{"entity": "researcher", "timestamp": "2026-09-29T00:39:25.086Z", "family": "Rendeiro", "given": "Andre", "initials": "A", "orcid": "0000-0001-9362-5373", "affiliations": ["CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/96fc1d829dbe4a308f6675cb3e193b04.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/96fc1d829dbe4a308f6675cb3e193b04"}}, "publications": [{"entity": "publication", "iuid": "27f5af1fc3694cc7970916e50e2be144", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/27f5af1fc3694cc7970916e50e2be144.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/27f5af1fc3694cc7970916e50e2be144"}}, "title": "Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes.", "authors": [{"family": "Romanov", "given": "Roman A", "initials": "RA"}, {"family": "Zeisel", "given": "Amit", "initials": "A"}, {"family": "Bakker", "given": "Joanne", "initials": "J"}, {"family": "Girach", "given": "Fatima", "initials": "F"}, {"family": "Hellysaz", "given": "Arash", "initials": "A"}, {"family": "Tomer", "given": "Raju", "initials": "R"}, {"family": "Alp\u00e1r", "given": "Al\u00e1n", "initials": "A"}, {"family": "Mulder", "given": "Jan", "initials": "J"}, {"family": "Clotman", "given": "Fr\u00e9d\u00e9ric", "initials": "F"}, {"family": "Keimpema", "given": "Erik", "initials": "E"}, {"family": "Hsueh", "given": "Brian", "initials": "B"}, {"family": "Crow", "given": "Ailey K", "initials": "AK"}, {"family": "Martens", "given": "Henrik", "initials": "H"}, {"family": "Schwindling", "given": "Christian", "initials": "C"}, {"family": "Calvigioni", "given": "Daniela", "initials": "D"}, {"family": "Bains", "given": "Jaideep S", "initials": "JS"}, {"family": "M\u00e1t\u00e9", "given": "Zolt\u00e1n", "initials": "Z"}, {"family": "Szab\u00f3", "given": "G\u00e1bor", "initials": "G"}, {"family": "Yanagawa", "given": "Yuchio", "initials": "Y"}, {"family": "Zhang", "given": "Ming-Dong", "initials": "MD"}, {"family": "Rendeiro", "given": "Andre", "initials": "A", "orcid": "0000-0001-9362-5373", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/96fc1d829dbe4a308f6675cb3e193b04.json"}}, {"family": "Farlik", "given": "Matthias", "initials": "M"}, {"family": "Uhl\u00e9n", "given": "Mathias", "initials": "M"}, {"family": "Wulff", "given": "Peer", "initials": "P"}, {"family": "Bock", "given": "Christoph", "initials": "C", "orcid": "0000-0001-6091-3088", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/78502e5803db472980b13c6f5d24f9e6.json"}}, {"family": "Broberger", "given": "Christian", "initials": "C"}, {"family": "Deisseroth", "given": "Karl", "initials": "K"}, {"family": "H\u00f6kfelt", "given": "Tomas", "initials": "T"}, {"family": "Linnarsson", "given": "Sten", "initials": "S"}, {"family": "Horvath", "given": "Tamas L", "initials": "TL"}, {"family": "Harkany", "given": "Tibor", "initials": "T"}], "type": "journal article", "published": "2017-02-00", "journal": {"title": "Nat. Neurosci.", "issn": "1546-1726", "volume": "20", "issue": "2", "pages": "176-188", "issn-l": "1097-6256"}, "abstract": "The hypothalamus contains the highest diversity of neurons in the brain. Many of these neurons can co-release neurotransmitters and neuropeptides in a use-dependent manner. Investigators have hitherto relied on candidate protein-based tools to correlate behavioral, endocrine and gender traits with hypothalamic neuron identity. Here we map neuronal identities in the hypothalamus by single-cell RNA sequencing. We distinguished 62 neuronal subtypes producing glutamatergic, dopaminergic or GABAergic markers for synaptic neurotransmission and harboring the ability to engage in task-dependent neurotransmitter switching. We identified dopamine neurons that uniquely coexpress the Onecut3 and Nmur2 genes, and placed these in the periventricular nucleus with many synaptic afferents arising from neuromedin S+ neurons of the suprachiasmatic nucleus. These neuroendocrine dopamine cells may contribute to the dopaminergic inhibition of prolactin secretion diurnally, as their neuromedin S+ inputs originate from neurons expressing Per2 and Per3 and their tyrosine hydroxylase phosphorylation is regulated in a circadian fashion. Overall, our catalog of neuronal subclasses provides new understanding of hypothalamic organization and function.", "doi": "10.1038/nn.4462", "pmid": "27991900", "labels": [], "xrefs": [{"db": "mid", "key": "EMS185297"}, {"db": "pmc", "key": "PMC7615022"}, {"db": "pii", "key": "nn.4462"}], "notes": [], "created": "2018-12-05T09:01:27.378Z", "modified": "2026-09-23T06:32:42.556Z"}]}