{"entity": "researcher", "timestamp": "2026-08-28T00:11:18.828Z", "family": "Giordano", "given": "Marco", "initials": "M", "orcid": "0000-0001-6335-0030", "affiliations": ["Unit of Gynecological Oncology Research, Program of Gynecological Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/9c8d4c5af209422c8e1d2256f19dec78.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/9c8d4c5af209422c8e1d2256f19dec78"}}, "publications": [{"entity": "publication", "iuid": "8f57aff656e14e0084e40ce7d6996e0e", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/8f57aff656e14e0084e40ce7d6996e0e.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/8f57aff656e14e0084e40ce7d6996e0e"}}, "title": "A novel L1CAM isoform with angiogenic activity generated by NOVA2-mediated alternative splicing.", "authors": [{"family": "Angiolini", "given": "Francesca", "initials": "F"}, {"family": "Belloni", "given": "Elisa", "initials": "E", "orcid": "0000-0001-6580-5553", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c02668c03fb745ce9e0477d53c4a3a20.json"}}, {"family": "Giordano", "given": "Marco", "initials": "M", "orcid": "0000-0001-6335-0030", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9c8d4c5af209422c8e1d2256f19dec78.json"}}, {"family": "Campioni", "given": "Matteo", "initials": "M"}, {"family": "Forneris", "given": "Federico", "initials": "F", "orcid": "0000-0002-7818-1804", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/eb128eb155cb48fa82dc6c201725ff11.json"}}, {"family": "Paronetto", "given": "Maria Paola", "initials": "MP"}, {"family": "Lupia", "given": "Michela", "initials": "M"}, {"family": "Brandas", "given": "Chiara", "initials": "C"}, {"family": "Pradella", "given": "Davide", "initials": "D", "orcid": "0000-0002-8649-7817", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/abdb317126a54917951196d09d3fc519.json"}}, {"family": "Di Matteo", "given": "Anna", "initials": "A"}, {"family": "Giampietro", "given": "Costanza", "initials": "C", "orcid": "0000-0001-5229-3835", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/679b7950fc0f4e7ebc68f82ec2cd73bc.json"}}, {"family": "Jodice", "given": "Giovanna", "initials": "G"}, {"family": "Luise", "given": "Chiara", "initials": "C"}, {"family": "Bertalot", "given": "Giovanni", "initials": "G", "orcid": "0000-0002-4862-7705", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1790ad92a0024f68a605d835f994edfd.json"}}, {"family": "Freddi", "given": "Stefano", "initials": "S"}, {"family": "Malinverno", "given": "Matteo", "initials": "M"}, {"family": "Irimia", "given": "Manuel", "initials": "M"}, {"family": "Moulton", "given": "Jon D", "initials": "JD", "orcid": "0000-0002-4977-0802", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b7c32d0dfe424e1aa1ba23cc99e79a91.json"}}, {"family": "Summerton", "given": "James", "initials": "J"}, {"family": "Chiapparino", "given": "Antonella", "initials": "A"}, {"family": "Ghilardi", "given": "Carmen", "initials": "C"}, {"family": "Giavazzi", "given": "Raffaella", "initials": "R"}, {"family": "Nyqvist", "given": "Daniel", "initials": "D"}, {"family": "Gabellini", "given": "Davide", "initials": "D", "orcid": "0000-0002-3811-4121", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3b1902c234cf4b11825479bfc945ea62.json"}}, {"family": "Dejana", "given": "Elisabetta", "initials": "E"}, {"family": "Cavallaro", "given": "Ugo", "initials": "U", "orcid": "0000-0002-0884-6460", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/46c7fbebd7f34d2b8f069eaf77989892.json"}}, {"family": "Ghigna", "given": "Claudia", "initials": "C", "orcid": "0000-0003-0362-783X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bde704f3f9d24956a650de3d3efe2131.json"}}], "type": "journal article", "published": "2019-03-04", "journal": {"title": "Elife", "issn": "2050-084X", "volume": "8", "issn-l": "2050-084X"}, "abstract": "The biological players involved in angiogenesis are only partially defined. Here, we report that endothelial cells (ECs) express a novel isoform of the cell-surface adhesion molecule L1CAM, termed L1-\u0394TM. The splicing factor NOVA2, which binds directly to L1CAM pre-mRNA, is necessary and sufficient for the skipping of L1CAM transmembrane domain in ECs, leading to the release of soluble L1-\u0394TM. The latter exerts high angiogenic function through both autocrine and paracrine activities. Mechanistically, L1-\u0394TM-induced angiogenesis requires fibroblast growth factor receptor-1 signaling, implying a crosstalk between the two molecules. NOVA2 and L1-\u0394TM are overexpressed in the vasculature of ovarian cancer, where L1-\u0394TM levels correlate with tumor vascularization, supporting the involvement of NOVA2-mediated L1-\u0394TM production in tumor angiogenesis. Finally, high NOVA2 expression is associated with poor outcome in ovarian cancer patients. Our results point to L1-\u0394TM as a novel, EC-derived angiogenic factor which may represent a target for innovative antiangiogenic therapies.", "doi": "10.7554/eLife.44305", "pmid": "30829570", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6398979"}, {"db": "pii", "key": "44305"}], "notes": [], "created": "2026-08-21T13:07:29.617Z", "modified": "2026-08-21T13:07:30.025Z"}]}