{"entity": "researcher", "timestamp": "2026-03-17T00:49:27.517Z", "family": "Nielsen", "given": "Henriette Svarre", "initials": "HS", "orcid": "0000-0003-2106-8103", "affiliations": ["The Recurrent Pregnancy Loss Unit, The Capital Region, Rigshospitalet and Hvidovre Hospital, Copenhagen University Hospitals, Copenhagen, Denmark.", "Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark.", "Department of Obstetrics and Gynecology, Copenhagen University Hospital, Hvidovre Hospital, Copenhagen, Denmark."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/9a99fa7ebb204c618ed70f29be0085b3.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/9a99fa7ebb204c618ed70f29be0085b3"}}, "publications": [{"entity": "publication", "iuid": "f90df874d6ad48c58ed647c139f3997e", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f90df874d6ad48c58ed647c139f3997e.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f90df874d6ad48c58ed647c139f3997e"}}, "title": "Defining Vaginal Community Dynamics: daily microbiome transitions, the role of menstruation, bacteriophages, and bacterial genes.", "authors": [{"family": "Hugerth", "given": "Luisa W", "initials": "LW", "orcid": "0000-0001-5432-1764", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/246ed7b405dd4c3f9ec5e7ff9f1d3ade.json"}}, {"family": "Krog", "given": "Maria Christine", "initials": "MC", "orcid": "0000-0002-2110-0479", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bdd65c5105f4480692383dae8d4ac986.json"}}, {"family": "Vomstein", "given": "Kilian", "initials": "K"}, {"family": "Du", "given": "Juan", "initials": "J", "orcid": "0000-0001-7649-9571", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f67834a614ca4cd4aff026e5e9a1a1e4.json"}}, {"family": "Bashir", "given": "Zahra", "initials": "Z", "orcid": "0000-0002-2497-282X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2d15fce497fe4cdabd82e994e7cd83ad.json"}}, {"family": "Kaldhusdal", "given": "Vilde", "initials": "V"}, {"family": "Fransson", "given": "Emma", "initials": "E", "orcid": "0000-0001-9010-8522", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8c05290187ec426b8804eefc3d954971.json"}}, {"family": "Engstrand", "given": "Lars", "initials": "L", "orcid": "0000-0002-7713-2373", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/02d8684df81e42169e613de803446fbf.json"}}, {"family": "Nielsen", "given": "Henriette Svarre", "initials": "HS", "orcid": "0000-0003-2106-8103", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9a99fa7ebb204c618ed70f29be0085b3.json"}}, {"family": "Schuppe-Koistinen", "given": "Ina", "initials": "I", "orcid": "0000-0002-1423-3089", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/659fb04e6a1a430cbd707b8a50d500a3.json"}}], "type": "journal article", "published": "2024-08-19", "journal": {"title": "Microbiome", "issn": "2049-2618", "volume": "12", "issue": "1", "pages": "153", "issn-l": "2049-2618"}, "abstract": "The composition of the vaginal microbiota during the menstrual cycle is dynamic, with some women remaining eu- or dysbiotic and others transitioning between these states. What defines these dynamics, and whether these differences are microbiome-intrinsic or mostly driven by the host is unknown. To address this, we characterized 49 healthy, young women by metagenomic sequencing of daily vaginal swabs during a menstrual cycle. We classified the dynamics of the vaginal microbiome and assessed the impact of host behavior as well as microbiome differences at the species, strain, gene, and phage levels.\n\nBased on the daily shifts in community state types (CSTs) during a menstrual cycle, the vaginal microbiome was classified into four Vaginal Community Dynamics (VCDs) and reported in a classification tool, named VALODY: constant eubiotic, constant dysbiotic, menses-related, and unstable dysbiotic. The abundance of bacteria, phages, and bacterial gene content was compared between the four VCDs. Women with different VCDs showed significant differences in relative phage abundance and bacterial composition even when assigned to the same CST. Women with unstable VCDs had higher phage counts and were more likely dominated by L. iners. Their Gardnerella spp. strains were also more likely to harbor bacteriocin-coding genes.\n\nThe VCDs present a novel time series classification that highlights the complexity of varying degrees of vaginal dysbiosis. Knowing the differences in phage gene abundances and the genomic strains present allows a deeper understanding of the initiation and maintenance of permanent dysbiosis. Applying the VCDs to further characterize the different types of microbiome dynamics qualifies the investigation of disease and enables comparisons at individual and population levels. Based on our data, to be able to classify a dysbiotic sample into the accurate VCD, clinicians would need two to three mid-cycle samples and two samples during menses. In the future, it will be important to address whether transient VCDs pose a similar risk profile to persistent dysbiosis with similar clinical outcomes. This framework may aid interdisciplinary translational teams in deciphering the role of the vaginal microbiome in women's health and reproduction. Video Abstract.", "doi": "10.1186/s40168-024-01870-5", "pmid": "39160615", "labels": {"Luisa Hugerth": null, "DDLS Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC11331738"}, {"db": "pii", "key": "10.1186/s40168-024-01870-5"}], "notes": [], "created": "2025-03-19T07:35:44.797Z", "modified": "2025-04-08T06:08:00.287Z"}, {"entity": "publication", "iuid": "b6884adebcd44c5f85555627116b94ea", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b6884adebcd44c5f85555627116b94ea.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b6884adebcd44c5f85555627116b94ea"}}, "title": "Investigations of microbiota composition and neuroactive pathways in association with symptoms of stress and depression in a cohort of healthy women.", "authors": [{"family": "Bashir", "given": "Zahra", "initials": "Z", "orcid": "0000-0002-2497-282X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2d15fce497fe4cdabd82e994e7cd83ad.json"}}, {"family": "Hugerth", "given": "Luisa W", "initials": "LW", "orcid": "0000-0001-5432-1764", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/246ed7b405dd4c3f9ec5e7ff9f1d3ade.json"}}, {"family": "Krog", "given": "Maria Christine", "initials": "MC", "orcid": "0000-0002-2110-0479", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bdd65c5105f4480692383dae8d4ac986.json"}}, {"family": "Prast-Nielsen", "given": "Stefanie", "initials": "S", "orcid": "0000-0001-5877-7988", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fe13dffa03b24588a919b6b028788a6e.json"}}, {"family": "Edfeldt", "given": "Gabriella", "initials": "G", "orcid": "0000-0003-0366-5588", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bc30318aa3ca4720ac5aa3a982c9f730.json"}}, {"family": "Boulund", "given": "Fredrik", "initials": "F", "orcid": "0000-0002-3806-323X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a5c6814a31e644b9bc544d4da759a438.json"}}, {"family": "Schacht", "given": "Simon R\u00f8nnow", "initials": "SR"}, {"family": "Tetens", "given": "Inge", "initials": "I"}, {"family": "Engstrand", "given": "Lars", "initials": "L", "orcid": "0000-0002-7713-2373", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/02d8684df81e42169e613de803446fbf.json"}}, {"family": "Schuppe-Koistinen", "given": "Ina", "initials": "I", "orcid": "0000-0002-1423-3089", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/659fb04e6a1a430cbd707b8a50d500a3.json"}}, {"family": "Fransson", "given": "Emma", "initials": "E", "orcid": "0000-0001-9010-8522", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8c05290187ec426b8804eefc3d954971.json"}}, {"family": "Nielsen", "given": "Henriette Svarre", "initials": "HS", "orcid": "0000-0003-2106-8103", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9a99fa7ebb204c618ed70f29be0085b3.json"}}], "type": "journal article", "published": "2024-07-02", "journal": {"title": "Front. Cell. Infect. Microbiol.", "issn": "2235-2988", "volume": "14", "pages": "1324794", "issn-l": "2235-2988"}, "abstract": "Despite mounting evidence of gut-brain involvement in psychiatric conditions, functional data remain limited, and analyses of other microbial niches, such as the vaginal microbiota, are lacking in relation to mental health. This aim of this study was to investigate if the connections between the gut microbiome and mental health observed in populations with a clinical diagnosis of mental illness extend to healthy women experiencing stress and depressive symptoms. Additionally, this study examined the functional pathways of the gut microbiota according to the levels of psychological symptoms. Furthermore, the study aimed to explore potential correlations between the vaginal microbiome and mental health parameters in young women without psychiatric diagnoses.\n\nIn this cross-sectional study, 160 healthy Danish women (aged 18-40 years) filled out questionnaires with validated scales measuring symptoms of stress and depression and frequency of dietary intake. Fecal and vaginal microbiota samples were collected at the beginning of the menstrual cycle and vaginal samples were also collected at cycle day 8-12 and 18-22. Shotgun metagenomic profiling of the gut and vaginal microbiome was performed. The Kyoto Encyclopedia of Genes and Genomes (KEGG) was used for functional profiling and 56 Gut Brain Modules were analyzed in the fecal samples.\n\nThe relative abundance in the gut of the genera Escherichia, Parabacteroides, and Shigella was higher in women with elevated depressive symptoms. Women with high perceived stress showed a tendency of increased abundance of Escherichia, Shigella, and Blautia. Amongst others, the potentially pathogenic genera, Escherichia and Shigella correlate with alterations in the neuroactive pathways such as the glutamatergic, GABAeric, dopaminergic, and Kynurenine pathways. Vaginosis symptoms were more prevalent in women reporting high levels of stress and depressive symptoms.\n\nThe findings of this study support the concept of a microbiota-associated effect on the neuroactive pathways even in healthy young women. This suggest, that targeting the gut microbiome could be a promising approach for future psychiatric interventions.", "doi": "10.3389/fcimb.2024.1324794", "pmid": "39015337", "labels": {"Luisa Hugerth": null, "DDLS Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC11249552"}], "notes": [], "created": "2025-03-19T07:35:43.556Z", "modified": "2025-04-08T06:08:56.327Z"}, {"entity": "publication", "iuid": "5abd3e284dc941a7adec38a1ed7d3bad", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/5abd3e284dc941a7adec38a1ed7d3bad.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/5abd3e284dc941a7adec38a1ed7d3bad"}}, "title": "The healthy female microbiome across body sites: effect of hormonal contraceptives and the menstrual cycle.", "authors": [{"family": "Krog", "given": "Maria Christine", "initials": "MC", "orcid": "0000-0002-2110-0479", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bdd65c5105f4480692383dae8d4ac986.json"}}, {"family": "Hugerth", "given": "Luisa W", "initials": "LW", "orcid": "0000-0001-5432-1764", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/246ed7b405dd4c3f9ec5e7ff9f1d3ade.json"}}, {"family": "Fransson", "given": "Emma", "initials": "E", "orcid": "0000-0001-9010-8522", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8c05290187ec426b8804eefc3d954971.json"}}, {"family": "Bashir", "given": "Zahra", "initials": "Z", "orcid": "0000-0002-2497-282X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2d15fce497fe4cdabd82e994e7cd83ad.json"}}, {"family": "Nyboe Andersen", "given": "Anders", "initials": "A"}, {"family": "Edfeldt", "given": "Gabriella", "initials": "G", "orcid": "0000-0003-0366-5588", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bc30318aa3ca4720ac5aa3a982c9f730.json"}}, {"family": "Engstrand", "given": "Lars", "initials": "L", "orcid": "0000-0002-7713-2373", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/02d8684df81e42169e613de803446fbf.json"}}, {"family": "Schuppe-Koistinen", "given": "Ina", "initials": "I", "orcid": "0000-0002-1423-3089", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/659fb04e6a1a430cbd707b8a50d500a3.json"}}, {"family": "Nielsen", "given": "Henriette Svarre", "initials": "HS", "orcid": "0000-0003-2106-8103", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9a99fa7ebb204c618ed70f29be0085b3.json"}}], "type": "journal article", "published": "2022-06-30", "journal": {"title": "Hum. Reprod.", "issn": "1460-2350", "volume": "37", "issue": "7", "pages": "1525-1543", "issn-l": "0268-1161"}, "abstract": "How does hormonal contraceptive use and menstrual cycle phase affect the female microbiome across different body sites?\n\nThe menstrual cycle phase, but not hormonal contraceptive use, is associated with the vaginal and oral but not the gut microbiome composition in healthy young women.\n\nWomen with low vaginal levels of Lactobacillus crispatus are at increased risk of pre-term birth, fertility treatment failure, sexually transmitted infections and gynaecological cancers. Little is known about the effect of hormonal fluctuations on other body site's microbiomes as well as the interplay between them.\n\nThis study includes a cohort of 160 healthy young Danish women using three different contraceptive regimens: non-hormonal methods (n = 54), combined oral contraceptive (COC, n = 52) or levonorgestrel intrauterine system (LNG-IUS, n = 54). Samples were collected from four body sites during the menstrual cycle (menses, follicular and luteal phases) at Copenhagen University Hospital, Rigshospitalet, Denmark.\n\nThe oral, vaginal, rectal and faecal microbiomes were characterized by shotgun sequencing. Microbial diversity and community distance measures were compared between study groups, menstrual phase timepoints and body sites. All participants answered an extensive questionnaire on current health, lifestyle and sex life. Confounding factors such as smoking, BMI and diet were analysed by PERMANOVA. Plasma oestradiol and progesterone levels are correlated with microbiome composition.\n\nThe use of COC and LNG-IUS was not associated with the microbiome composition or diversity. However, increased diversity in the vaginal microbiome was observed during menses, followed by a subsequent expansion of Lactobacillus spp. during the follicular and luteal phases which correlated with measured serum oestradiol levels (r = 0.11, P < 0.001). During menses, 89 women (58%) had a dysbiotic vaginal microbiome with <60% Lactobacillus spp. This declined to 49 (32%) in the follicular phase (P < 0.001) and 44 (29%) in the luteal phase (P < 0.001). During menses, bacterial richness and diversity in saliva reached its lowest point while no differences were observed in the faecal microbiome. The microbiome in different body sites was on average more similar within the same individual than between individuals, despite phase or hormonal treatment. Only the vagina presented a clear cluster structure with dominance of either L. crispatus, Lactobacillus iners, Gardnerella vaginalis or Prevotella spp.\n\nThe microbiome samples analysed in this study were submitted to the European Nucleotide Archive under project number PRJEB37731, samples ERS4421369-ERS4422941.\n\nThe cohort is homogenous which limits extrapolation of the effects of ethnicity and socio-economic status on the microbiome. We only present three defined timepoints across the menstrual phase and miss potential important day to day fluctuations.\n\nThe use of hormonal contraception did not significantly associate with the microbiome composition in the vagina, faeces, rectum or saliva in healthy young women. This is a welcome finding considering the widespread and prolonged use of these highly efficient contraceptive methods. The menstrual cycle is, however, a major confounding factor for the vaginal microbiome. As such, the time point in the menstrual cycle should be considered when analysing the microbiome of women of reproductive age, since stratifying by vaginal dysbiosis status during menstruation could be misleading. This is the first study to confirm by direct measurements of oestradiol, a correlation with the presence of L. crispatus, adding evidence of a possible hormonal mechanism for the maintenance of this desirable microbe.\n\nThis work was partly funded by the Ferring Pharmaceuticals through a research collaboration with The Centre for Translational Microbiome Research (CTMR) at the Karolinska Institutet (L.W.H., E.F., G.E. and I.S.-K.). Ferring Pharmaceuticals also funded the infrastructure to obtain the clinical samples at Copenhagen University Hospital ([#MiHSN01], M.C.K., Z.B., and H.S.N.). This work was also supported by funding from Rigshospitalet's Research Funds ([#E-22614-01 and #E-22614-02] to M.C.K.) and Oda and Hans Svenningsen's Foundation ([#F-22614-08] to H.S.N.). M.C.K., L.W.H., E.F., Z.B., G.E., L.E., I.S.-K. and H.S.N., are partially funded by Ferring Pharmaceuticals, which also provided funds for the collection and processing of the samples analysed in this study. H.S.N.'s research is further supported by Freya Biosciences and the BioInnovation Institute. H.S.N. has received honoraria from Ferring Pharmaceuticals, Merck A/S, Astra-Zeneca, Cook Medical and Ibsa Nordic. A.N.A. reports no competing interests.", "doi": "10.1093/humrep/deac094", "pmid": "35553675", "labels": {"Luisa Hugerth": null, "DDLS Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC9247429"}, {"db": "pii", "key": "6584540"}], "notes": [], "created": "2022-11-08T07:02:56.315Z", "modified": "2023-10-27T09:27:54.965Z"}, {"entity": "publication", "iuid": "5da495110d404371b5693f5854cbfca2", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/5da495110d404371b5693f5854cbfca2.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/5da495110d404371b5693f5854cbfca2"}}, "title": "The microbiome in reproductive health: protocol for a systems biology approach using a prospective, observational study design.", "authors": [{"family": "Krog", "given": "Maria Christine", "initials": "MC", "orcid": "0000-0002-2110-0479", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bdd65c5105f4480692383dae8d4ac986.json"}}, {"family": "Madsen", "given": "Mette Elkj\u00e6r", "initials": "ME", "orcid": "0000-0001-7767-9849", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1c8d263e2f4d4507bc2510f04869a5a5.json"}}, {"family": "Bliddal", "given": "Sofie", "initials": "S", "orcid": "0000-0002-2456-1019", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/58a6059b93a14a6e80514e744893acdd.json"}}, {"family": "Bashir", "given": "Zahra", "initials": "Z", "orcid": "0000-0002-2497-282X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2d15fce497fe4cdabd82e994e7cd83ad.json"}}, {"family": "Vex\u00f8", "given": "Laura Emilie", "initials": "LE"}, {"family": "Hartwell", "given": "Dorthe", "initials": "D"}, {"family": "Hugerth", "given": "Luisa W", "initials": "LW", "orcid": "0000-0001-5432-1764", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/246ed7b405dd4c3f9ec5e7ff9f1d3ade.json"}}, {"family": "Fransson", "given": "Emma", "initials": "E", "orcid": "0000-0001-9010-8522", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8c05290187ec426b8804eefc3d954971.json"}}, {"family": "Hamsten", "given": "Marica", "initials": "M"}, {"family": "Boulund", "given": "Fredrik", "initials": "F", "orcid": "0000-0002-3806-323X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a5c6814a31e644b9bc544d4da759a438.json"}}, {"family": "Wannerberger", "given": "Kristin", "initials": "K"}, {"family": "Engstrand", "given": "Lars", "initials": "L", "orcid": "0000-0002-7713-2373", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/02d8684df81e42169e613de803446fbf.json"}}, {"family": "Schuppe-Koistinen", "given": "Ina", "initials": "I", "orcid": "0000-0002-1423-3089", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/659fb04e6a1a430cbd707b8a50d500a3.json"}}, {"family": "Nielsen", "given": "Henriette Svarre", "initials": "HS", "orcid": "0000-0003-2106-8103", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9a99fa7ebb204c618ed70f29be0085b3.json"}}], "type": "journal article", "published": "2022-03-23", "journal": {"title": "Hum Reprod Open", "issn": "2399-3529", "volume": "2022", "issue": "2", "pages": "hoac015", "issn-l": null}, "abstract": "What is the microbiome profile across different body sites in relation to the normal menstrual cycle (with and without hormonal contraception), recurrent pregnancy loss (RPL) (before and during pregnancy, pregnancy loss or birth) and endometriosis (before, during and after surgery)? How do these profiles interact with genetics, environmental exposures, immunological and endocrine biomarkers?\n\nThe microbiome is a key factor influencing human health and disease in areas as diverse as immune functioning, gastrointestinal disease and mental and metabolic disorders. There is mounting evidence to suggest that the reproductive microbiome may be influential in general and reproductive health, fertility and pregnancy outcomes.\n\nThis is a prospective, longitudinal, observational study using a systems biology approach in three cohorts totalling 920 participants. Since microbiome profiles by shot-gun sequencing have never been investigated in healthy controls during varying phases of the menstrual cycle, patients with RPL and patients with endometriosis, no formal sample size calculation can be performed. The study period is from 2017 to 2024 and allows for longitudinal profiling of study participants to enable deeper understanding of the role of the microbiome and of host-microbe interactions in reproductive health.\n\nParticipants in each cohort are as follows: Part 1 MiMens-150 healthy women with or without hormonal contraception; Part 2 MiRPL-200 couples with RPL, 50 healthy couples with prior uncomplicated pregnancy and 150 newborns; Part 3 MiEndo-120 patients with endometriosis requiring surgery with or without hormonal treatment. Microbiome profiles from saliva, faeces, rectal mucosa, vaginal fluid and endometrium will be studied, as well as the Omics profile, endocrine disrupting chemicals and endocrine and immune factors in blood, hair, saliva and urine. Pregnancy loss products, seminal microbiome, HLA types, endometriotic tissue and genetic risk and comprehensive questionnaire data will also be studied, where appropriate. Correlations with mental and physical health will be evaluated.\n\nThis work is supported by funding from Ferring Pharmaceuticals ([#MiHSN01] to H.S.N., M.C.K., M.E.M., L.E.V., L.E., I.S.-K., F.B., L.W.H., E.F. and M.H.), Rigshospitalet's Research Funds ([#E-22614-01 and #E-22614-02] to M.C.K. and [#E-22222-06] to S.B.), Niels and Desiree Yde's Foundation (S.B., endocrine analyses [#2015-2784]), the Musikforl\u00e6ggerne Agnes and Knut M\u00f8rk's Foundation (S.B., endocrine and immune analyses [#35108-001]) and Oda and Hans Svenningsen's Foundation ([#F-22614-08] to H.S.N.). Medical writing assistance with this manuscript was provided by Caroline Loat, PhD, and funded by Ferring Pharmaceuticals. H.S.N. reports personal fees from Ferring Pharmaceuticals, Merck Denmark A/S, Ibsa Nordic, Astra Zeneca and Cook Medical outside the submitted work. K.W. is a full-time employee of Ferring Pharmaceuticals. No other conflicts are reported.\n\nN/A.\n\nN/A.\n\nN/A.", "doi": "10.1093/hropen/hoac015", "pmid": "35441092", "labels": {"DDLS Fellow": null, "Luisa Hugerth": null}, "xrefs": [{"db": "pmc", "key": "PMC9014536"}, {"db": "pii", "key": "hoac015"}], "notes": [], "created": "2023-05-12T13:20:12.988Z", "modified": "2023-10-27T09:28:00.116Z"}]}