{"entity": "researcher", "timestamp": "2026-08-20T21:40:56.409Z", "family": "Evert", "given": "J S Hoogstad-van", "initials": "JSH", "orcid": "0000-0001-9838-0977", "affiliations": ["Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Geert Grooteplein Zuid 8, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.", "Department of Obstetrics and Gynecology, Radboud University Medical Center, Nijmegen, the Netherlands."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/9c4e67260bf64a2d963820d64cd4b162.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/9c4e67260bf64a2d963820d64cd4b162"}}, "publications": [{"entity": "publication", "iuid": "6087ac4b304c4b82a815ab2e05edcc5b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/6087ac4b304c4b82a815ab2e05edcc5b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/6087ac4b304c4b82a815ab2e05edcc5b"}}, "title": "Correction to: IL\u201115 superagonist N\u2011803 improves IFN\u03b3 production and killing of leukemia and ovarian cancer cells by CD34+ progenitor\u2011derived NK cells.", "authors": [{"family": "Van der Meer", "given": "J M R", "initials": "JMR", "orcid": "0000-0001-9288-1500", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ec374420f13d480ba3e342acba183a7c.json"}}, {"family": "Maas", "given": "R J A", "initials": "RJA", "orcid": "0000-0002-3185-5226", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a4de8f2b519342279c7578490873c4a6.json"}}, {"family": "Guldevall", "given": "K", "initials": "K", "orcid": "0000-0003-1016-2460", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/24a750602b1a47d48d92974f972f1c72.json"}}, {"family": "Klarenaar", "given": "K", "initials": "K"}, {"family": "De Jonge", "given": "P K J D", "initials": "PKJD"}, {"family": "Hoogstad-van Evert", "given": "J S", "initials": "JS", "orcid": "0000-0001-9838-0977", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9c4e67260bf64a2d963820d64cd4b162.json"}}, {"family": "van der Waart", "given": "A B", "initials": "AB", "orcid": "0000-0001-5986-3060", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8a4ab943bebb4a518668d1f1e9dd7363.json"}}, {"family": "Cany", "given": "J", "initials": "J", "orcid": "0000-0002-5214-639X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a526e4e6cde24c6c8807b27101e35ea3.json"}}, {"family": "Safrit", "given": "J T", "initials": "JT", "orcid": "0000-0001-7441-4423", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fb8265befd554a1aba34b695852a1016.json"}}, {"family": "Lee", "given": "J H", "initials": "JH"}, {"family": "Wagena", "given": "E", "initials": "E"}, {"family": "Friedl", "given": "P", "initials": "P", "orcid": "0000-0002-0119-4041", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5d4fb98a43c1442f9cd904e323dc2769.json"}}, {"family": "\u00d6nfelt", "given": "B", "initials": "B", "orcid": "0000-0001-5178-7593", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6b4b8fcbedb54e2ba38633687f417ae8.json"}}, {"family": "Massuger", "given": "L F", "initials": "LF", "orcid": "0000-0002-1539-8985", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cd1dab07b61e43b29f9bcdda0383ed00.json"}}, {"family": "Schaap", "given": "N P M", "initials": "NPM", "orcid": "0000-0001-7696-4752", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2e6c952987b149e1b97baab1b815b600.json"}}, {"family": "Jansen", "given": "J H", "initials": "JH", "orcid": "0000-0001-9459-568X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f4dda0ce64c04555834f61ba0d31278d.json"}}, {"family": "Hobo", "given": "W", "initials": "W", "orcid": "0000-0002-8206-8185", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3d9d1653bbb04e1cb8ec62f49217057d.json"}}, {"family": "Dolstra", "given": "H", "initials": "H", "orcid": "0000-0002-3998-687X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a45d0970dc374c218087801fef1baa2a.json"}}], "type": "published erratum", "published": "2021-11-00", "journal": {"title": "Cancer Immunol. Immunother.", "issn": "1432-0851", "volume": "70", "issue": "11", "pages": "3367", "issn-l": "0340-7004"}, "abstract": null, "doi": "10.1007/s00262-021-03049-5", "pmid": "34524494", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8505330"}, {"db": "pii", "key": "10.1007/s00262-021-03049-5"}], "notes": [], "created": "2026-08-20T06:39:30.255Z", "modified": "2026-08-20T06:39:30.394Z"}, {"entity": "publication", "iuid": "960e80f94c714e4d9469b1e3e2d8d29d", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/960e80f94c714e4d9469b1e3e2d8d29d.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/960e80f94c714e4d9469b1e3e2d8d29d"}}, "title": "IL-15 superagonist N-803 improves IFN\u03b3 production and killing of leukemia and ovarian cancer cells by CD34+ progenitor-derived NK cells.", "authors": [{"family": "Van der Meer", "given": "J M R", "initials": "JMR", "orcid": "0000-0001-9288-1500", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ec374420f13d480ba3e342acba183a7c.json"}}, {"family": "Maas", "given": "R J A", "initials": "RJA", "orcid": "0000-0002-3185-5226", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a4de8f2b519342279c7578490873c4a6.json"}}, {"family": "Guldevall", "given": "K", "initials": "K", "orcid": "0000-0003-1016-2460", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/24a750602b1a47d48d92974f972f1c72.json"}}, {"family": "Klarenaar", "given": "K", "initials": "K"}, {"family": "de Jonge", "given": "P K J D", "initials": "PKJD"}, {"family": "Evert", "given": "J S Hoogstad-van", "initials": "JSH", "orcid": "0000-0001-9838-0977", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9c4e67260bf64a2d963820d64cd4b162.json"}}, {"family": "van der Waart", "given": "A B", "initials": "AB", "orcid": "0000-0001-5986-3060", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8a4ab943bebb4a518668d1f1e9dd7363.json"}}, {"family": "Cany", "given": "J", "initials": "J", "orcid": "0000-0002-5214-639X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a526e4e6cde24c6c8807b27101e35ea3.json"}}, {"family": "Safrit", "given": "J T", "initials": "JT", "orcid": "0000-0001-7441-4423", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fb8265befd554a1aba34b695852a1016.json"}}, {"family": "Lee", "given": "J H", "initials": "JH"}, {"family": "Wagena", "given": "E", "initials": "E"}, {"family": "Friedl", "given": "P", "initials": "P", "orcid": "0000-0002-0119-4041", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5d4fb98a43c1442f9cd904e323dc2769.json"}}, {"family": "\u00d6nfelt", "given": "B", "initials": "B", "orcid": "0000-0001-5178-7593", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6b4b8fcbedb54e2ba38633687f417ae8.json"}}, {"family": "Massuger", "given": "L F", "initials": "LF", "orcid": "0000-0002-1539-8985", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cd1dab07b61e43b29f9bcdda0383ed00.json"}}, {"family": "Schaap", "given": "N P M", "initials": "NPM", "orcid": "0000-0001-7696-4752", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2e6c952987b149e1b97baab1b815b600.json"}}, {"family": "Jansen", "given": "J H", "initials": "JH", "orcid": "0000-0001-9459-568X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f4dda0ce64c04555834f61ba0d31278d.json"}}, {"family": "Hobo", "given": "W", "initials": "W", "orcid": "0000-0002-8206-8185", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3d9d1653bbb04e1cb8ec62f49217057d.json"}}, {"family": "Dolstra", "given": "H", "initials": "H", "orcid": "0000-0002-3998-687X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a45d0970dc374c218087801fef1baa2a.json"}}], "type": "journal article", "published": "2021-05-00", "journal": {"title": "Cancer Immunol. Immunother.", "issn": "1432-0851", "volume": "70", "issue": "5", "pages": "1305-1321", "issn-l": "0340-7004"}, "abstract": "Allogeneic natural killer (NK) cell transfer is a potential immunotherapy to eliminate and control cancer. A promising source are CD34 + hematopoietic progenitor cells (HPCs), since large numbers of cytotoxic NK cells can be generated. Effective boosting of NK cell function can be achieved by interleukin (IL)-15. However, its in vivo half-life is short and potent trans-presentation by IL-15 receptor \u03b1 (IL-15R\u03b1) is absent. Therefore, ImmunityBio developed IL-15 superagonist N-803, which combines IL-15 with an activating mutation, an IL-15R\u03b1 sushi domain for trans-presentation, and IgG1-Fc for increased half-life. Here, we investigated whether and how N-803 improves HPC-NK cell functionality in leukemia and ovarian cancer (OC) models in vitro and in vivo in OC-bearing immunodeficient mice. We used flow cytometry-based assays, enzyme-linked immunosorbent assay, microscopy-based serial killing assays, and bioluminescence imaging, for in vitro and in vivo experiments. N-803 increased HPC-NK cell proliferation and interferon (IFN)\u03b3 production. On leukemia cells, co-culture with HPC-NK cells and N-803 increased ICAM-1 expression. Furthermore, N-803 improved HPC-NK cell-mediated (serial) leukemia killing. Treating OC spheroids with HPC-NK cells and N-803 increased IFN\u03b3-induced CXCL10 secretion, and target killing after prolonged exposure. In immunodeficient mice bearing human OC, N-803 supported HPC-NK cell persistence in combination with total human immunoglobulins to prevent Fc-mediated HPC-NK cell depletion. Moreover, this combination treatment decreased tumor growth. In conclusion, N-803 is a promising IL-15-based compound that boosts HPC-NK cell expansion and functionality in vitro and in vivo. Adding N-803 to HPC-NK cell therapy could improve cancer immunotherapy.", "doi": "10.1007/s00262-020-02749-8", "pmid": "33140189", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8053152"}, {"db": "pii", "key": "10.1007/s00262-020-02749-8"}], "notes": [], "created": "2026-08-20T06:39:27.597Z", "modified": "2026-08-20T06:39:28.213Z"}]}