{"entity": "researcher", "timestamp": "2026-09-28T12:20:36.105Z", "family": "Mantovani", "given": "Giulia", "initials": "G", "orcid": "0000-0002-5307-165X", "affiliations": ["Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/9497b224930b4459aa8915e51c47e919.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/9497b224930b4459aa8915e51c47e919"}}, "publications": [{"entity": "publication", "iuid": "f5a13cab1efc4c65bcb105b04185acb8", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f5a13cab1efc4c65bcb105b04185acb8.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f5a13cab1efc4c65bcb105b04185acb8"}}, "title": "Spatial transcriptomics of B cell and T cell receptors reveals lymphocyte clonal dynamics.", "authors": [{"family": "Engblom", "given": "Camilla", "initials": "C", "orcid": "0000-0001-5090-4161", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7e39a73daed74f38be122ae9c564810c.json"}}, {"family": "Thrane", "given": "Kim", "initials": "K", "orcid": "0000-0003-3109-5551", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/614fde5d55514a1e8199062647806eec.json"}}, {"family": "Lin", "given": "Qirong", "initials": "Q", "orcid": "0000-0001-5298-7861", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3d232b4567694b6f80b59ad262e7ff54.json"}}, {"family": "Andersson", "given": "Alma", "initials": "A", "orcid": "0000-0002-4773-9975", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/82aebb401f644b2fbd015827dc916078.json"}}, {"family": "Toosi", "given": "Hosein", "initials": "H", "orcid": "0000-0002-5525-4724", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a82ccdfe786246c5b813d9361d62c0e2.json"}}, {"family": "Chen", "given": "Xinsong", "initials": "X", "orcid": "0000-0002-3214-9075", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4a7d95a9799a4c23bb01bf05fa6351cc.json"}}, {"family": "Steiner", "given": "Embla", "initials": "E"}, {"family": "Lu", "given": "Chang", "initials": "C", "orcid": "0000-0001-6304-2820", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dcdd5ebdb20848f9960c0f8d7bacf42f.json"}}, {"family": "Mantovani", "given": "Giulia", "initials": "G", "orcid": "0000-0002-5307-165X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9497b224930b4459aa8915e51c47e919.json"}}, {"family": "Hagemann-Jensen", "given": "Michael", "initials": "M", "orcid": "0000-0002-6423-8216", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7a67d94769764d37a2bf3febd4f79101.json"}}, {"family": "Saarenp\u00e4\u00e4", "given": "Sami", "initials": "S", "orcid": "0000-0003-4731-6857", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/642b3b7751434194b4f55f2af8d746a4.json"}}, {"family": "Jangard", "given": "Mattias", "initials": "M", "orcid": "0000-0003-3772-2026", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0fd4438472764db09961f035401a7d6f.json"}}, {"family": "Saez-Rodriguez", "given": "Julio", "initials": "J", "orcid": "0000-0002-8552-8976", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/504df2e61c124714b9afecf767798a00.json"}}, {"family": "Micha\u00eblsson", "given": "Jakob", "initials": "J"}, {"family": "Hartman", "given": "Johan", "initials": "J", "orcid": "0000-0002-6500-8527", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d62d622200d443b7b5be34ff3c0945be.json"}}, {"family": "Lagergren", "given": "Jens", "initials": "J", "orcid": "0000-0002-4552-0240", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4024d2a29dc14b5289616d90a4265863.json"}}, {"family": "Mold", "given": "Jeff E", "initials": "JE", "orcid": "0000-0003-2195-2978", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3190bb256fcb4a9eb4f4ef06bb99eb5c.json"}}, {"family": "Lundeberg", "given": "Joakim", "initials": "J", "orcid": "0000-0003-4313-1601", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d9fa47767cd14ef2b9528c8b998cf095.json"}}, {"family": "Fris\u00e9n", "given": "Jonas", "initials": "J", "orcid": "0000-0001-5819-458X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6c428941167b42c495b9fcdb6eb85729.json"}}], "type": "journal article", "published": "2023-12-08", "journal": {"title": "Science (New York, N.Y.)", "issn": "1095-9203", "volume": "382", "issue": "6675", "pages": "eadf8486", "issn-l": "0036-8075"}, "abstract": "The spatial distribution of lymphocyte clones within tissues is critical to their development, selection, and expansion. We have developed spatial transcriptomics of variable, diversity, and joining (VDJ) sequences (Spatial VDJ), a method that maps B cell and T cell receptor sequences in human tissue sections. Spatial VDJ captures lymphocyte clones that match canonical B and T cell distributions and amplifies clonal sequences confirmed by orthogonal methods. We found spatial congruency between paired receptor chains, developed a computational framework to predict receptor pairs, and linked the expansion of distinct B cell clones to different tumor-associated gene expression programs. Spatial VDJ delineates B cell clonal diversity and lineage trajectories within their anatomical niche. Thus, Spatial VDJ captures lymphocyte spatial clonal architecture across tissues, providing a platform to harness clonal sequences for therapy.", "doi": "10.1126/science.adf8486", "pmid": "38060664", "labels": {"SciLifeLab Fellow": "", "Camilla Engblom": ""}, "xrefs": [], "notes": [], "created": "2026-09-23T07:29:32.990Z", "modified": "2026-09-23T07:29:33.273Z"}, {"entity": "publication", "iuid": "2be4c0bb8c4d4b1ebadf5f42ae2ab3d4", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/2be4c0bb8c4d4b1ebadf5f42ae2ab3d4.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/2be4c0bb8c4d4b1ebadf5f42ae2ab3d4"}}, "title": "Prostate cancer disease recurrence after radical prostatectomy is associated with HLA type and local cytomegalovirus immunity.", "authors": [{"family": "Classon", "given": "Johanna", "initials": "J", "orcid": "0000-0003-0392-7605", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c9f51e78f4e04793abac00c22d972363.json"}}, {"family": "Zamboni", "given": "Margherita", "initials": "M"}, {"family": "Engblom", "given": "Camilla", "initials": "C"}, {"family": "Alkass", "given": "Kanar", "initials": "K"}, {"family": "Mantovani", "given": "Giulia", "initials": "G", "orcid": "0000-0002-5307-165X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9497b224930b4459aa8915e51c47e919.json"}}, {"family": "Pou", "given": "Christian", "initials": "C"}, {"family": "Nkulikiyimfura", "given": "Dieudonn\u00e9", "initials": "D"}, {"family": "Brodin", "given": "Petter", "initials": "P"}, {"family": "Druid", "given": "Henrik", "initials": "H"}, {"family": "Mold", "given": "Jeff", "initials": "J"}, {"family": "Fris\u00e9n", "given": "Jonas", "initials": "J"}], "type": "journal article", "published": "2022-10-00", "journal": {"title": "Mol Oncol", "issn": "1878-0261", "volume": "16", "issue": "19", "pages": "3452-3464", "issn-l": "1574-7891"}, "abstract": "Prostate cancer is a heterogeneous disease with a need for new prognostic biomarkers. Human leukocyte antigen (HLA) genes are highly polymorphic genes central to antigen presentation to T-cells. Two alleles, HLA-A*02:01 and HLA-A*24:02, have been associated with prognosis in patients diagnosed with de novo metastatic prostate cancer. We leveraged the next-generation sequenced cohorts CPC-GENE and TCGA-PRAD to examine HLA alleles, antiviral T-cell receptors and prostate cancer disease recurrence after prostatectomy. Carrying HLA-A*02:01 (111/229; 48% of patients) was independently associated with disease recurrence in patients with low-intermediate risk prostate cancer. HLA-A*11 (carried by 42/441; 10% of patients) was independently associated with rapid disease recurrence in patients with high-risk prostate cancer. Moreover, HLA-A*02:01 carriers in which anti-cytomegalovirus T-cell receptors (CMV-TCR) were identified in tumors (13/144; 10% of all patients in the cohort) had a higher risk of disease recurrence than CMV-TCR-negative patients. These findings suggest that HLA-type and CMV immunity may be valuable biomarkers for prostate cancer progression.", "doi": "10.1002/1878-0261.13273", "pmid": "35712787", "labels": {"SciLifeLab Fellow": "", "Camilla Engblom": ""}, "xrefs": [{"db": "pmc", "key": "PMC9533687"}, {"db": "RefSeq", "key": "NC_006273.2"}], "notes": [], "created": "2026-09-23T12:11:25.234Z", "modified": "2026-09-23T12:11:25.332Z"}]}