{"entity": "researcher", "timestamp": "2026-08-20T21:26:11.984Z", "family": "Hansen", "given": "Torben", "initials": "T", "orcid": "0000-0001-8748-3831", "affiliations": ["The Novo Nordisk Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, DK-2100, Denmark."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/9e9a365eccb44b28b293c7decc6f4b9f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/9e9a365eccb44b28b293c7decc6f4b9f"}}, "publications": [{"entity": "publication", "iuid": "97dcb877641d4da1b812ef995b72d5d3", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/97dcb877641d4da1b812ef995b72d5d3.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/97dcb877641d4da1b812ef995b72d5d3"}}, "title": "Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits.", "authors": [{"family": "Brown", "given": "Andrew A", "initials": "AA", "orcid": "0000-0002-8087-3033", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b690d27df56b44dc8a070e4265afc8ca.json"}}, {"family": "Fernandez-Tajes", "given": "Juan J", "initials": "JJ"}, {"family": "Hong", "given": "Mun-Gwan", "initials": "MG", "orcid": "0000-0001-8603-8293", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d12504acae5c4f31b83f75c3d7786cd4.json"}}, {"family": "Brorsson", "given": "Caroline A", "initials": "CA"}, {"family": "Koivula", "given": "Robert W", "initials": "RW"}, {"family": "Davtian", "given": "David", "initials": "D"}, {"family": "Dupuis", "given": "Th\u00e9o", "initials": "T"}, {"family": "Sartori", "given": "Ambra", "initials": "A"}, {"family": "Michalettou", "given": "Theodora-Dafni", "initials": "TD", "orcid": "0000-0003-2119-1099", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f0a44cd4ea604ce4a93b16870965dcc2.json"}}, {"family": "Forgie", "given": "Ian M", "initials": "IM"}, {"family": "Adam", "given": "Jonathan", "initials": "J"}, {"family": "Allin", "given": "Kristine H", "initials": "KH"}, {"family": "Caiazzo", "given": "Robert", "initials": "R", "orcid": "0000-0001-5383-0540", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/155b9c8799064e04be5118147542a25c.json"}}, {"family": "Cederberg", "given": "Henna", "initials": "H"}, {"family": "De Masi", "given": "Federico", "initials": "F"}, {"family": "Elders", "given": "Petra J M", "initials": "PJM"}, {"family": "Giordano", "given": "Giuseppe N", "initials": "GN", "orcid": "0000-0002-6719-6680", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dc30138be60e49d481bfc5f03a8fe61f.json"}}, {"family": "Haid", "given": "Mark", "initials": "M", "orcid": "0000-0001-6118-1333", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c4398da6ddb245bdb982ac3a0b352c40.json"}}, {"family": "Hansen", "given": "Torben", "initials": "T", "orcid": "0000-0001-8748-3831", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9e9a365eccb44b28b293c7decc6f4b9f.json"}}, {"family": "Hansen", "given": "Tue H", "initials": "TH", "orcid": "0000-0001-5948-8993", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/73418e2efdc1459483138da74b0abad6.json"}}, {"family": "Hattersley", "given": "Andrew T", "initials": "AT", "orcid": "0000-0001-5620-473X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dfbb9bb951f04ed3ac56eb4890d3186a.json"}}, {"family": "Heggie", "given": "Alison J", "initials": "AJ"}, {"family": "Howald", "given": "C\u00e9dric", "initials": "C"}, {"family": "Jones", "given": "Angus G", "initials": "AG", "orcid": "0000-0002-0883-7599", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fb98d0951469460d8e87bbd7e71741db.json"}}, {"family": "Kokkola", "given": "Tarja", "initials": "T", "orcid": "0000-0002-3303-3912", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fc389880431a46e49fcbe0eae12908ea.json"}}, {"family": "Laakso", "given": "Markku", "initials": "M", "orcid": "0000-0002-3394-7749", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/81c631c24b2e4c479ac6976eab7b1e88.json"}}, {"family": "Mahajan", "given": "Anubha", "initials": "A"}, {"family": "Mari", "given": "Andrea", "initials": "A", "orcid": "0000-0002-1436-5591", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3b7dd1ab06074d1188e40713d8807c48.json"}}, {"family": "McDonald", "given": "Timothy J", "initials": "TJ"}, {"family": "McEvoy", "given": "Donna", "initials": "D"}, {"family": "Mourby", "given": "Miranda", "initials": "M"}, {"family": "Musholt", "given": "Petra B", "initials": "PB"}, {"family": "Nilsson", "given": "Birgitte", "initials": "B"}, {"family": "Pattou", "given": "Francois", "initials": "F", "orcid": "0000-0001-8388-3766", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0769cc7e166943cb98978c45c12d749a.json"}}, {"family": "Penet", "given": "Deborah", "initials": "D"}, {"family": "Raverdy", "given": "Violeta", "initials": "V"}, {"family": "Ridderstr\u00e5le", "given": "Martin", "initials": "M"}, {"family": "Romano", "given": "Luciana", "initials": "L"}, {"family": "Rutters", "given": "Femke", "initials": "F"}, {"family": "Sharma", "given": "Sapna", "initials": "S"}, {"family": "Teare", "given": "Harriet", "initials": "H"}, {"family": "'t Hart", "given": "Leen", "initials": "L", "orcid": "0000-0003-4401-2938", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c36c8ed413ed4d6f975341fe511035e3.json"}}, {"family": "Tsirigos", "given": "Konstantinos D", "initials": "KD"}, {"family": "Vangipurapu", "given": "Jagadish", "initials": "J"}, {"family": "Vestergaard", "given": "Henrik", "initials": "H", "orcid": "0000-0003-3090-269X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e2fa5c4f74894d6a833afd105ec72848.json"}}, {"family": "Brunak", "given": "S\u00f8ren", "initials": "S"}, {"family": "Franks", "given": "Paul W", "initials": "PW", "orcid": "0000-0002-0520-7604", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8263a26f474946de8b61a2080051d37b.json"}}, {"family": "Frost", "given": "Gary", "initials": "G", "orcid": "0000-0003-0529-6325", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/894534933d064d1f802f1690ea56f162.json"}}, {"family": "Grallert", "given": "Harald", "initials": "H"}, {"family": "Jablonka", "given": "Bernd", "initials": "B"}, {"family": "McCarthy", "given": "Mark I", "initials": "MI"}, {"family": "Pavo", "given": "Imre", "initials": "I", "orcid": "0000-0002-2016-7049", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1691b459fdb84772b1e8595e8de617f3.json"}}, {"family": "Pedersen", "given": "Oluf", "initials": "O", "orcid": "0000-0002-3321-3972", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a0ef37542aea4e67a322b0d6179cd59e.json"}}, {"family": "Ruetten", "given": "Hartmut", "initials": "H"}, {"family": "Walker", "given": "Mark", "initials": "M"}, {"family": "DIRECT Consortium", "given": "", "initials": ""}, {"family": "Adamski", "given": "Jerzy", "initials": "J", "orcid": "0000-0001-9259-0199", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6871f2a0d4414a58be2e7f26a59d3ca9.json"}}, {"family": "Schwenk", "given": "Jochen M", "initials": "JM", "orcid": "0000-0001-8141-8449", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/022e140799b6466ea123319c3d70c76e.json"}}, {"family": "Pearson", "given": "Ewan R", "initials": "ER", "orcid": "0000-0001-9237-8585", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e27e9e47f1cc4a969268eb5a65b8045b.json"}}, {"family": "Dermitzakis", "given": "Emmanouil T", "initials": "ET", "orcid": "0000-0002-9302-6490", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6683f17defc34cad9389fd7fef36aca4.json"}}, {"family": "Vi\u00f1uela", "given": "Ana", "initials": "A", "orcid": "0000-0003-3771-8537", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/02cba70871df48eb84c17e82f95baae4.json"}}], "type": "journal article", "published": "2023-08-21", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "14", "issue": "1", "pages": "5062", "issn-l": "2041-1723"}, "abstract": "We evaluate the shared genetic regulation of mRNA molecules, proteins and metabolites derived from whole blood from 3029 human donors. We find abundant allelic heterogeneity, where multiple variants regulate a particular molecular phenotype, and pleiotropy, where a single variant associates with multiple molecular phenotypes over multiple genomic regions. The highest proportion of share genetic regulation is detected between gene expression and proteins (66.6%), with a further median shared genetic associations across 49 different tissues of 78.3% and 62.4% between plasma proteins and gene expression. We represent the genetic and molecular associations in networks including 2828 known GWAS variants, showing that GWAS variants are more often connected to gene expression in trans than other molecular phenotypes in the network. Our work provides a roadmap to understanding molecular networks and deriving the underlying mechanism of action of GWAS variants using different molecular phenotypes in an accessible tissue.", "doi": "10.1038/s41467-023-40569-3", "pmid": "37604891", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10442420"}, {"db": "pii", "key": "10.1038/s41467-023-40569-3"}], "notes": [], "created": "2026-08-20T08:52:44.576Z", "modified": "2026-08-20T08:52:45.407Z"}, {"entity": "publication", "iuid": "ca320476e9aa498aaac894559da40b92", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ca320476e9aa498aaac894559da40b92.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ca320476e9aa498aaac894559da40b92"}}, "title": "Author Correction: Discovery of drug-omics associations in type 2 diabetes with generative deep-learning models.", "authors": [{"family": "Alles\u00f8e", "given": "Rosa Lundbye", "initials": "RL"}, {"family": "Lundgaard", "given": "Agnete Troen", "initials": "AT", "orcid": "0000-0001-7447-6560", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e6d31459d60f4ce789790f6a6ef62328.json"}}, {"family": "Hern\u00e1ndez Medina", "given": "Ricardo", "initials": "R", "orcid": "0000-0001-6373-2362", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca886502c85a48b88ffca91c7bfd4199.json"}}, {"family": "Aguayo-Orozco", "given": "Alejandro", "initials": "A"}, {"family": "Johansen", "given": "Joachim", "initials": "J", "orcid": "0000-0001-7052-1870", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6632c093611e4773aa14b1e81d23e32d.json"}}, {"family": "Nissen", "given": "Jakob Nybo", "initials": "JN"}, {"family": "Brorsson", "given": "Caroline", "initials": "C"}, {"family": "Mazzoni", "given": "Gianluca", "initials": "G"}, {"family": "Niu", "given": "Lili", "initials": "L", "orcid": "0000-0003-4571-4368", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0bd02c00c9ed4bf6998b7d53a4869eaa.json"}}, {"family": "Biel", "given": "Jorge Hernansanz", "initials": "JH", "orcid": "0000-0002-3125-2951", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b4f7b4e611404a14babf48998278717b.json"}}, {"family": "Leal Rodr\u00edguez", "given": "Cristina", "initials": "C", "orcid": "0000-0002-3133-0630", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/191706530d834312a25dc1135308064c.json"}}, {"family": "Brasas", "given": "Valentas", "initials": "V"}, {"family": "Webel", "given": "Henry", "initials": "H"}, {"family": "Benros", "given": "Michael Eriksen", "initials": "ME", "orcid": "0000-0003-4939-9465", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0d2caccd100b4dbcba0be788cdcafedc.json"}}, {"family": "Pedersen", "given": "Anders Gorm", "initials": "AG", "orcid": "0000-0001-9650-8965", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3131dd5c0ceb4935a15971a8f621d41d.json"}}, {"family": "Chmura", "given": "Piotr Jaroslaw", "initials": "PJ"}, {"family": "Jacobsen", "given": "Ulrik Plesner", "initials": "UP", "orcid": "0000-0001-9181-6854", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ce035ed82b6f456d8a1f08b12f77f68e.json"}}, {"family": "Mari", "given": "Andrea", "initials": "A"}, {"family": "Koivula", "given": "Robert", "initials": "R", "orcid": "0000-0002-1646-4163", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2ceb821c78774b9f8931463351046f1f.json"}}, {"family": "Mahajan", "given": "Anubha", "initials": "A"}, {"family": "Vinuela", "given": "Ana", "initials": "A", "orcid": "0000-0003-3771-8537", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/02cba70871df48eb84c17e82f95baae4.json"}}, {"family": "Tajes", "given": "Juan Fernandez", "initials": "JF"}, {"family": "Sharma", "given": "Sapna", "initials": "S"}, {"family": "Haid", "given": "Mark", "initials": "M", "orcid": "0000-0001-6118-1333", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c4398da6ddb245bdb982ac3a0b352c40.json"}}, {"family": "Hong", "given": "Mun-Gwan", "initials": "MG", "orcid": "0000-0001-8603-8293", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d12504acae5c4f31b83f75c3d7786cd4.json"}}, {"family": "Musholt", "given": "Petra B", "initials": "PB"}, {"family": "De Masi", "given": "Federico", "initials": "F"}, {"family": "Vogt", "given": "Josef", "initials": "J"}, {"family": "Pedersen", "given": "Helle Krogh", "initials": "HK"}, {"family": "Gudmundsdottir", "given": "Valborg", "initials": "V"}, {"family": "Jones", "given": "Angus", "initials": "A"}, {"family": "Kennedy", "given": "Gwen", "initials": "G", "orcid": "0000-0002-9856-3236", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/06b17b204aaa442293ac0b9981b84b43.json"}}, {"family": "Bell", "given": "Jimmy", "initials": "J"}, {"family": "Thomas", "given": "E Louise", "initials": "EL", "orcid": "0000-0003-4235-4694", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9b85b142cc9748669e6b24272efb4728.json"}}, {"family": "Frost", "given": "Gary", "initials": "G", "orcid": "0000-0003-0529-6325", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/894534933d064d1f802f1690ea56f162.json"}}, {"family": "Thomsen", "given": "Henrik", "initials": "H"}, {"family": "Hansen", "given": "Elizaveta", "initials": "E"}, {"family": "Hansen", "given": "Tue Haldor", "initials": "TH", "orcid": "0000-0001-5948-8993", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/73418e2efdc1459483138da74b0abad6.json"}}, {"family": "Vestergaard", "given": "Henrik", "initials": "H"}, {"family": "Muilwijk", "given": "Mirthe", "initials": "M"}, {"family": "Blom", "given": "Marieke T", "initials": "MT"}, {"family": "'t Hart", "given": "Leen M", "initials": "LM"}, {"family": "Pattou", "given": "Francois", "initials": "F"}, {"family": "Raverdy", "given": "Violeta", "initials": "V"}, {"family": "Brage", "given": "Soren", "initials": "S"}, {"family": "Kokkola", "given": "Tarja", "initials": "T"}, {"family": "Heggie", "given": "Alison", "initials": "A"}, {"family": "McEvoy", "given": "Donna", "initials": "D"}, {"family": "Mourby", "given": "Miranda", "initials": "M"}, {"family": "Kaye", "given": "Jane", "initials": "J", "orcid": "0000-0002-7311-4725", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/119626aab80347b08e5143547fc8d921.json"}}, {"family": "Hattersley", "given": "Andrew", "initials": "A", "orcid": "0000-0001-5620-473X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dfbb9bb951f04ed3ac56eb4890d3186a.json"}}, {"family": "McDonald", "given": "Timothy", "initials": "T"}, {"family": "Ridderstr\u00e5le", "given": "Martin", "initials": "M", "orcid": "0000-0002-3270-9167", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ce961d525f784428b1b6cdd4d3ed0c1a.json"}}, {"family": "Walker", "given": "Mark", "initials": "M"}, {"family": "Forgie", "given": "Ian", "initials": "I"}, {"family": "Giordano", "given": "Giuseppe N", "initials": "GN"}, {"family": "Pavo", "given": "Imre", "initials": "I"}, {"family": "Ruetten", "given": "Hartmut", "initials": "H"}, {"family": "Pedersen", "given": "Oluf", "initials": "O", "orcid": "0000-0002-3321-3972", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a0ef37542aea4e67a322b0d6179cd59e.json"}}, {"family": "Hansen", "given": "Torben", "initials": "T", "orcid": "0000-0001-8748-3831", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9e9a365eccb44b28b293c7decc6f4b9f.json"}}, {"family": "Dermitzakis", "given": "Emmanouil", "initials": "E"}, {"family": "Franks", "given": "Paul W", "initials": "PW"}, {"family": "Schwenk", "given": "Jochen M", "initials": "JM", "orcid": "0000-0001-8141-8449", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/022e140799b6466ea123319c3d70c76e.json"}}, {"family": "Adamski", "given": "Jerzy", "initials": "J"}, {"family": "McCarthy", "given": "Mark I", "initials": "MI"}, {"family": "Pearson", "given": "Ewan", "initials": "E"}, {"family": "Banasik", "given": "Karina", "initials": "K"}, {"family": "Rasmussen", "given": "Simon", "initials": "S", "orcid": "0000-0001-6323-9041", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/65dab4aefc624749a6b8d003bcd54200.json"}}, {"family": "Brunak", "given": "S\u00f8ren", "initials": "S", "orcid": "0000-0003-0316-5866", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/560f89e3ea56424fb96ca55aad9b9814.json"}}, {"family": "IMI DIRECT Consortium", "given": "", "initials": ""}], "type": "published erratum", "published": "2023-07-00", "journal": {"title": "Nat. Biotechnol.", "issn": "1546-1696", "volume": "41", "issue": "7", "pages": "1026", "issn-l": "1087-0156"}, "abstract": null, "doi": "10.1038/s41587-023-01805-9", "pmid": "37130959", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10344774"}, {"db": "pii", "key": "10.1038/s41587-023-01805-9"}], "notes": [], "created": "2026-08-20T08:59:30.416Z", "modified": "2026-08-20T08:59:31.137Z"}, {"entity": "publication", "iuid": "967be0398ae444168838f6c87c44e030", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/967be0398ae444168838f6c87c44e030.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/967be0398ae444168838f6c87c44e030"}}, "title": "Physical activity and sedentary behavior; mechanistic insights and role in disease prevention", "authors": [{"family": "Hoed", "given": "Marcel den", "initials": "Md", "orcid": "0000-0001-8081-428X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1d3e34c06cff4446ad703cde901c5033.json"}}, {"family": "Wang", "given": "Zhe", "initials": "Z", "orcid": "0000-0002-8046-4969", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f925d8ce81524036b0566ce2990b55bc.json"}}, {"family": "Emmerich", "given": "Andrew", "initials": "A", "orcid": "0000-0002-0908-9924", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/aa4f587b046548b29aecace3562ec035.json"}}, {"family": "Pillon", "given": "Nicolas", "initials": "N"}, {"family": "Moore", "given": "Timothy", "initials": "T", "orcid": "0000-0003-4250-3370", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0934cc091f0543e78ca8251fa85c33d4.json"}}, {"family": "Hemerich", "given": "Daiane", "initials": "D"}, {"family": "Cornelis", "given": "Marilyn", "initials": "M"}, {"family": "Mazzaferro", "given": "Eugenia", "initials": "E"}, {"family": "Broos", "given": "Siacia", "initials": "S"}, {"family": "Ameur", "given": "Adam", "initials": "A", "orcid": "0000-0001-6085-6749", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a8b8ce05cf7f49aeb3199b5938b9f160.json"}}, {"family": "Bandinelli", "given": "Stefania", "initials": "S"}, {"family": "Bis", "given": "Joshua", "initials": "J", "orcid": "0000-0002-3409-1110", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/de8dd43c6fe64ebbaf718500e4fef3d9.json"}}, {"family": "Boehnke", "given": "Michael", "initials": "M", "orcid": "0000-0002-6442-7754", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e36dfed05bd94a1588f0ad628a9e39c5.json"}}, {"family": "Bouchard", "given": "Claude", "initials": "C", "orcid": "0000-0002-0048-491X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/232ca34e3fab46d1a0d0c97bfb35cbab.json"}}, {"family": "Chasman", "given": "Daniel", "initials": "D", "orcid": "0000-0003-3357-0862", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dd69cafe762f44979e924c682f237d03.json"}}, {"family": "de Geus", "given": "Eco", "initials": "E", "orcid": "0000-0001-6022-2666", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cfe61063c4644006a01e837b72ae3345.json"}}, {"family": "Deldicque", "given": "Louise", "initials": "L"}, {"family": "D\u00f6rr", "given": "Marcus", "initials": "M", "orcid": "0000-0001-7471-475X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8d6c5c674ee34552a9af45e6855dff62.json"}}, {"family": "Evans", "given": "Michele", "initials": "M"}, {"family": "Ferrucci", "given": "Luigi", "initials": "L", "orcid": "0000-0002-6273-1613", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3157462173f3465395d0bd7f5cec4331.json"}}, {"family": "Fornage", "given": "Myriam", "initials": "M", "orcid": "0000-0003-0677-8158", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f637ca1a5edd4ece9dd2f88f3620f0b2.json"}}, {"family": "Fox", "given": "Caroline", "initials": "C"}, {"family": "Garland", "given": "Theodore", "initials": "T", "orcid": "0000-0002-7916-3552", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/57175d38e8f54654816e74bd900c7bd9.json"}}, {"family": "Gyllensten", "given": "Ulf", "initials": "U", "orcid": "0000-0002-6316-3355", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/eacfdf2095e947e99ac45fe994261b72.json"}}, {"family": "Hansen", "given": "Torben", "initials": "T", "orcid": "0000-0001-8748-3831", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9e9a365eccb44b28b293c7decc6f4b9f.json"}}, {"family": "Hayward", "given": "Caroline", "initials": "C", "orcid": "0000-0002-9405-9550", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/542b00d650124ce4a3776ae95571e2c1.json"}}, {"family": "Horta", "given": "Bernardo", "initials": "B", "orcid": "0000-0001-9843-412X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3325c1f67b0b4b0c9aee1ed32a2c75aa.json"}}, {"family": "Hypponen", "given": "Elina", "initials": "E", "orcid": "0000-0003-3670-9399", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d94560345b1343afaa26232764e5e509.json"}}, {"family": "Johnson", "given": "W Craig", "initials": "WC", "orcid": "0000-0002-3161-3753", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9f8dba0003084728816528474628d698.json"}}, {"family": "Kardia", "given": "Sharon", "initials": "S"}, {"family": "Kiemeney", "given": "Lambertus", "initials": "L", "orcid": "0000-0002-2368-1326", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/77aa9edd1eb24487850c429f7c2d33ea.json"}}, {"family": "Laakso", "given": "Markku", "initials": "M", "orcid": "0000-0002-3394-7749", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/81c631c24b2e4c479ac6976eab7b1e88.json"}}, {"family": "Langenberg", "given": "Claudia", "initials": "C", "orcid": "0000-0002-5017-7344", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f287f3248cc24c6cbfc100c249b87418.json"}}, {"family": "Lehtim\u00e4ki", "given": "Terho", "initials": "T", "orcid": "0000-0002-2555-4427", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/74306ef9629647f7a0297b890df37cd0.json"}}, {"family": "Marchand", "given": "Loic Le", "initials": "LL"}, {"family": "Magnusson", "given": "Patrik", "initials": "P", "orcid": "0000-0002-7315-7899", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d6fa8b01df9f4bf68607603c51c5a106.json"}}, {"family": "Martin", "given": "Nicholas", "initials": "N", "orcid": "0000-0003-4069-8020", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5e77e96035ab425f93ef18778dfceb04.json"}}, {"family": "Melbye", "given": "Mads", "initials": "M"}, {"family": "Metspalu", "given": "Andres", "initials": "A", "orcid": "0000-0002-3718-796X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f7b8013339e249c1a7a650b8c2f9bc28.json"}}, {"family": "Meyre", "given": "David", "initials": "D", "orcid": "0000-0003-4850-7444", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1380453d703c4d2bb0be645bffabe7a9.json"}}, {"family": "North", "given": "Kari", "initials": "K"}, {"family": "Ohlsson", "given": "Claes", "initials": "C", "orcid": "0000-0002-9633-2805", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f3787ec4ade6486ba486cd97e4bc8f62.json"}}, {"family": "Oldehinkel", "given": "Albertine", "initials": "A", "orcid": "0000-0003-3925-3913", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5b41e3ece7d3475c821424ec9e04fbd5.json"}}, {"family": "Orho-Melander", "given": "Marju", "initials": "M"}, {"family": "Pare", "given": "Guillaume", "initials": "G", "orcid": "0000-0002-6795-4760", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ef5b393b30f54b5f9c4531ceddc51b90.json"}}, {"family": "Park", "given": "Taesung", "initials": "T", "orcid": "0000-0002-8294-590X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ab257ac529544ecbb25f376a9b820bf0.json"}}, {"family": "Pedersen", "given": "Oluf", "initials": "O", "orcid": "0000-0002-3321-3972", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a0ef37542aea4e67a322b0d6179cd59e.json"}}, {"family": "Penninx", "given": "Brenda", "initials": "B"}, {"family": "Pers", "given": "Tune", "initials": "T", "orcid": "0000-0003-0207-4831", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5229243d3ee54140b73924a3c221ecf1.json"}}, {"family": "Polasek", "given": "Ozren", "initials": "O", "orcid": "0000-0002-5765-1862", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e353bda316a54235b6145065c4ad8552.json"}}, {"family": "Prokopenko", "given": "Inga", "initials": "I", "orcid": "0000-0003-1624-7457", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/aa86d82a5dc54f53b4ff6e622b7f07fb.json"}}, {"family": "Rotimi", "given": "Charles", "initials": "C", "orcid": "0000-0001-5759-053X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8406c9c754bd469e826667907e1dbfce.json"}}, {"family": "Samani", "given": "Nilesh", "initials": "N"}, {"family": "Sim", "given": "Xueling", "initials": "X", "orcid": "0000-0002-1233-7642", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b9aec75e482049f5b169a9cfc517a351.json"}}, {"family": "Smith", "given": "George Davey", "initials": "GD", "orcid": "0000-0002-1407-8314", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/436568943f784bfca4d2321ceadb0d47.json"}}, {"family": "Snieder", "given": "Harold", "initials": "H", "orcid": "0000-0003-1949-2298", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb5a2135b774429596606e980c9268ec.json"}}, {"family": "Sorensen", "given": "Thorkild", "initials": "T", "orcid": "0000-0003-4821-430X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1d9d701ecbbd4346a484b74d37ce9ff6.json"}}, {"family": "Spector", "given": "Tim", "initials": "T", "orcid": "0000-0002-9795-0365", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6d79b7af2d7a4f1da46ac2ee2bb1eb0b.json"}}, {"family": "Timpson", "given": "Nicholas", "initials": "N", "orcid": "0000-0002-7141-9189", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4746ddba0e7f40a5af1e2fee8c7b6b7c.json"}}, {"family": "Dam", "given": "Rob van", "initials": "Rv"}, {"family": "Velde", "given": "Nathalie van der", "initials": "Nvd"}, {"family": "Vollenweider", "given": "Peter", "initials": "P"}, {"family": "V\u00f6lzke", "given": "Henry", "initials": "H"}, {"family": "Voortman", "given": "Trudy", "initials": "T", "orcid": "0000-0003-2830-6813", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e76bee260269414fb91878cfe2dc561d.json"}}, {"family": "Waeber", "given": "Gerard", "initials": "G", "orcid": "0000-0003-4193-788X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b3685d2c24024c2eb613b4009fed9b69.json"}}, {"family": "Wareham", "given": "Nick", "initials": "N", "orcid": "0000-0003-1422-2993", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/462fd4169f41418887a5a979e0808d87.json"}}, {"family": "Weir", "given": "David", "initials": "D", "orcid": "0000-0002-1661-2402", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4105b31d72044f76bfd07ca12a274569.json"}}, {"family": "Wichmann", "given": "Erich", "initials": "E"}, {"family": "Wilson", "given": "James", "initials": "J", "orcid": "0000-0001-5751-9178", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/513b6983cc9d478ab9d81c2f21579961.json"}}, {"family": "Hevener", "given": "Andrea", "initials": "A"}, {"family": "Krook", "given": "Anna", "initials": "A", "orcid": "0000-0002-0891-0258", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8d8fcbad28984a36a6c9e733546fe827.json"}}, {"family": "Zierath", "given": "Juleen", "initials": "J", "orcid": "0000-0001-6891-7497", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3b0413eb05054827b1b18ffe9003e744.json"}}, {"family": "Thomis", "given": "Martine", "initials": "M"}, {"family": "Loos", "given": "Ruth", "initials": "R", "orcid": "0000-0002-8532-5087", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/179eb6511eba4d33b633599c5652e344.json"}}], "type": "posted-content", "published": "2021-12-16", "journal": {"issn-l": null}, "abstract": null, "doi": "10.21203/rs.3.rs-1129252/v1", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T12:58:05.052Z", "modified": "2026-08-20T12:58:06.215Z"}, {"entity": "publication", "iuid": "77910c659eba495088c76361a47a6739", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/77910c659eba495088c76361a47a6739.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/77910c659eba495088c76361a47a6739"}}, "title": "Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study.", "authors": [{"family": "Bizzotto", "given": "Roberto", "initials": "R", "orcid": "0000-0002-8251-1730", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8e59c1b67213459d9ade9f1dc87ea865.json"}}, {"family": "Jennison", "given": "Christopher", "initials": "C"}, {"family": "Jones", "given": "Angus G", "initials": "AG", "orcid": "0000-0002-0883-7599", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fb98d0951469460d8e87bbd7e71741db.json"}}, {"family": "Kurbasic", "given": "Azra", "initials": "A"}, {"family": "Tura", "given": "Andrea", "initials": "A"}, {"family": "Kennedy", "given": "Gwen", "initials": "G"}, {"family": "Bell", "given": "Jimmy D", "initials": "JD"}, {"family": "Thomas", "given": "E Louise", "initials": "EL"}, {"family": "Frost", "given": "Gary", "initials": "G", "orcid": "0000-0003-0529-6325", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/894534933d064d1f802f1690ea56f162.json"}}, {"family": "Eriksen", "given": "Rebeca", "initials": "R"}, {"family": "Koivula", "given": "Robert W", "initials": "RW", "orcid": "0000-0002-1646-4163", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2ceb821c78774b9f8931463351046f1f.json"}}, {"family": "Brage", "given": "Soren", "initials": "S"}, {"family": "Kaye", "given": "Jane", "initials": "J"}, {"family": "Hattersley", "given": "Andrew T", "initials": "AT", "orcid": "0000-0001-5620-473X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dfbb9bb951f04ed3ac56eb4890d3186a.json"}}, {"family": "Heggie", "given": "Alison", "initials": "A"}, {"family": "McEvoy", "given": "Donna", "initials": "D"}, {"family": "'t Hart", "given": "Leen M", "initials": "LM"}, {"family": "Beulens", "given": "Joline W", "initials": "JW", "orcid": "0000-0002-4181-0937", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/26b2b48b79a942e8ab9cb7382585ce21.json"}}, {"family": "Elders", "given": "Petra", "initials": "P"}, {"family": "Musholt", "given": "Petra B", "initials": "PB"}, {"family": "Ridderstr\u00e5le", "given": "Martin", "initials": "M", "orcid": "0000-0002-3270-9167", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ce961d525f784428b1b6cdd4d3ed0c1a.json"}}, {"family": "Hansen", "given": "Tue H", "initials": "TH"}, {"family": "Allin", "given": "Kristine H", "initials": "KH", "orcid": "0000-0002-6880-5759", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/57d2acb6ed9146908728b751c105a37c.json"}}, {"family": "Hansen", "given": "Torben", "initials": "T", "orcid": "0000-0001-8748-3831", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9e9a365eccb44b28b293c7decc6f4b9f.json"}}, {"family": "Vestergaard", "given": "Henrik", "initials": "H"}, {"family": "Lundgaard", "given": "Agnete T", "initials": "AT"}, {"family": "Thomsen", "given": "Henrik S", "initials": "HS"}, {"family": "De Masi", "given": "Federico", "initials": "F"}, {"family": "Tsirigos", "given": "Konstantinos D", "initials": "KD"}, {"family": "Brunak", "given": "S\u00f8ren", "initials": "S"}, {"family": "Vi\u00f1uela", "given": "Ana", "initials": "A"}, {"family": "Mahajan", "given": "Anubha", "initials": "A", "orcid": "0000-0001-5585-3420", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/41b3d44662484e0289f07fa25d045cf4.json"}}, {"family": "McDonald", "given": "Timothy J", "initials": "TJ", "orcid": "0000-0003-3559-6660", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/11b833983c5d4416bceac079dcee38d6.json"}}, {"family": "Kokkola", "given": "Tarja", "initials": "T"}, {"family": "Forgie", "given": "Ian M", "initials": "IM"}, {"family": "Giordano", "given": "Giuseppe N", "initials": "GN"}, {"family": "Pavo", "given": "Imre", "initials": "I"}, {"family": "Ruetten", "given": "Hartmut", "initials": "H"}, {"family": "Dermitzakis", "given": "Emmanouil", "initials": "E"}, {"family": "McCarthy", "given": "Mark I", "initials": "MI"}, {"family": "Pedersen", "given": "Oluf", "initials": "O"}, {"family": "Schwenk", "given": "Jochen M", "initials": "JM"}, {"family": "Adamski", "given": "Jerzy", "initials": "J"}, {"family": "Franks", "given": "Paul W", "initials": "PW", "orcid": "0000-0002-0520-7604", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8263a26f474946de8b61a2080051d37b.json"}}, {"family": "Walker", "given": "Mark", "initials": "M"}, {"family": "Pearson", "given": "Ewan R", "initials": "ER", "orcid": "0000-0001-9237-8585", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e27e9e47f1cc4a969268eb5a65b8045b.json"}}, {"family": "Mari", "given": "Andrea", "initials": "A", "orcid": "0000-0002-1436-5591", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3b7dd1ab06074d1188e40713d8807c48.json"}}, {"family": "IMI DIRECT consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2021-02-00", "journal": {"title": "Diabetes Care", "issn": "1935-5548", "volume": "44", "issue": "2", "pages": "511-518", "issn-l": null}, "abstract": "We investigated the processes underlying glycemic deterioration in type 2 diabetes (T2D).\n\nA total of 732 recently diagnosed patients with T2D from the Innovative Medicines Initiative Diabetes Research on Patient Stratification (IMI DIRECT) study were extensively phenotyped over 3 years, including measures of insulin sensitivity (OGIS), \u03b2-cell glucose sensitivity (GS), and insulin clearance (CLIm) from mixed meal tests, liver enzymes, lipid profiles, and baseline regional fat from MRI. The associations between the longitudinal metabolic patterns and HbA1c deterioration, adjusted for changes in BMI and in diabetes medications, were assessed via stepwise multivariable linear and logistic regression.\n\nFaster HbA1c progression was independently associated with faster deterioration of OGIS and GS and increasing CLIm; visceral or liver fat, HDL-cholesterol, and triglycerides had further independent, though weaker, roles (R 2 = 0.38). A subgroup of patients with a markedly higher progression rate (fast progressors) was clearly distinguishable considering these variables only (discrimination capacity from area under the receiver operating characteristic = 0.94). The proportion of fast progressors was reduced from 56% to 8-10% in subgroups in which only one trait among OGIS, GS, and CLIm was relatively stable (odds ratios 0.07-0.09). T2D polygenic risk score and baseline pancreatic fat, glucagon-like peptide 1, glucagon, diet, and physical activity did not show an independent role.\n\nDeteriorating insulin sensitivity and \u03b2-cell function, increasing insulin clearance, high visceral or liver fat, and worsening of the lipid profile are the crucial factors mediating glycemic deterioration of patients with T2D in the initial phase of the disease. Stabilization of a single trait among insulin sensitivity, \u03b2-cell function, and insulin clearance may be relevant to prevent progression.", "doi": "10.2337/dc20-1567", "pmid": "33323478", "labels": [], "xrefs": [{"db": "pii", "key": "dc20-1567"}, {"db": "figshare", "key": "10.2337/figshare.13222205"}], "notes": [], "created": "2026-08-20T13:03:02.855Z", "modified": "2026-08-20T13:03:03.150Z"}]}