{"entity": "researcher", "timestamp": "2026-09-28T11:20:34.188Z", "family": "Richichi", "given": "Barbara", "initials": "B", "orcid": "0000-0001-7093-9513", "affiliations": ["Department of Chemistry 'Ugo Schiff', University of Firenze, Via della Lastruccia 13, 50019, Sesto, Fiorentino (Firenze, Italy."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/98324cd50ebd43f0a08923112e3b870c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/98324cd50ebd43f0a08923112e3b870c"}}, "publications": [{"entity": "publication", "iuid": "b97dd95b2dc240b0a55c8d26bac0f843", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b97dd95b2dc240b0a55c8d26bac0f843.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b97dd95b2dc240b0a55c8d26bac0f843"}}, "title": "Stereoselective Synthesis of the Gal-\u03b1-(1\u21923)-Gal-\u03b2-(1\u21923)-GlcNAc Trisaccharide: a new Ligand for DCAR and Mincle C-Type Lectin Receptors.", "authors": [{"family": "Tricomi", "given": "Jacopo", "initials": "J"}, {"family": "Aoun", "given": "Mike", "initials": "M"}, {"family": "Xu", "given": "Bingze", "initials": "B"}, {"family": "Holmdahl", "given": "Rikard", "initials": "R"}, {"family": "Richichi", "given": "Barbara", "initials": "B", "orcid": "0000-0001-7093-9513", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/98324cd50ebd43f0a08923112e3b870c.json"}}], "type": "journal article", "published": "2024-05-02", "journal": {"title": "Chembiochem", "issn": "1439-7633", "volume": "25", "issue": "9", "pages": "e202400026", "issn-l": "1439-4227"}, "abstract": "In this work, we have discovered that the Gal-\u03b1-(1\u21923)-Gal-\u03b2-(1\u21923)-GlcNAc trisaccharide, a fragment of the B antigen Type-1, is a new ligand of two C-type lectin receptors (CLRs) i. e. DCAR and Mincle which are key players in different types of autoimmune diseases. Accordingly, we report here on a straightforward methodology to access pure Gal-\u03b1-(1\u21923)-Gal-\u03b2-(1\u21923)-GlcNAc trisaccharide. A spacer with a terminal primary amine group was included at the reducing end of the GlcNAc residue thus ensuring the further functionalization of the trisaccharide Gal-\u03b1-(1\u21923)-Gal-\u03b2-(1\u21923)-GlcNAc.", "doi": "10.1002/cbic.202400026", "pmid": "38506247", "labels": [], "xrefs": [], "notes": [], "created": "2026-09-23T15:32:59.383Z", "modified": "2026-09-23T15:32:59.459Z"}]}