{"entity": "researcher", "timestamp": "2026-08-28T00:12:25.221Z", "family": "Groop", "given": "Per-Henrik", "initials": "PH", "orcid": "0000-0003-4055-6954", "affiliations": ["Folkh\u00e4lsan Institute of Genetics, Folkh\u00e4lsan Research Center, Biomedicum, Haartmaninkatu 8, 00290 Helsinki, Finland.", "Department of Nephrology, University of Helsinki and Helsinki University Hospital, Haartmaninkatu 4, 00290 Helsinki, Finland.", "Clinical and Molecular Metabolism, Faculty of Medicine Research Programs, University of Helsinki, Biomedicum, Haartmaninkatu 8, 00290 Helsinki, Finland.", "Department of Diabetes, Central Clinical School, Monash University, Alfred Centre, 99 Commercial Road, Melbourne 3004, VIC, Australia."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/962aab864e3f4ca398958c7477395fce.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/962aab864e3f4ca398958c7477395fce"}}, "publications": [{"entity": "publication", "iuid": "2adc312cf96b448ea9fc7bdc3973981c", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/2adc312cf96b448ea9fc7bdc3973981c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/2adc312cf96b448ea9fc7bdc3973981c"}}, "title": "Long-chain polyphosphates inhibit type I interferon signaling and augment LPS-induced cytokine secretion in human leukocytes.", "authors": [{"family": "Pirttiniemi", "given": "Anniina", "initials": "A", "orcid": "0000-0002-1567-6834", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4a38c94a8af146018215ff04df305755.json"}}, {"family": "Adeshara", "given": "Krishna", "initials": "K"}, {"family": "Happonen", "given": "Natalie", "initials": "N"}, {"family": "Einarsdottir", "given": "Elisabet", "initials": "E"}, {"family": "Katayama", "given": "Shintaro", "initials": "S"}, {"family": "Salmenkari", "given": "Hanne", "initials": "H"}, {"family": "H\u00f6rkk\u00f6", "given": "Sohvi", "initials": "S"}, {"family": "Kere", "given": "Juha", "initials": "J"}, {"family": "Groop", "given": "Per-Henrik", "initials": "PH", "orcid": "0000-0003-4055-6954", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/962aab864e3f4ca398958c7477395fce.json"}}, {"family": "Lehto", "given": "Markku", "initials": "M"}], "type": "journal article", "published": "2023-09-01", "journal": {"title": "J Leukoc Biol", "issn": "1938-3673", "volume": "114", "issue": "3", "pages": "250-265", "issn-l": "0741-5400"}, "abstract": "Inorganic polyphosphates are evolutionarily conserved bioactive phosphate polymers found as various chain lengths in all living organisms. In mammals, polyphosphates play a vital role in the regulation of cellular metabolism, coagulation, and inflammation. Long-chain polyphosphates are found along with endotoxins in pathogenic gram-negative bacteria and can participate in bacterial virulence. We aimed to investigate whether exogenously administered polyphosphates modulate human leukocyte function in vitro by treating the cells with 3 different chain lengths of polyphosphates (P14, P100, and P700). The long-chain polyphosphates, P700, had a remarkable capacity to downregulate type I interferon signaling dose dependently in THP1-Dual cells while only a slight elevation could be observed in the NF-\u03baB pathway with the highest dose of P700. P700 treatment decreased lipopolysaccharide-induced IFN\u03b2 transcription and secretion, reduced STAT1 phosphorylation, and downregulated subsequent interferon-stimulated gene expression in primary human peripheral blood mononuclear cells. P700 also augmented lipopolysaccharide-induced secretion of IL-1\u03b1, IL-1\u03b2, IL-4, IL-5, IL-10, and IFN\u03b3. Furthermore, P700 has previously been reported to increase the phosphorylation of several intracellular signaling mediators, such as AKT, mTOR, ERK, p38, GSK3\u03b1/\u03b2, HSP27, and JNK pathway components, which was supported by our findings. Taken together, these observations demonstrate the extensive modulatory effects P700 has on cytokine signaling and the inhibitory effects specifically targeted to type I interferon signaling in human leukocytes.", "doi": "10.1093/jleuko/qiad058", "pmid": "37224571", "labels": [], "xrefs": [{"db": "pii", "key": "7177896"}], "notes": [], "created": "2026-08-21T12:10:05.745Z", "modified": "2026-08-21T12:10:05.838Z"}]}