{"entity": "researcher", "timestamp": "2026-08-20T21:19:57.177Z", "family": "Chivers", "given": "Phillip R A", "initials": "PRA", "orcid": "0000-0001-9966-2669", "affiliations": ["Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, 171 77, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/8b32e150ef704231b3e94725fb32acd2.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/8b32e150ef704231b3e94725fb32acd2"}}, "publications": [{"entity": "publication", "iuid": "993232a1e9454cecaa1fb94ab18b0073", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/993232a1e9454cecaa1fb94ab18b0073.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/993232a1e9454cecaa1fb94ab18b0073"}}, "title": "Tailored Biocompatible Polyurethane-Poly(ethylene glycol) Hydrogels as a Versatile Nonfouling Biomaterial.", "authors": [{"family": "Speidel", "given": "Alessondra T", "initials": "AT", "orcid": "0000-0002-2576-2015", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a20aeac321eb4c3ba0f749f636e7cad5.json"}}, {"family": "Chivers", "given": "Phillip R A", "initials": "PRA", "orcid": "0000-0001-9966-2669", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8b32e150ef704231b3e94725fb32acd2.json"}}, {"family": "Wood", "given": "Christopher S", "initials": "CS"}, {"family": "Roberts", "given": "Derrick A", "initials": "DA", "orcid": "0000-0002-4663-7475", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/10927315f8fa412da08f23523766f122.json"}}, {"family": "Correia", "given": "In\u00eas P", "initials": "IP", "orcid": "0000-0003-4424-5563", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e50a91523cdb45ee8e58cbc9e5d4e38f.json"}}, {"family": "Caravaca", "given": "April S", "initials": "AS", "orcid": "0000-0001-6921-8700", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/65637d0352f74e03b8187153801e60bd.json"}}, {"family": "Chan", "given": "Yu Kiu Victor", "initials": "YKV"}, {"family": "Hansel", "given": "Catherine S", "initials": "CS", "orcid": "0000-0002-2525-1856", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1ef344d052404906b81ed716a295fd7d.json"}}, {"family": "Heimg\u00e4rtner", "given": "Johannes", "initials": "J", "orcid": "0000-0003-0059-9888", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4ec13a513f5840648bde7466a1dba06a.json"}}, {"family": "M\u00fcller", "given": "Eliane", "initials": "E"}, {"family": "Ziesmer", "given": "Jill", "initials": "J", "orcid": "0000-0002-0294-0114", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ef5df63881704fd89ebbdf40a2506db6.json"}}, {"family": "Sotiriou", "given": "Georgios A", "initials": "GA", "orcid": "0000-0001-5040-620X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f4b529432ad344308c9529badf192efd.json"}}, {"family": "Olofsson", "given": "Peder S", "initials": "PS", "orcid": "0000-0003-3473-5948", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/73d56afd13ab429e83548b20601823b7.json"}}, {"family": "Stevens", "given": "Molly M", "initials": "MM", "orcid": "0000-0002-1146-7090", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5532560b18a24056b91667f18c40face.json"}}], "type": "journal article", "published": "2022-11-00", "journal": {"title": "Adv Healthc Mater", "issn": "2192-2659", "volume": "11", "issue": "21", "pages": "e2201378", "issn-l": null}, "abstract": "Polyurethane-based hydrogels are relatively inexpensive and mechanically robust biomaterials with ideal properties for various applications, including drug delivery, prosthetics, implant coatings, soft robotics, and tissue engineering. In this report, a simple method is presented for synthesizing and casting biocompatible polyurethane-poly(ethylene glycol) (PU-PEG) hydrogels with tunable mechanical properties, nonfouling characteristics, and sustained tolerability as an implantable material or coating. The hydrogels are synthesized via a simple one-pot method using commercially available precursors and low toxicity solvents and reagents, yielding a consistent and biocompatible gel platform primed for long-term biomaterial applications. The mechanical and physical properties of the gels are easily controlled by varying the curing concentration, producing networks with complex shear moduli of 0.82-190 kPa, similar to a range of human soft tissues. When evaluated against a mechanically matched poly(dimethylsiloxane) (PDMS) formulation, the PU-PEG hydrogels demonstrated favorable nonfouling characteristics, including comparable adsorption of plasma proteins (albumin and fibrinogen) and significantly reduced cellular adhesion. Moreover, preliminary murine implant studies reveal a mild foreign body response after 41 days. Due to the tunable mechanical properties, excellent biocompatibility, and sustained in vivo tolerability of these hydrogels, it is proposed that this method offers a simplified platform for fabricating soft PU-based biomaterials for a variety of applications.", "doi": "10.1002/adhm.202201378", "pmid": "35981326", "labels": [], "xrefs": [{"db": "mid", "key": "EMS156636"}, {"db": "pmc", "key": "PMC7615486"}], "notes": [], "created": "2026-08-20T06:27:51.749Z", "modified": "2026-08-20T06:27:52.215Z"}]}