{"entity": "researcher", "timestamp": "2026-08-20T21:26:34.871Z", "family": "De Hoyos", "given": "Henry N", "initials": "HN", "orcid": "0000-0002-2083-1261", "affiliations": ["Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/9ec61e9e0f2b4d40ba33538dbb560702.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/9ec61e9e0f2b4d40ba33538dbb560702"}}, "publications": [{"entity": "publication", "iuid": "a386bee03a3a431eada00c785785e925", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/a386bee03a3a431eada00c785785e925.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/a386bee03a3a431eada00c785785e925"}}, "title": "Hematopoietic loss of Y chromosome leads to cardiac fibrosis and heart failure mortality.", "authors": [{"family": "Sano", "given": "Soichi", "initials": "S", "orcid": "0000-0002-3361-0839", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9862fb8d024948fdbd707bb9fb03161b.json"}}, {"family": "Horitani", "given": "Keita", "initials": "K"}, {"family": "Ogawa", "given": "Hayato", "initials": "H", "orcid": "0000-0002-1313-4230", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c4ea30d3ba2d4e28b033737208005501.json"}}, {"family": "Halvardson", "given": "Jonatan", "initials": "J", "orcid": "0000-0002-5533-1953", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fd5990b9edc749c9baa53290222e9255.json"}}, {"family": "Chavkin", "given": "Nicholas W", "initials": "NW", "orcid": "0000-0001-9058-0245", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d743aefa38fa4698a3c8a2df945e85ae.json"}}, {"family": "Wang", "given": "Ying", "initials": "Y", "orcid": "0000-0002-6249-1859", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7956bc76076d48d7ab8e109a0a628997.json"}}, {"family": "Sano", "given": "Miho", "initials": "M"}, {"family": "Mattisson", "given": "Jonas", "initials": "J", "orcid": "0000-0002-4456-9667", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/55ab3f88462844d9884e8787bd46236a.json"}}, {"family": "Hata", "given": "Atsushi", "initials": "A", "orcid": "0000-0002-9578-683X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/54d30610e72b4509919ce747a42d639a.json"}}, {"family": "Danielsson", "given": "Marcus", "initials": "M", "orcid": "0000-0003-4418-0165", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d41181bacaa34f13ad8e4455e36566d4.json"}}, {"family": "Miura-Yura", "given": "Emiri", "initials": "E", "orcid": "0000-0002-5477-5886", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fa27affe09e14c889e91a8f3c2f72593.json"}}, {"family": "Zaghlool", "given": "Ammar", "initials": "A"}, {"family": "Evans", "given": "Megan A", "initials": "MA"}, {"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7dbbd468e6da4727b69333ade942c071.json"}}, {"family": "De Hoyos", "given": "Henry N", "initials": "HN", "orcid": "0000-0002-2083-1261", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9ec61e9e0f2b4d40ba33538dbb560702.json"}}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J", "orcid": "0000-0003-2247-8454", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2e1b8ae02d2949acaa8c2e18349b33a1.json"}}, {"family": "Yura", "given": "Yoshimitsu", "initials": "Y", "orcid": "0000-0003-2618-8569", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/154bd289c3f84d9c841212642cb4b044.json"}}, {"family": "Kour", "given": "Anupreet", "initials": "A"}, {"family": "Arai", "given": "Yohei", "initials": "Y"}, {"family": "Thel", "given": "Mark C", "initials": "MC"}, {"family": "Arai", "given": "Yuka", "initials": "Y"}, {"family": "Mychaleckyj", "given": "Josyf C", "initials": "JC", "orcid": "0000-0003-2595-0005", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/eb04d147da184365831b33aedfef9cad.json"}}, {"family": "Hirschi", "given": "Karen K", "initials": "KK", "orcid": "0000-0001-7116-0130", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d70c2feaf8b74f75b80a0fb9dbb5f040.json"}}, {"family": "Forsberg", "given": "Lars A", "initials": "LA", "orcid": "0000-0002-1701-755X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8954f351ff414d1899bc0715d74ff86d.json"}}, {"family": "Walsh", "given": "Kenneth", "initials": "K", "orcid": "0000-0001-7580-2276", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d3d341f0f05e499f98ca01d583703783.json"}}], "type": "journal article", "published": "2022-07-15", "journal": {"title": "Science (New York, N.Y.)", "issn": "1095-9203", "volume": "377", "issue": "6603", "pages": "292-297", "issn-l": "0036-8075"}, "abstract": "Hematopoietic mosaic loss of Y chromosome (mLOY) is associated with increased risk of mortality and age-related diseases in men, but the causal and mechanistic relationships have yet to be established. Here, we show that male mice reconstituted with bone marrow cells lacking the Y chromosome display increased mortality and age-related profibrotic pathologies including reduced cardiac function. Cardiac macrophages lacking the Y chromosome exhibited polarization toward a more fibrotic phenotype, and treatment with a transforming growth factor \u03b21-neutralizing antibody ameliorated cardiac dysfunction in mLOY mice. A prospective study revealed that mLOY in blood is associated with an increased risk for cardiovascular disease and heart failure-associated mortality. Together, these results indicate that hematopoietic mLOY causally contributes to fibrosis, cardiac dysfunction, and mortality in men.", "doi": "10.1126/science.abn3100", "pmid": "35857592", "labels": [], "xrefs": [{"db": "mid", "key": "NIHMS1830716"}, {"db": "pmc", "key": "PMC9437978"}], "notes": [], "created": "2026-08-20T11:59:34.066Z", "modified": "2026-08-20T11:59:34.628Z"}]}