{"entity": "researcher", "timestamp": "2026-08-20T21:02:02.837Z", "family": "Schulz", "given": "Eike C", "initials": "EC", "orcid": "0000-0002-1685-8605", "affiliations": ["University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.", "Max-Planck-Institute for Structure and Dynamics of Matter, Hamburg, Germany.", "Institute for Nanostructure and Solid State Physics, Universit\u00e4t Hamburg, Hamburg, Germany."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/911f2e3f43ff48aa848b8a7c77756d0e.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/911f2e3f43ff48aa848b8a7c77756d0e"}}, "publications": [{"entity": "publication", "iuid": "c5a0289f354249e6bef64467dd3d572e", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/c5a0289f354249e6bef64467dd3d572e.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/c5a0289f354249e6bef64467dd3d572e"}}, "title": "Dynamically chiral phosphonic acid-type metallo-\u03b2-lactamase inhibitors.", "authors": [{"family": "Guly\u00e1s", "given": "Kinga Vir\u00e1g", "initials": "KV"}, {"family": "Zhou", "given": "Liping", "initials": "L"}, {"family": "Salamonsen", "given": "Daniel", "initials": "D"}, {"family": "Prester", "given": "Andreas", "initials": "A", "orcid": "0000-0003-2738-7682", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2c442f90408b4da78e8e57db6a5a5439.json"}}, {"family": "Bartels", "given": "Kim", "initials": "K"}, {"family": "Bosman", "given": "Robert", "initials": "R"}, {"family": "Haffke", "given": "Paul", "initials": "P"}, {"family": "Li", "given": "Jintian", "initials": "J"}, {"family": "Tam\u00e1si", "given": "Viola", "initials": "V"}, {"family": "Deufel", "given": "Fritz", "initials": "F", "orcid": "0000-0003-4910-3388", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/42d0d8db764e44f594b21afccbac4e88.json"}}, {"family": "Thoma", "given": "Johannes", "initials": "J", "orcid": "0000-0003-3584-8274", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/797e143cdbef4336b6e16033bef5350b.json"}}, {"family": "Andersson Rasmussen", "given": "Anna", "initials": "A"}, {"family": "Csala", "given": "Mikl\u00f3s", "initials": "M", "orcid": "0000-0002-3829-4361", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bdfdd49618a1404ea56bd91cadfe6878.json"}}, {"family": "Schroder Leiros", "given": "Hanna-Kirsti", "initials": "HK", "orcid": "0000-0002-2726-6322", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/001e1fa1af7249d5a5ab0b5fd321f750.json"}}, {"family": "Xu", "given": "Zhijian", "initials": "Z", "orcid": "0000-0002-3063-8473", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5f196d16a71a42d88bfda54f494333b7.json"}}, {"family": "Widersten", "given": "Mikael", "initials": "M", "orcid": "0000-0002-3203-3793", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e6504282ed7b439b804cdc51f8b4d43b.json"}}, {"family": "Rohde", "given": "Holger", "initials": "H", "orcid": "0000-0001-8587-4433", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fb2556337b3e483bac077fc710db4bd6.json"}}, {"family": "Schulz", "given": "Eike C", "initials": "EC", "orcid": "0000-0002-1685-8605", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/911f2e3f43ff48aa848b8a7c77756d0e.json"}}, {"family": "Zhu", "given": "Weiliang", "initials": "W", "orcid": "0000-0001-6699-5299", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f45a8519ecb24a92a52cd584a6f82638.json"}}, {"family": "Erd\u00e9lyi", "given": "M\u00e1t\u00e9", "initials": "M", "orcid": "0000-0003-0359-5970", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/541eea95344a4e918d30bc1a0f0429c9.json"}}], "type": "journal article", "published": "2025-04-19", "journal": {"title": "Commun Chem", "issn": "2399-3669", "volume": "8", "issue": "1", "pages": "119", "issn-l": null}, "abstract": "Antibiotic resistance is a growing global health threat that risks the lives of millions. Among the resistance mechanisms, that mediated by metallo-\u03b2-lactamases is of particular concern as these bacterial enzymes dismantle most \u03b2-lactam antibiotics, which are our widest applied and cheapest to produce antibiotic agents. So far, no clinically applicable metallo-\u03b2-lactamase inhibitors are available. Aiming to adapt to structural variations, we introduce the inhibitor concept: dynamically chiral phosphonic acids. We demonstrate that they are straightforward to synthesize, penetrate bacterial membranes, inhibit the metallo-\u03b2-lactamase enzymes NDM-1, VIM-2 and GIM-1, and are non-toxic to human cells. Mimicking the transition state of \u03b2-lactam hydrolysis, they target the Zn ions of the metallo-\u03b2-lactamase active site. As a unique feature, both of their stereoisomers bind metallo-\u03b2-lactamases, which provides them unparalleled adaptability to the structural diversity of these enzymes, and may allow them to hamper bacteria's ability for resistance development.", "doi": "10.1038/s42004-025-01510-5", "pmid": "40253435", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12009420"}, {"db": "pii", "key": "10.1038/s42004-025-01510-5"}], "notes": [], "created": "2026-08-20T09:25:38.528Z", "modified": "2026-08-20T09:25:38.883Z"}]}