{"entity": "researcher", "timestamp": "2026-08-20T20:43:20.010Z", "family": "Hadizadeh", "given": "Fatemeh", "initials": "F", "orcid": "0000-0002-9855-7610", "affiliations": ["Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/8d0b9d82968f456798ee9dd0b1dfa7d9.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/8d0b9d82968f456798ee9dd0b1dfa7d9"}}, "publications": [{"entity": "publication", "iuid": "ed511d19a3f441d1a367517382c34730", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ed511d19a3f441d1a367517382c34730.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ed511d19a3f441d1a367517382c34730"}}, "title": "Breast cancer risk during oral contraceptive use in women with high polygenic risk.", "authors": [{"family": "Chatsatourian", "given": "Christina", "initials": "C"}, {"family": "Lo Faro", "given": "Valeria", "initials": "V", "orcid": "0000-0003-4931-7327", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a3ed8bac701d4dcd9551e4cdfdfba5d7.json"}}, {"family": "Karlsson", "given": "Torgny", "initials": "T", "orcid": "0000-0001-8095-6149", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c8b2bb8ecf4545ad946ae2203c870282.json"}}, {"family": "Hadizadeh", "given": "Fatemeh", "initials": "F", "orcid": "0000-0002-9855-7610", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8d0b9d82968f456798ee9dd0b1dfa7d9.json"}}, {"family": "Johansson", "given": "\u00c5sa", "initials": "\u00c5", "orcid": "0000-0002-2915-4498", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a0bac3e1e64949fcbac4b4d839e1144d.json"}}], "type": "journal article", "published": "2025-12-01", "journal": {"title": "Breast Cancer Res.", "issn": "1465-542X", "volume": "27", "issue": "1", "pages": "215", "issn-l": "1465-5411"}, "abstract": "BACKGROUND: Oral contraceptive (OC) use is widespread globally. Despite their significant benefits, concerns persist about a potential rise in breast cancer risk linked to their use. Genetic predisposition also influences breast cancer risk; however, its interaction with OC use remains inconclusive. This study aims to explore the association between OC use and breast cancer risk in women with varying genetic predispositions to breast cancer, as measured by polygenic risk scores (PRS). METHOD: A total of 257,185 white female participants from the UK Biobank were included. Time-varying Cox regression was used to estimate hazard ratios (HRs) with 95% confidence intervals (CIs) to examine the association between OC and invasive breast cancer events, stratified by PRS. Age was used as the primary time scale, and analyses were adjusted for year of birth, Townsend Deprivation Index, body mass index, smoking status, age at menarche, menopausal status, family history of breast cancer, parity, hormone replacement therapy use, history of hysterectomy, as well as genetic principal components. RESULTS: Current use of OC was associated with an increased risk of breast cancer, with a HR of 1.21 (95% CI: 1.03\u20131.41). In contrast, previous use showed no association (HR = 0.99, 95% CI: 0.92\u20131.05). Genetic risk, as measured by the PRS, was strongly associated with breast cancer risk (P < 0.001). Individuals in the highest PRS decile had approximately three times higher risk compared to those in the mid deciles. Importantly, for the association between current OC use and breast cancer risk, a statistically significant trend was observed across both PRS deciles (P = 0.04) and tertiles (P = 0.05), with decreasing HRs as genetic risk increased. Specifically, the HR for current OC use was 1.43 (95% CI: 1.02\u20132.01) in the lowest PRS tertile, 1.14 (95% CI: 0.89\u20131.45) in the middle tertile, and 0.96 (95% CI: 0.80\u20131.14) in the highest tertile. CONCLUSION: Both OC use and a high PRS increase the risk of breast cancer. There is a trend toward a decreased relative risk associated with OC use among those with higher genetic predisposition. Therefore, there is no evidence to suggest that women with a high genetic risk for breast cancer are more adversely affected by OC use.", "doi": "10.1186/s13058-025-02177-5", "pmid": "41327462", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12690897"}, {"db": "pii", "key": "10.1186/s13058-025-02177-5"}], "notes": [], "created": "2026-08-20T12:21:32.258Z", "modified": "2026-08-20T12:21:32.337Z"}, {"entity": "publication", "iuid": "d81ca7a5afc947f893085bcf904db3c3", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/d81ca7a5afc947f893085bcf904db3c3.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/d81ca7a5afc947f893085bcf904db3c3"}}, "title": "Time-resolved Mendelian randomization detects substantial variation in the detrimental effect of obesity throughout life.", "authors": [{"family": "Karlsson", "given": "Torgny", "initials": "T", "orcid": "0000-0001-8095-6149", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c8b2bb8ecf4545ad946ae2203c870282.json"}}, {"family": "Hadizadeh", "given": "Fatemeh", "initials": "F", "orcid": "0000-0002-9855-7610", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8d0b9d82968f456798ee9dd0b1dfa7d9.json"}}, {"family": "Rask-Andersen", "given": "Mathias", "initials": "M", "orcid": "0000-0002-8008-4659", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f4efeec022fc40828f71781ecad2df00.json"}}, {"family": "Schmitz", "given": "Daniel", "initials": "D", "orcid": "0000-0003-4480-891X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/30e1b982f81a4c11ba59043beab3e4df.json"}}, {"family": "Johansson", "given": "\u00c5sa", "initials": "\u00c5", "orcid": "0000-0002-2915-4498", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a0bac3e1e64949fcbac4b4d839e1144d.json"}}], "type": "journal article", "published": "2025-10-24", "journal": {"title": "Sci Adv", "issn": "2375-2548", "volume": "11", "issue": "43", "pages": "eadv0926", "issn-l": "2375-2548"}, "abstract": "The global burden of disease attributable to obesity continues to rise. The disease incidence is substantially higher in elderly populations, but how obesity affects disease risk across a lifetime is largely unknown. To quantify the long-term temporal impact of obesity, access to large-scale longitudinal cohorts spanning many decades would typically be required. However, these longitudinal studies are rare and may be heavily biased by the presence of unaccountable confounding. Here, we develop a method-time-resolved Mendelian randomization-to estimate the cumulative effect of body mass index on disease risk at different ages. Using the UK Biobank, we find strong age-varying patterns for type 2 diabetes mellitus, coronary artery disease, and atrial fibrillation, as well as for osteoarthritis. We demonstrate that some of the most notable temporal characteristics are sex specific, while other features are shared between sexes. Analyses suggest that these features can be manifestations of primary prevention strategies.", "doi": "10.1126/sciadv.adv0926", "pmid": "41134883", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12551696"}], "notes": [], "created": "2026-08-20T11:59:07.462Z", "modified": "2026-08-20T11:59:07.682Z"}, {"entity": "publication", "iuid": "6b8afd3a9f3a494cbeaf99132631b8b3", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/6b8afd3a9f3a494cbeaf99132631b8b3.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/6b8afd3a9f3a494cbeaf99132631b8b3"}}, "title": "Effects of oral contraceptives and menopausal hormone therapy on the risk of rheumatoid arthritis: a prospective cohort study.", "authors": [{"family": "Hadizadeh", "given": "Fatemeh", "initials": "F", "orcid": "0000-0002-9855-7610", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8d0b9d82968f456798ee9dd0b1dfa7d9.json"}}, {"family": "Johansson", "given": "Therese", "initials": "T"}, {"family": "Johansson", "given": "\u00c5sa", "initials": "\u00c5", "orcid": "0000-0002-2915-4498", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a0bac3e1e64949fcbac4b4d839e1144d.json"}}, {"family": "Karlsson", "given": "Torgny", "initials": "T", "orcid": "0000-0001-8095-6149", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c8b2bb8ecf4545ad946ae2203c870282.json"}}, {"family": "Ek", "given": "Weronica E", "initials": "WE"}], "type": "journal article", "published": "2024-08-01", "journal": {"title": "Rheumatology (Oxford)", "issn": "1462-0332", "volume": "63", "issue": "8", "pages": "2101-2108", "issn-l": "1462-0324"}, "abstract": "Oral contraceptives (OC) and menopausal hormone therapy (MHT) contain exogenous sex hormones and are used by millions of women around the world. However, their effect on the development of rheumatoid arthritis (RA) is still debated and the current literature suggests that they may exert opposite effects on the risk of RA. The present study aimed to estimate the effects of exogenous hormones on the development of RA, both during the reproductive lifespan and later in life.\n\nThe association between OC and RA, as well as between MHT and late-onset RA (LORA), was investigated using time-dependent Cox regression modelling in white British women from the UK Biobank (n = 236 602 and n = 102 466, respectively) and replicated in women from all ethnic groups.\n\nOC use was associated with a decreased risk of RA in ever-users [hazard ratio (HR) = 0.89; 95% CI = 0.82-0.96], as well as in current (HR = 0.81; 0.73-0.91) and former users (HR = 0.92; 0.84 -1.00), compared with never-users. In contrast, MHT use was associated with an increased risk of LORA in ever-users (HR = 1.16; 1.06-1.26) as well as in former users (HR = 1.13; 1.03-1.24) compared with never-users.\n\nOC use appears to protect against RA, while MHT may increase the risk of LORA. This study provides new insights into the possible inverse effect of exposure to different exogenous sex hormones on the risk of RA.", "doi": "10.1093/rheumatology/kead513", "pmid": "37773999", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11292047"}, {"db": "pii", "key": "7286437"}], "notes": [], "created": "2026-08-20T09:51:44.110Z", "modified": "2026-08-20T09:51:44.224Z"}, {"entity": "publication", "iuid": "640c7c9b41264e4592e88f52f9e5ef26", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/640c7c9b41264e4592e88f52f9e5ef26.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/640c7c9b41264e4592e88f52f9e5ef26"}}, "title": "Using genotyping and whole-exome sequencing data to improve genetic risk prediction in deep venous thrombosis", "authors": [{"family": "Lo Faro", "given": "Valeria", "initials": "V", "orcid": "0000-0003-4931-7327", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a3ed8bac701d4dcd9551e4cdfdfba5d7.json"}}, {"family": "Johansson", "given": "Therese", "initials": "T", "orcid": "0000-0003-1043-7065", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d4005242bc4c45f6a0899226560837f8.json"}}, {"family": "H\u00f6glund", "given": "Julia", "initials": "J", "orcid": "0000-0001-8061-3947", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bca098a65a67444899762a18f654f447.json"}}, {"family": "Hadizadeh", "given": "Fatemeh", "initials": "F", "orcid": "0000-0002-9855-7610", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8d0b9d82968f456798ee9dd0b1dfa7d9.json"}}, {"family": "Johansson", "given": "\u00c5sa", "initials": "\u00c5", "orcid": "0000-0002-2915-4498", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a0bac3e1e64949fcbac4b4d839e1144d.json"}}], "type": "posted-content", "published": "2022-04-27", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2022.04.24.22274229", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:11:00.559Z", "modified": "2026-08-20T10:11:00.678Z"}]}