{"entity": "researcher", "timestamp": "2026-08-11T07:59:24.326Z", "family": "Han", "given": "Zijian", "initials": "Z", "orcid": "0009-0000-0839-6386", "affiliations": ["State Key Laboratory of Drug Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/9925a5bcd3ca4e3c887c263623b4ff66.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/9925a5bcd3ca4e3c887c263623b4ff66"}}, "publications": [{"entity": "publication", "iuid": "1420ececd2134ddcbcc5afea473b949a", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/1420ececd2134ddcbcc5afea473b949a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/1420ececd2134ddcbcc5afea473b949a"}}, "title": "A Base-Mediated Rearrangement of the Benzylic 1,5-Hexadipyridynyl Moiety.", "authors": [{"family": "Remmerswaal", "given": "Wouter A", "initials": "WA", "orcid": "0000-0002-1040-4311", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/269410f13fa643de88e9da17ce8f0828.json"}}, {"family": "Nguyen", "given": "Thai-Tony", "initials": "TT", "orcid": "0009-0001-6232-8322", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1545880bf2de48fa98245cd5b41745fa.json"}}, {"family": "Han", "given": "Zijian", "initials": "Z", "orcid": "0009-0000-0839-6386", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9925a5bcd3ca4e3c887c263623b4ff66.json"}}, {"family": "Krasovski Slobodian", "given": "Fedor", "initials": "F", "orcid": "0009-0007-7775-3691", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/045537ba74c04020ab63fe0b23a43536.json"}}, {"family": "Xiong", "given": "Ruisheng", "initials": "R", "orcid": "0000-0002-8165-5863", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dae96fef517b437e98175b2d85feb0ac.json"}}, {"family": "Kessler", "given": "Vadim", "initials": "V", "orcid": "0000-0001-7570-2814", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/533fb38671914f9189160687d00e5360.json"}}, {"family": "Xu", "given": "Zhijian", "initials": "Z", "orcid": "0000-0002-3063-8473", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5f196d16a71a42d88bfda54f494333b7.json"}}, {"family": "Zhu", "given": "Weiliang", "initials": "W", "orcid": "0000-0001-6699-5299", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f45a8519ecb24a92a52cd584a6f82638.json"}}, {"family": "Erdelyi", "given": "Mate", "initials": "M", "orcid": "0000-0003-0359-5970", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/541eea95344a4e918d30bc1a0f0429c9.json"}}], "type": "journal article", "published": "2025-09-00", "journal": {"title": "Chempluschem", "issn": "2192-6506", "volume": "90", "issue": "9", "pages": "e202500252", "issn-l": null}, "abstract": "A previously unrecognized base-mediated rearrangement of a benzylic 1,5-hexadipyridynyl moiety is reported. Upon exposure to base, this structural motif rearranges into a constrained vinyl-pyridine substituted cyclobutene. Computational modeling indicates that the rearrangement takes place following a route involving stepwise deprotonation, shifted reprotonation, and 4\u03c0-electrocyclization. The reaction rate and the stereochemical outcome is consistent with the experimental observations. Furthermore, nonbase mediates rearrangements, through well-known Cope-like [3,3]-sigmatropic shifts, are found to be high in energy, and therefore, take a backseat to the base-mediated pathway. This rearrangement may provide a novel reactivity pathway of conjugated systems for synthetic methodology development.", "doi": "10.1002/cplu.202500252", "pmid": "40608800", "labels": {"Ruisheng Xiong": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC12435124"}], "notes": [], "created": "2025-11-27T17:22:44.712Z", "modified": "2025-11-27T17:22:45.021Z"}]}