{"entity": "researcher", "timestamp": "2026-08-20T20:47:32.687Z", "family": "Kere", "given": "Maura M", "initials": "MM", "orcid": "0000-0002-5725-2773", "affiliations": ["Department of Clinical Science and Education, S\u00f6dersjukhuset, Karolinska Institutet, Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/93f66ce5010c496fab5dc5b3ff75075a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/93f66ce5010c496fab5dc5b3ff75075a"}}, "publications": [{"entity": "publication", "iuid": "04f7e360d43948619b65adb648cdd42d", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/04f7e360d43948619b65adb648cdd42d.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/04f7e360d43948619b65adb648cdd42d"}}, "title": "Distinct Phenotypes of Peripheral Innate Lymphoid Cells and T Cells in Type 2 and Non-Type 2 Asthma.", "authors": [{"family": "Kere", "given": "Maura M", "initials": "MM", "orcid": "0000-0002-5725-2773", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/93f66ce5010c496fab5dc5b3ff75075a.json"}}, {"family": "Bj\u00f6rkander", "given": "Sophia", "initials": "S"}, {"family": "Merid", "given": "Simon Kebede", "initials": "SK"}, {"family": "Hernandez-Pacheco", "given": "Natalia", "initials": "N"}, {"family": "Maier", "given": "Paul", "initials": "P"}, {"family": "Merritt", "given": "Anne-Sophie", "initials": "AS"}, {"family": "Bergstr\u00f6m", "given": "Anna", "initials": "A"}, {"family": "Kull", "given": "Inger", "initials": "I"}, {"family": "Daub", "given": "Carsten O", "initials": "CO"}, {"family": "Mj\u00f6sberg", "given": "Jenny", "initials": "J"}, {"family": "Tibbitt", "given": "Christopher Andrew", "initials": "CA"}, {"family": "Mel\u00e9n", "given": "Erik", "initials": "E"}], "type": "journal article", "published": "2025-09-00", "journal": {"title": "Clin Transl Allergy", "issn": "2045-7022", "volume": "15", "issue": "9", "pages": "e70108", "issn-l": null}, "abstract": "Investigation of T cell and innate lymphoid cell (ILC) subsets in type 2 (T2) and non-type 2 (non-T2) asthma are needed to elucidate disease mechanisms. In this study, we aimed to identify ILC, CD4+, and CD8+ T cell populations in blood that differentiate between T2 and non-T2 features in subjects with and without asthma.\n\nThe study population included 86 young adults selected from the Swedish population-based BAMSE cohort. Asthma and non-asthma subjects with sensitization to inhalant allergens and/or blood eosinophil count \u2265 0.3 \u00d7 109/L were classified into T2 groups. Non-T2 groups were defined by the absence of sensitization to inhalant allergens and blood eosinophil count < 0.3 \u00d7 109/L. PBMC samples underwent 18-parameter flow cytometry to identify ILC and CD4+ and CD8+ T cell populations. Logistic regression models were employed on normalized flow cytometry data after hierarchical clustering.\n\nA higher frequency of CD4+ CRTH2+ T memory cells was associated with T2 features independent of asthma status. The frequency of CD62L+ ILC2s was higher and CD4+ KLRG1+ central memory T cells was lower specifically in T2 asthma. Non-T2 asthma was associated with increased frequencies of CD45RO+ ILC2s and CD8+ memory T cells.\n\nOur results suggest that T2 asthma and non-T2 asthma are characterized by distinct features related to ILC and T cell populations. Further investigation of particularly ILC and CD8+ T cell subsets in non-T2 asthma could offer a deeper understanding of underlying disease mechanisms for this endotype.", "doi": "10.1002/clt2.70108", "pmid": "40965120", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12444775"}], "notes": [], "created": "2026-08-20T06:31:20.668Z", "modified": "2026-08-20T06:31:20.764Z"}]}