{"entity": "researcher", "timestamp": "2026-09-25T23:03:44.213Z", "family": "Schmierer", "given": "Bernhard", "initials": "B", "orcid": "0000-0002-9082-7022", "affiliations": ["CRISPR Functional Genomics, SciLifeLab and Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17165, Solna, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/95decb70bc9d4dc2820259b5971e342f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/95decb70bc9d4dc2820259b5971e342f"}}, "publications": [{"entity": "publication", "iuid": "f5aa84a9852742eeb7c097da2a0a9e4f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f5aa84a9852742eeb7c097da2a0a9e4f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f5aa84a9852742eeb7c097da2a0a9e4f"}}, "title": "An injury-associated lobular microniche is associated with the classical tumor cell phenotype in pancreatic cancer.", "authors": [{"family": "S\u00f6derqvist", "given": "Sara", "initials": "S"}, {"family": "Viljamaa", "given": "Annika", "initials": "A", "orcid": "0009-0002-8511-8181", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ad54bd86380f48b99fc405a6466f5e5e.json"}}, {"family": "Geyer", "given": "Natalie", "initials": "N"}, {"family": "Keller", "given": "Anna-Lena", "initials": "AL"}, {"family": "Ruksha", "given": "Kseniya", "initials": "K"}, {"family": "Strell", "given": "Carina", "initials": "C", "orcid": "0000-0002-3783-7256", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f288539ea7eb406480c84ec1a5605a91.json"}}, {"family": "Hekmati", "given": "Neda", "initials": "N"}, {"family": "Niculae", "given": "Alexandra", "initials": "A"}, {"family": "Engstrand", "given": "Jennie", "initials": "J", "orcid": "0000-0003-1123-7022", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/972ae8ebf2634566bed8ebca7caa68ec.json"}}, {"family": "Sparrelid", "given": "Ernesto", "initials": "E"}, {"family": "Salm\u00e9n", "given": "Caroline", "initials": "C"}, {"family": "Costa", "given": "T\u00e2nia D F", "initials": "TDF", "orcid": "0000-0002-6296-5225", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/93606f4fc34a4e088f63303d4bb9b7dc.json"}}, {"family": "Zhao", "given": "Miao", "initials": "M", "orcid": "0000-0002-4895-1177", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/75b5d6dc5cde46b8aca859fb961bf1de.json"}}, {"family": "Str\u00f6mblad", "given": "Staffan", "initials": "S", "orcid": "0000-0002-1236-6339", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/eaaec7c2564a4cb5827a794027518796.json"}}, {"family": "Zacharouli", "given": "Argyro", "initials": "A"}, {"family": "Ghorbani", "given": "Poya", "initials": "P"}, {"family": "Harrizi", "given": "Sara", "initials": "S"}, {"family": "Hamidi", "given": "Yousra", "initials": "Y"}, {"family": "Khorosjutina", "given": "Olga", "initials": "O", "orcid": "0009-0001-0786-0260", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d758b02263464940ab8c7922b68b580a.json"}}, {"family": "Milanova", "given": "Stefina", "initials": "S"}, {"family": "Schmierer", "given": "Bernhard", "initials": "B", "orcid": "0000-0002-9082-7022", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/95decb70bc9d4dc2820259b5971e342f.json"}}, {"family": "Boz\u00f3ky", "given": "B\u00e9la", "initials": "B"}, {"family": "Fern\u00e1ndez Moro", "given": "Carlos", "initials": "C", "orcid": "0000-0001-6863-5959", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6b9e861a77874d87a34a4894bd38daf5.json"}}, {"family": "Gerling", "given": "Marco", "initials": "M", "orcid": "0000-0002-1810-0662", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/73d0af14271b446b8ce3779d6beea16c.json"}}], "type": "journal article", "published": "2025-09-26", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "16", "issue": "1", "pages": "8307", "issn-l": "2041-1723"}, "abstract": "Pancreatic cancer is an aggressive disease with a dense fibrotic stroma and is often accompanied by chronic inflammation. Peritumoral inflammation is typically viewed as a reaction to nearby tumor growth. Here, we report that the inflamed pancreatic lobules are frequently invaded by tumor cells, forming a distinct, non-fibrotic tumor niche. Using a semi-supervised machine learning approach for annotations of clinical samples and multiplex protein profiling, we show that tumor cells at the invasion front are closely associated with acinar cells undergoing damage-induced changes, and with activated fibroblasts expressing markers of injury. The invaded lobules are linked to classical tumor phenotypes, in contrast to fibrotic areas where tumor cells display a more basal profile, highlighting microenvironment-dependent tumor subtype differences. In female mice, lobular invasion similarly aligns with the classical tumor phenotype. Together, our data reveal that pancreatic tumors colonize injured lobules, creating a unique niche that shapes tumor characteristics and contributes to disease biology.", "doi": "10.1038/s41467-025-63864-7", "pmid": "41006303", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12475445"}, {"db": "pii", "key": "10.1038/s41467-025-63864-7"}], "notes": [], "created": "2026-09-23T11:34:17.684Z", "modified": "2026-09-23T11:34:17.901Z"}, {"entity": "publication", "iuid": "91f9678080f2426a8d65f88d7779e811", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/91f9678080f2426a8d65f88d7779e811.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/91f9678080f2426a8d65f88d7779e811"}}, "title": "Identification of a SNAI1 enhancer RNA that drives cancer cell plasticity.", "authors": [{"family": "Fan", "given": "Chuannan", "initials": "C", "orcid": "0000-0001-8754-4913", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3883a7dff51e4a8e9cb677ccd8c4857e.json"}}, {"family": "Wang", "given": "Qian", "initials": "Q", "orcid": "0000-0002-5196-4972", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6df148a1ae5249e79d51bf00aa9e0dc0.json"}}, {"family": "Krijger", "given": "Peter H L", "initials": "PHL", "orcid": "0000-0003-1702-348X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0ff516ab32ea4d4b9f5a772ca5a34313.json"}}, {"family": "Cats", "given": "Davy", "initials": "D", "orcid": "0000-0001-9684-220X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/24e0936de4a94d2897a553394a72b46c.json"}}, {"family": "Selle", "given": "Miriam", "initials": "M"}, {"family": "Khorosjutina", "given": "Olga", "initials": "O", "orcid": "0009-0001-0786-0260", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d758b02263464940ab8c7922b68b580a.json"}}, {"family": "Dhanjal", "given": "Soniya", "initials": "S"}, {"family": "Schmierer", "given": "Bernhard", "initials": "B", "orcid": "0000-0002-9082-7022", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/95decb70bc9d4dc2820259b5971e342f.json"}}, {"family": "Mei", "given": "Hailiang", "initials": "H"}, {"family": "de Laat", "given": "Wouter", "initials": "W", "orcid": "0000-0002-5603-0095", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6e6fadae5d7d4169bdf8742e9eb18270.json"}}, {"family": "Ten Dijke", "given": "Peter", "initials": "P", "orcid": "0000-0002-7234-342X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2193ff2b5f924395ac6d4a9ddd53f20e.json"}}], "type": "journal article", "published": "2025-03-25", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "16", "issue": "1", "pages": "2890", "issn-l": "2041-1723"}, "abstract": "Enhancer RNAs (eRNAs) are a pivotal class of enhancer-derived non-coding RNAs that drive gene expression. Here we identify the SNAI1 enhancer RNA (SNAI1e; SCREEM2) as a key activator of SNAI1 expression and a potent enforcer of transforming growth factor-\u03b2 (TGF-\u03b2)/SMAD signaling in cancer cells. SNAI1e depletion impairs TGF-\u03b2-induced epithelial-mesenchymal transition (EMT), migration, in vivo extravasation, stemness, and chemotherapy resistance in breast cancer cells. SNAI1e functions as an eRNA to cis-regulate SNAI1 enhancer activity by binding to and strengthening the enrichment of the transcriptional co-activator bromodomain containing protein 4 (BRD4) at the local enhancer. SNAI1e selectively promotes the expression of SNAI1, which encodes the EMT transcription factor SNAI1. Furthermore, we reveal that SNAI1 interacts with and anchors the inhibitory SMAD7 in the nucleus, and thereby prevents TGF-\u03b2 type I receptor (T\u03b2RI) polyubiquitination and proteasomal degradation. Our findings establish SNAI1e as a critical driver of SNAI1 expression and TGF-\u03b2-induced cell plasticity.", "doi": "10.1038/s41467-025-58032-w", "pmid": "40133308", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11937597"}, {"db": "pii", "key": "10.1038/s41467-025-58032-w"}], "notes": [], "created": "2026-09-23T11:30:25.667Z", "modified": "2026-09-23T11:30:25.939Z"}, {"entity": "publication", "iuid": "d80208623ecd4ef49e02c37304e34242", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/d80208623ecd4ef49e02c37304e34242.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/d80208623ecd4ef49e02c37304e34242"}}, "title": "CRISPR-Cas9 Knockout Screens Identify DNA Damage Response Pathways and BTK as Essential for Cisplatin Response in Diffuse Large B-Cell Lymphoma.", "authors": [{"family": "Issa", "given": "Issa Ismail", "initials": "II"}, {"family": "Due", "given": "Hanne", "initials": "H"}, {"family": "Br\u00f8ndum", "given": "Rasmus Froberg", "initials": "RF", "orcid": "0000-0001-5537-6767", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2d75d656b0794ec4a84c3f26326b082b.json"}}, {"family": "Veeravakaran", "given": "Vidthdyan", "initials": "V", "orcid": "0009-0008-4046-3612", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f45ea3a5dcc9415383475195a2a8b5e9.json"}}, {"family": "Haraldsd\u00f3ttir", "given": "Hulda", "initials": "H"}, {"family": "Sylvester", "given": "Cathrine", "initials": "C", "orcid": "0009-0002-5277-9434", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ba73d771c226450eb18d2ab7c5c40a03.json"}}, {"family": "Brogaard", "given": "Asta", "initials": "A"}, {"family": "Dhanjal", "given": "Soniya", "initials": "S"}, {"family": "Schmierer", "given": "Bernhard", "initials": "B", "orcid": "0000-0002-9082-7022", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/95decb70bc9d4dc2820259b5971e342f.json"}}, {"family": "Dybk\u00e6r", "given": "Karen", "initials": "K", "orcid": "0000-0003-2488-435X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/428be4d228f04981a383b30b3f82da4d.json"}}], "type": "journal article", "published": "2024-07-02", "journal": {"title": "Cancers (Basel)", "issn": "2072-6694", "volume": "16", "issue": "13", "issn-l": "2072-6694"}, "abstract": "The recurrence of diffuse large B-cell lymphoma (DLBCL) has been observed in 40% of cases. The standard of care for refractory/relapsed DLBCL (RR-DLBCL) is platinum-based treatment prior to autologous stem cell transplantation; however, the prognosis for RR-DLBCL patients remains poor. Thus, to identify genes affecting the cisplatin response in DLBCL, cisplatin-based whole-genome CRISPR-Cas9 knockout screens were performed in this study. We discovered DNA damage response (DDR) pathways as enriched among identified sensitizing CRISPR-mediated gene knockouts. In line, the knockout of the nucleotide excision repair genes XPA and ERCC6 sensitized DLBCL cells to platinum drugs irrespective of proliferation rate, thus documenting DDR as essential for cisplatin sensitivity in DLBCL. Functional analysis revealed that the loss of XPA and ERCC6 increased DNA damage levels and altered cell cycle distribution. Interestingly, we also identified BTK, which is involved in B-cell receptor signaling, to affect cisplatin response. The knockout of BTK increased cisplatin sensitivity in DLBCL cells, and combinatory drug screens revealed a synergistic effect of the BTK inhibitor, ibrutinib, with platinum drugs at low concentrations. Applying local and external DLBCL cohorts, we addressed the clinical relevance of the genes identified in the CRISPR screens. BTK was among the most frequently mutated genes with a frequency of 3-5%, and XPA and ERCC6 were also mutated, albeit at lower frequencies. Furthermore, 27-54% of diagnostic DLBCL samples had mutations in pathways that can sensitize cells to cisplatin. In conclusion, this study shows that XPA and ERCC6, in addition to BTK, are essential for the response to platinum-based drugs in DLBCL.", "doi": "10.3390/cancers16132437", "pmid": "39001501", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11240649"}, {"db": "pii", "key": "cancers16132437"}], "notes": [], "created": "2026-09-23T12:24:52.447Z", "modified": "2026-09-23T12:24:52.647Z"}, {"entity": "publication", "iuid": "d26a4278f9b14c14ba5410b71cfecc50", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/d26a4278f9b14c14ba5410b71cfecc50.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/d26a4278f9b14c14ba5410b71cfecc50"}}, "title": "A distinctive tumor compartment in pancreatic lobules defined by nascent stroma and classical tumor cell phenotype", "authors": [{"family": "S\u00f6derqvist", "given": "Sara", "initials": "S", "orcid": "0009-0003-2133-6400", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/00a39720179d4e38aa6e224299d4117c.json"}}, {"family": "Viljamaa", "given": "Annika", "initials": "A", "orcid": "0009-0002-8511-8181", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ad54bd86380f48b99fc405a6466f5e5e.json"}}, {"family": "Geyer", "given": "Natalie", "initials": "N", "orcid": "0000-0003-1026-968X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c229df5d458445d995fadff597d6a0d4.json"}}, {"family": "Strell", "given": "Carina", "initials": "C", "orcid": "0000-0002-3783-7256", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f288539ea7eb406480c84ec1a5605a91.json"}}, {"family": "Hekmati", "given": "Neda", "initials": "N", "orcid": "0009-0009-4814-869X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1627d2402a114b7ea2aed6cb0774e930.json"}}, {"family": "Engstrand", "given": "Jennie", "initials": "J", "orcid": "0000-0003-1123-7022", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/972ae8ebf2634566bed8ebca7caa68ec.json"}}, {"family": "Sparrelid", "given": "Ernesto", "initials": "E"}, {"family": "Salm\u00e9n", "given": "Caroline", "initials": "C"}, {"family": "Heuchel", "given": "Rainer L", "initials": "RL", "orcid": "0000-0002-2782-585X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b61dc159c5764feba88e3fa2a35d1ad7.json"}}, {"family": "Zacharouli", "given": "Argyro", "initials": "A"}, {"family": "Ghorbani", "given": "Poya", "initials": "P", "orcid": "0000-0003-2102-7168", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/37d164f0a26d4bf4aa8ad1aa4505f92e.json"}}, {"family": "Harrizi", "given": "Sara", "initials": "S"}, {"family": "Hamidi", "given": "Yousra", "initials": "Y"}, {"family": "Khorosjutina", "given": "Olga", "initials": "O", "orcid": "0009-0001-0786-0260", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d758b02263464940ab8c7922b68b580a.json"}}, {"family": "Milanova", "given": "Stefina", "initials": "S", "orcid": "0000-0001-9865-857X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/653b408e1e894d3a9bd22564ac3ec1dd.json"}}, {"family": "Schmierer", "given": "Bernhard", "initials": "B", "orcid": "0000-0002-9082-7022", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/95decb70bc9d4dc2820259b5971e342f.json"}}, {"family": "Boz\u00f3ky", "given": "B\u00e9la", "initials": "B"}, {"family": "Moro", "given": "Carlos Fern\u00e1ndez", "initials": "CF", "orcid": "0000-0001-6863-5959", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6b9e861a77874d87a34a4894bd38daf5.json"}}, {"family": "Gerling", "given": "Marco", "initials": "M", "orcid": "0000-0002-1810-0662", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/73d0af14271b446b8ce3779d6beea16c.json"}}], "type": "posted-content", "published": "2024-03-15", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2024.03.14.584614", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-09-23T15:33:01.279Z", "modified": "2026-09-23T15:33:01.532Z"}, {"entity": "publication", "iuid": "13fa501d26b9449a9183d85612341085", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/13fa501d26b9449a9183d85612341085.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/13fa501d26b9449a9183d85612341085"}}, "title": "An idiosyncratic zonated stroma encapsulates desmoplastic liver metastases and originates from injured liver.", "authors": [{"family": "Fern\u00e1ndez Moro", "given": "Carlos", "initials": "C", "orcid": "0000-0001-6863-5959", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6b9e861a77874d87a34a4894bd38daf5.json"}}, {"family": "Geyer", "given": "Natalie", "initials": "N"}, {"family": "Harrizi", "given": "Sara", "initials": "S"}, {"family": "Hamidi", "given": "Yousra", "initials": "Y"}, {"family": "S\u00f6derqvist", "given": "Sara", "initials": "S"}, {"family": "Kuznyecov", "given": "Danyil", "initials": "D", "orcid": "0009-0007-8218-557X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c523efe51e1e4d719e76739066a1c3e6.json"}}, {"family": "Tidholm Qvist", "given": "Evelina", "initials": "E"}, {"family": "Salmonson Schaad", "given": "Media", "initials": "M"}, {"family": "Hermann", "given": "Laura", "initials": "L"}, {"family": "Lindberg", "given": "Amanda", "initials": "A"}, {"family": "Heuchel", "given": "Rainer L", "initials": "RL", "orcid": "0000-0002-2782-585X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b61dc159c5764feba88e3fa2a35d1ad7.json"}}, {"family": "Mart\u00edn-Bernab\u00e9", "given": "Alfonso", "initials": "A"}, {"family": "Dhanjal", "given": "Soniya", "initials": "S"}, {"family": "Navis", "given": "Anna C", "initials": "AC", "orcid": "0000-0002-5267-4678", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/09390010aa754532bf22d007ddd4682c.json"}}, {"family": "Villard", "given": "Christina", "initials": "C"}, {"family": "Del Valle", "given": "Andrea C", "initials": "AC", "orcid": "0000-0002-1698-9533", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/640e1c5e98904433b89a85fd6dbaf857.json"}}, {"family": "Boz\u00f3ky", "given": "Lorand", "initials": "L"}, {"family": "Sparrelid", "given": "Ernesto", "initials": "E"}, {"family": "Dirix", "given": "Luc", "initials": "L", "orcid": "0000-0002-6248-1677", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/beca0559e23c4af49618f0400b57cced.json"}}, {"family": "Strell", "given": "Carina", "initials": "C"}, {"family": "\u00d6stman", "given": "Arne", "initials": "A", "orcid": "0000-0003-3993-0021", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9c904facaa544895ba08014225e5060f.json"}}, {"family": "Schmierer", "given": "Bernhard", "initials": "B", "orcid": "0000-0002-9082-7022", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/95decb70bc9d4dc2820259b5971e342f.json"}}, {"family": "Vermeulen", "given": "Peter B", "initials": "PB"}, {"family": "Engstrand", "given": "Jennie", "initials": "J", "orcid": "0000-0003-1123-7022", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/972ae8ebf2634566bed8ebca7caa68ec.json"}}, {"family": "Boz\u00f3ky", "given": "B\u00e9la", "initials": "B"}, {"family": "Gerling", "given": "Marco", "initials": "M", "orcid": "0000-0002-1810-0662", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/73d0af14271b446b8ce3779d6beea16c.json"}}], "type": "journal article", "published": "2023-08-18", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "14", "issue": "1", "pages": "5024", "issn-l": "2041-1723"}, "abstract": "A perimetastatic capsule is a strong positive prognostic factor in liver metastases, but its origin remains unclear. Here, we systematically quantify the capsule's extent and cellular composition in 263 patients with colorectal cancer liver metastases to investigate its clinical significance and origin. We show that survival improves proportionally with increasing encapsulation and decreasing tumor-hepatocyte contact. Immunostaining reveals the gradual zonation of the capsule, transitioning from benign-like NGFRhigh stroma at the liver edge to FAPhigh stroma towards the tumor. Encapsulation correlates with decreased tumor viability and preoperative chemotherapy. In mice, chemotherapy and tumor cell ablation induce capsule formation. Our results suggest that encapsulation develops where tumor invasion into the liver plates stalls, representing a reparative process rather than tumor-induced desmoplasia. We propose a model of metastases growth, where the efficient tumor colonization of the liver parenchyma and a reparative liver injury reaction are opposing determinants of metastasis aggressiveness.", "doi": "10.1038/s41467-023-40688-x", "pmid": "37596278", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10439160"}, {"db": "pii", "key": "10.1038/s41467-023-40688-x"}], "notes": [], "created": "2026-09-23T09:03:01.015Z", "modified": "2026-09-23T09:03:01.748Z"}, {"entity": "publication", "iuid": "45b03ef57dca42eb9367e0b541e18bb6", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/45b03ef57dca42eb9367e0b541e18bb6.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/45b03ef57dca42eb9367e0b541e18bb6"}}, "title": "Reply to \"CRISPR screens are feasible in TP53 wild-type cells\".", "authors": [{"family": "Haapaniemi", "given": "Emma", "initials": "E"}, {"family": "Botla", "given": "Sandeep", "initials": "S", "orcid": "0000-0001-9937-0455", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e071d6ce45504e3588093f5d50751956.json"}}, {"family": "Persson", "given": "Jenna", "initials": "J"}, {"family": "Schmierer", "given": "Bernhard", "initials": "B", "orcid": "0000-0002-9082-7022", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/95decb70bc9d4dc2820259b5971e342f.json"}}, {"family": "Taipale", "given": "Jussi", "initials": "J", "orcid": "0000-0003-4204-0951", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/512ddc03d00c4e3984a44489be715610.json"}}], "type": "letter", "published": "2019-08-00", "journal": {"title": "Mol Syst Biol", "issn": "1744-4292", "volume": "15", "issue": "8", "pages": "e9059", "issn-l": "1744-4292"}, "abstract": "Haapaniemi et al address the issues raised by Brown et al and discuss several differences between the analyses performed by the two groups.", "doi": "10.15252/msb.20199059", "pmid": "31464368", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6686827"}], "notes": [], "created": "2026-09-23T13:53:54.498Z", "modified": "2026-09-23T13:53:54.617Z"}, {"entity": "publication", "iuid": "1d32a81d03ee4b2587539b1c3edcb5e9", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/1d32a81d03ee4b2587539b1c3edcb5e9.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/1d32a81d03ee4b2587539b1c3edcb5e9"}}, "title": "TGF-\u03b2 family ligands exhibit distinct signaling dynamics that are driven by receptor localization", "authors": [{"family": "Miller", "given": "Daniel S J", "initials": "DSJ"}, {"family": "Schmierer", "given": "Bernhard", "initials": "B", "orcid": "0000-0002-9082-7022", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/95decb70bc9d4dc2820259b5971e342f.json"}}, {"family": "Hill", "given": "Caroline S", "initials": "CS"}], "type": "posted-content", "published": "2019-03-01", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/565416", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-09-23T13:53:44.535Z", "modified": "2026-09-23T13:53:44.579Z"}]}