{"entity": "researcher", "timestamp": "2026-08-20T21:18:38.054Z", "family": "Ciceri", "given": "Fabio", "initials": "F", "orcid": "0000-0003-0873-0123", "affiliations": ["IRCCS San Raffaele Scientific Institute, Hematology and Hematopoietic Stem Cell Transplantation Unit, via Olgettina 60, Milan 20132, Italy.", "IRCCS San Raffaele Scientific Institute, Division of Immunology, Transplantation and Infectious Disease, Innovative Immunotherapies Unit, via Olgettina 60, Milan 20132, Italy."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/9631c85f2abe41ecb26c2b96f662c19c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/9631c85f2abe41ecb26c2b96f662c19c"}}, "publications": [{"entity": "publication", "iuid": "8dbdd622a6684fc09a07dc19fa3bf37f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/8dbdd622a6684fc09a07dc19fa3bf37f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/8dbdd622a6684fc09a07dc19fa3bf37f"}}, "title": "Harnessing T cell exhaustion and trogocytosis to isolate patient-derived tumor-specific TCR.", "authors": [{"family": "Manfredi", "given": "Francesco", "initials": "F", "orcid": "0000-0003-2409-944X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8f8173a6adb74503a2c2636bc7cd6187.json"}}, {"family": "Stasi", "given": "Lorena", "initials": "L", "orcid": "0000-0001-8044-2295", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/103e396d7f714d0eadf42ae463e23006.json"}}, {"family": "Buonanno", "given": "Silvia", "initials": "S"}, {"family": "Marzuttini", "given": "Francesca", "initials": "F"}, {"family": "Noviello", "given": "Maddalena", "initials": "M"}, {"family": "Mastaglio", "given": "Sara", "initials": "S"}, {"family": "Abbati", "given": "Danilo", "initials": "D", "orcid": "0000-0001-8517-7937", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1cf52edec41c48e7a085130d6a0f538a.json"}}, {"family": "Potenza", "given": "Alessia", "initials": "A", "orcid": "0000-0003-0298-7315", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5c2f5b34a8444def99ed10d6922b29b2.json"}}, {"family": "Balestrieri", "given": "Chiara", "initials": "C", "orcid": "0000-0001-7362-3530", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c720c467b1714e78bd49b928d1df4717.json"}}, {"family": "Cianciotti", "given": "Beatrice Claudia", "initials": "BC", "orcid": "0000-0002-1337-5915", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b80a1fa9b2d14bfe8ba9e3103fe581d6.json"}}, {"family": "Tassi", "given": "Elena", "initials": "E", "orcid": "0000-0002-2921-8666", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/650c1981b70b4dbf866d21221e0d18b7.json"}}, {"family": "Feola", "given": "Sara", "initials": "S", "orcid": "0000-0002-4012-4310", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/81e8d2f15fcf4e1aabf7b5a41a977f3f.json"}}, {"family": "Toffalori", "given": "Cristina", "initials": "C", "orcid": "0000-0002-8313-3057", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/41008f14a9b94192a9cacd2ab0710976.json"}}, {"family": "Punta", "given": "Marco", "initials": "M", "orcid": "0000-0002-0050-0676", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/083075f454224bf1a13724e85cf2bf7c.json"}}, {"family": "Magnani", "given": "Zulma", "initials": "Z", "orcid": "0000-0001-7612-6097", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8b56dd0945ff4ebf941b8c1ed107378c.json"}}, {"family": "Camisa", "given": "Barbara", "initials": "B", "orcid": "0000-0002-3867-2457", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9f967aca004f41e59f1e8e182851d732.json"}}, {"family": "Tiziano", "given": "Elena", "initials": "E", "orcid": "0000-0002-1794-4265", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3818be60d8a34864943b9697aa4e11bd.json"}}, {"family": "Lupo-Stanghellini", "given": "Maria Teresa", "initials": "MT"}, {"family": "Branca", "given": "Rui Mamede", "initials": "RM", "orcid": "0000-0003-3890-6476", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7f557cf4f7ed402c8843173ab0bbef04.json"}}, {"family": "Lehti\u00f6", "given": "Janne", "initials": "J", "orcid": "0000-0002-8100-9562", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/561efcf32e2648c8a10fee692fc4e908.json"}}, {"family": "Sikanen", "given": "Tiina M", "initials": "TM", "orcid": "0000-0002-0788-1301", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ee477a2ee578421c889c078b35324ce5.json"}}, {"family": "Haapala", "given": "Markus J", "initials": "MJ", "orcid": "0000-0001-7828-8663", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d2241723f3734c5390b4fa4014563668.json"}}, {"family": "Cerullo", "given": "Vincenzo", "initials": "V", "orcid": "0000-0003-4901-3796", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d46c756e18bb49268b98a75a5234664a.json"}}, {"family": "Casucci", "given": "Monica", "initials": "M", "orcid": "0000-0003-4500-9060", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a0f5a535676445f5b871cfffd7d98560.json"}}, {"family": "Vago", "given": "Luca", "initials": "L", "orcid": "0000-0003-4247-3175", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4e307dc8f3774bbfa97926dd1d1464d1.json"}}, {"family": "Ciceri", "given": "Fabio", "initials": "F", "orcid": "0000-0003-0873-0123", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9631c85f2abe41ecb26c2b96f662c19c.json"}}, {"family": "Bonini", "given": "Chiara", "initials": "C", "orcid": "0000-0002-0772-1674", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/72025c797fe74a749bb9b5945a1c4cc1.json"}}, {"family": "Ruggiero", "given": "Eliana", "initials": "E", "orcid": "0000-0002-2954-8278", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/58dd81c18e944546b46ad24074911897.json"}}], "type": "journal article", "published": "2023-12-00", "journal": {"title": "Sci Adv", "issn": "2375-2548", "volume": "9", "issue": "48", "pages": "eadg8014", "issn-l": "2375-2548"}, "abstract": "To study and then harness the tumor-specific T cell dynamics after allogeneic hematopoietic stem cell transplant, we typed the frequency, phenotype, and function of lymphocytes directed against tumor-associated antigens (TAAs) in 39 consecutive transplanted patients, for 1 year after transplant. We showed that TAA-specific T cells circulated in 90% of patients but display a limited effector function associated to an exhaustion phenotype, particularly in the subgroup of patients deemed to relapse, where exhausted stem cell memory T cells accumulated. Accordingly, cancer-specific cytolytic functions were relevant only when the TAA-specific T cell receptors (TCRs) were transferred into healthy, genome-edited T cells. We then exploited trogocytosis and ligandome-on-chip technology to unveil the specificities of tumor-specific TCRs retrieved from the exhausted T cell pool. Overall, we showed that harnessing circulating TAA-specific and exhausted T cells allow to isolate TCRs against TAAs and previously not described acute myeloid leukemia antigens, potentially relevant for T cell-based cancer immunotherapy.", "doi": "10.1126/sciadv.adg8014", "pmid": "38039364", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10691777"}], "notes": [], "created": "2026-08-20T11:58:45.183Z", "modified": "2026-08-20T11:58:46.172Z"}]}