{"entity": "researcher", "timestamp": "2026-08-20T20:47:14.670Z", "family": "Jain", "given": "Saumey", "initials": "S", "orcid": "0000-0002-2810-2151", "affiliations": ["Division of Nanobiotechnology, Department of Protein Science, Science for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Solna, 171 65, Sweden.", "Division of Micro and Nanosystems, Department of Intelligent Systems, School of Electrical Engineering and Computer Science, KTH Royal Institute of Technology, Stockholm, 100 44, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/969496e3da804b54bea1cf345294433f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/969496e3da804b54bea1cf345294433f"}}, "publications": [{"entity": "publication", "iuid": "7d836b85756546f1b18f2851412b8d7e", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/7d836b85756546f1b18f2851412b8d7e.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/7d836b85756546f1b18f2851412b8d7e"}}, "title": "Localized Nanopore Fabrication in Silicon Nitride Membranes by Femtosecond Laser Exposure and Subsequent Controlled Breakdown.", "authors": [{"family": "Leva", "given": "Chrysovalantou V", "initials": "CV"}, {"family": "Jain", "given": "Saumey", "initials": "S", "orcid": "0000-0002-2810-2151", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/969496e3da804b54bea1cf345294433f.json"}}, {"family": "Kistermann", "given": "Kevin", "initials": "K"}, {"family": "Sakurai", "given": "Kasumi", "initials": "K"}, {"family": "Stemme", "given": "G\u00f6ran", "initials": "G", "orcid": "0000-0001-9552-4234", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/122f084eea624e5a801c8fafa6d48f6a.json"}}, {"family": "Herland", "given": "Anna", "initials": "A", "orcid": "0000-0002-5002-2537", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/367ed0d139fe4136808b62ee61baa4f0.json"}}, {"family": "Mayer", "given": "Joachim", "initials": "J", "orcid": "0000-0003-3292-5342", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6b355f200cc346b389e9dc7901872fe7.json"}}, {"family": "Niklaus", "given": "Frank", "initials": "F", "orcid": "0000-0002-0525-8647", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cbba7fd047e8468288fc79b7b0275ff3.json"}}, {"family": "Raja", "given": "Shyamprasad N", "initials": "SN", "orcid": "0000-0002-2278-1368", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/58df34262ccf4569b54162cfd38525be.json"}}], "type": "journal article", "published": "2025-02-05", "journal": {"title": "ACS Appl Mater Interfaces", "issn": "1944-8252", "volume": "17", "issue": "5", "pages": "8737-8748", "issn-l": "1944-8244"}, "abstract": "Controlled breakdown has emerged as an effective method for fabricating solid-state nanopores in thin suspended dielectric membranes for various biomolecular sensing applications. On an unpatterned membrane, the site of nanopore formation by controlled breakdown is random. Nanopore formation on a specific site on the membrane has previously been realized using local thinning of the membrane by lithographic processes or laser-assisted photothermal etching under immersion in an aqueous salt solution. However, these approaches require elaborate and expensive cleanroom-based lithography processes or involve intricate procedures using custom-made equipment. Here, we present a rapid cleanroom-free approach using single pulse femtosecond laser exposures of 50 nm thick silicon nitride membranes in air to localize the site of nanopore formation by subsequent controlled breakdown to an area less than 500 nm in diameter on the membrane. The precise positioning of the nanopores on the membrane could be produced both using laser exposure powers which caused significant thinning of the silicon nitride membrane (up to 60% of the original thickness locally), as well as at laser powers which caused no visible modification of the membrane at all. We show that nanopores made using our approach can work as single-molecule sensors by performing dsDNA translocation experiments. Due to the applicability of femtosecond laser processing to a wide range of membrane materials, we expect our approach to simplify the fabrication of localized nanopores by controlled breakdown in a variety of thin film material stacks, thereby enabling more sophisticated nanopore sensors.", "doi": "10.1021/acsami.5c00255", "pmid": "39870574", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11803561"}], "notes": [], "created": "2026-08-20T08:08:29.746Z", "modified": "2026-08-20T08:08:29.834Z"}, {"entity": "publication", "iuid": "db35fa2c43da4f12accee901dc796a29", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/db35fa2c43da4f12accee901dc796a29.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/db35fa2c43da4f12accee901dc796a29"}}, "title": "In Situ Functionalization of Polar Polythiophene-Based Organic Electrochemical Transistor to Interface In Vitro Models.", "authors": [{"family": "Buchmann", "given": "Sebastian", "initials": "S", "orcid": "0000-0001-7442-3020", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5d7fa19b55964898b15740e469f423a8.json"}}, {"family": "Stoop", "given": "Pepijn", "initials": "P"}, {"family": "Roekevisch", "given": "Kim", "initials": "K"}, {"family": "Jain", "given": "Saumey", "initials": "S", "orcid": "0000-0002-2810-2151", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/969496e3da804b54bea1cf345294433f.json"}}, {"family": "Kroon", "given": "Renee", "initials": "R", "orcid": "0000-0001-8053-4288", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8edb30ab10ad4bf3b9122d9ca6f6380d.json"}}, {"family": "M\u00fcller", "given": "Christian", "initials": "C", "orcid": "0000-0001-7859-7909", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c72e3ff85aa545c0a6ddec76712541db.json"}}, {"family": "Hamedi", "given": "Mahiar M", "initials": "MM", "orcid": "0000-0001-9088-1064", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ea65bd8c3fd642cbbd308e0641a0bc01.json"}}, {"family": "Zeglio", "given": "Erica", "initials": "E"}, {"family": "Herland", "given": "Anna", "initials": "A", "orcid": "0000-0002-5002-2537", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/367ed0d139fe4136808b62ee61baa4f0.json"}}], "type": "journal article", "published": "2024-10-09", "journal": {"title": "ACS Appl Mater Interfaces", "issn": "1944-8252", "volume": "16", "issue": "40", "pages": "54292-54303", "issn-l": "1944-8244"}, "abstract": "Organic mixed ionic-electronic conductors are promising materials for interfacing and monitoring biological systems, with the aim of overcoming current challenges based on the mismatch between biological materials and convectional inorganic conductors. The conjugated polymer/polyelectrolyte complex poly(3,4-ethylenedioxythiophene):polystyrenesulfonate (PEDOT/PSS) is, up to date, the most widely used polymer for in vitro or in vivo measurements in the field of organic bioelectronics. However, PEDOT/PSS organic electrochemical transistors (OECTs) are limited by depletion mode operation and lack chemical groups that enable synthetic modifications for biointerfacing. Recently introduced thiophene-based polymers with oligoether side chains can operate in accumulation mode, and their chemical structure can be tuned during synthesis, for example, by the introduction of hydroxylated side chains. Here, we introduce a new thiophene-based conjugated polymer, p(g42T-T)-8% OH, where 8% of the glycol side chains are functionalized with a hydroxyl group. We report for the first time the compatibility of conjugated polymers containing ethylene glycol side chains in direct contact with cells. The additional hydroxyl group allows covalent modification of the surface of polymer films, enabling fine-tuning of the surface interaction properties of p(g42T-T)-8% OH with biological materials, either hindering or promoting cell adhesion. We further use p(g42T-T)-8% OH to fabricate the OECTs and demonstrate for the first time the monitoring of epithelial barrier formation of Caco-2 cells in vitro using accumulation mode OECTs. The conjugated polymer p(g42T-T)-8% OH allows organic-electronic-based materials to be easily modified and optimized to interface and monitor biological systems.", "doi": "10.1021/acsami.4c09197", "pmid": "39327895", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11472309"}], "notes": [], "created": "2026-08-20T08:08:22.084Z", "modified": "2026-08-20T08:08:22.221Z"}, {"entity": "publication", "iuid": "e154fdd25c074698958523cd700c4ae6", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/e154fdd25c074698958523cd700c4ae6.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/e154fdd25c074698958523cd700c4ae6"}}, "title": "Electromigrated Gold Nanogap Tunnel Junction Arrays: Fabrication and Electrical Behavior in Liquid and Gaseous Media.", "authors": [{"family": "Raja", "given": "Shyamprasad N", "initials": "SN", "orcid": "0000-0002-2278-1368", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/58df34262ccf4569b54162cfd38525be.json"}}, {"family": "Jain", "given": "Saumey", "initials": "S", "orcid": "0000-0002-2810-2151", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/969496e3da804b54bea1cf345294433f.json"}}, {"family": "Kipen", "given": "Javier", "initials": "J"}, {"family": "Jald\u00e9n", "given": "Joakim", "initials": "J"}, {"family": "Stemme", "given": "G\u00f6ran", "initials": "G", "orcid": "0000-0001-9552-4234", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/122f084eea624e5a801c8fafa6d48f6a.json"}}, {"family": "Herland", "given": "Anna", "initials": "A", "orcid": "0000-0002-5002-2537", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/367ed0d139fe4136808b62ee61baa4f0.json"}}, {"family": "Niklaus", "given": "Frank", "initials": "F", "orcid": "0000-0002-0525-8647", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cbba7fd047e8468288fc79b7b0275ff3.json"}}], "type": "journal article", "published": "2024-07-17", "journal": {"title": "ACS Appl Mater Interfaces", "issn": "1944-8252", "volume": "16", "issue": "28", "pages": "37131-37146", "issn-l": "1944-8244"}, "abstract": "Tunnel junctions have been suggested as high-throughput electronic single molecule sensors in liquids with several seminal experiments conducted using break junctions with reconfigurable gaps. For practical single molecule sensing applications, arrays of on-chip integrated fixed-gap tunnel junctions that can be built into compact systems are preferable. Fabricating nanogaps by electromigration is one of the most promising approaches to realize on-chip integrated tunnel junction sensors. However, the electrical behavior of fixed-gap tunnel junctions immersed in liquid media has not been systematically studied to date, and the formation of electromigrated nanogap tunnel junctions in liquid media has not yet been demonstrated. In this work, we perform a comparative study of the formation and electrical behavior of arrays of gold nanogap tunnel junctions made by feedback-controlled electromigration immersed in various liquid and gaseous media (deionized water, mesitylene, ethanol, nitrogen, and air). We demonstrate that tunnel junctions can be obtained from microfabricated gold nanoconstrictions inside liquid media. Electromigration of junctions in air produces the highest yield (61-67%), electromigration in deionized water and mesitylene results in a lower yield than in air (44-48%), whereas electromigration in ethanol fails to produce viable tunnel junctions due to interfering electrochemical processes. We map out the stability of the conductance characteristics of the resulting tunnel junctions and identify medium-specific operational conditions that have an impact on the yield of forming stable junctions. Furthermore, we highlight the unique challenges associated with working with arrays of large numbers of tunnel junctions in batches. Our findings will inform future efforts to build single molecule sensors using on-chip integrated tunnel junctions.", "doi": "10.1021/acsami.4c03282", "pmid": "38954436", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11261569"}], "notes": [], "created": "2026-08-20T08:08:20.105Z", "modified": "2026-08-20T08:08:20.211Z"}, {"entity": "publication", "iuid": "6fa75e177c024da89b7fef0fa4426c5b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/6fa75e177c024da89b7fef0fa4426c5b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/6fa75e177c024da89b7fef0fa4426c5b"}}, "title": "On-Chip Neural Induction Boosts Neural Stem Cell Commitment: Toward a Pipeline for iPSC-Based Therapies.", "authors": [{"family": "Jain", "given": "Saumey", "initials": "S", "orcid": "0000-0002-2810-2151", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/969496e3da804b54bea1cf345294433f.json"}}, {"family": "Voulgaris", "given": "Dimitrios", "initials": "D", "orcid": "0000-0003-4574-1702", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c43e99f191f944d9a8ecf9363b80b87c.json"}}, {"family": "Thongkorn", "given": "Surangrat", "initials": "S", "orcid": "0000-0003-4149-9381", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a1cef026dbc14c9bb57ceebedbe517ee.json"}}, {"family": "Hesen", "given": "Rick", "initials": "R", "orcid": "0000-0003-2503-8139", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0a9fc8dbf8af48d1bc615f8cc313ad73.json"}}, {"family": "H\u00e4gg", "given": "Alice", "initials": "A", "orcid": "0000-0002-6022-8977", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cd455c34f49d4bd68fb3ee542e57233b.json"}}, {"family": "Moslem", "given": "Mohsen", "initials": "M", "orcid": "0000-0002-2440-9586", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ac548b831c044a53ac324691083df9e1.json"}}, {"family": "Falk", "given": "Anna", "initials": "A", "orcid": "0000-0003-1634-8610", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4a8825c33511418a83eceffdb530dadb.json"}}, {"family": "Herland", "given": "Anna", "initials": "A", "orcid": "0000-0002-5002-2537", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/367ed0d139fe4136808b62ee61baa4f0.json"}}], "type": "journal article", "published": "2024-07-00", "journal": {"title": "Adv Sci (Weinh)", "issn": "2198-3844", "volume": "11", "issue": "25", "pages": "e2401859", "issn-l": null}, "abstract": "The clinical translation of induced pluripotent stem cells (iPSCs) holds great potential for personalized therapeutics. However, one of the main obstacles is that the current workflow to generate iPSCs is expensive, time-consuming, and requires standardization. A simplified and cost-effective microfluidic approach is presented for reprogramming fibroblasts into iPSCs and their subsequent differentiation into neural stem cells (NSCs). This method exploits microphysiological technology, providing a 100-fold reduction in reagents for reprogramming and a ninefold reduction in number of input cells. The iPSCs generated from microfluidic reprogramming of fibroblasts show upregulation of pluripotency markers and downregulation of fibroblast markers, on par with those reprogrammed in standard well-conditions. The NSCs differentiated in microfluidic chips show upregulation of neuroectodermal markers (ZIC1, PAX6, SOX1), highlighting their propensity for nervous system development. Cells obtained on conventional well plates and microfluidic chips are compared for reprogramming and neural induction by bulk RNA sequencing. Pathway enrichment analysis of NSCs from chip showed neural stem cell development enrichment and boosted commitment to neural stem cell lineage in initial phases of neural induction, attributed to a confined environment in a microfluidic chip. This method provides a cost-effective pipeline to reprogram and differentiate iPSCs for therapeutics compliant with current good manufacturing practices.", "doi": "10.1002/advs.202401859", "pmid": "38655836", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11220685"}], "notes": [], "created": "2026-08-20T06:28:18.034Z", "modified": "2026-08-20T06:28:18.345Z"}, {"entity": "publication", "iuid": "d0787480eb844c68a8304e4a05170e87", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/d0787480eb844c68a8304e4a05170e87.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/d0787480eb844c68a8304e4a05170e87"}}, "title": "Mixing Insulating Commodity Polymers with Semiconducting n-type Polymers Enables High-Performance Electrochemical Transistors.", "authors": [{"family": "Zeglio", "given": "Erica", "initials": "E", "orcid": "0000-0002-6428-0633", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e9f9fe3dcb5e4c9891c6f463c32a1679.json"}}, {"family": "Wang", "given": "Yazhou", "initials": "Y"}, {"family": "Jain", "given": "Saumey", "initials": "S", "orcid": "0000-0002-2810-2151", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/969496e3da804b54bea1cf345294433f.json"}}, {"family": "Lin", "given": "Yunfan", "initials": "Y"}, {"family": "Avila Ramirez", "given": "Alan Eduardo", "initials": "AE", "orcid": "0000-0001-9549-1516", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/900a9e8a82fd4708b025f91c613428fe.json"}}, {"family": "Feng", "given": "Kui", "initials": "K"}, {"family": "Guo", "given": "Xugang", "initials": "X"}, {"family": "Ose", "given": "Helena", "initials": "H", "orcid": "0009-0008-5546-4095", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8eb950bfbdc4441b83d6cbd43bc2a8f4.json"}}, {"family": "Mozolevskis", "given": "Gatis", "initials": "G", "orcid": "0000-0001-7418-9123", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/59ff8fe8b6d74ecaab2998c57ad69032.json"}}, {"family": "Mawad", "given": "Damia", "initials": "D"}, {"family": "Yue", "given": "Wan", "initials": "W"}, {"family": "Hamedi", "given": "Mahiar Max", "initials": "MM"}, {"family": "Herland", "given": "Anna", "initials": "A", "orcid": "0000-0002-5002-2537", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/367ed0d139fe4136808b62ee61baa4f0.json"}}], "type": "journal article", "published": "2024-06-00", "journal": {"title": "Adv. Mater. Weinheim", "issn": "1521-4095", "volume": "36", "issue": "23", "pages": "e2302624", "issn-l": "0935-9648"}, "abstract": "Diluting organic semiconductors with a host insulating polymer is used to increase the electronic mobility in organic electronic devices, such as thin film transistors, while considerably reducing material costs. In contrast to organic electronics, bioelectronic devices such as the organic electrochemical transistor (OECT) rely on both electronic and ionic mobility for efficient operation, making it challenging to integrate hydrophobic polymers as the predominant blend component. This work shows that diluting the n-type conjugated polymer p(N-T) with high molecular weight polystyrene (10 KDa) leads to OECTs with over three times better mobility-volumetric capacitance product (\u00b5C*) with respect to the pristine p(N-T) (from 4.3 to 13.4 F V-1 cm-1 s-1) while drastically decreasing the amount of conjugated polymer (six times less). This improvement in \u00b5C* is due to a dramatic increase in electronic mobility by two orders of magnitude, from 0.059 to 1.3 cm2 V-1 s-1 for p(N-T):Polystyrene 10 KDa 1:6. Moreover, devices made with this polymer blend show better stability, retaining 77% of the initial drain current after 60 minutes operation in contrast to 12% for pristine p(N-T). These results open a new generation of low-cost organic mixed ionic-electronic conductors where the bulk of the film is made by a commodity polymer.", "doi": "10.1002/adma.202302624", "pmid": "38431796", "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T06:27:58.514Z", "modified": "2026-08-20T06:27:58.783Z"}]}