{"entity": "researcher", "timestamp": "2026-09-30T01:26:23.165Z", "family": "Zareba-Paslawska", "given": "Justyna", "initials": "J", "orcid": "0000-0001-6193-5908", "affiliations": ["Translational Neuropharmacology, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/966c469818f74df19b93d4a0d775182a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/966c469818f74df19b93d4a0d775182a"}}, "publications": [{"entity": "publication", "iuid": "45bf1d6bcca54873ab10a14c9742c11c", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/45bf1d6bcca54873ab10a14c9742c11c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/45bf1d6bcca54873ab10a14c9742c11c"}}, "title": "Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents.", "authors": [{"family": "He", "given": "Yachao", "initials": "Y", "orcid": "0000-0002-0241-2901", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dda541fb10974d769b81a896c34c8947.json"}}, {"family": "Kaya", "given": "Ibrahim", "initials": "I", "orcid": "0000-0003-3345-5602", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/43885795cb254e2cba6fe8b538fbfaef.json"}}, {"family": "Shariatgorji", "given": "Reza", "initials": "R", "orcid": "0000-0001-9484-0921", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/76faa76e9dc445a3bbb1f470e9d33a23.json"}}, {"family": "Lundkvist", "given": "Johan", "initials": "J"}, {"family": "Wahlberg", "given": "Lars U", "initials": "LU"}, {"family": "Nilsson", "given": "Anna", "initials": "A"}, {"family": "Mamula", "given": "Dejan", "initials": "D"}, {"family": "Kehr", "given": "Jan", "initials": "J"}, {"family": "Zareba-Paslawska", "given": "Justyna", "initials": "J", "orcid": "0000-0001-6193-5908", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/966c469818f74df19b93d4a0d775182a.json"}}, {"family": "Biverst\u00e5l", "given": "Henrik", "initials": "H", "orcid": "0000-0002-2097-7658", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/603a87443b7b4315b6331a51e8103fb5.json"}}, {"family": "Chergui", "given": "Karima", "initials": "K"}, {"family": "Zhang", "given": "Xiaoqun", "initials": "X"}, {"family": "Andren", "given": "Per E", "initials": "PE", "orcid": "0000-0002-4062-7743", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f1dd27e8b238475383983480e10099f6.json"}}, {"family": "Svenningsson", "given": "Per", "initials": "P", "orcid": "0000-0001-6727-3802", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b01bbacfa24e4b9794734bf1121d1c38.json"}}], "type": "journal article", "published": "2023-09-19", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "14", "issue": "1", "pages": "5804", "issn-l": "2041-1723"}, "abstract": "Prosaposin (PSAP) modulates glycosphingolipid metabolism and variants have been linked to Parkinson's disease (PD). Here, we find altered PSAP levels in the plasma, CSF and post-mortem brain of PD patients. Altered plasma and CSF PSAP levels correlate with PD-related motor impairments. Dopaminergic PSAP-deficient (cPSAPDAT) mice display hypolocomotion and depression/anxiety-like symptoms with mildly impaired dopaminergic neurotransmission, while serotonergic PSAP-deficient (cPSAPSERT) mice behave normally. Spatial lipidomics revealed an accumulation of highly unsaturated and shortened lipids and reduction of sphingolipids throughout the brains of cPSAPDAT mice. The overexpression of \u03b1-synuclein via AAV lead to more severe dopaminergic degeneration and higher p-Ser129 \u03b1-synuclein levels in cPSAPDAT mice compared to WT mice. Overexpression of PSAP via AAV and encapsulated cell biodelivery protected against 6-OHDA and \u03b1-synuclein toxicity in wild-type rodents. Thus, these findings suggest PSAP may maintain dopaminergic lipid homeostasis, which is dysregulated in PD, and counteract experimental parkinsonism.", "doi": "10.1038/s41467-023-41539-5", "pmid": "37726325", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10509278"}, {"db": "pii", "key": "10.1038/s41467-023-41539-5"}], "notes": [], "created": "2026-09-23T08:39:33.144Z", "modified": "2026-09-23T08:39:33.375Z"}]}