{"entity": "researcher", "timestamp": "2026-09-23T21:55:44.480Z", "family": "de Bruin", "given": "Odette", "initials": "O", "orcid": "0000-0001-6295-3411", "affiliations": ["Department of Data Science & Biostatistics, Julius Global Health, University Medical Center Utrecht (UMCU), Utrecht, The Netherlands.", "Division Woman and Baby, Department of Obstetrics, Wilhelmina Children's Hospital, University Medical Center Utrecht (UMCU), Utrecht, The Netherlands."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/911b45cf22ce454cbd479115c0e9a977.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/911b45cf22ce454cbd479115c0e9a977"}}, "publications": [{"entity": "publication", "iuid": "d14d88da772c48dd8b7ac6d0a4e53cb3", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/d14d88da772c48dd8b7ac6d0a4e53cb3.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/d14d88da772c48dd8b7ac6d0a4e53cb3"}}, "title": "Adverse outcomes among pregnant women with COVID-19 according to hospitalization status: A prospective individual participant data meta-analysis in Europe and North America.", "authors": [{"family": "de Bruin", "given": "Odette", "initials": "O", "orcid": "0000-0001-6295-3411", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/911b45cf22ce454cbd479115c0e9a977.json"}}, {"family": "Maisonneuve", "given": "Emeline", "initials": "E"}, {"family": "Hurley", "given": "Eimir", "initials": "E"}, {"family": "Nordeng", "given": "Hedvig M E", "initials": "HME"}, {"family": "B\u00e9rard", "given": "Anick", "initials": "A"}, {"family": "Sheehy", "given": "Odile", "initials": "O"}, {"family": "Kaul", "given": "Padma", "initials": "P"}, {"family": "Shinde", "given": "Mayura U", "initials": "MU"}, {"family": "Cosgrove", "given": "Austin", "initials": "A"}, {"family": "Lyons", "given": "Jennifer G", "initials": "JG"}, {"family": "Messenger-Jones", "given": "Elizabeth", "initials": "E"}, {"family": "Kempner", "given": "Maria E", "initials": "ME"}, {"family": "Toh", "given": "Sengwee", "initials": "S"}, {"family": "Hua", "given": "Wei", "initials": "W"}, {"family": "Hern\u00e1ndez-Mu\u00f1oz", "given": "Jos\u00e9 J", "initials": "JJ"}, {"family": "Sahin", "given": "Leyla", "initials": "L"}, {"family": "Cesta", "given": "Carolyn E", "initials": "CE"}, {"family": "H\u00e4gg", "given": "David", "initials": "D"}, {"family": "Gini", "given": "Rosa", "initials": "R"}, {"family": "Paoletti", "given": "Olga", "initials": "O"}, {"family": "Poblador-Plou", "given": "Beatriz", "initials": "B"}, {"family": "Jordan", "given": "Sue", "initials": "S"}, {"family": "Rodr\u00edguez-Bernal", "given": "Clara L", "initials": "CL"}, {"family": "S\u00e1nchez-S\u00e1ez", "given": "Francisco", "initials": "F"}, {"family": "Lassalle", "given": "R\u00e9gis", "initials": "R"}, {"family": "Bernard", "given": "Marie-Agn\u00e8s", "initials": "MA"}, {"family": "Ahmadizar", "given": "Fariba", "initials": "F"}, {"family": "Favre", "given": "Guillaume", "initials": "G"}, {"family": "Panchaud", "given": "Alice", "initials": "A"}, {"family": "Bloemenkamp", "given": "Kitty W M", "initials": "KWM"}, {"family": "Plueschke", "given": "Kelly", "initials": "K"}, {"family": "de Vries", "given": "Corinne", "initials": "C"}, {"family": "Siiskonen", "given": "Satu J", "initials": "SJ"}, {"family": "Sturkenboom", "given": "Miriam C J M", "initials": "MCJM"}, {"family": "CONSIGN Collaboration Group", "given": "", "initials": ""}], "type": "journal article", "published": "2026-06-00", "journal": {"title": "Int J Gynaecol Obstet", "issn": "1879-3479", "volume": "173", "issue": "3", "pages": "1197-1206", "issn-l": null}, "abstract": "Understanding the varied impact of COVID-19 severity on pregnancy outcomes is crucial for informed clinical management and targeted interventions.\n\nTo evaluate the impact of COVID-19 on pregnancy outcomes, distinguishing between pregnant women managed in primary care and those requiring hospitalization.\n\nRegulatory authorities actively promoted global cooperation on COVID-19's impact during pregnancy. Data were obtained through these regulatory bodies and direct researcher communication rather than through systematic searches.\n\nData sources required secondary population-based data to identify pregnancies with COVID-19, along with hospitalization, diagnostic and medication codes. Eligibility for the meta-analysis was determined through protocol evaluation and researcher consultations.\n\nPRISMA-IPD and Cochrane guidelines for prospective meta-analysis were followed. Protocols and definitions were standardized across sources, and a common R script was developed. Initially, crude and adjusted relative risks (aRR) with 95% confidence intervals (CI) were calculated to assess adverse outcomes in pregnant women with and without COVID-19 in each data source. Estimates were stratified by trimester at infection and hospitalization status. Subsequently, data were pooled using a random-effects meta-analysis.\n\nData from 10 sources across seven countries contributed to the meta-analysis, including 86 210 pregnant women diagnosed with COVID-19, of whom 4.4% were hospitalized. Non-hospitalized pregnant women with COVID-19 had no increased risks of adverse outcomes compared to pregnant women without COVID-19. However, hospitalized women with COVID-19 in each trimester had higher risks of cesarean section, preterm birth, and LBW compared to pregnant women without COVID-19. Hospitalization due to COVID-19 in the third trimester was associated with increased risk of stillbirth (aRR 5.90, 95% CI: 2.22-15.71, I2 = 0%). First-trimester hospitalizations due to COVID-19 did not show heightened risks of GDM (aRR 2.08, 95% CI: 0.93-4.64, I2 = 65%), pre-eclampsia (aRR 1.79, 95% CI: 0.48-6.66, I2 = 71%), or major congenital anomalies (aRR 1.30, 95% CI: 0.55-3.06, I2 = 0%).\n\nCOVID-19 requiring hospitalization is associated with adverse pregnancy outcomes, emphasizing the need to prevent severe illness during pregnancy. This study also highlights the importance of international collaboration for gathering pregnancy data and shows that building global research networks is essential for responding to future health crises.", "doi": "10.1002/ijgo.70694", "pmid": "41392882", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC13173624"}], "notes": [], "created": "2026-09-23T13:25:57.534Z", "modified": "2026-09-23T13:25:57.611Z"}, {"entity": "publication", "iuid": "bba7632240c546a7a007346eb6498360", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/bba7632240c546a7a007346eb6498360.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/bba7632240c546a7a007346eb6498360"}}, "title": "Medications Used Among Nonhospitalized Pregnant Women With COVID-19: A Prospective Individual Patient Data Meta-Analysis in Europe and North America.", "authors": [{"family": "de Bruin", "given": "Odette", "initials": "O", "orcid": "0000-0001-6295-3411", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/911b45cf22ce454cbd479115c0e9a977.json"}}, {"family": "Maisonneuve", "given": "Emeline", "initials": "E", "orcid": "0000-0001-5765-4468", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5bc34a21a3ac4d2697742e3e797f2c8c.json"}}, {"family": "Hurley", "given": "Eimir", "initials": "E", "orcid": "0000-0001-6776-1224", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/63d83f6bbc844b73ac52cf4a188a1b77.json"}}, {"family": "Nordeng", "given": "Hedvig M E", "initials": "HME", "orcid": "0000-0001-6361-2918", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e149ec4deccc4c02a3d77948d4a3355d.json"}}, {"family": "B\u00e9rard", "given": "Anick", "initials": "A", "orcid": "0000-0001-7535-5517", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/945643632770419fb139cd993c07305d.json"}}, {"family": "Sheehy", "given": "Odile", "initials": "O", "orcid": "0000-0002-6784-2080", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7dcc3a2109bd4d0fb3773ca84bb17eb2.json"}}, {"family": "Kaul", "given": "Padma", "initials": "P", "orcid": "0000-0003-2239-3944", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0042e499f7b24cb794e2d7ee22286eab.json"}}, {"family": "Shinde", "given": "Mayura U", "initials": "MU"}, {"family": "Cosgrove", "given": "Austin", "initials": "A"}, {"family": "Lyons", "given": "Jennifer G", "initials": "JG"}, {"family": "Messenger-Jones", "given": "Elizabeth", "initials": "E"}, {"family": "Kempner", "given": "Maria E", "initials": "ME"}, {"family": "Toh", "given": "Sengwee", "initials": "S"}, {"family": "Hua", "given": "Wei", "initials": "W"}, {"family": "Hern\u00e1ndez-Mu\u00f1oz", "given": "Jos\u00e9 J", "initials": "JJ", "orcid": "0000-0002-2553-3159", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/617e214e65ab41b18b8b27c0e7ad2b2d.json"}}, {"family": "Sahin", "given": "Leyla", "initials": "L", "orcid": "0000-0002-7685-7524", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b2ce6da32e354740a5a2ee9f9848195c.json"}}, {"family": "Cesta", "given": "Carolyn E", "initials": "CE", "orcid": "0000-0001-5759-9366", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/35e1b896082549c2b69ead371bf4e3a8.json"}}, {"family": "H\u00e4gg", "given": "David", "initials": "D", "orcid": "0000-0002-2610-5033", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cc4f13f046ee49f39b92677eaaa41e79.json"}}, {"family": "Gini", "given": "Rosa", "initials": "R", "orcid": "0000-0002-6250-877X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/10b66693cdc04e80ac5450f2e63a6d92.json"}}, {"family": "Paoletti", "given": "Olga", "initials": "O"}, {"family": "Poblador-Plou", "given": "Beatriz", "initials": "B"}, {"family": "Jordan", "given": "Sue", "initials": "S"}, {"family": "Thayer", "given": "Daniel", "initials": "D"}, {"family": "Rodr\u00edguez-Bernal", "given": "Clara L", "initials": "CL", "orcid": "0000-0003-2617-8635", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/812191eadd56405789ddb971577c4d6e.json"}}, {"family": "S\u00e1nchez-S\u00e1ez", "given": "Francisco", "initials": "F"}, {"family": "Lassalle", "given": "R\u00e9gis", "initials": "R"}, {"family": "Bernard", "given": "Marie-Agn\u00e8s", "initials": "MA"}, {"family": "Alsina", "given": "Ema", "initials": "E"}, {"family": "Ahmadizar", "given": "Fariba", "initials": "F"}, {"family": "Favre", "given": "Guillaume", "initials": "G", "orcid": "0000-0001-6181-3126", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/43764a2eb9544b559c88b0ab425bb9ad.json"}}, {"family": "Panchaud", "given": "Alice", "initials": "A", "orcid": "0000-0001-6086-2401", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/abd99a5f06aa401a86e0c14de367c914.json"}}, {"family": "Bloemenkamp", "given": "Kitty W M", "initials": "KWM", "orcid": "0000-0002-1377-4625", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9d38c9f319f442be810979223a78883c.json"}}, {"family": "Plueschke", "given": "Kelly", "initials": "K"}, {"family": "de Vries", "given": "Corinne", "initials": "C"}, {"family": "Siiskonen", "given": "Satu J", "initials": "SJ", "orcid": "0000-0003-3095-9530", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/effb583f45be406190adc4db3d0ee036.json"}}, {"family": "Sturkenboom", "given": "Miriam C J M", "initials": "MCJM", "orcid": "0000-0003-1360-2388", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4ac7233f5331454b9215810cbc940939.json"}}, {"family": "CONSIGN Collaboration Group", "given": "", "initials": ""}], "type": "journal article", "published": "2026-01-00", "journal": {"title": "Pharmacoepidemiol Drug Saf", "issn": "1099-1557", "volume": "35", "issue": "1", "pages": "e70303", "issn-l": null}, "abstract": "To estimate the prevalence of medication use in nonhospitalized pregnant women with COVID-19.\n\nA prospective two-stage individual patient meta-analysis across 10 data sources in Europe and North America studied medication use among nonhospitalized pregnant women with COVID-19 between January 2020 and December 2022. Comparisons were made between medication use within 30 days pre- and post-COVID-19 diagnosis in this cohort and two comparator groups: pregnant women without COVID-19 and nonpregnant women with COVID-19. Prevalence estimates were pooled using a random-effects model stratified by trimester.\n\n50 335 nonhospitalized pregnant women with COVID-19 were identified. The pooled prevalence of antibacterial use in the third trimester was higher post-COVID-19 diagnosis (6.8%, 95% confidence interval [CI] = 5.5-8.4, I2 = 94%) compared with the same women pre-COVID-19 (3.9%, 95% CI = 3.1-4.9, I2 = 89%). Overall, pregnant women with COVID-19 had higher medication use compared to pregnant women without COVID-19, although the CIs of the prevalence overlapped. Post-COVID-19, antithrombotic prevalence was 4.5% (95% CI = 1.1-16.5, I2 = 100%) among pregnant women with COVID-19 in the third trimester, compared to 2.1% (95% CI = 1.2-3.6, I2 = 99%) among those without COVID-19 in the third trimester. Compared to nonpregnant women with COVID-19, pregnant women with COVID-19 were less likely to be prescribed analgesics, antiprotozoals, corticosteroids, psychoanaleptics and psycholeptics, and more likely to be prescribed antithrombotics, cough and cold and nasal preparations, and drugs used in diabetes across all trimesters. High heterogeneity existed in nearly all analyses.\n\nThis international meta-analysis reveals low medication use and country-specific variations, enhancing insight into the management of COVID-19 in nonhospitalized pregnant women. Higher antithrombotic use post-COVID-19 suggests prophylactic treatment in this population, but variation between countries emphasizes the challenges of combining multinational data.", "doi": "10.1002/pds.70303", "pmid": "41449787", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12741507"}], "notes": [], "created": "2026-09-23T15:58:48.095Z", "modified": "2026-09-23T15:58:48.684Z"}]}