{"entity": "researcher", "timestamp": "2026-03-10T03:25:44.787Z", "family": "Hansson", "given": "Markus", "initials": "M", "orcid": "0000-0002-7715-4548", "affiliations": [], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/9aabef8e26ba40d9abd8e229d954795d.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/9aabef8e26ba40d9abd8e229d954795d"}}, "publications": [{"entity": "publication", "iuid": "c0fc1ac6d9704cacb375132e24f50c91", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/c0fc1ac6d9704cacb375132e24f50c91.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/c0fc1ac6d9704cacb375132e24f50c91"}}, "title": "Deciphering the genetics and mechanisms of predisposition to multiple myeloma.", "authors": [{"family": "Went", "given": "Molly", "initials": "M", "orcid": "0000-0003-3271-975X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0ec75486d11444c89b8f8a8d81d22bda.json"}}, {"family": "Duran-Lozano", "given": "Laura", "initials": "L"}, {"family": "Halldorsson", "given": "Gisli H", "initials": "GH", "orcid": "0000-0001-7067-9862", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/28549aa56c4543178dd7626dbc9e4667.json"}}, {"family": "Gunnell", "given": "Andrea", "initials": "A", "orcid": "0000-0001-5162-5391", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/879f235469b443259ce663d029e7cdf8.json"}}, {"family": "Ugidos-Damboriena", "given": "Nerea", "initials": "N"}, {"family": "Law", "given": "Philip", "initials": "P", "orcid": "0000-0001-9663-4611", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/499974f99dfe4fdd87a73034acb98d3e.json"}}, {"family": "Ekdahl", "given": "Ludvig", "initials": "L"}, {"family": "Sud", "given": "Amit", "initials": "A", "orcid": "0000-0002-6133-0164", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/058d01f444ad44469b82a5b08ffe6aa2.json"}}, {"family": "Thorleifsson", "given": "Gudmar", "initials": "G", "orcid": "0000-0003-4623-9087", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3460ce8189d243829543bd5919c42588.json"}}, {"family": "Thodberg", "given": "Malte", "initials": "M", "orcid": "0000-0001-6244-3841", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7f2c232400714922bdbd28e77ede971e.json"}}, {"family": "Olafsdottir", "given": "Thorunn", "initials": "T", "orcid": "0000-0001-5454-938X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/417237ea231141ce83a9f314aacc4714.json"}}, {"family": "Lamarca-Arrizabalaga", "given": "Antton", "initials": "A", "orcid": "0009-0008-3426-2347", "researcher": {"href": 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{"family": "Stefansdottir", "given": "Lilja", "initials": "L"}, {"family": "Kristinsson", "given": "Sigurdur Y", "initials": "SY"}, {"family": "Stacey", "given": "Simon N", "initials": "SN", "orcid": "0000-0002-4732-7380", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c0dcdf7567e1416482442d565b8005c0.json"}}, {"family": "Love", "given": "Thorvardur J", "initials": "TJ"}, {"family": "Rognvaldsson", "given": "Saemundur", "initials": "S"}, {"family": "Hajek", "given": "Roman", "initials": "R", "orcid": "0000-0001-6955-6267", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7099912b8d2d400d864ba440cacd434c.json"}}, {"family": "Vodicka", "given": "Pavel", "initials": "P"}, {"family": "Pettersson-Kymmer", "given": "Ulrika", "initials": "U", "orcid": "0000-0002-0557-9803", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6e219143aebf4a5386f19f01f6e1d237.json"}}, {"family": "Sp\u00e4th", "given": "Florentin", "initials": "F"}, {"family": "Schinke", "given": "Carolina", "initials": "C", "orcid": "0000-0002-2699-1741", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a0367de9c18a41b5ba34821157acc0b1.json"}}, {"family": "Van Rhee", "given": "Frits", "initials": "F", "orcid": "0000-0001-9959-1282", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b7cb56c62bce4c51947aed1b0ee21887.json"}}, {"family": "Sulem", "given": "Patrick", "initials": "P", "orcid": "0000-0001-7123-6123", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/587ca1614f654c4e9a96a84fdab962f4.json"}}, {"family": "Ferkingstad", "given": "Egil", "initials": "E", "orcid": "0000-0001-8090-7988", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/503c894e23fc4ceea1316b6a089ab889.json"}}, {"family": "Hjorleifsson Eldjarn", "given": "Grimur", "initials": "G", "orcid": "0000-0002-9580-6685", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/98aff0e76e114696aaaabadc5ec18388.json"}}, {"family": "Mellqvist", "given": "Ulf-Henrik", "initials": "UH"}, {"family": "Jonsdottir", "given": "Ingileif", "initials": "I", "orcid": "0000-0001-8339-150X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f4e82de44504a55b50b0378447318f8.json"}}, {"family": "Morgan", "given": "Gareth", "initials": "G", "orcid": "0000-0002-4271-6360", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bf94973d06d4414a98855c4506453f6c.json"}}, {"family": "Sonneveld", "given": "Pieter", "initials": "P"}, {"family": "Waage", "given": "Anders", "initials": "A", "orcid": "0000-0001-9072-1220", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/04b9b219373b4dea9950e8a7ae9f6f0b.json"}}, {"family": "Weinhold", "given": "Niels", "initials": "N"}, {"family": "Thomsen", "given": "Hauke", "initials": "H"}, {"family": "F\u00f6rsti", "given": "Asta", "initials": "A", "orcid": "0000-0002-9857-4728", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a2356cdc19c040348a7924e3dd4b8c32.json"}}, {"family": "Hansson", "given": "Markus", "initials": "M", "orcid": "0000-0002-7715-4548", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9aabef8e26ba40d9abd8e229d954795d.json"}}, {"family": "Juul-Vangsted", "given": "Annette", "initials": "A", "orcid": "0000-0002-2131-731X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7eadc85ce9564aeb838718479df147ff.json"}}, {"family": "Thorsteinsdottir", "given": "Unnur", "initials": "U"}, {"family": "Hemminki", "given": "Kari", "initials": "K"}, {"family": "Kaiser", "given": "Martin", "initials": "M", "orcid": "0000-0002-3677-4804", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/61695044f08e4490a7feaf7db2aacc07.json"}}, {"family": "Rafnar", "given": "Thorunn", "initials": "T", "orcid": "0000-0003-0491-7046", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/67a01e1ebd79473dbc0059d38f066e55.json"}}, {"family": "Stefansson", "given": "Kari", "initials": "K", "orcid": "0000-0003-1676-864X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9edf80871ac84e76a4d1316fc7079d7d.json"}}, {"family": "Houlston", "given": "Richard", "initials": "R", "orcid": "0000-0002-5268-0242", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e7605f3f03f94e1b95c011318f5e5d4c.json"}}, {"family": "Nilsson", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0001-5542-0254", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2e9df5bbe6f948b196a65176963748c8.json"}}], "type": "journal article", "published": "2024-08-05", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "15", "issue": "1", "pages": "6644", "issn-l": "2041-1723"}, "abstract": "Multiple myeloma (MM) is an incurable malignancy of plasma cells. Epidemiological studies indicate a substantial heritable component, but the underlying mechanisms remain unclear. Here, in a genome-wide association study totaling 10,906 cases and 366,221 controls, we identify 35 MM risk loci, 12 of which are novel. Through functional fine-mapping and Mendelian randomization, we uncover two causal mechanisms for inherited MM risk: longer telomeres; and elevated levels of B-cell maturation antigen (BCMA) and interleukin-5 receptor alpha (IL5RA) in plasma. The largest increase in BCMA and IL5RA levels is mediated by the risk variant rs34562254-A at TNFRSF13B. While individuals with loss-of-function variants in TNFRSF13B develop B-cell immunodeficiency, rs34562254-A exerts a gain-of-function effect, increasing MM risk through amplified B-cell responses. Our results represent an analysis of genetic MM predisposition, highlighting causal mechanisms contributing to MM development.", "doi": "10.1038/s41467-024-50932-7", "pmid": "39103364", "labels": {"Abhishek Niroula": null, "DDLS Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC11300596"}, {"db": "pii", "key": "10.1038/s41467-024-50932-7"}], "notes": [], "created": "2025-03-18T15:48:53.213Z", "modified": "2025-03-18T15:49:12.903Z"}, {"entity": "publication", "iuid": "a23f439e8d27436ea664d32986586d76", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/a23f439e8d27436ea664d32986586d76.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/a23f439e8d27436ea664d32986586d76"}}, "title": "Germline variants at SOHLH2 influence multiple myeloma risk.", "authors": [{"family": "Duran-Lozano", "given": "Laura", "initials": "L", "orcid": "0000-0003-3557-5018", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/de2e3fde2a084b76bb3951025f53fe43.json"}}, {"family": "Thorleifsson", "given": "Gudmar", "initials": "G"}, {"family": "Lopez de Lapuente Portilla", "given": "Aitzkoa", "initials": "A"}, {"family": "Niroula", "given": "Abhishek", "initials": "A"}, {"family": "Went", "given": "Molly", "initials": "M"}, {"family": "Thodberg", "given": "Malte", "initials": "M"}, {"family": "Pertesi", "given": "Maroulio", "initials": "M"}, {"family": "Ajore", "given": "Ram", "initials": "R"}, {"family": "Cafaro", "given": "Caterina", "initials": "C"}, {"family": "Olason", "given": "Pall I", "initials": "PI"}, {"family": "Stefansdottir", "given": "Lilja", "initials": "L"}, {"family": "Bragi Walters", "given": "G", "initials": "G", "orcid": "0000-0002-5415-6487", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/82463c5a2ff44538a81559d5b83fb76b.json"}}, {"family": "Halldorsson", "given": "Gisli H", "initials": "GH", "orcid": "0000-0001-7067-9862", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/28549aa56c4543178dd7626dbc9e4667.json"}}, {"family": "Turesson", "given": "Ingemar", "initials": "I"}, {"family": "Kaiser", "given": "Martin F", "initials": "MF", "orcid": "0000-0002-3677-4804", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/61695044f08e4490a7feaf7db2aacc07.json"}}, {"family": "Weinhold", "given": "Niels", "initials": "N"}, {"family": "Abildgaard", "given": "Niels", "initials": "N"}, {"family": "Andersen", "given": "Niels Frost", "initials": "NF"}, {"family": "Mellqvist", "given": "Ulf-Henrik", "initials": "UH"}, {"family": "Waage", "given": "Anders", "initials": "A"}, {"family": "Juul-Vangsted", "given": "Annette", "initials": "A", "orcid": "0000-0002-2131-731X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7eadc85ce9564aeb838718479df147ff.json"}}, {"family": "Thorsteinsdottir", "given": "Unnur", "initials": "U"}, {"family": "Hansson", "given": "Markus", "initials": "M", "orcid": "0000-0002-7715-4548", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9aabef8e26ba40d9abd8e229d954795d.json"}}, {"family": "Houlston", "given": "Richard", "initials": "R", "orcid": "0000-0002-5268-0242", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e7605f3f03f94e1b95c011318f5e5d4c.json"}}, {"family": "Rafnar", "given": "Thorunn", "initials": "T", "orcid": "0000-0003-0491-7046", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/67a01e1ebd79473dbc0059d38f066e55.json"}}, {"family": "Stefansson", "given": "Kari", "initials": "K"}, {"family": "Nilsson", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0001-5542-0254", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2e9df5bbe6f948b196a65176963748c8.json"}}], "type": "journal article", "published": "2021-04-19", "journal": {"title": "Blood Cancer J", "issn": "2044-5385", "volume": "11", "issue": "4", "pages": "76", "issn-l": null}, "abstract": "Multiple myeloma (MM) is caused by the uncontrolled, clonal expansion of plasma cells. While there is epidemiological evidence for inherited susceptibility, the molecular basis remains incompletely understood. We report a genome-wide association study totalling 5,320 cases and 422,289 controls from four Nordic populations, and find a novel MM risk variant at SOHLH2 at 13q13.3 (risk allele frequency = 3.5%; odds ratio = 1.38; P = 2.2 \u00d7 10-14). This gene encodes a transcription factor involved in gametogenesis that is normally only weakly expressed in plasma cells. The association is represented by 14 variants in linkage disequilibrium. Among these, rs75712673 maps to a genomic region with open chromatin in plasma cells, and upregulates SOHLH2 in this cell type. Moreover, rs75712673 influences transcriptional activity in luciferase assays, and shows a chromatin looping interaction with the SOHLH2 promoter. Our work provides novel insight into MM susceptibility.", "doi": "10.1038/s41408-021-00468-6", "pmid": "33875642", "labels": {"Abhishek Niroula": null, "DDLS Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC8055668"}, {"db": "pii", "key": "10.1038/s41408-021-00468-6"}], "notes": [], "created": "2023-11-20T11:27:50.066Z", "modified": "2023-11-20T11:27:50.552Z"}, {"entity": "publication", "iuid": "1f3b363ef193467690a01579a4ff3b49", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/1f3b363ef193467690a01579a4ff3b49.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/1f3b363ef193467690a01579a4ff3b49"}}, "title": "The multiple myeloma risk allele at 5q15 lowers ELL2 expression and increases ribosomal gene expression.", "authors": [{"family": "Ali", "given": "Mina", "initials": "M"}, {"family": "Ajore", "given": "Ram", "initials": "R"}, {"family": "Wihlborg", "given": "Anna-Karin", "initials": "AK"}, {"family": "Niroula", "given": "Abhishek", "initials": "A", "orcid": "0000-0002-5904-0635", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/05df7afc7a494ba5af8a378e5ffa53f0.json"}}, {"family": "Swaminathan", "given": "Bhairavi", "initials": "B"}, {"family": "Johnsson", "given": "Ellinor", "initials": "E"}, {"family": "Stephens", "given": "Owen W", "initials": "OW"}, {"family": "Morgan", "given": "Gareth", "initials": "G"}, {"family": "Meissner", "given": "Tobias", "initials": "T"}, {"family": "Turesson", "given": "Ingemar", "initials": "I"}, {"family": "Goldschmidt", "given": "Hartmut", "initials": "H"}, {"family": "Mellqvist", "given": "Ulf-Henrik", "initials": "UH"}, {"family": "Gullberg", "given": "Urban", "initials": "U"}, {"family": "Hansson", "given": "Markus", "initials": "M", "orcid": "0000-0002-7715-4548", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9aabef8e26ba40d9abd8e229d954795d.json"}}, {"family": "Hemminki", "given": "Kari", "initials": "K"}, {"family": "Nahi", "given": "Hareth", "initials": "H"}, {"family": "Waage", "given": "Anders", "initials": "A"}, {"family": "Weinhold", "given": "Niels", "initials": "N"}, {"family": "Nilsson", "given": "Bj\u00f6rn", "initials": "B"}], "type": "journal article", "published": "2018-04-25", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "9", "issue": "1", "pages": "1649", "issn-l": "2041-1723"}, "abstract": "Recently, we identified ELL2 as a susceptibility gene for multiple myeloma (MM). To understand its mechanism of action, we performed expression quantitative trait locus analysis in CD138+ plasma cells from 1630 MM patients from four populations. We show that the MM risk allele lowers ELL2 expression in these cells (Pcombined = 2.5 \u00d7 10-27; \u03b2combined = -0.24 SD), but not in peripheral blood or other tissues. Consistent with this, several variants representing the MM risk allele map to regulatory genomic regions, and three yield reduced transcriptional activity in plasmocytoma cell lines. One of these (rs3777189-C) co-locates with the best-supported lead variants for ELL2 expression and MM risk, and reduces binding of MAFF/G/K family transcription factors. Moreover, further analysis reveals that the MM risk allele associates with upregulation of gene sets related to ribosome biogenesis, and knockout/knockdown and rescue experiments in plasmocytoma cell lines support a cause-effect relationship. Our results provide mechanistic insight into MM predisposition.", "doi": "10.1038/s41467-018-04082-2", "pmid": "29695719", "labels": {"Abhishek Niroula": null, "DDLS Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC5917026"}, {"db": "pii", "key": "10.1038/s41467-018-04082-2"}], "notes": [], "created": "2023-11-20T11:21:43.002Z", "modified": "2023-11-20T11:21:43.218Z"}, {"entity": "publication", "iuid": "c60829088cbd43c2a1d0f3b8e3359dee", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/c60829088cbd43c2a1d0f3b8e3359dee.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/c60829088cbd43c2a1d0f3b8e3359dee"}}, "title": "Variants in ELL2 influencing immunoglobulin levels associate with multiple myeloma.", "authors": [{"family": "Swaminathan", "given": "Bhairavi", "initials": "B"}, {"family": "Thorleifsson", "given": "Gu\u00f0mar", "initials": "G"}, {"family": "J\u00f6ud", "given": "Magnus", "initials": "M"}, {"family": "Ali", "given": "Mina", "initials": "M"}, {"family": "Johnsson", "given": "Ellinor", "initials": "E"}, {"family": "Ajore", "given": "Ram", "initials": "R"}, {"family": "Sulem", "given": "Patrick", "initials": "P", "orcid": "0000-0001-7123-6123", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/587ca1614f654c4e9a96a84fdab962f4.json"}}, {"family": "Halvarsson", "given": "Britt-Marie", "initials": "BM"}, {"family": "Eyjolfsson", "given": "Gu\u00f0mundur", "initials": "G"}, {"family": "Haraldsdottir", "given": "Vilhelmina", "initials": "V"}, {"family": "Hultman", "given": "Christina", "initials": "C"}, {"family": "Ingelsson", "given": "Erik", "initials": "E"}, {"family": "Kristinsson", "given": "Sigur\u00f0ur Y", "initials": "SY"}, {"family": "K\u00e4hler", "given": "Anna K", "initials": "AK"}, {"family": "Lenhoff", "given": "Stig", "initials": "S"}, {"family": "Masson", "given": "Gisli", "initials": "G"}, {"family": "Mellqvist", "given": "Ulf-Henrik", "initials": "UH"}, {"family": "M\u00e5nsson", "given": "Robert", "initials": "R"}, {"family": "Nelander", "given": "Sven", "initials": "S"}, {"family": "Olafsson", "given": "Isleifur", "initials": "I"}, {"family": "Sigur\u00f0ardottir", "given": "Olof", "initials": "O"}, {"family": "Steingrimsd\u00f3ttir", "given": "Hlif", "initials": "H"}, {"family": "Vangsted", "given": "Annette", "initials": "A"}, {"family": "Vogel", "given": "Ulla", "initials": "U"}, {"family": "Waage", "given": "Anders", "initials": "A"}, {"family": "Nahi", "given": "Hareth", "initials": "H"}, {"family": "Gudbjartsson", "given": "Daniel F", "initials": "DF"}, {"family": "Rafnar", "given": "Thorunn", "initials": "T"}, {"family": "Turesson", "given": "Ingemar", "initials": "I"}, {"family": "Gullberg", "given": "Urban", "initials": "U"}, {"family": "Stef\u00e1nsson", "given": "K\u00e1ri", "initials": "K"}, {"family": "Hansson", "given": "Markus", "initials": "M", "orcid": "0000-0002-7715-4548", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9aabef8e26ba40d9abd8e229d954795d.json"}}, {"family": "Thorsteinsd\u00f3ttir", "given": "Unnur", "initials": "U"}, {"family": "Nilsson", "given": "Bj\u00f6rn", "initials": "B"}], "type": "journal article", "published": "2015-05-26", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "6", "issue": "1", "pages": "7213", "issn-l": "2041-1723"}, "abstract": "Multiple myeloma (MM) is characterized by an uninhibited, clonal growth of plasma cells. While first-degree relatives of patients with MM show an increased risk of MM, the genetic basis of inherited MM susceptibility is incompletely understood. Here we report a genome-wide association study in the Nordic region identifying a novel MM risk locus at ELL2 (rs56219066T; odds ratio (OR)=1.25; P=9.6 \u00d7 10(-10)). This gene encodes a stoichiometrically limiting component of the super-elongation complex that drives secretory-specific immunoglobulin mRNA production and transcriptional regulation in plasma cells. We find that the MM risk allele harbours a Thr298Ala missense variant in an ELL2 domain required for transcription elongation. Consistent with a hypomorphic effect, we find that the MM risk allele also associates with reduced levels of immunoglobulin A (IgA) and G (IgG) in healthy subjects (P=8.6 \u00d7 10(-9) and P=6.4 \u00d7 10(-3), respectively) and, potentially, with an increased risk of bacterial meningitis (OR=1.30; P=0.0024).", "doi": "10.1038/ncomms8213", "pmid": "26007630", "labels": {"Affiliated researcher": null}, "xrefs": [{"db": "pmc", "key": "PMC4455110"}, {"db": "pii", "key": "ncomms8213"}], "notes": [], "created": "2018-12-05T09:24:22.512Z", "modified": "2023-06-19T14:03:56.557Z"}]}