{"entity": "researcher", "timestamp": "2026-09-06T14:34:58.980Z", "family": "Williams", "given": "Cecilia", "initials": "C", "orcid": "0000-0002-0602-2062", "affiliations": ["Department of Biosciences and Nutrition, Karolinska Institute, Stockholm, Sweden.", "Department of Protein Science, KTH Royal Institute of Technology, Science for Life Laboratory, Solna, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/872c978997c74e89ae75efd90d592b42.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/872c978997c74e89ae75efd90d592b42"}}, "publications": [{"entity": "publication", "iuid": "d0e6a278cc86431f96831c9ff0365e4b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/d0e6a278cc86431f96831c9ff0365e4b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/d0e6a278cc86431f96831c9ff0365e4b"}}, "title": "YCharOS protocol for antibody validation.", "authors": [{"family": "Monteiro", "given": "F\u00e1tima L", "initials": "FL"}, {"family": "Voskuil", "given": "Jan L A", "initials": "JLA", "orcid": "0000-0003-0799-0548", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a0003cf176da4ba58c145e6d5cb6d19a.json"}}, {"family": "Williams", "given": "Cecilia", "initials": "C", "orcid": "0000-0002-0602-2062", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/872c978997c74e89ae75efd90d592b42.json"}}], "type": "journal article", "published": "2025-06-00", "journal": {"title": "Nat Protoc", "issn": "1750-2799", "volume": "20", "issue": "6", "pages": "1389-1390", "issn-l": null}, "abstract": null, "doi": "10.1038/s41596-024-01108-6", "pmid": "39690207", "labels": [], "xrefs": [{"db": "pii", "key": "10.1038/s41596-024-01108-6"}], "notes": [], "created": "2026-08-20T09:04:03.274Z", "modified": "2026-08-20T09:04:03.400Z"}, {"entity": "publication", "iuid": "278526fecb314b238660d6b572890816", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/278526fecb314b238660d6b572890816.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/278526fecb314b238660d6b572890816"}}, "title": "Estrogen receptor activation remodelsTEAD1gene expression to alleviate nonalcoholic fatty liver disease", "authors": [{"family": "Sommerauer", "given": "Christian", "initials": "C", "orcid": "0000-0001-7132-7172", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1fdc4a7e8f774940b9982c40ead59c30.json"}}, {"family": "Gallardo-Dodd", "given": "Carlos J", "initials": "CJ", "orcid": "0000-0002-6086-0550", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5443c47c986d419c9210bef02afb49f3.json"}}, {"family": "Savva", "given": "Christina", "initials": "C", "orcid": "0000-0002-8019-1104", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/362b35529bd04532b8de35647f8a6ea2.json"}}, {"family": "Hases", "given": "Linnea", "initials": "L", "orcid": "0000-0001-6741-7204", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/26eed4147e0c4b36873b7aec8aa7e2f7.json"}}, {"family": "Birgersson", "given": "Madeleine", "initials": "M"}, {"family": "Indukuri", "given": "Rajitha", "initials": "R", "orcid": "0000-0001-6570-842X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5e347b901b624b45a9a24a609c1b2aea.json"}}, {"family": "Shen", "given": "Joanne X", "initials": "JX", "orcid": "0009-0008-0322-5615", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5f20c24c767544028a6d3f6de972dd95.json"}}, {"family": "Carravilla", "given": "Pablo", "initials": "P", "orcid": "0000-0001-6592-7630", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/efe34d3b01fe49a0af258f71281a4e82.json"}}, {"family": "Geng", "given": "Keyi", "initials": "K", "orcid": "0000-0003-0892-7460", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a56ac387ab324409b2c0dc24b9be5d73.json"}}, {"family": "N\u00f8rskov S\u00f8ndergaard", "given": "Jonas", "initials": "J", "orcid": "0000-0002-4438-6756", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/85be14546c6e4c28a3171880521ed29c.json"}}, {"family": "Ferrer-Aumatell", "given": "Cl\u00e0udia", "initials": "C", "orcid": "0009-0008-9828-6209", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3859df23cb3946e7872f97a340f810ac.json"}}, {"family": "Mercier", "given": "Gr\u00e9goire", "initials": "G", "orcid": "0009-0002-9966-9910", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/27451810167641f39b468314926df6f7.json"}}, {"family": "Sezgin", "given": "Erdinc", "initials": "E", "orcid": "0000-0002-4915-388X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f7bd3619c7fd48318bc4c1e7a9910df8.json"}}, {"family": "Korach-Andr\u00e9", "given": "Marion", "initials": "M", "orcid": "0000-0003-3292-9124", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8ade738ae02d493b869fd9543d1b3065.json"}}, {"family": "Petersson", "given": "Carl", "initials": "C"}, {"family": "Hagstr\u00f6m", "given": "Hannes", "initials": "H", "orcid": "0000-0002-8474-1759", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0b05e4e602654a5fa81f1479e53c0237.json"}}, {"family": "Lauschke", "given": "Volker M", "initials": "VM", "orcid": "0000-0002-1140-6204", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/82048d4da61547d08aa9d2bb3bae12dd.json"}}, {"family": "Archer", "given": "Amena", "initials": "A", "orcid": "0000-0002-0400-4151", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4a3047fb2c2a4995a68babe1204dfe44.json"}}, {"family": "Williams", "given": "Cecilia", "initials": "C", "orcid": "0000-0002-0602-2062", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/872c978997c74e89ae75efd90d592b42.json"}}, {"family": "Kutter", "given": "Claudia", "initials": "C", "orcid": "0000-0002-8047-0058", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a4c9dcde56304ab2a99bb1032e4ce834.json"}}], "type": "posted-content", "published": "2023-09-08", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2023.09.07.556687", "pmid": null, "labels": {"Claudia Kutter": null, "SciLifeLab Fellow": null}, "xrefs": [], "notes": [], "created": "2023-11-21T20:25:27.235Z", "modified": "2023-11-21T20:29:26.819Z"}, {"entity": "publication", "iuid": "b7bede86645a4c3faefaee73a03bf35b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b7bede86645a4c3faefaee73a03bf35b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b7bede86645a4c3faefaee73a03bf35b"}}, "title": "ER\u03b2 in Granulosa Cell Tumors and Its Clinical Potential.", "authors": [{"family": "Birgersson", "given": "Madeleine", "initials": "M"}, {"family": "Indukuri", "given": "Rajitha", "initials": "R"}, {"family": "Antonson", "given": "Per", "initials": "P"}, {"family": "Nalvarte", "given": "Ivan", "initials": "I"}, {"family": "Archer", "given": "Amena", "initials": "A"}, {"family": "Williams", "given": "Cecilia", "initials": "C", "orcid": "0000-0002-0602-2062", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/872c978997c74e89ae75efd90d592b42.json"}}], "type": "review", "published": "2023-04-17", "journal": {"title": "Endocrinology", "issn": "1945-7170", "volume": "164", "issue": "6", "issn-l": "0013-7227"}, "abstract": "Granulosa cell tumors (GCTs) are rare ovarian tumors comprising an adult and a juvenile subtype. They have a generally good prognosis, but the survival rate drastically declines in patients with late-stage or recurring tumors. Due to the rarity of GCTs, the tumor type is largely understudied and lacks a specific treatment strategy. Estrogen receptor beta (ER\u03b2/ESR2) has been found to be highly expressed in GCTs, which could be of therapeutic importance since it can be targeted with small molecules. However, its role in GCTs is not known. In this review, we summarize the current knowledge about the action of ER\u03b2 in the ovary and discuss its prospective role in GCTs.", "doi": "10.1210/endocr/bqad063", "pmid": "37075218", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10184458"}, {"db": "pii", "key": "7131283"}], "notes": [], "created": "2026-08-20T12:38:00.094Z", "modified": "2026-08-20T12:38:00.163Z"}, {"entity": "publication", "iuid": "0f5d8ce225074872b93a3d28783c5900", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/0f5d8ce225074872b93a3d28783c5900.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/0f5d8ce225074872b93a3d28783c5900"}}, "title": "Statistical Analysis of SARS-CoV-2 Using Wastewater-Based Data of Stockholm, Sweden.", "authors": [{"family": "Chekkala", "given": "Aashlesha", "initials": "A", "orcid": "0000-0002-3821-5352", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/307a7abda01d4a1ba4e12528e83ebbe3.json"}}, {"family": "Atasoy", "given": "Merve", "initials": "M", "orcid": "0000-0003-4046-1592", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8cdf80723fb244ee99c0b78f2df19d1c.json"}}, {"family": "Williams", "given": "Cecilia", "initials": "C", "orcid": "0000-0002-0602-2062", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/872c978997c74e89ae75efd90d592b42.json"}}, {"family": "Cetecioglu", "given": "Zeynep", "initials": "Z", "orcid": "0000-0002-8170-379X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7cd2bf37c08b4c88a62e48130c066c61.json"}}], "type": "journal article", "published": "2023-02-26", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "20", "issue": "5", "issn-l": null}, "abstract": "An approach based on wastewater epidemiology can be used to monitor the COVID-19 pandemic by assessing the gene copy number of SARS-CoV-2 in wastewater. In the present study, we statistically analyzed such data from six inlets of three wastewater treatment plants, covering six regions of Stockholm, Sweden, collected over an approximate year period (week 16 of 2020 to week 22 of 2021). SARS-CoV-2 gene copy number and population-based biomarker PMMoV, as well as clinical data, such as the number of positive cases, intensive care unit numbers, and deaths, were analyzed statistically using correlations and principal component analysis (PCA). Despite the population differences, the PCA for the Stockholm dataset showed that the case numbers are well grouped across wastewater treatment plants. Furthermore, when considering the data from the whole of Stockholm, the wastewater characteristics (flow rate m3/day, PMMoV Ct value, and SARS-CoV gene copy number) were significantly correlated with the public health agency's report of SARS-CoV-2 infection rates (0.419 to 0.95, p-value < 0.01). However, while the PCA results showed that the case numbers for each wastewater treatment plant were well grouped concerning PC1 (37.3%) and PC2 (19.67%), the results from the correlation analysis for the individual wastewater treatment plants showed varied trends. SARS-CoV-2 fluctuations can be accurately predicted through statistical analyses of wastewater-based epidemiology, as demonstrated in this study.", "doi": "10.3390/ijerph20054181", "pmid": "36901194", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10002411"}, {"db": "pii", "key": "ijerph20054181"}], "notes": [], "created": "2026-08-20T13:41:05.384Z", "modified": "2026-08-20T13:41:05.523Z"}, {"entity": "publication", "iuid": "01390ab2ce884be48530a8af7618b4af", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/01390ab2ce884be48530a8af7618b4af.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/01390ab2ce884be48530a8af7618b4af"}}, "title": "SETD7 Expression Is Associated with Breast Cancer Survival Outcomes for Specific Molecular Subtypes: A Systematic Analysis of Publicly Available Datasets.", "authors": [{"family": "Monteiro", "given": "F\u00e1tima Liliana", "initials": "FL", "orcid": "0000-0002-8438-0332", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f6e6e222aed84d8486992b8d40e98aa5.json"}}, {"family": "Stepanauskaite", "given": "Lina", "initials": "L", "orcid": "0000-0003-4173-6009", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/742f111301f045c595480a9f3480bc04.json"}}, {"family": "Williams", "given": "Cecilia", "initials": "C", "orcid": "0000-0002-0602-2062", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/872c978997c74e89ae75efd90d592b42.json"}}, {"family": "Helguero", "given": "Luisa A", "initials": "LA", "orcid": "0000-0001-8237-2390", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/797b23be6b5942fdabdf3c7042d208ab.json"}}], "type": "journal article", "published": "2022-12-07", "journal": {"title": "Cancers (Basel)", "issn": "2072-6694", "volume": "14", "issue": "24", "issn-l": "2072-6694"}, "abstract": "SETD7 is a lysine N-methyltransferase that targets many proteins important in breast cancer (BC). However, its role and clinical significance remain unclear. Here, we used online tools and multiple public datasets to explore the predictive potential of SETD7 expression (high or low quartile) considering BC subtype, grade, stage, and therapy. We also investigated overrepresented biological processes associated with its expression using TCGA-BRCA data. SETD7 expression was highest in the Her2 (ERBB2)-enriched molecular subtype and lowest in the basal-like subtype. For the basal-like subtype specifically, higher SETD7 was consistently correlated with worse recurrence-free survival (p < 0.009). High SETD7-expressing tumours further exhibited a higher rate of ERBB2 mutation (20% vs. 5%) along with a poorer response to anti-Her2 therapy. Overall, high SETD7-expressing tumours showed higher stromal and lower immune scores. This was specifically related to higher counts of cancer-associated fibroblasts and endothelial cells, but lower B and T cell signatures, especially in the luminal A subtype. Genes significantly associated with SETD7 expression were accordingly overrepresented in immune response processes, with distinct subtype characteristics. We conclude that the prognostic value of SETD7 depends on the BC subtype and that SETD7 may be further explored as a potential treatment-predictive marker for immune checkpoint inhibitors.", "doi": "10.3390/cancers14246029", "pmid": "36551516", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9775934"}, {"db": "pii", "key": "cancers14246029"}], "notes": [], "created": "2026-08-20T13:39:58.397Z", "modified": "2026-08-20T13:39:58.547Z"}, {"entity": "publication", "iuid": "a049ee7daf044387a486f8b11b72099b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/a049ee7daf044387a486f8b11b72099b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/a049ee7daf044387a486f8b11b72099b"}}, "title": "Estrogen Receptor \u03b2 (ESR2) Transcriptome and Chromatin Binding in a Mantle Cell Lymphoma Tumor Model Reveal the Tumor-Suppressing Mechanisms of Estrogens.", "authors": [{"family": "Huang", "given": "Dan", "initials": "D"}, {"family": "Huang", "given": "Zhiqiang", "initials": "Z", "orcid": "0000-0001-5208-008X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0aa102a218c9464f9f763f1e18efb49b.json"}}, {"family": "Indukuri", "given": "Rajitha", "initials": "R", "orcid": "0000-0001-6570-842X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5e347b901b624b45a9a24a609c1b2aea.json"}}, {"family": "Bangalore Revanna", "given": "Chandrashekar", "initials": "C"}, {"family": "Berglund", "given": "Mattias", "initials": "M"}, {"family": "Guan", "given": "Jiyu", "initials": "J"}, {"family": "Yakimchuk", "given": "Konstantin", "initials": "K"}, {"family": "Damdimopoulos", "given": "Anastasios", "initials": "A"}, {"family": "Williams", "given": "Cecilia", "initials": "C", "orcid": "0000-0002-0602-2062", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/872c978997c74e89ae75efd90d592b42.json"}}, {"family": "Okret", "given": "Sam", "initials": "S", "orcid": "0000-0003-0822-1847", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f70ec786b1684947a233de45e7d00579.json"}}], "type": "journal article", "published": "2022-06-24", "journal": {"title": "Cancers (Basel)", "issn": "2072-6694", "volume": "14", "issue": "13", "issn-l": "2072-6694"}, "abstract": "Mantle cell lymphoma (MCL) is a non-Hodgkin lymphoma with one of the highest male-to-female incidence ratios. The reason for this is not clear, but epidemiological as well as experimental data have suggested a role for estrogens, particularly acting through estrogen receptor \u03b2 (ESR2). To study the ESR2 effects on MCL progression, MCL cells sensitive and resistant to the Bruton tyrosine kinase inhibitor ibrutinib were grafted to mice and treated with the ESR2-selective agonist diarylpropionitrile (DPN). The results showed that the DPN treatment of mice grafted with both ibrutinib-sensitive and -resistant MCL tumors resulted in impaired tumor progression. To identify the signaling pathways involved in the impaired tumor progression following ESR2 agonist treatment, the transcriptome and ESR2 binding to target genes were investigated by genome-wide chromatin immunoprecipitation in Granta-519 MCL tumors. DPN-regulated genes were enriched in several biological processes that included cell-cell adhesion, endothelial-mesenchymal transition, nuclear factor-kappaB signaling, vasculogenesis, lymphocyte proliferation, and apoptosis. In addition, downregulation of individual genes, such as SOX11 and MALAT1, that play a role in MCL progression was also observed. Furthermore, the data suggested an interplay between the lymphoma cells and the tumor microenvironment in response to the ESR2 agonist. In conclusion, the results clarify the mechanisms by which estrogens, via ESR2, impair MCL tumor progression and provide a possible explanation for the sex-dependent difference in incidence. Furthermore, targeting ESR2 with a selective agonist may be an additional option when considering the treatment of both ibrutinib-sensitive and -resistant MCL tumors.", "doi": "10.3390/cancers14133098", "pmid": "35804870", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9264873"}, {"db": "pii", "key": "cancers14133098"}], "notes": [], "created": "2026-08-20T13:39:54.033Z", "modified": "2026-08-20T13:39:54.187Z"}, {"entity": "publication", "iuid": "808b48c8739043f99e7ed9f1db64df21", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/808b48c8739043f99e7ed9f1db64df21.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/808b48c8739043f99e7ed9f1db64df21"}}, "title": "A Systematic Review to Define the Multi-Faceted Role of Lysine Methyltransferase SETD7 in Cancer.", "authors": [{"family": "Monteiro", "given": "F\u00e1tima Liliana", "initials": "FL", "orcid": "0000-0002-8438-0332", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f6e6e222aed84d8486992b8d40e98aa5.json"}}, {"family": "Williams", "given": "Cecilia", "initials": "C", "orcid": "0000-0002-0602-2062", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/872c978997c74e89ae75efd90d592b42.json"}}, {"family": "Helguero", "given": "Luisa A", "initials": "LA", "orcid": "0000-0001-8237-2390", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/797b23be6b5942fdabdf3c7042d208ab.json"}}], "type": "journal article", "published": "2022-03-10", "journal": {"title": "Cancers (Basel)", "issn": "2072-6694", "volume": "14", "issue": "6", "issn-l": "2072-6694"}, "abstract": "Histone-lysine N-methyltransferase SETD7 regulates a variety of cancer-related processes, in a tissue-type and signalling context-dependent manner. To date, there is no consensus regarding SETD7\u00b4s biological functions, or potential for cancer diagnostics and therapeutics. In this work, we summarised the literature on SETD7 expression and function in cancer, to identify the contexts where SETD7 expression and targeting can lead to improvements in cancer diagnosis and therapy. The most studied cancers were found to be lung and osteosarcoma followed by colorectal and breast cancers. SETD7 mRNA and/or protein expression in human cancer tissue was evaluated using public databases and/or in-house cohorts, but its prognostic significance remains inconclusive. The most studied cancer-related processes regulated by SETD7 were cell proliferation, apoptosis, epithelial-mesenchymal transition, migration and invasion with special relevance to the pRb/E2F-1 pathway. SETD7 consistently prevented epithelial to mesenchymal transition in different cancer types, and inhibition of its function appears to be associated with improved response to DNA-damaging agents in most of the analysed studies. Stabilising mutations in SETD7 target proteins prevent their methylation or promote other competing post-translational modifications that can override the SETD7 effect. This indicates that a clear discrimination of these mutations and competing signalling pathways must be considered in future functional studies.", "doi": "10.3390/cancers14061414", "pmid": "35326563", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8946661"}, {"db": "pii", "key": "cancers14061414"}], "notes": [], "created": "2026-08-20T13:39:43.786Z", "modified": "2026-08-20T13:39:43.916Z"}, {"entity": "publication", "iuid": "c29cb99b1375413998c193d65188b4dc", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/c29cb99b1375413998c193d65188b4dc.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/c29cb99b1375413998c193d65188b4dc"}}, "title": "Long-Term SARS-CoV-2 Surveillance in the Wastewater of Stockholm: What Lessons Can Be Learned from the Swedish Perspective?", "authors": [{"family": "Perez-Zabaleta", "given": "Mariel", "initials": "M"}, {"family": "Archer", "given": "Amena", "initials": "A"}, {"family": "Khatami", "given": "Kasra", "initials": "K"}, {"family": "Jafferali", "given": "Mohammed Hakim", "initials": "MH"}, {"family": "Nandy", "given": "Prachi", "initials": "P"}, {"family": "Atasoy", "given": "Merve", "initials": "M"}, {"family": "Birgersson", "given": "Madeleine", "initials": "M"}, {"family": "Williams", "given": "Cecilia", "initials": "C", "orcid": "0000-0002-0602-2062", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/872c978997c74e89ae75efd90d592b42.json"}}, {"family": "Cetecioglu", "given": "Zeynep", "initials": "Z", "orcid": "0000-0002-8170-379X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7cd2bf37c08b4c88a62e48130c066c61.json"}}], "type": "posted-content", "published": "2022-00-00", "journal": {"issn-l": null}, "abstract": null, "doi": "10.2139/ssrn.4186675", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T13:01:21.029Z", "modified": "2026-08-20T13:01:21.096Z"}, {"entity": "publication", "iuid": "c4ed885ada874ce4b3f9dbc60c99302d", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/c4ed885ada874ce4b3f9dbc60c99302d.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/c4ed885ada874ce4b3f9dbc60c99302d"}}, "title": "The Antibody Society's antibody validation webinar series.", "authors": [{"family": "Voskuil", "given": "Jan L A", "initials": "JLA", "orcid": "0000-0003-0799-0548", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a0003cf176da4ba58c145e6d5cb6d19a.json"}}, {"family": "Bandrowski", "given": "Anita", "initials": "A", "orcid": "0000-0002-5497-0243", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1e849d72ddc647b4aafdcd49f82fb885.json"}}, {"family": "Begley", "given": "C Glenn", "initials": "CG", "orcid": "0000-0003-2419-6215", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1b4ab33febaf477c86f868cbee626127.json"}}, {"family": "Bradbury", "given": "Andrew R M", "initials": "ARM", "orcid": "0000-0002-5567-8172", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7d2858eb88a64faf83ff3f9d8af0f787.json"}}, {"family": "Chalmers", "given": "Andrew D", "initials": "AD", "orcid": "0000-0003-4182-6717", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5c975985b391465e91c43d18cec734c7.json"}}, {"family": "Gomes", "given": "Aldrin V", "initials": "AV", "orcid": "0000-0002-9819-3036", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/642028a35d3f4447bf1216f74ffadf6a.json"}}, {"family": "Hardcastle", "given": "Travis", "initials": "T"}, {"family": "Lund-Johansen", "given": "Fridtjof", "initials": "F", "orcid": "0000-0002-2445-1258", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fcf92e25850e40d2b04f731c951b9cd7.json"}}, {"family": "Pl\u00fcckthun", "given": "Andreas", "initials": "A", "orcid": "0000-0003-4191-5306", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b2dcb348825441cd95919df8fa712402.json"}}, {"family": "Roncador", "given": "Giovanna", "initials": "G", "orcid": "0000-0002-9807-2875", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/81f3d302781d4bc9b8a145a54ce0d3ff.json"}}, {"family": "Solache", "given": "Alejandra", "initials": "A"}, {"family": "Taussig", "given": "Michael J", "initials": "MJ"}, {"family": "Trimmer", "given": "James S", "initials": "JS", "orcid": "0000-0002-6117-3912", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/08542c9466f14b339508b58d7f6e1674.json"}}, {"family": "Williams", "given": "Cecilia", "initials": "C", "orcid": "0000-0002-0602-2062", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/872c978997c74e89ae75efd90d592b42.json"}}, {"family": "Goodman", "given": "Simon L", "initials": "SL", "orcid": "0000-0002-3480-1346", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9d45463b61a349e2918f4069fb3adcdb.json"}}], "type": "journal article", "published": "2020-08-05", "journal": {"title": "MAbs", "issn": "1942-0870", "volume": "12", "issue": "1", "pages": "1794421", "issn-l": null}, "abstract": "In the wake of the reproducibility crisis and numerous discussions on how commercially available antibodies as research tool contribute to it, The Antibody Society developed a series of 10 webinars to address the issues involved. The webinars were delivered by speakers with both academic and commercial backgrounds. This report highlights the problems, and offers solutions to help the scientific community appropriately identify the right antibodies and to validate them for their research and development projects. Despite the various solutions proposed here, they must be applied on a case-by-case basis. Each antibody must be verified based on the content of the product sheet, and subsequently through experimentation to confirm integrity, specificity and selectivity. Verification needs to focus on the precise application and tissue/cell type for which the antibody will be used, and all verification data must be reported openly. The various approaches discussed here all have caveats, so a combination of solutions must be considered.", "doi": "10.1080/19420862.2020.1794421", "pmid": "32748696", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7531563"}], "notes": [], "created": "2026-08-20T09:37:10.240Z", "modified": "2026-08-20T09:37:10.682Z"}, {"entity": "publication", "iuid": "f6456a18a50c455281df38cda8ad502b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f6456a18a50c455281df38cda8ad502b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f6456a18a50c455281df38cda8ad502b"}}, "title": "A miR-206 regulated gene landscape enhances mammary epithelial differentiation.", "authors": [{"family": "Wang", "given": "Jun", "initials": "J"}, {"family": "Aydo\u011fdu", "given": "Eylem", "initials": "E"}, {"family": "Mukhopadhyay", "given": "Srijita", "initials": "S"}, {"family": "Helguero", "given": "Luisa A", "initials": "LA"}, {"family": "Williams", "given": "Cecilia", "initials": "C", "orcid": "0000-0002-0602-2062", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/872c978997c74e89ae75efd90d592b42.json"}}], "type": "journal article", "published": "2019-12-00", "journal": {"title": "J. Cell. Physiol.", "issn": "1097-4652", "volume": "234", "issue": "12", "pages": "22220-22233", "issn-l": "0021-9541"}, "abstract": "miR-206 is known to suppress breast cancer. However, while it is expressed in mammary stem cells, its function in such nontumor cells is not well understood. Here, we explore the role of miR-206 in undifferentiated, stem-like mammary cells using the murine mammary differentiation model HC11, genome-wide gene expression analysis, and functional assays. We describe the miR-206-regulated gene landscape and propose a network whereby miR-206 suppresses tumor development. We functionally demonstrate that miR-206 in nontumor stem-like cells induces a G1-S cell cycle arrest, and reduces colony formation and epithelial-to-mesenchymal transition markers. Finally, we show that addition of miR-206 accelerates the mammary differentiation process along with related accumulation of lipids. We conclude that miR-206 impacts a network of signaling pathways, and acts as a regulator of proliferation, stemness, and mammary cell differentiation in nontumor stem-like mammary cells. Our study provides a broad insight into the breast cancer suppressive functions of miR-206.", "doi": "10.1002/jcp.28789", "pmid": "31069797", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6767383"}], "notes": [], "created": "2026-08-20T06:33:57.143Z", "modified": "2026-08-20T06:33:57.214Z"}, {"entity": "publication", "iuid": "10e0b502a55d48469ccb8202a1649d73", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/10e0b502a55d48469ccb8202a1649d73.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/10e0b502a55d48469ccb8202a1649d73"}}, "title": "Colitis-induced colorectal cancer and intestinal epithelial estrogen receptor beta impact gut microbiota diversity.", "authors": [{"family": "Ibrahim", "given": "Ahmed", "initials": "A"}, {"family": "Hugerth", "given": "Luisa W", "initials": "LW"}, {"family": "Hases", "given": "Linnea", "initials": "L"}, {"family": "Saxena", "given": "Ashish", "initials": "A"}, {"family": "Seifert", "given": "Maike", "initials": "M"}, {"family": "Thomas", "given": "Quentin", "initials": "Q"}, {"family": "Gustafsson", "given": "Jan-\u00c5ke", "initials": "J\u00c5"}, {"family": "Engstrand", "given": "Lars", "initials": "L"}, {"family": "Williams", "given": "Cecilia", "initials": "C", "orcid": "0000-0002-0602-2062", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/872c978997c74e89ae75efd90d592b42.json"}}], "type": "journal article", "published": "2019-06-15", "journal": {"title": "Int. J. Cancer", "issn": "1097-0215", "volume": "144", "issue": "12", "pages": "3086-3098", "issn-l": "0020-7136"}, "abstract": "Chronic inflammation of the colon (colitis) is a risk factor for colorectal cancer (CRC). Hormone-replacement therapy reduces CRC incidences, and the estrogen receptor beta (ER\u03b2/ESR2) has been implicated in this protection. Gut microbiota is altered in both colitis and CRC and may influence the severity of both. Here we test the hypothesis that intestinal ER\u03b2 impacts the gut microbiota. Mice with and without intestine-specific deletion of ER\u03b2 (ER\u03b2KOVil ) were generated using the Cre-LoxP system. Colitis and CRC were induced with a single intraperitoneal injection of azoxymethane (AOM) followed by administration of three cycles of dextran sulfate sodium (DSS) in drinking water. The microbiota population were characterized by high-throughput 16S rRNA gene sequencing of DNA extracted from fecal samples (N = 39). Differences in the microbiota due to AOM/DSS and absence of ER\u03b2 were identified through bioinformatic analyses of the 16S-Seq data, and the distribution of bacterial species was corroborated using qPCR. We demonstrate that colitis-induced CRC reduced the gut microbiota diversity and that loss of ER\u03b2 enhanced this process. Further, the Bacteroidetes genus Prevotellaceae_UCG_001 was overrepresented in AOM/DSS mice compared to untreated controls (3.5-fold, p = 0.004), and this was enhanced in females and in ER\u03b2KOVil mice. Overall, AOM/DSS enriched for microbiota impacting immune system diseases and metabolic functions, and lack of ER\u03b2 in combination with AOM/DSS enriched for microbiota impacting carbohydrate metabolism and cell motility, while reducing those impacting the endocrine system. Our data support that intestinal ER\u03b2 contributes to a more favorable microbiome that could attenuate CRC development.", "doi": "10.1002/ijc.32037", "pmid": "30515752", "labels": {"Luisa Hugerth": null, "DDLS Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC6519213"}], "notes": [], "created": "2022-11-08T06:59:16.768Z", "modified": "2023-10-27T09:33:48.374Z"}]}