{"entity": "researcher", "timestamp": "2026-08-25T09:31:58.779Z", "family": "Smith", "given": "Ruben", "initials": "R", "orcid": "0000-0001-7147-0112", "affiliations": ["Clinical Memory Research Unit, Department of Clinical Sciences, Malm\u00f6, Lund University, Lund, Sweden.", "Department of Neurology, Sk\u00e5ne University Hospital, Lund, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/9c69d9e76c884720afe20ce34b2c4d81.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/9c69d9e76c884720afe20ce34b2c4d81"}}, "publications": [{"entity": "publication", "iuid": "41296afe1fb94394af66909057750160", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/41296afe1fb94394af66909057750160.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/41296afe1fb94394af66909057750160"}}, "title": "Hemispheric asymmetry of tau pathology is related to asymmetric amyloid deposition in Alzheimer's Disease.", "authors": [{"family": "Anij\u00e4rv", "given": "Toomas Erik", "initials": "TE", "orcid": "0000-0002-3650-4230", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/478837ec8fef4a8d9d4b39e088049614.json"}}, {"family": "Ossenkoppele", "given": "Rik", "initials": "R", "orcid": "0000-0003-1584-7477", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9486d27ddd1b4b6485fa3ca10e0f3d82.json"}}, {"family": "Smith", "given": "Ruben", "initials": "R", "orcid": "0000-0001-7147-0112", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9c69d9e76c884720afe20ce34b2c4d81.json"}}, {"family": "Pichet Binette", "given": "Alexa", "initials": "A", "orcid": "0000-0001-5218-3337", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e8f0967b7b694bcf96e30a051a5bbe9a.json"}}, {"family": "Collij", "given": "Lyduine E", "initials": "LE", "orcid": "0000-0001-6263-1762", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6612222d48fd4bdcaa7c091d38efcc2b.json"}}, {"family": "Behjat", "given": "Harry H", "initials": "HH", "orcid": "0000-0001-6729-6801", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e5d1b40c4a8342eb841754961f1b3593.json"}}, {"family": "Rittmo", "given": "Jonathan", "initials": "J", "orcid": "0000-0001-5075-0166", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f46afd59d3a44a18a35c560c3d2e37f3.json"}}, {"family": "Karlsson", "given": "Linda", "initials": "L", "orcid": "0000-0002-0630-772X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ead4d76d56ff439ba30689e7dfe3aae2.json"}}, {"family": "Ahmadi", "given": "Khazar", "initials": "K", "orcid": "0000-0002-3371-6211", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5295cea5ead34b96a887d4055ccd659b.json"}}, {"family": "Strandberg", "given": "Olof", "initials": "O"}, {"family": "Alzheimer\u2019s Disease Neuroimaging Initiative", "given": "", "initials": ""}, {"family": "van Westen", "given": "Danielle", "initials": "D", "orcid": "0000-0001-8649-9874", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/38afd81dca574f4a9884a1ce97b78e50.json"}}, {"family": "Vogel", "given": "Jacob W", "initials": "JW", "orcid": "0000-0001-6394-9940", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d2ad5af780c245da9b59a8c80a0b00ff.json"}}, {"family": "Stomrud", "given": "Erik", "initials": "E"}, {"family": "Palmqvist", "given": "Sebastian", "initials": "S", "orcid": "0000-0002-9267-1930", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6fbd05e87cfb4057a1a7e41d9fb94aef.json"}}, {"family": "Mattsson-Carlgren", "given": "Niklas", "initials": "N", "orcid": "0000-0002-8885-7724", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb26ae59b2a04f369c5ebc2f2375195a.json"}}, {"family": "Spotorno", "given": "Nicola", "initials": "N", "orcid": "0000-0001-5404-8788", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4851c8ec84264207bdf67c2fd04643da.json"}}, {"family": "Hansson", "given": "Oskar", "initials": "O", "orcid": "0000-0001-8467-7286", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9292115deece4d9fafc8a02d4a430707.json"}}], "type": "journal article", "published": "2025-09-05", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "16", "issue": "1", "pages": "8232", "issn-l": "2041-1723"}, "abstract": "The distribution of tau pathology in Alzheimer's disease (AD) shows remarkable inter-individual heterogeneity, including hemispheric asymmetry. However, the factors driving this asymmetry remain poorly understood. Here we explore whether tau asymmetry is linked to i) reduced inter-hemispheric brain connectivity (potentially restricting tau spread), or ii) asymmetry in amyloid-beta (A\u03b2) distribution (indicating greater hemisphere-specific vulnerability to AD pathology). We include 452 participants from the Swedish BioFINDER-2 cohort with evidence of both A\u03b2 pathology (CSF A\u03b242/40 or neocortical A\u03b2-PET) and tau pathology (temporal tau-PET), categorising them as left asymmetric (n = 102), symmetric (n = 306), or right asymmetric (n = 44) based on temporal lobe tau-PET uptake distribution. We assess edge-wise inter-hemispheric functional (RSfMRI; n = 318) and structural connectivity (dMRI; n = 352) but find no association between tau asymmetry and connectivity. In contrast, we observe a strong association between tau and A\u03b2 laterality patterns based on PET uptake (n = 233; \u03b2 = 0.632, p < 0.001), which we replicate in three independent cohorts (n = 234; \u03b2 = 0.535, p < 0.001). In a longitudinal A\u03b2-positive sample, we show that baseline A\u03b2 asymmetry predicts progression of tau laterality over time (n = 289; \u03b2 = 0.025, p = 0.028). These findings suggest that tau asymmetry is not associated with a weaker inter-hemispheric connectivity but might reflect hemispheric differences in vulnerability to A\u03b2 pathology, underscoring the role of regional vulnerability in determining the distribution of AD pathology.", "doi": "10.1038/s41467-025-63564-2", "pmid": "40913038", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12413461"}, {"db": "pii", "key": "10.1038/s41467-025-63564-2"}], "notes": [], "created": "2026-08-21T11:50:12.353Z", "modified": "2026-08-21T11:50:12.696Z"}, {"entity": "publication", "iuid": "a65f11f0359742e6a21dd3cbf58360f3", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/a65f11f0359742e6a21dd3cbf58360f3.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/a65f11f0359742e6a21dd3cbf58360f3"}}, "title": "The \u03b1-synuclein PET tracer [18F] ACI-12589 distinguishes multiple system atrophy from other neurodegenerative diseases.", "authors": [{"family": "Smith", "given": "Ruben", "initials": "R", "orcid": "0000-0001-7147-0112", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9c69d9e76c884720afe20ce34b2c4d81.json"}}, {"family": "Capotosti", "given": "Francesca", "initials": "F", "orcid": "0000-0003-2819-3206", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/98085f4a79864d11bb4fa333a21ecb46.json"}}, {"family": "Schain", "given": "Martin", "initials": "M"}, {"family": "Ohlsson", "given": "Tomas", "initials": "T"}, {"family": "Vokali", "given": "Efthymia", "initials": "E"}, {"family": "Molette", "given": "Jerome", "initials": "J", "orcid": "0009-0000-5381-5535", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f58f07b26b304c5e8e987bfe26f83657.json"}}, {"family": "Touilloux", "given": "Tanja", "initials": "T"}, {"family": "Hliva", "given": "Valerie", "initials": "V", "orcid": "0000-0002-1252-0033", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/99ad856e12934c2189cfbd802a27439c.json"}}, {"family": "Dimitrakopoulos", "given": "Ioannis K", "initials": "IK"}, {"family": "Puschmann", "given": "Andreas", "initials": "A"}, {"family": "J\u00f6gi", "given": "Jonas", "initials": "J"}, {"family": "Svenningsson", "given": "Per", "initials": "P", "orcid": "0000-0001-6727-3802", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b01bbacfa24e4b9794734bf1121d1c38.json"}}, {"family": "Andr\u00e9asson", "given": "Mattias", "initials": "M"}, {"family": "Sandiego", "given": "Christine", "initials": "C"}, {"family": "Russell", "given": "David S", "initials": "DS", "orcid": "0000-0002-9105-2943", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3dc53d41eaee40eb9bfd5ebd1f52c75f.json"}}, {"family": "Miranda-Azpiazu", "given": "Patricia", "initials": "P"}, {"family": "Halldin", "given": "Christer", "initials": "C"}, {"family": "Stomrud", "given": "Erik", "initials": "E"}, {"family": "Hall", "given": "Sara", "initials": "S", "orcid": "0000-0001-6585-9105", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/979b72b3747a49239ed61ad4ce5d632f.json"}}, {"family": "Bratteby", "given": "Klas", "initials": "K", "orcid": "0000-0003-0930-2390", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/12c1720331d1450eb3ef335e4ea43a02.json"}}, {"family": "Tampio L'Estrade", "given": "Elina", "initials": "E"}, {"family": "Luthi-Carter", "given": "Ruth", "initials": "R"}, {"family": "Pfeifer", "given": "Andrea", "initials": "A"}, {"family": "Kosco-Vilbois", "given": "Marie", "initials": "M"}, {"family": "Streffer", "given": "Johannes", "initials": "J", "orcid": "0000-0002-9387-5951", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8f93444b34f4453aaf8a5d524976200d.json"}}, {"family": "Hansson", "given": "Oskar", "initials": "O", "orcid": "0000-0001-8467-7286", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9292115deece4d9fafc8a02d4a430707.json"}}], "type": "journal article", "published": "2023-10-27", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "14", "issue": "1", "pages": "6750", "issn-l": "2041-1723"}, "abstract": "A positron emission tomography (PET) tracer detecting \u03b1-synuclein pathology will improve the diagnosis, and ultimately the treatment of \u03b1-synuclein-related diseases. Here we show that the PET ligand, [18F]ACI-12589, displays good in vitro affinity and specificity for pathological \u03b1-synuclein in tissues from patients with different \u03b1-synuclein-related disorders including Parkinson's disease (PD) and Multiple-System Atrophy (MSA) using autoradiography and radiobinding techniques. In the initial clinical evaluation we include 23 participants with \u03b1-synuclein related disorders, 11 with other neurodegenerative disorders and eight controls. In vivo [18F]ACI-12589 demonstrates clear binding in the cerebellar white matter and middle cerebellar peduncles of MSA patients, regions known to be highly affected by \u03b1-synuclein pathology, but shows limited binding in PD. The binding statistically separates MSA patients from healthy controls and subjects with other neurodegenerative disorders, including other synucleinopathies. Our results indicate that \u03b1-synuclein pathology in MSA can be identified using [18F]ACI-12589 PET imaging, potentially improving the diagnostic work-up of MSA and allowing for detection of drug target engagement in vivo of novel \u03b1-synuclein targeting therapies.", "doi": "10.1038/s41467-023-42305-3", "pmid": "37891183", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10611796"}, {"db": "pii", "key": "10.1038/s41467-023-42305-3"}], "notes": [], "created": "2026-08-21T11:49:37.336Z", "modified": "2026-08-21T11:49:37.764Z"}]}