{"entity": "researcher", "timestamp": "2026-08-26T22:48:04.238Z", "family": "Iglesias", "given": "Maria-Jesus", "initials": "MJ", "orcid": "0000-0003-4122-1945", "affiliations": ["Science for Life Laboratory, Department of Protein Science, School of Engineering Sciences in Chemistry/Biotechnology and Health, KTH Royal Institute of Technology, 11428 Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/922c6babe48c4829b9eabb01324e00fc.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/922c6babe48c4829b9eabb01324e00fc"}}, "publications": [{"entity": "publication", "iuid": "80cf30b3a9064286a1aa875cd4208e80", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/80cf30b3a9064286a1aa875cd4208e80.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/80cf30b3a9064286a1aa875cd4208e80"}}, "title": "Biliverdin Reductase B Is a Plasma Biomarker for Intraplaque Hemorrhage and a Predictor of Ischemic Stroke in Patients with Symptomatic Carotid Atherosclerosis.", "authors": [{"family": "Chemaly", "given": "Melody", "initials": "M", "orcid": "0000-0001-6211-7595", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7f7c9c91386a45e38a964823c4b7da77.json"}}, {"family": "Marlevi", "given": "David", "initials": "D"}, {"family": "Iglesias", "given": "Maria-Jesus", "initials": "MJ", "orcid": "0000-0003-4122-1945", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/922c6babe48c4829b9eabb01324e00fc.json"}}, {"family": "Lengquist", "given": "Mariette", "initials": "M"}, {"family": "Kronqvist", "given": "Malin", "initials": "M"}, {"family": "Bos", "given": "Daniel", "initials": "D"}, {"family": "van Dam-Nolen", "given": "Dianne H K", "initials": "DHK", "orcid": "0000-0002-4527-3876", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f413f645484f4380b145bad5b86e4632.json"}}, {"family": "van der Kolk", "given": "Anja", "initials": "A", "orcid": "0000-0002-8267-8848", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4c40a3cd088c4ebf9eb6e9e0389b7179.json"}}, {"family": "Hendrikse", "given": "Jeroen", "initials": "J"}, {"family": "Kassem", "given": "Mohamed", "initials": "M", "orcid": "0000-0001-8392-2323", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6fe0d4f8238e48a3a3195d62ec8d283f.json"}}, {"family": "Matic", "given": "Ljubica", "initials": "L"}, {"family": "Odeberg", "given": "Jacob", "initials": "J"}, {"family": "de Vries", "given": "Margreet R", "initials": "MR", "orcid": "0000-0002-3648-9130", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/514b56fc967b4c21af5bf620e6b92268.json"}}, {"family": "Kooi", "given": "M Eline", "initials": "ME", "orcid": "0000-0001-7562-5724", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/973dcc38142e422ab074e3b3895e61a6.json"}}, {"family": "Hedin", "given": "Ulf", "initials": "U"}], "type": "journal article", "published": "2023-05-24", "journal": {"title": "Biomolecules", "issn": "2218-273X", "volume": "13", "issue": "6", "issn-l": null}, "abstract": "Intraplaque hemorrhage (IPH) is a hallmark of atherosclerotic plaque instability. Biliverdin reductase B (BLVRB) is enriched in plasma and plaques from patients with symptomatic carotid atherosclerosis and functionally associated with IPH.\n\nWe explored the biomarker potential of plasma BLVRB through (1) its correlation with IPH in carotid plaques assessed by magnetic resonance imaging (MRI), and with recurrent ischemic stroke, and (2) its use for monitoring pharmacotherapy targeting IPH in a preclinical setting.\n\nPlasma BLVRB levels were measured in patients with symptomatic carotid atherosclerosis from the PARISK study (n = 177, 5 year follow-up) with and without IPH as indicated by MRI. Plasma BLVRB levels were also measured in a mouse vein graft model of IPH at baseline and following antiangiogenic therapy targeting vascular endothelial growth factor receptor 2 (VEGFR-2).\n\nPlasma BLVRB levels were significantly higher in patients with IPH (737.32 \u00b1 693.21 vs. 520.94 \u00b1 499.43 mean fluorescent intensity (MFI), p = 0.033), but had no association with baseline clinical and biological parameters. Plasma BLVRB levels were also significantly higher in patients who developed recurrent ischemic stroke (1099.34 \u00b1 928.49 vs. 582.07 \u00b1 545.34 MFI, HR = 1.600, CI [1.092-2.344]; p = 0.016). Plasma BLVRB levels were significantly reduced following prevention of IPH by anti-VEGFR-2 therapy in mouse vein grafts (1189 \u00b1 258.73 vs. 1752 \u00b1 366.84 MFI; p = 0.004).\n\nPlasma BLVRB was associated with IPH and increased risk of recurrent ischemic stroke in patients with symptomatic low- to moderate-grade carotid stenosis, indicating the capacity to monitor the efficacy of IPH-preventive pharmacotherapy in an animal model. Together, these results suggest the utility of plasma BLVRB as a biomarker for atherosclerotic plaque instability.", "doi": "10.3390/biom13060882", "pmid": "37371462", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10296390"}, {"db": "pii", "key": "biom13060882"}], "notes": [], "created": "2026-08-20T13:38:43.908Z", "modified": "2026-08-20T13:38:44.275Z"}, {"entity": "publication", "iuid": "6db246dca255403e939317dbf88c1c6c", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/6db246dca255403e939317dbf88c1c6c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/6db246dca255403e939317dbf88c1c6c"}}, "title": "Adaptive Resetting of Tuberoinfundibular Dopamine (TIDA) Network Activity during Lactation in Mice.", "authors": [{"family": "Th\u00f6rn P\u00e9rez", "given": "Carolina", "initials": "C", "orcid": "0000-0002-3480-8599", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e28f75c282114a0190a259924b04a0f1.json"}}, {"family": "Ferraris", "given": "Jimena", "initials": "J", "orcid": "0000-0001-7472-0439", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/be3ffad1274f49fca9805b647d9e38c1.json"}}, {"family": "van Lunteren", "given": "Josina Anna", "initials": "JA", "orcid": "0000-0002-2788-3101", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/16a877c23b4e454bbc7e496bd779790f.json"}}, {"family": "Hellysaz", "given": "Arash", "initials": "A", "orcid": "0000-0003-4512-3795", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b000a4a076a14f2aa21ed25c27729218.json"}}, {"family": "Iglesias", "given": "Mar\u00eda Jes\u00fas", "initials": "MJ", "orcid": "0000-0003-4122-1945", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/922c6babe48c4829b9eabb01324e00fc.json"}}, {"family": "Broberger", "given": "Christian", "initials": "C", "orcid": "0000-0002-7050-8809", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2921589a648349e090a2751cce15914d.json"}}], "type": "journal article", "published": "2020-04-15", "journal": {"title": "J. Neurosci.", "issn": "1529-2401", "volume": "40", "issue": "16", "pages": "3203-3216", "issn-l": "0270-6474"}, "abstract": "Giving birth triggers a wide repertoire of physiological and behavioral changes in the mother to enable her to feed and care for her offspring. These changes require coordination and are often orchestrated from the CNS, through as of yet poorly understood mechanisms. A neuronal population with a central role in puerperal changes is the tuberoinfundibular dopamine (TIDA) neurons that control release of the pituitary hormone, prolactin, which triggers key maternal adaptations, including lactation and maternal care. Here, we used Ca2+ imaging on mice from both sexes and whole-cell recordings on female mouse TIDA neurons in vitro to examine whether they adapt their cellular and network activity according to reproductive state. In the high-prolactin state of lactation, TIDA neurons shift to faster membrane potential oscillations, a reconfiguration that reverses upon weaning. During the estrous cycle, however, which includes a brief, but pronounced, prolactin peak, oscillation frequency remains stable. An increase in the hyperpolarization-activated mixed cation current, Ih, possibly through unmasking as dopamine release drops during nursing, may partially explain the reconfiguration of TIDA rhythms. These findings identify a reversible plasticity in hypothalamic network activity that can serve to adapt the dam for motherhood.SIGNIFICANCE STATEMENT Motherhood requires profound behavioral and physiological adaptations to enable caring for offspring, but the underlying CNS changes are poorly understood. Here, we show that, during lactation, neuroendocrine dopamine neurons, the \"TIDA\" cells that control prolactin secretion, reorganize their trademark oscillations to discharge in faster frequencies. Unlike previous studies, which typically have focused on structural and transcriptional changes during pregnancy and lactation, we demonstrate a functional switch in activity and one that, distinct from previously described puerperal modifications, reverses fully on weaning. We further provide evidence that a specific conductance (Ih) contributes to the altered network rhythm. These findings identify a new facet of maternal brain plasticity at the level of membrane properties and consequent ensemble activity.", "doi": "10.1523/JNEUROSCI.1553-18.2020", "pmid": "32209609", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7159885"}, {"db": "pii", "key": "JNEUROSCI.1553-18.2020"}], "notes": [], "created": "2026-08-21T12:53:33.546Z", "modified": "2026-08-21T12:53:33.777Z"}]}