{"entity": "researcher", "timestamp": "2026-08-20T20:46:24.985Z", "family": "Orchard", "given": "Sandra", "initials": "S", "orcid": "0000-0002-8878-3972", "affiliations": ["European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Cambridge, UK.", "Open Targets, Wellcome Genome Campus, Cambridge, UK."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/869478a873ea4465ab43ecef5aee865c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/869478a873ea4465ab43ecef5aee865c"}}, "publications": [{"entity": "publication", "iuid": "4fb1dd6f5f864787baae2144e261cca4", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/4fb1dd6f5f864787baae2144e261cca4.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/4fb1dd6f5f864787baae2144e261cca4"}}, "title": "A tissue-specific atlas of protein-protein associations enables prioritization of candidate disease genes.", "authors": [{"family": "Laman Trip", "given": "Diederik S", "initials": "DS", "orcid": "0000-0001-6635-0626", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a30f1c008f82468c8ae1d8964d997067.json"}}, {"family": "van Oostrum", "given": "Marc", "initials": "M", "orcid": "0000-0001-8747-9787", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/141897b2c0e748a9abb86cdea8bd8614.json"}}, {"family": "Memon", "given": "Danish", "initials": "D"}, {"family": "Frommelt", "given": "Fabian", "initials": "F", "orcid": "0000-0003-3666-8005", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1e71a93da1624a17bcbace26ba50c5a5.json"}}, {"family": "Baptista", "given": "Delora", "initials": "D"}, {"family": "Panneerselvam", "given": "Kalpana", "initials": "K", "orcid": "0000-0003-2534-198X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e2cfb623f9d74273a76b9d5ddc894129.json"}}, {"family": "Bradley", "given": "Glyn", "initials": "G"}, {"family": "Licata", "given": "Luana", "initials": "L", "orcid": "0000-0001-5084-9000", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dbfb64fa4d6a4c61b68d808a13e173b7.json"}}, {"family": "Hermjakob", "given": "Henning", "initials": "H", "orcid": "0000-0001-8479-0262", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7ef7fa5ba29447fba798a69b305c0228.json"}}, {"family": "Orchard", "given": "Sandra", "initials": "S", "orcid": "0000-0002-8878-3972", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/869478a873ea4465ab43ecef5aee865c.json"}}, {"family": "Trynka", "given": "Gosia", "initials": "G", "orcid": "0000-0002-6955-9529", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/22558d9cbf844bf6bd0063c2dde6f513.json"}}, {"family": "McDonagh", "given": "Ellen M", "initials": "EM"}, {"family": "Fossati", "given": "Andrea", "initials": "A"}, {"family": "Aebersold", "given": "Ruedi", "initials": "R", "orcid": "0000-0002-9576-3267", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4aa50db862e94831b8cac04c4426daf1.json"}}, {"family": "Gstaiger", "given": "Matthias", "initials": "M", "orcid": "0000-0002-3245-3253", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8370f12358274bb2a5a4cd524ae4f465.json"}}, {"family": "Wollscheid", "given": "Bernd", "initials": "B"}, {"family": "Beltrao", "given": "Pedro", "initials": "P", "orcid": "0000-0002-2724-7703", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/952eba119d2e4d4b89e14b294c5c6885.json"}}], "type": "journal article", "published": "2026-04-00", "journal": {"title": "Nat. Biotechnol.", "issn": "1546-1696", "volume": "44", "issue": "4", "pages": "654-667", "issn-l": "1087-0156"}, "abstract": "Despite progress in mapping protein-protein interactions, their tissue specificity is understudied. Here, given that protein coabundance is predictive of functional association, we compiled and analyzed protein abundance data of 7,811 proteomic samples from 11 human tissues to produce an atlas of tissue-specific protein associations. We find that this method recapitulates known protein complexes and the larger structural organization of the cell. Interactions of stable protein complexes are well preserved across tissues, while cell-type-specific cellular structures, such as synaptic components, are found to represent a substantial driver of differences between tissues. Over 25% of associations are tissue specific, of which <7% are because of differences in gene expression. We validate protein associations for the brain through cofractionation experiments in synaptosomes, curation of brain-derived pulldown data and AlphaFold2 modeling. We also construct a network of brain interactions for schizophrenia-related genes, indicating that our approach can functionally prioritize candidate disease genes in loci linked to brain disorders.", "doi": "10.1038/s41587-025-02659-z", "pmid": "40316700", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC13090126"}, {"db": "pii", "key": "10.1038/s41587-025-02659-z"}], "notes": [], "created": "2026-08-20T08:59:34.792Z", "modified": "2026-08-20T08:59:35.114Z"}, {"entity": "publication", "iuid": "2598dba6b2ec40e6a4e38faa37025e37", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/2598dba6b2ec40e6a4e38faa37025e37.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/2598dba6b2ec40e6a4e38faa37025e37"}}, "title": "Translon: a single term for translated regions.", "authors": [{"family": "\u015awirski", "given": "Micha\u0142 I", "initials": "MI", "orcid": "0000-0002-8585-136X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/daf5a142439546a7b7cd210439724554.json"}}, {"family": "Tierney", "given": "Jack A S", "initials": "JAS", "orcid": "0000-0002-5331-3604", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/536a9d74aa5045a68dcc3d2433e8686c.json"}}, {"family": "Alb\u00e0", "given": "M Mar", "initials": "MM", "orcid": "0000-0002-7963-7375", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1b14dd79387c4f75bfbf24b67f1d4ca9.json"}}, {"family": "Andreev", "given": "Dmitry E", "initials": "DE", "orcid": "0000-0001-5320-3045", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/36a203947cc34c35af7fca9c277faff5.json"}}, {"family": "Aspden", "given": "Julie L", "initials": "JL", "orcid": "0000-0002-8537-6204", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/30d5ae77bf134cf39c5120417a94d034.json"}}, {"family": "Atkins", "given": "John 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Methods", "issn": "1548-7105", "volume": "22", "issue": "10", "pages": "2002-2006", "issn-l": "1548-7091"}, "abstract": null, "doi": "10.1038/s41592-025-02810-3", "pmid": "40890551", "labels": [], "xrefs": [{"db": "pii", "key": "10.1038/s41592-025-02810-3"}], "notes": [], "created": "2026-08-20T09:03:33.962Z", "modified": "2026-08-20T09:03:37.514Z"}, {"entity": "publication", "iuid": "740e1cc8cc814157a7284bda1a857b55", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/740e1cc8cc814157a7284bda1a857b55.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/740e1cc8cc814157a7284bda1a857b55"}}, "title": "An intrinsically disordered proteins community for ELIXIR.", "authors": [{"family": "Davey", "given": "Norman E", "initials": "NE"}, {"family": "Babu", "given": "M Madan", "initials": "MM"}, {"family": "Blackledge", "given": "Martin", "initials": "M"}, {"family": "Bridge", "given": "Alan", "initials": "A"}, {"family": 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"Christos A", "initials": "CA"}, {"family": "Pancsa", "given": "Rita", "initials": "R"}, {"family": "Papaleo", "given": "Elena", "initials": "E"}, {"family": "Pierattelli", "given": "Roberta", "initials": "R", "orcid": "0000-0001-7755-0885", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/76fb4aa8c0824df09a4d8af9bfd2990f.json"}}, {"family": "Piovesan", "given": "Damiano", "initials": "D"}, {"family": "Promponas", "given": "Vasilis J", "initials": "VJ", "orcid": "0000-0003-3352-4831", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/814e650453b44d0c99b86091ee27669a.json"}}, {"family": "Ruch", "given": "Patrick", "initials": "P"}, {"family": "Rustici", "given": "Gabriella", "initials": "G"}, {"family": "Romero", "given": "Pedro", "initials": "P", "orcid": "0000-0002-6995-5193", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5b6be817efdc4e1fb23cc30dd2a1f6ba.json"}}, {"family": "Sarntivijai", "given": "Sirarat", "initials": "S"}, {"family": "Saunders", "given": "Gary", "initials": "G"}, {"family": "Schuler", "given": "Benjamin", "initials": "B"}, {"family": "Sharan", "given": "Malvika", "initials": "M"}, {"family": "Shields", "given": "Denis C", "initials": "DC"}, {"family": "Sussman", "given": "Joel L", "initials": "JL"}, {"family": "Tedds", "given": "Jonathan A", "initials": "JA"}, {"family": "Tompa", "given": "Peter", "initials": "P"}, {"family": "Turewicz", "given": "Michael", "initials": "M", "orcid": "0000-0003-0737-1114", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d6f5ef7ecd8f429f8a1a19026ae254b0.json"}}, {"family": "Vondrasek", "given": "Jiri", "initials": "J"}, {"family": "Vranken", "given": "Wim F", "initials": "WF"}, {"family": "Wallace", "given": "Bonnie Ann", "initials": "BA"}, {"family": "Wichapong", "given": "Kanin", "initials": "K"}, {"family": "Tosatto", "given": "Silvio C E", "initials": "SCE"}], "type": "journal article", "published": "2019-10-15", "journal": {"title": "F1000Res", "issn": "2046-1402", "volume": "8", "issn-l": "2046-1402"}, "abstract": "Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) are now recognised as major determinants in cellular regulation. This white paper presents a roadmap for future e-infrastructure developments in the field of IDP research within the ELIXIR framework. The goal of these developments is to drive the creation of high-quality tools and resources to support the identification, analysis and functional characterisation of IDPs. The roadmap is the result of a workshop titled \"An intrinsically disordered protein user community proposal for ELIXIR\" held at the University of Padua. The workshop, and further consultation with the members of the wider IDP community, identified the key priority areas for the roadmap including the development of standards for data annotation, storage and dissemination; integration of IDP data into the ELIXIR Core Data Resources; and the creation of benchmarking criteria for IDP-related software. Here, we discuss these areas of priority, how they can be implemented in cooperation with the ELIXIR platforms, and their connections to existing ELIXIR Communities and international consortia. The article provides a preliminary blueprint for an IDP Community in ELIXIR and is an appeal to identify and involve new stakeholders.", "doi": "10.12688/f1000research.20136.1", "pmid": "31824649", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6880265"}, {"db": "pii", "key": "ELIXIR-1753"}], "notes": [], "created": "2026-08-20T12:41:35.065Z", "modified": "2026-08-20T12:41:35.308Z"}]}