{"entity": "researcher", "timestamp": "2026-09-26T00:54:12.246Z", "family": "Engstrand", "given": "Jennie", "initials": "J", "orcid": "0000-0003-1123-7022", "affiliations": ["Department of Clinical Science, Intervention and Technology, Division of Surgery, Karolinska Institutet, Karolinska University Hospital, 14152, Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/972ae8ebf2634566bed8ebca7caa68ec.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/972ae8ebf2634566bed8ebca7caa68ec"}}, "publications": [{"entity": "publication", "iuid": "f5aa84a9852742eeb7c097da2a0a9e4f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f5aa84a9852742eeb7c097da2a0a9e4f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f5aa84a9852742eeb7c097da2a0a9e4f"}}, "title": "An injury-associated lobular microniche is associated with the classical tumor cell phenotype in pancreatic cancer.", "authors": [{"family": "S\u00f6derqvist", "given": "Sara", "initials": "S"}, {"family": "Viljamaa", "given": "Annika", "initials": "A", "orcid": "0009-0002-8511-8181", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ad54bd86380f48b99fc405a6466f5e5e.json"}}, {"family": "Geyer", "given": "Natalie", "initials": "N"}, {"family": "Keller", "given": "Anna-Lena", "initials": "AL"}, {"family": "Ruksha", "given": "Kseniya", "initials": "K"}, {"family": "Strell", "given": "Carina", "initials": "C", "orcid": "0000-0002-3783-7256", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f288539ea7eb406480c84ec1a5605a91.json"}}, {"family": "Hekmati", "given": "Neda", "initials": "N"}, {"family": "Niculae", "given": "Alexandra", "initials": "A"}, {"family": "Engstrand", "given": "Jennie", "initials": "J", "orcid": "0000-0003-1123-7022", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/972ae8ebf2634566bed8ebca7caa68ec.json"}}, {"family": "Sparrelid", "given": "Ernesto", "initials": "E"}, {"family": "Salm\u00e9n", "given": "Caroline", "initials": "C"}, {"family": "Costa", "given": "T\u00e2nia D F", "initials": "TDF", "orcid": "0000-0002-6296-5225", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/93606f4fc34a4e088f63303d4bb9b7dc.json"}}, {"family": "Zhao", "given": "Miao", "initials": "M", "orcid": "0000-0002-4895-1177", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/75b5d6dc5cde46b8aca859fb961bf1de.json"}}, {"family": "Str\u00f6mblad", "given": "Staffan", "initials": "S", "orcid": "0000-0002-1236-6339", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/eaaec7c2564a4cb5827a794027518796.json"}}, {"family": "Zacharouli", "given": "Argyro", "initials": "A"}, {"family": "Ghorbani", "given": "Poya", "initials": "P"}, {"family": "Harrizi", "given": "Sara", "initials": "S"}, {"family": "Hamidi", "given": "Yousra", "initials": "Y"}, {"family": "Khorosjutina", "given": "Olga", "initials": "O", "orcid": "0009-0001-0786-0260", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d758b02263464940ab8c7922b68b580a.json"}}, {"family": "Milanova", "given": "Stefina", "initials": "S"}, {"family": "Schmierer", "given": "Bernhard", "initials": "B", "orcid": "0000-0002-9082-7022", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/95decb70bc9d4dc2820259b5971e342f.json"}}, {"family": "Boz\u00f3ky", "given": "B\u00e9la", "initials": "B"}, {"family": "Fern\u00e1ndez Moro", "given": "Carlos", "initials": "C", "orcid": "0000-0001-6863-5959", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6b9e861a77874d87a34a4894bd38daf5.json"}}, {"family": "Gerling", "given": "Marco", "initials": "M", "orcid": "0000-0002-1810-0662", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/73d0af14271b446b8ce3779d6beea16c.json"}}], "type": "journal article", "published": "2025-09-26", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "16", "issue": "1", "pages": "8307", "issn-l": "2041-1723"}, "abstract": "Pancreatic cancer is an aggressive disease with a dense fibrotic stroma and is often accompanied by chronic inflammation. Peritumoral inflammation is typically viewed as a reaction to nearby tumor growth. Here, we report that the inflamed pancreatic lobules are frequently invaded by tumor cells, forming a distinct, non-fibrotic tumor niche. Using a semi-supervised machine learning approach for annotations of clinical samples and multiplex protein profiling, we show that tumor cells at the invasion front are closely associated with acinar cells undergoing damage-induced changes, and with activated fibroblasts expressing markers of injury. The invaded lobules are linked to classical tumor phenotypes, in contrast to fibrotic areas where tumor cells display a more basal profile, highlighting microenvironment-dependent tumor subtype differences. In female mice, lobular invasion similarly aligns with the classical tumor phenotype. Together, our data reveal that pancreatic tumors colonize injured lobules, creating a unique niche that shapes tumor characteristics and contributes to disease biology.", "doi": "10.1038/s41467-025-63864-7", "pmid": "41006303", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12475445"}, {"db": "pii", "key": "10.1038/s41467-025-63864-7"}], "notes": [], "created": "2026-09-23T11:34:17.684Z", "modified": "2026-09-23T11:34:17.901Z"}, {"entity": "publication", "iuid": "d26a4278f9b14c14ba5410b71cfecc50", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/d26a4278f9b14c14ba5410b71cfecc50.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/d26a4278f9b14c14ba5410b71cfecc50"}}, "title": "A distinctive tumor compartment in pancreatic lobules defined by nascent stroma and classical tumor cell phenotype", "authors": [{"family": "S\u00f6derqvist", "given": "Sara", "initials": "S", "orcid": "0009-0003-2133-6400", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/00a39720179d4e38aa6e224299d4117c.json"}}, {"family": "Viljamaa", "given": "Annika", "initials": "A", "orcid": "0009-0002-8511-8181", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ad54bd86380f48b99fc405a6466f5e5e.json"}}, {"family": "Geyer", "given": "Natalie", "initials": "N", "orcid": "0000-0003-1026-968X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c229df5d458445d995fadff597d6a0d4.json"}}, {"family": "Strell", "given": "Carina", "initials": "C", "orcid": "0000-0002-3783-7256", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f288539ea7eb406480c84ec1a5605a91.json"}}, {"family": "Hekmati", "given": "Neda", "initials": "N", "orcid": "0009-0009-4814-869X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1627d2402a114b7ea2aed6cb0774e930.json"}}, {"family": "Engstrand", "given": "Jennie", "initials": "J", "orcid": "0000-0003-1123-7022", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/972ae8ebf2634566bed8ebca7caa68ec.json"}}, {"family": "Sparrelid", "given": "Ernesto", "initials": "E"}, {"family": "Salm\u00e9n", "given": "Caroline", "initials": "C"}, {"family": "Heuchel", "given": "Rainer L", "initials": "RL", "orcid": "0000-0002-2782-585X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b61dc159c5764feba88e3fa2a35d1ad7.json"}}, {"family": "Zacharouli", "given": "Argyro", "initials": "A"}, {"family": "Ghorbani", "given": "Poya", "initials": "P", "orcid": "0000-0003-2102-7168", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/37d164f0a26d4bf4aa8ad1aa4505f92e.json"}}, {"family": "Harrizi", "given": "Sara", "initials": "S"}, {"family": "Hamidi", "given": "Yousra", "initials": "Y"}, {"family": "Khorosjutina", "given": "Olga", "initials": "O", "orcid": "0009-0001-0786-0260", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d758b02263464940ab8c7922b68b580a.json"}}, {"family": "Milanova", "given": "Stefina", "initials": "S", "orcid": "0000-0001-9865-857X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/653b408e1e894d3a9bd22564ac3ec1dd.json"}}, {"family": "Schmierer", "given": "Bernhard", "initials": "B", "orcid": "0000-0002-9082-7022", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/95decb70bc9d4dc2820259b5971e342f.json"}}, {"family": "Boz\u00f3ky", "given": "B\u00e9la", "initials": "B"}, {"family": "Moro", "given": "Carlos Fern\u00e1ndez", "initials": "CF", "orcid": "0000-0001-6863-5959", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6b9e861a77874d87a34a4894bd38daf5.json"}}, {"family": "Gerling", "given": "Marco", "initials": "M", "orcid": "0000-0002-1810-0662", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/73d0af14271b446b8ce3779d6beea16c.json"}}], "type": "posted-content", "published": "2024-03-15", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2024.03.14.584614", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-09-23T15:33:01.279Z", "modified": "2026-09-23T15:33:01.532Z"}, {"entity": "publication", "iuid": "13fa501d26b9449a9183d85612341085", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/13fa501d26b9449a9183d85612341085.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/13fa501d26b9449a9183d85612341085"}}, "title": "An idiosyncratic zonated stroma encapsulates desmoplastic liver metastases and originates from injured liver.", "authors": [{"family": "Fern\u00e1ndez Moro", "given": "Carlos", "initials": "C", "orcid": "0000-0001-6863-5959", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6b9e861a77874d87a34a4894bd38daf5.json"}}, {"family": "Geyer", "given": "Natalie", "initials": "N"}, {"family": "Harrizi", "given": "Sara", "initials": "S"}, {"family": "Hamidi", "given": "Yousra", "initials": "Y"}, {"family": "S\u00f6derqvist", "given": "Sara", "initials": "S"}, {"family": "Kuznyecov", "given": "Danyil", "initials": "D", "orcid": "0009-0007-8218-557X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c523efe51e1e4d719e76739066a1c3e6.json"}}, {"family": "Tidholm Qvist", "given": "Evelina", "initials": "E"}, {"family": "Salmonson Schaad", "given": "Media", "initials": "M"}, {"family": "Hermann", "given": "Laura", "initials": "L"}, {"family": "Lindberg", "given": "Amanda", "initials": "A"}, {"family": "Heuchel", "given": "Rainer L", "initials": "RL", "orcid": "0000-0002-2782-585X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b61dc159c5764feba88e3fa2a35d1ad7.json"}}, {"family": "Mart\u00edn-Bernab\u00e9", "given": "Alfonso", "initials": "A"}, {"family": "Dhanjal", "given": "Soniya", "initials": "S"}, {"family": "Navis", "given": "Anna C", "initials": "AC", "orcid": "0000-0002-5267-4678", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/09390010aa754532bf22d007ddd4682c.json"}}, {"family": "Villard", "given": "Christina", "initials": "C"}, {"family": "Del Valle", "given": "Andrea C", "initials": "AC", "orcid": "0000-0002-1698-9533", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/640e1c5e98904433b89a85fd6dbaf857.json"}}, {"family": "Boz\u00f3ky", "given": "Lorand", "initials": "L"}, {"family": "Sparrelid", "given": "Ernesto", "initials": "E"}, {"family": "Dirix", "given": "Luc", "initials": "L", "orcid": "0000-0002-6248-1677", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/beca0559e23c4af49618f0400b57cced.json"}}, {"family": "Strell", "given": "Carina", "initials": "C"}, {"family": "\u00d6stman", "given": "Arne", "initials": "A", "orcid": "0000-0003-3993-0021", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9c904facaa544895ba08014225e5060f.json"}}, {"family": "Schmierer", "given": "Bernhard", "initials": "B", "orcid": "0000-0002-9082-7022", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/95decb70bc9d4dc2820259b5971e342f.json"}}, {"family": "Vermeulen", "given": "Peter B", "initials": "PB"}, {"family": "Engstrand", "given": "Jennie", "initials": "J", "orcid": "0000-0003-1123-7022", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/972ae8ebf2634566bed8ebca7caa68ec.json"}}, {"family": "Boz\u00f3ky", "given": "B\u00e9la", "initials": "B"}, {"family": "Gerling", "given": "Marco", "initials": "M", "orcid": "0000-0002-1810-0662", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/73d0af14271b446b8ce3779d6beea16c.json"}}], "type": "journal article", "published": "2023-08-18", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "14", "issue": "1", "pages": "5024", "issn-l": "2041-1723"}, "abstract": "A perimetastatic capsule is a strong positive prognostic factor in liver metastases, but its origin remains unclear. Here, we systematically quantify the capsule's extent and cellular composition in 263 patients with colorectal cancer liver metastases to investigate its clinical significance and origin. We show that survival improves proportionally with increasing encapsulation and decreasing tumor-hepatocyte contact. Immunostaining reveals the gradual zonation of the capsule, transitioning from benign-like NGFRhigh stroma at the liver edge to FAPhigh stroma towards the tumor. Encapsulation correlates with decreased tumor viability and preoperative chemotherapy. In mice, chemotherapy and tumor cell ablation induce capsule formation. Our results suggest that encapsulation develops where tumor invasion into the liver plates stalls, representing a reparative process rather than tumor-induced desmoplasia. We propose a model of metastases growth, where the efficient tumor colonization of the liver parenchyma and a reparative liver injury reaction are opposing determinants of metastasis aggressiveness.", "doi": "10.1038/s41467-023-40688-x", "pmid": "37596278", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10439160"}, {"db": "pii", "key": "10.1038/s41467-023-40688-x"}], "notes": [], "created": "2026-09-23T09:03:01.015Z", "modified": "2026-09-23T09:03:01.748Z"}]}