{"entity": "researcher", "timestamp": "2026-08-22T06:57:49.250Z", "family": "Warrier", "given": "Neerada Meenakshi", "initials": "NM", "orcid": "0000-0001-9321-2923", "affiliations": ["Department of Biotechnology, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/9168f58729714ba78078ebd3cfdb1887.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/9168f58729714ba78078ebd3cfdb1887"}}, "publications": [{"entity": "publication", "iuid": "a4da366bb1884075ad1301a02942d0fd", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/a4da366bb1884075ad1301a02942d0fd.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/a4da366bb1884075ad1301a02942d0fd"}}, "title": "Survivin Inhibition by Piperine Sensitizes Glioblastoma Cancer Stem Cells and Leads to Better Drug Response.", "authors": [{"family": "Warrier", "given": "Neerada Meenakshi", "initials": "NM", "orcid": "0000-0001-9321-2923", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9168f58729714ba78078ebd3cfdb1887.json"}}, {"family": "Krishnan", "given": "Ramesh Kumar", "initials": "RK"}, {"family": "Prabhu", "given": "Vijendra", "initials": "V", "orcid": "0000-0001-5927-2180", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2d42a40b917e49f2a2d5ab19e228f84f.json"}}, {"family": "Hariharapura", "given": "Raghu Chandrashekhar", "initials": "RC", "orcid": "0000-0002-6538-7758", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/770c56add28c4d3797db5252bafa4b85.json"}}, {"family": "Agarwal", "given": "Prasoon", "initials": "P", "orcid": "0000-0003-1813-7606", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/84c99f839d45463aa14e7fbe322439ce.json"}}, {"family": "Kumar", "given": "Praveen", "initials": "P", "orcid": "0000-0002-6330-7355", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/26c2bf9b534746ffb8b213b86ef6d3d6.json"}}], "type": "journal article", "published": "2022-07-09", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "volume": "23", "issue": "14", "issn-l": null}, "abstract": "Glioblastoma multiforme (GBM) cancer stem cells (GSCs) are one of the strongest contributing factors to treatment resistance in GBM. Identification of biomarkers capable of directly affecting these cells within the bulk tumor is a major challenge associated with the development of new targeting strategies. In this study, we focus on understanding the potential of the multifunctional extraordinaire survivin as a biomarker for GSCs. We analyzed the expression profiles of this gene using various publicly available datasets to understand its importance in stemness and other cancer processes. The findings from these studies were further validated using human GSCs isolated from a GBM cell line. In these GSCs, survivin was inhibited using the dietary phytochemical piperine (PIP) and the subsequent effects on stemness, cancer processes and Temozolomide were investigated. In silico analysis identified survivin to be one of the most significant differentially regulated gene in GSCs, in comparison to common stemness markers. Further validation studies on the isolated GSCs showed the importance of survivin in stemness, cancer progression and therapy resistance. Taken together, our study identifies survivin as a more consistent GSC marker and also suggests the possibility of using survivin inhibitors along with standard of care drugs for better therapeutic outcomes.", "doi": "10.3390/ijms23147604", "pmid": "35886952", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9323232"}, {"db": "pii", "key": "ijms23147604"}], "notes": [], "created": "2026-08-21T13:03:31.527Z", "modified": "2026-08-21T13:03:31.656Z"}, {"entity": "publication", "iuid": "aecbf4d086604e75b03d2c2b9eeda7ca", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/aecbf4d086604e75b03d2c2b9eeda7ca.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/aecbf4d086604e75b03d2c2b9eeda7ca"}}, "title": "Integrative Analysis to Identify Genes Associated with Stemness and Immune Infiltration in Glioblastoma.", "authors": [{"family": "Warrier", "given": "Neerada Meenakshi", "initials": "NM", "orcid": "0000-0001-9321-2923", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9168f58729714ba78078ebd3cfdb1887.json"}}, {"family": "Agarwal", "given": "Prasoon", "initials": "P", "orcid": "0000-0003-1813-7606", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/84c99f839d45463aa14e7fbe322439ce.json"}}, {"family": "Kumar", "given": "Praveen", "initials": "P", "orcid": "0000-0002-6330-7355", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/26c2bf9b534746ffb8b213b86ef6d3d6.json"}}], "type": "journal article", "published": "2021-10-15", "journal": {"title": "Cells", "issn": "2073-4409", "volume": "10", "issue": "10", "issn-l": "2073-4409"}, "abstract": "It is imperative to identify the mechanisms that confer stemness to the cancer cells for more effective targeting. Moreover, there are not many studies on the link between stemness characteristics and the immune response in tumours. Therefore, in the current study involving GBM, we started with the study of BIRC5 (one of the rare genes differentially expressed in normal and cancer cells) and CXCR4 (gene involved in the survival and proliferation of CSCs). Together, these genes have not been systematically explored. We used a set of 27 promoter methylated regions in GBM. Our analysis showed that four genes corresponding to these regions, namely EOMES, BDNF, HLA-A, and PECAM1, were involved with BIRC5 and CXCR4. Interestingly, we found EOMES to be very significantly involved in stemness and immunology and it was positively correlated to CXCR4. Additionally, BDNF, which was significant in methylation, was negatively correlated to BIRC5.", "doi": "10.3390/cells10102765", "pmid": "34685742", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8534801"}, {"db": "pii", "key": "cells10102765"}], "notes": [], "created": "2026-08-21T13:02:03.592Z", "modified": "2026-08-21T13:02:03.728Z"}]}