{"entity": "researcher", "timestamp": "2026-08-20T20:57:48.265Z", "family": "Han", "given": "Yi", "initials": "Y", "orcid": "0000-0001-7605-8979", "affiliations": ["Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/89c55c3679f54fd290f5dbfec2d745a4.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/89c55c3679f54fd290f5dbfec2d745a4"}}, "publications": [{"entity": "publication", "iuid": "3d4b597954a24919a6db9e22504ea7dd", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/3d4b597954a24919a6db9e22504ea7dd.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/3d4b597954a24919a6db9e22504ea7dd"}}, "title": "Single cell long read whole genome sequencing reveals somatic transposon activity in human brain.", "authors": [{"family": "Izydorczyk", "given": "Michal B", "initials": "MB", "orcid": "0000-0003-3461-1224", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ee36660501274e7b875147dea0722222.json"}}, {"family": "Kalef-Ezra", "given": "Ester", "initials": "E", "orcid": "0000-0002-1297-3315", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6a779ab7230a48dfa8207eddcf5a71be.json"}}, {"family": "Horner", "given": "Dominic W", "initials": "DW", "orcid": "0009-0002-1988-3838", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/121678b4750f4f75adb6b8addca949fa.json"}}, {"family": "Zheng", "given": "Xinchang", "initials": "X", "orcid": "0000-0001-5739-861X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c3c6c28330874468a66a6c4204c1fb35.json"}}, {"family": "Holmes", "given": "Nadine", "initials": "N", "orcid": "0000-0001-7470-3786", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4cd0ffa784b743f5abf231190919670c.json"}}, {"family": "Toffoli", "given": "Marco", "initials": "M", "orcid": "0000-0002-3255-9648", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e56796fc43134df0b7367daec79fe36f.json"}}, {"family": "Sahin", "given": "Zeliha Gozde", "initials": "ZG", "orcid": "0000-0001-8312-7725", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9ac2e42ddaf2492098c3469377c3a867.json"}}, {"family": "Han", "given": "Yi", "initials": "Y", "orcid": "0000-0001-7605-8979", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/89c55c3679f54fd290f5dbfec2d745a4.json"}}, {"family": "Mehta", "given": "Heer H", "initials": "HH", "orcid": "0000-0002-5357-2112", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4e5f50686efe4878b0a87fbfc7ccd23e.json"}}, {"family": "Muzny", "given": "Donna M", "initials": "DM", "orcid": "0000-0002-3055-0359", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3712b56ad8fb4c6497db57bd37063933.json"}}, {"family": "Ameur", "given": "Adam", "initials": "A", "orcid": "0000-0001-6085-6749", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a8b8ce05cf7f49aeb3199b5938b9f160.json"}}, {"family": "Sedlazeck", "given": "Fritz J", "initials": "FJ", "orcid": "0000-0001-6040-2691", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bc75e97f5c124c1ead6517762e084821.json"}}, {"family": "Proukakis", "given": "Christos", "initials": "C", "orcid": "0000-0001-6423-6539", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ef57132ea4214d91b00b44e316a18e05.json"}}], "type": "journal article", "published": "2024-11-11", "journal": {"title": "medRxiv", "issn-l": null}, "abstract": "The advent of single cell DNA sequencing revealed astonishing dynamics of genomic variability, but failed at characterizing smaller to mid size variants that on the germline level have a profound impact. In this work we discover novel dynamics in three brains utilizing single cell long-read sequencing. This provides key insights into the dynamic of the genomes of individual cells and further highlights brain specific activity of transposable elements.", "doi": "10.1101/2024.11.11.24317113", "pmid": "39606404", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11601780"}, {"db": "pii", "key": "2024.11.11.24317113"}], "notes": [], "created": "2026-08-20T10:59:12.995Z", "modified": "2026-08-20T10:59:13.483Z"}]}