials": "A"}, {"family": "Dulewicz", "given": "Maciej", "initials": "M", "orcid": "0000-0002-7149-017X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9ed234121de64d68a933a30e3f059099.json"}}, {"family": "Mroczko", "given": "Jan", "initials": "J"}, {"family": "Borawska", "given": "Renata", "initials": "R"}, {"family": "S\u0142owik", "given": "Agnieszka", "initials": "A"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Hanrieder", "given": "J\u00f6rg", "initials": "J"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Mroczko", "given": "Barbara", "initials": "B", "orcid": "0000-0002-4075-8479", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/eeb5c6402eae4d43996bb6b76e6804ec.json"}}], "type": "journal article", "published": "2024-07-09", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "volume": "25", "issue": "14", "issn-l": null}, "abstract": "Recent investigations implicate neuroinflammatory changes, including astrocyte and microglia activation, as crucial in the progression of Alzheimer's disease (AD) Thus, we compared selected proteins reflecting neuroinflammatory processes to establish their connection to AD pathologies. Our study, encompassing 80 subjects with (n = 42) AD, (n = 18) mild cognitive impairment (MCI) and (n = 20) non-demented controls compares the clinical potential of tested molecules. Using antibody-based methods, we assessed concentrations of NGAL, CXCL-11, sTREM1, and sTREM2 in cerebrospinal fluid (CSF). Proinflammatory proteins, NGAL, and CXCL-11 reached a peak in the early stage of the disease and allowed for the identification of patients with MCI. Furthermore, the concentration of the anti-inflammatory molecule sTREM2 was highest in the more advanced stage of the disease and permitted differentiation between AD and non-demented controls. Additionally, sTREM2 was biochemically linked to tau and pTau in the AD group. Notably, NGAL demonstrated superior diagnostic performance compared to classical AD biomarkers in discriminating MCI patients from controls. These findings suggest that proteins secreted mainly through microglia dysfunction might play not only a detrimental but also a protective role in the development of AD pathology.", "doi": "10.3390/ijms25147543", "pmid": "39062786", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11277045"}, {"db": "pii", "key": "ijms25147543"}], "notes": [], "created": "2026-08-20T13:41:48.926Z", "modified": "2026-08-20T13:41:49.005Z"}, {"entity": "publication", "iuid": "1328d8b8f0e9431bbdf7a57efa782690", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/1328d8b8f0e9431bbdf7a57efa782690.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/1328d8b8f0e9431bbdf7a57efa782690"}}, "title": "The Relationships between Cerebrospinal Fluid Glial (CXCL12, CX3CL, YKL-40) and Synaptic Biomarkers (Ng, NPTXR) in Early Alzheimer's Disease.", "authors": [{"family": "Kulczy\u0144ska-Przybik", "given": "Agnieszka", "initials": "A"}, {"family": "Dulewicz", "given": "Maciej", "initials": "M", "orcid": "0000-0002-7149-017X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9ed234121de64d68a933a30e3f059099.json"}}, {"family": "Doroszkiewicz", "given": "Julia", "initials": "J"}, {"family": "Borawska", "given": "Renata", "initials": "R"}, {"family": "S\u0142owik", "given": "Agnieszka", "initials": "A"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Hanrieder", "given": "J\u00f6rg", "initials": "J"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Mroczko", "given": "Barbara", "initials": "B", "orcid": "0000-0002-4075-8479", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/eeb5c6402eae4d43996bb6b76e6804ec.json"}}], "type": "journal article", "published": "2023-08-24", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "volume": "24", "issue": "17", "issn-l": null}, "abstract": "In addition to amyloid and tau pathology in the central nervous system (CNS), inflammatory processes and synaptic dysfunction are highly important mechanisms involved in the development and progression of dementia diseases. In the present study, we conducted a comparative analysis of selected pro-inflammatory proteins in the CNS with proteins reflecting synaptic damage and core biomarkers in mild cognitive impairment (MCI) and early Alzheimer's disease (AD). To our knowledge, no studies have yet compared CXCL12 and CX3CL1 with markers of synaptic disturbance in cerebrospinal fluid (CSF) in the early stages of dementia. The quantitative assessment of selected proteins in the CSF of patients with MCI, AD, and non-demented controls (CTRL) was performed using immunoassays (single- and multiplex techniques). In this study, increased CSF concentration of CX3CL1 in MCI and AD patients correlated positively with neurogranin (r = 0.74; p < 0.001, and r = 0.40; p = 0.020, respectively), ptau181 (r = 0.49; p = 0.040), and YKL-40 (r = 0.47; p = 0.050) in MCI subjects. In addition, elevated CSF levels of CXCL12 in the AD group were significantly associated with mini-mental state examination score (r = -0.32; p = 0.040). We found significant evidence to support an association between CX3CL1 and neurogranin, already in the early stages of cognitive decline. Furthermore, our findings indicate that CXCL12 might be a useful marker for tract severity of cognitive impairment.", "doi": "10.3390/ijms241713166", "pmid": "37685973", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10487764"}, {"db": "pii", "key": "ijms241713166"}], "notes": [], "created": "2026-08-20T13:41:42.369Z", "modified": "2026-08-20T13:41:42.489Z"}]}