{"entity": "researcher", "timestamp": "2026-09-26T23:58:08.499Z", "family": "Vermonden", "given": "Tina", "initials": "T", "orcid": "0000-0002-6047-5900", "affiliations": ["Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Science for Life, Utrecht University, Universiteitsweg 99, 3508 TB, Utrecht, The Netherlands."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/8cbf6d1567214a2ca80e241437a27601.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/8cbf6d1567214a2ca80e241437a27601"}}, "publications": [{"entity": "publication", "iuid": "00a3187289bc4277a6605b4bde8c1c2c", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/00a3187289bc4277a6605b4bde8c1c2c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/00a3187289bc4277a6605b4bde8c1c2c"}}, "title": "LCST polymers with UCST behavior.", "authors": [{"family": "Najafi", "given": "Marzieh", "initials": "M"}, {"family": "Habibi", "given": "Mehdi", "initials": "M", "orcid": "0000-0003-4672-0516", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d84a99fec3cf440087a10bd9919b4af3.json"}}, {"family": "Fokkink", "given": "Remco", "initials": "R"}, {"family": "Hennink", "given": "Wim E", "initials": "WE", "orcid": "0000-0002-5750-714X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1c0571fba35d4f9e855e155d502763d5.json"}}, {"family": "Vermonden", "given": "Tina", "initials": "T", "orcid": "0000-0002-6047-5900", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8cbf6d1567214a2ca80e241437a27601.json"}}], "type": "journal article", "published": "2021-03-04", "journal": {"title": "Soft Matter", "issn": "1744-6848", "volume": "17", "issue": "8", "pages": "2132-2141", "issn-l": null}, "abstract": "In this study, temperature dependent behavior of dense dispersions of core crosslinked flower-like micelles is investigated. Micelles were prepared by mixing aqueous solutions of two ABA block copolymers with PEG B-blocks and thermosensitive A-blocks containing PNIPAM and crosslinkable moieties. At a temperature above the lower critical solution temperature (LCST), self-assembly of the polymers resulted in the formation of flower-like micelles with a hydrophilic PEG shell and a hydrophobic core. The micellar core was stabilized by native chemical ligation (NCL). Above the LCST, micelles displayed a radius of \u223c35 nm, while a radius of \u223c48 nm was found below the LCST due to hydration of the PNIPAM core. Concentrated dispersions of these micelles (\u22657.5 wt%) showed glassy state behavior below a critical temperature (Tc: 28 \u00b0C) which is close to the LCST of the polymers. Below this Tc, the increase in the micelle volume resulted in compression of micelles together above a certain concentration and formation of a glass. We quantified and compared micelle packing at different concentrations and temperatures. The storage moduli (G') of the dispersions showed a universal dependence on the effective volume fraction, which increased substantially above a certain effective volume fraction of \u03c6 = 1.2. Furthermore, a disordered lattice model describing this behavior fitted the experimental data and revealed a critical volume fraction of \u03c6c = 1.31 close to the experimental value of \u03c6 = 1.2. The findings reported provide insights for the molecular design of novel thermosensitive PNIPAM nanoparticles with tunable structural and mechanical properties.", "doi": "10.1039/d0sm01505a", "pmid": "33439188", "labels": [], "xrefs": [], "notes": [], "created": "2026-09-23T09:46:32.753Z", "modified": "2026-09-23T10:20:43.036Z"}, {"entity": "publication", "iuid": "3969b0fc459e47e58e83c93814ffc0de", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/3969b0fc459e47e58e83c93814ffc0de.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/3969b0fc459e47e58e83c93814ffc0de"}}, "title": "Rapid and cytocompatible cell-laden silk hydrogel formation via riboflavin-mediated crosslinking.", "authors": [{"family": "Piluso", "given": "Susanna", "initials": "S", "orcid": "0000-0003-0508-711X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2eef7cc933bc437f9bbfc8a5eb548fb8.json"}}, {"family": "Flores Gomez", "given": "Daniela", "initials": "D"}, {"family": "Dokter", "given": "Inge", "initials": "I"}, {"family": "Moreira Texeira", "given": "Liliana", "initials": "L"}, {"family": "Li", "given": "Yang", "initials": "Y"}, {"family": "Leijten", "given": "Jeroen", "initials": "J"}, {"family": "van Weeren", "given": "Ren\u00e9", "initials": "R"}, {"family": "Vermonden", "given": "Tina", "initials": "T", "orcid": "0000-0002-6047-5900", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8cbf6d1567214a2ca80e241437a27601.json"}}, {"family": "Karperien", "given": "Marcel", "initials": "M"}, {"family": "Malda", "given": "Jos", "initials": "J"}], "type": "journal article", "published": "2020-10-28", "journal": {"title": "J Mater Chem B", "issn": "2050-7518", "volume": "8", "issue": "41", "pages": "9566-9575", "issn-l": null}, "abstract": "Bioactive hydrogels based on naturally-derived polymers are of great interest for regenerative medicine applications. Among naturally-derived polymers, silk fibroin has been extensively explored as a biomaterial for tissue engineering due to its unique mechanical properties. Here, we demonstrate the rapid gelation of cell-laden silk fibroin hydrogels by visible light-induced crosslinking using riboflavin as a photo-initiator, in presence of an electron acceptor. The gelation kinetics were monitored by in situ photo-rheometry. Gelation was achieved in minutes and could be tuned owing to its direct proportionality to the electron acceptor concentration. The concentration of the electron acceptor did not affect the elastic modulus of the hydrogels, which could be altered by varying the polymer content. Further, the biocompatible riboflavin photo-initiator combined with sodium persulfate allowed for the encapsulation of cells within silk fibroin hydrogels. To confirm the cytocompatibility of the silk fibroin formulations, three cell types (articular cartilage-derived progenitor cells, mesenchymal stem cells and dental-pulp-derived stem cells) were encapsulated within the hydrogels, which associated with a viability >80% for all cell types. These results demonstrated that fast gelation of silk fibroin can be achieved by combining it with riboflavin and electron acceptors, which results in a hydrogel that can be used in tissue engineering and cell delivery applications.", "doi": "10.1039/d0tb01731k", "pmid": "33001117", "labels": [], "xrefs": [], "notes": [], "created": "2026-09-23T08:30:18.851Z", "modified": "2026-09-23T08:30:19.025Z"}]}