{"entity": "researcher", "timestamp": "2026-08-22T06:57:46.814Z", "family": "H\u00fcbel", "given": "Christopher", "initials": "C", "orcid": "0000-0002-1267-8287", "affiliations": ["Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.", "UK National Institute for Health Research (NIHR) Biomedical Research Centre for Mental Health, South London and Maudsley Hospital, London, UK.", "National Centre for Register-based Research, Aarhus BSS Business and Social Sciences, Aarhus University, Aarhus, Denmark.", "Department of Pediatric Neurology, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/92f1603ade2a4f19aa71e9d280c59421.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/92f1603ade2a4f19aa71e9d280c59421"}}, "publications": [{"entity": "publication", "iuid": "45dba291f52546d384c97f4c2bc570f7", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/45dba291f52546d384c97f4c2bc570f7.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/45dba291f52546d384c97f4c2bc570f7"}}, "title": "Latent anxiety and depression dimensions differ amongst patients with eating disorders: A Swedish nationwide investigation.", "authors": [{"family": "H\u00fcbel", "given": "Christopher", "initials": "C", "orcid": "0000-0002-1267-8287", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/92f1603ade2a4f19aa71e9d280c59421.json"}}, {"family": "Birgeg\u00e5rd", "given": "Andreas", "initials": "A", "orcid": "0000-0003-1220-9680", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b4ad1d7976c9415990fc7292a7052e97.json"}}, {"family": "Johansson", "given": "Therese", "initials": "T"}, {"family": "Petersen", "given": "Liselotte V", "initials": "LV"}, {"family": "Isomaa", "given": "Rasmus", "initials": "R"}, {"family": "Herle", "given": "Moritz", "initials": "M"}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "Int J Methods Psychiatr Res", "issn": "1557-0657", "volume": "32", "issue": "3", "pages": "e1961", "issn-l": null}, "abstract": "Anxiety and depression symptoms are common in individuals with eating disorders. To study these co-occurrences, we need high-quality self-report questionnaires. The 19-item self-rated Comprehensive Psychopathological Rating Scale for Affective Syndromes (CPRS-S-A) is not validated in patients with eating disorders. We tested its factor structure, invariance, and differences in its latent dimensions.\n\nPatients were registered by 45 treatment units in the Swedish nationwide Stepwise quality assurance database for specialised eating disorder care (n = 9509). Patients self-reported their anxiety and depression symptoms on the CPRS-S-A. Analyses included exploratory and confirmatory factor analyses (CFA) in split samples, and testing of invariance and differences in subscales across eating disorder types.\n\nResults suggested a four-factor solution: Depression, Somatic and fear symptoms, Disinterest, and Worry. Multigroup CFA indicated an invariant factor structure. We detected the following differences: Patients with anorexia nervosa binge-eating/purging subtype scored the highest and patients with unspecified feeding and eating disorders the lowest on all subscales. Patients with anorexia nervosa or purging disorder show more somatic and fear symptoms than individuals with either bulimia nervosa or binge-eating disorder.\n\nOur four-factor solution of the CPRS-S-A is suitable for patients with eating disorders and may help to identify differences in anxiety and depression dimensions amongst patients with eating disorders.", "doi": "10.1002/mpr.1961", "pmid": "36775941", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10485306"}], "notes": [], "created": "2026-08-21T11:03:33.070Z", "modified": "2026-08-21T11:03:33.194Z"}, {"entity": "publication", "iuid": "4aff5e9eabd6453a80078bc7d104a5d4", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/4aff5e9eabd6453a80078bc7d104a5d4.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/4aff5e9eabd6453a80078bc7d104a5d4"}}, "title": "Polygenic association with severity and long-term outcome in eating disorder cases.", "authors": [{"family": "Johansson", "given": "Therese", "initials": "T", "orcid": "0000-0003-1043-7065", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d4005242bc4c45f6a0899226560837f8.json"}}, {"family": "Birgeg\u00e5rd", "given": "Andreas", "initials": "A"}, {"family": "Zhang", "given": "Ruyue", "initials": "R", "orcid": "0000-0001-5747-9428", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fbb1e76ba7dc49c3808f95f563fe21d1.json"}}, {"family": "Bergen", "given": "Sarah E", "initials": "SE"}, {"family": "Land\u00e9n", "given": "Mikael", "initials": "M"}, {"family": "Petersen", "given": "Liselotte V", "initials": "LV"}, {"family": "Bulik", "given": "Cynthia M", "initials": "CM"}, {"family": "H\u00fcbel", "given": "Christopher", "initials": "C", "orcid": "0000-0002-1267-8287", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/92f1603ade2a4f19aa71e9d280c59421.json"}}], "type": "journal article", "published": "2022-02-16", "journal": {"title": "Transl Psychiatry", "issn": "2158-3188", "volume": "12", "issue": "1", "pages": "61", "issn-l": "2158-3188"}, "abstract": "About 20% of individuals with anorexia nervosa (AN) remain chronically ill. Therefore, early identification of poor outcome could improve care. Genetic research has identified regions of the genome associated with AN. Patients with anorexia nervosa were identified via the Swedish eating disorder quality registers Stepwise and Riks\u00e4t and invited to participate in the Anorexia Nervosa Genetics Initiative. First, we associated genetic information longitudinally with eating disorder severity indexed by scores on the Clinical Impairment Assessment (CIA) in 2843 patients with lifetime AN with or without diagnostic migration to other forms of eating disorders followed for up to 16 years (mean = 5.3 years). Second, we indexed the development of a severe and enduring eating disorder (SEED) by a high CIA score plus a follow-up time \u22655 years. We associated individual polygenic scores (PGSs) indexing polygenic liability for AN, schizophrenia, and body mass index (BMI) with severity and SEED. After multiple testing correction, only the BMI PGS when calculated with traditional clumping and p value thresholding was robustly associated with disorder severity (\u03b2PGS = 1.30; 95% CI: 0.72, 1.88; p = 1.2 \u00d7 10-5) across all p value thresholds at which we generated the PGS. However, using the alternative PGS calculation method PRS-CS yielded inconsistent results for all PGS. The positive association stands in contrast to the negative genetic correlation between BMI and AN. Larger discovery GWASs to calculate PGS will increase power, and it is essential to increase sample sizes of the AN GWASs to generate clinically meaningful PGS as adjunct risk prediction variables. Nevertheless, this study provides the first evidence of potential clinical utility of PGSs for eating disorders.", "doi": "10.1038/s41398-022-01831-2", "pmid": "35173158", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8850420"}, {"db": "pii", "key": "10.1038/s41398-022-01831-2"}], "notes": [], "created": "2026-08-21T11:47:15.434Z", "modified": "2026-08-21T11:47:15.536Z"}]}