{"entity": "researcher", "timestamp": "2026-08-20T20:58:22.949Z", "family": "Angeletti", "given": "Davide", "initials": "D", "orcid": "0000-0002-5256-1972", "affiliations": ["Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden. davide.angeletti@gu.se.", "SciLifeLab, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden. davide.angeletti@gu.se."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/9dc9fbaf7b004246ba528c17909d5a48.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/9dc9fbaf7b004246ba528c17909d5a48"}}, "publications": [{"entity": "publication", "iuid": "889bc5e924064822b37a5e6d2ca3344a", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/889bc5e924064822b37a5e6d2ca3344a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/889bc5e924064822b37a5e6d2ca3344a"}}, "title": "Ectopic germinal centers in the nasal turbinates contribute to B cell immunity to intranasal viral infection and vaccination.", "authors": [{"family": "Gailleton", "given": "Romain", "initials": "R"}, {"family": "Mathew", "given": "Nimitha R", "initials": "NR", "orcid": "0000-0003-3942-695X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ba839db2655a4f5fb006c8e531e6d1c1.json"}}, {"family": "Reusch", "given": "Laura", "initials": "L", "orcid": "0009-0005-6024-5637", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1ff5711342e343e4a71a51609e993a05.json"}}, {"family": "Sch\u00f6n", "given": "Karin", "initials": "K"}, {"family": "Scharf", "given": "Lydia", "initials": "L"}, {"family": "Str\u00f6mberg", "given": "Anneli", "initials": "A"}, {"family": "Cvjetkovic", "given": "Andrea", "initials": "A"}, {"family": "Aziz", "given": "Luaay", "initials": "L", "orcid": "0000-0002-0408-8738", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/38978179896c4b6b84db7260f66b5fcd.json"}}, {"family": "Hellgren", "given": "Johan", "initials": "J"}, {"family": "Tang", "given": "Ka-Wei", "initials": "KW"}, {"family": "Bemark", "given": "Mats", "initials": "M", "orcid": "0000-0001-7416-9819", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0a9796a58ffa4f99908723059301ac0a.json"}}, {"family": "Angeletti", "given": "Davide", "initials": "D", "orcid": "0000-0002-5256-1972", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9dc9fbaf7b004246ba528c17909d5a48.json"}}], "type": "journal article", "published": "2025-03-25", "journal": {"title": "Proc. Natl. Acad. Sci. U.S.A.", "issn": "1091-6490", "volume": "122", "issue": "12", "pages": "e2421724122", "issn-l": "0027-8424"}, "abstract": "The nasal mucosa is the first immunologically active site that respiratory viruses encounter and establishing immunity at the initial point of pathogen contact is essential for preventing viral spread. Influenza A virus (IAV) in humans preferentially replicates in the upper respiratory tract (URT) but mouse models of infection result in lower respiratory tract infection. Here, we optimize IAV inoculation to enhance replication in the nasal turbinate (NT) and study local B cell immunity. We demonstrate that URT-targeted IAV infection stimulates robust local B cell responses, including germinal center (GC) B cell formation in the NT, outside of classical nasal-associated lymphoid tissues. NT GC contributes to local tissue-resident B cell generation and enhances local antibody production. Furthermore, URT-focused immunization also induces significant GC formation in the NT. Finally, we detect steady-state GC in the NT of both mice and healthy humans, suggesting continuous immune surveillance triggered by environmental stimuli. These findings highlight the pivotal role of the NT in local and systemic immunity, with important implications for future mucosal vaccines targeting the upper airways.", "doi": "10.1073/pnas.2421724122", "pmid": "40112112", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11962485"}], "notes": [], "created": "2026-08-20T09:31:53.277Z", "modified": "2026-08-20T09:31:53.484Z"}, {"entity": "publication", "iuid": "b0a1ff75664646ee960b74b2774bb49b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b0a1ff75664646ee960b74b2774bb49b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b0a1ff75664646ee960b74b2774bb49b"}}, "title": "Influenza A Virus H7 nanobody recognizes a conserved immunodominant epitope on hemagglutinin head and confers heterosubtypic protection.", "authors": [{"family": "Chen", "given": "Zhao-Shan", "initials": "ZS"}, {"family": "Huang", "given": "Hsiang-Chi", "initials": "HC"}, {"family": "Wang", "given": "Xiangkun", "initials": "X"}, {"family": "Sch\u00f6n", "given": "Karin", "initials": "K"}, {"family": "Jia", "given": "Yane", "initials": "Y"}, {"family": "Lebens", "given": "Michael", "initials": "M"}, {"family": "Besavilla", "given": "Danica F", "initials": "DF", "orcid": "0009-0000-8420-9853", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/df2501d8d7fc4f58a87cd757fda3ce61.json"}}, {"family": "Murti", "given": "Janarthan R", "initials": "JR"}, {"family": "Ji", "given": "Yanhong", "initials": "Y"}, {"family": "Sarshad", "given": "Aishe A", "initials": "AA", "orcid": "0000-0001-7153-5959", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d8343203f318415f9b943e3bdfb22f19.json"}}, {"family": "Deng", "given": "Guohua", "initials": "G"}, {"family": "Zhu", "given": "Qiyun", "initials": "Q", "orcid": "0000-0003-3748-948X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8e39dafddd9f49a9a69fba20f992f8d8.json"}}, {"family": "Angeletti", "given": "Davide", "initials": "D", "orcid": "0000-0002-5256-1972", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9dc9fbaf7b004246ba528c17909d5a48.json"}}], "type": "journal article", "published": "2025-01-09", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "16", "issue": "1", "pages": "432", "issn-l": "2041-1723"}, "abstract": "Influenza remains a persistent global health challenge, largely due to the virus' continuous antigenic drift and occasional shift, which impede the development of a universal vaccine. To address this, the identification of broadly neutralizing antibodies and their epitopes is crucial. Nanobodies, with their unique characteristics and binding capacity, offer a promising avenue to identify such epitopes. Here, we isolate and purify a hemagglutinin (HA)-specific nanobody that recognizes an H7 subtype of influenza A virus. The nanobody, named E10, exhibits broad-spectrum binding, cross-group neutralization and in vivo protection across various influenza A subtypes. Through phage display and in vitro characterization, we demonstrate that E10 specifically targets an epitope on HA head which is part of the conserved lateral patch and is highly immunodominant upon H7 infection. Importantly, immunization with a peptide including the E10 epitope elicits cross-reactive antibodies and mediates partial protection from lethal viral challenge. Our data highlights the potential of E10 and its associated epitope as a candidate for future influenza prevention strategies.", "doi": "10.1038/s41467-024-55193-y", "pmid": "39788944", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11718266"}, {"db": "pii", "key": "10.1038/s41467-024-55193-y"}], "notes": [], "created": "2026-08-20T08:53:49.632Z", "modified": "2026-08-20T08:53:49.816Z"}, {"entity": "publication", "iuid": "fe769fb0e4a541319166e9eba47c0a58", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/fe769fb0e4a541319166e9eba47c0a58.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/fe769fb0e4a541319166e9eba47c0a58"}}, "title": "Nasal tissue-resident memory CD4 + T cells persist after influenza A virus infection and provide heterosubtypic protection", "authors": [{"family": "Mathew", "given": "Nimitha R", "initials": "NR"}, {"family": "Gailleton", "given": "Romain", "initials": "R"}, {"family": "Scharf", "given": "Lydia", "initials": "L"}, {"family": "Sch\u00f6n", "given": "Karin", "initials": "K"}, {"family": "Enriquez", "given": "Josue", "initials": "J"}, {"family": "Axelsson", "given": "Hannes", "initials": "H"}, {"family": "Str\u00f6mberg", "given": "Anneli", "initials": "A"}, {"family": "Lycke", "given": "Nils", "initials": "N"}, {"family": "Bemark", "given": "Mats", "initials": "M"}, {"family": "Tang", "given": "Ka Wei", "initials": "KW"}, {"family": "Angeletti", "given": "Davide", "initials": "D", "orcid": "0000-0002-5256-1972", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9dc9fbaf7b004246ba528c17909d5a48.json"}}], "type": "posted-content", "published": "2024-07-10", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2024.07.06.602325", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:55:34.108Z", "modified": "2026-08-20T10:55:34.149Z"}, {"entity": "publication", "iuid": "6237220a91454d238344d0f7b62732d6", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/6237220a91454d238344d0f7b62732d6.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/6237220a91454d238344d0f7b62732d6"}}, "title": "Loss of Lamin A leads to the nuclear translocation of AGO2 and compromised RNA interference", "authors": [{"family": "Lobo", "given": "Vivian", "initials": "V"}, {"family": "Nowak", "given": "Iwona", "initials": "I"}, {"family": "Fernandez", "given": "Carola", "initials": "C"}, {"family": "Correa Muler", "given": "Ana Iris", "initials": "AI"}, {"family": "Westholm", "given": "Jakub O", "initials": "JO"}, {"family": "Huang", "given": "Hsiang Chi", "initials": "HC"}, {"family": "Fabrik", "given": "Ivo", "initials": "I"}, {"family": "Huynh", "given": "Hang Thuy", "initials": "HT"}, {"family": "Shcherbinina", "given": "Evgeniia", "initials": "E"}, {"family": "Poyraz", "given": "Melis", "initials": "M"}, {"family": "H\u00e4rtlova", "given": "Anetta", "initials": "A"}, {"family": "Benhalevy", "given": "Daniel", "initials": "D", "orcid": "0000-0001-6998-1933", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/24b8fda88abc4f15985f61d61695a59d.json"}}, {"family": "Angeletti", "given": "Davide", "initials": "D", "orcid": "0000-0002-5256-1972", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9dc9fbaf7b004246ba528c17909d5a48.json"}}, {"family": "Sarshad", "given": "Aishe A", "initials": "AA", "orcid": "0000-0001-7153-5959", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d8343203f318415f9b943e3bdfb22f19.json"}}], "type": "posted-content", "published": "2023-06-05", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2023.06.05.543674", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:46:25.647Z", "modified": "2026-08-20T10:46:25.805Z"}]}