{"entity": "researcher", "timestamp": "2026-09-26T23:56:35.346Z", "family": "Hui", "given": "Lisa", "initials": "L", "orcid": "0000-0002-9720-3562", "affiliations": ["Reproductive Epidemiology Group, Murdoch Children's Research Institute, Parkville, Victoria, Australia.", "Department of Perinatal Medicine, Mercy Hospital for Women, Heidelberg, Victoria, Australia.", "Department of Obstetrics and Gynaecology, Northern Health, Epping, Victoria, Australia."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/97eb2b74c30a4cdc84cc74f61a8e195a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/97eb2b74c30a4cdc84cc74f61a8e195a"}}, "publications": [{"entity": "publication", "iuid": "b0f163c4c2644abcba8ba0f8e72b6095", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b0f163c4c2644abcba8ba0f8e72b6095.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b0f163c4c2644abcba8ba0f8e72b6095"}}, "title": "Factors that impact on women's decision-making around prenatal genomic tests: An international discrete choice survey.", "authors": [{"family": "Buchanan", "given": "James", "initials": "J", "orcid": "0000-0002-6285-2028", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/576cd96c41d74874ab2c58b5f850b9e2.json"}}, {"family": "Hill", "given": "Melissa", "initials": "M", "orcid": "0000-0003-3900-1425", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e21ffa87962d48d5a350d43301d20c42.json"}}, {"family": "Vass", "given": "Caroline M", "initials": "CM", "orcid": "0000-0002-6385-2812", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b500862fff1d4df29c952cec3c8ac8ce.json"}}, {"family": "Hammond", "given": "Jennifer", "initials": "J", "orcid": "0000-0002-2637-5818", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/582c6cd07232495899bc3a9c3febb173.json"}}, {"family": "Riedijk", "given": "Sam", "initials": "S", "orcid": "0000-0003-3400-4969", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4080c929c2ea44138c93e55e0ffb191b.json"}}, {"family": "Klapwijk", "given": "Jasmijn E", "initials": "JE", "orcid": "0000-0002-6775-6561", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/22bd88fea402453db4e975e0085c902f.json"}}, {"family": "Harding", "given": "Eleanor", "initials": "E"}, {"family": "Lou", "given": "Stina", "initials": "S", "orcid": "0000-0001-6177-5780", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fb06bbdb35b14f0899410cac88f2d1bd.json"}}, {"family": "Vogel", "given": "Ida", "initials": "I", "orcid": "0000-0002-1125-0393", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/155fd724871e4117bb9696a993ba9209.json"}}, {"family": "Hui", "given": "Lisa", "initials": "L", "orcid": "0000-0002-9720-3562", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/97eb2b74c30a4cdc84cc74f61a8e195a.json"}}, {"family": "Ingvoldstad-Malmgren", "given": "Charlotta", "initials": "C", "orcid": "0000-0003-1915-2453", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b16acdb5c5ba4aedb5a3dab578722ee9.json"}}, {"family": "Soller", "given": "Maria Johansson", "initials": "MJ", "orcid": "0000-0001-9980-8971", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b279540f951a4e088fc659a388d46225.json"}}, {"family": "Ormond", "given": "Kelly E", "initials": "KE", "orcid": "0000-0002-1033-0818", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4c9f40c3c064469f8564ca944ad1d810.json"}}, {"family": "Choolani", "given": "Mahesh", "initials": "M", "orcid": "0000-0001-8336-0973", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b1ab3153908f403cb51c954b1332b214.json"}}, {"family": "Zheng", "given": "Qian", "initials": "Q"}, {"family": "Chitty", "given": "Lyn S", "initials": "LS", "orcid": "0000-0002-4857-7138", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/451e184e4af64d0988a537bb66d8d4d0.json"}}, {"family": "Lewis", "given": "Celine", "initials": "C", "orcid": "0000-0001-7169-1521", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6a5b0224e38a4613bf20e174c2e16363.json"}}], "type": "journal article", "published": "2022-06-00", "journal": {"title": "Prenat. Diagn.", "issn": "1097-0223", "volume": "42", "issue": "7", "pages": "934-946", "issn-l": "0197-3851"}, "abstract": "We conducted a survey-based discrete-choice experiment (DCE) to understand the test features that drive women's preferences for prenatal genomic testing, and explore variation across countries.\n\nFive test attributes were identified as being important for decision-making through a literature review, qualitative interviews and quantitative scoring exercise. Twelve scenarios were constructed in which respondents choose between two invasive tests or no test. Women from eight countries who delivered a baby in the previous 24 months completed a DCE presenting these scenarios. Choices were modeled using conditional logit regression analysis.\n\nSurveys from 1239 women (Australia: n = 178; China: n = 179; Denmark: n = 88; Netherlands: n = 177; Singapore: n = 90; Sweden: n = 178; UK: n = 174; USA: n = 175) were analyzed. The key attribute affecting preferences was a test with the highest diagnostic yield (p < 0.01). Women preferred tests with short turnaround times (p < 0.01), and tests reporting variants of uncertain significance (VUS; p < 0.01) and secondary findings (SFs; p < 0.01). Several country-specific differences were identified, including time to get a result, who explains the result, and the return of VUS and SFs.\n\nMost women want maximum information from prenatal genomic tests, but our findings highlight country-based differences. Global consensus on how to return uncertain results is not necessarily realistic or desirable.", "doi": "10.1002/pd.6159", "pmid": "35476801", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9325352"}], "notes": [], "created": "2026-09-23T12:01:26.960Z", "modified": "2026-09-23T12:01:27.613Z"}]}