{"entity": "researcher", "timestamp": "2026-09-23T21:35:52.657Z", "family": "Schmitt-Egenolf", "given": "Marcus", "initials": "M", "orcid": "0000-0002-3858-8474", "affiliations": ["Dermatology, Department of Public Health and Clinical Medicine, Ume\u00e5 University, Ume\u00e5, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/8656f121cd504cddaf2cd658fbeed9d8.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/8656f121cd504cddaf2cd658fbeed9d8"}}, "publications": [{"entity": "publication", "iuid": "e54d21cb09054df6965e55d1ace75d60", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/e54d21cb09054df6965e55d1ace75d60.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/e54d21cb09054df6965e55d1ace75d60"}}, "title": "Drug Persistence of Biologic Treatments in Psoriasis: A Swedish National Population Study.", "authors": [{"family": "Schmitt-Egenolf", "given": "Marcus", "initials": "M", "orcid": "0000-0002-3858-8474", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8656f121cd504cddaf2cd658fbeed9d8.json"}}, {"family": "Freilich", "given": "Jonatan", "initials": "J"}, {"family": "Stelmaszuk-Zadykowicz", "given": "Natalia M", "initials": "NM"}, {"family": "Apol", "given": "Eydna", "initials": "E"}, {"family": "Hansen", "given": "Jes B", "initials": "JB"}, {"family": "Levin", "given": "Lars-\u00c5ke", "initials": "L\u00c5"}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Dermatol Ther (Heidelb)", "issn": "2193-8210", "volume": "11", "issue": "6", "pages": "2107-2121", "issn-l": null}, "abstract": "Biologic treatments for psoriasis are commonly switched. Treatment persistence represents an important parameter related to long-term therapeutic performance. The objective of the study was to analyse the real-world persistence with biologics over time in the treatment of psoriasis.\n\nA retrospective observational study of adults with psoriasis was conducted based on Swedish national registry data from 2010 to 2018. Patients included were treated with a biologic between 2010 and 2018. Treatment episodes were identified from the drug's date of dispensation recorded in the Prescribed Drug Register to the end of supply of the drug. Median persistence was estimated by Kaplan-Meier survival curves for patients who received adalimumab, etanercept, secukinumab, ustekinumab and ixekizumab. Descriptive analysis of change in persistence over time for 3-year running cohorts was also carried out.\n\nA total of 2292 patients were analysed. Patients who received ustekinumab had the longest median persistence [49.3 months, 95% confidence interval (CI) 38.0-59.1] and etanercept the shortest (16.3 months, 95% CI 14.5-19.0). Median persistence was longer in biologic-naive than biologic-exposed patients. Persistence for ustekinumab decreased by almost 50% over the study period, from a median of 62.3 (95% CI 45.6-\u221e) months in 2010-2011 to 32.7 (21.2-49.3) months in 2014-2016.\n\nPersistence with biologics was, on average, relatively low, given the chronic nature of psoriasis. Changes in persistence over time seemed to be attributable to changes in the therapeutic landscape, providing patients with more options to switch biologic treatments if their current management was considered suboptimal.", "doi": "10.1007/s13555-021-00616-7", "pmid": "34661864", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8611161"}, {"db": "pii", "key": "10.1007/s13555-021-00616-7"}], "notes": [], "created": "2026-09-23T09:44:51.510Z", "modified": "2026-09-23T10:19:06.869Z"}, {"entity": "publication", "iuid": "eb86ffc075d6438fad7c08928e821b3a", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/eb86ffc075d6438fad7c08928e821b3a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/eb86ffc075d6438fad7c08928e821b3a"}}, "title": "Anti-TNF treatment during pregnancy and birth outcomes: A population-based study from Denmark, Finland, and Sweden.", "authors": [{"family": "Br\u00f6ms", "given": "Gabriella", "initials": "G", "orcid": "0000-0002-2423-1968", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ba30331e2aad4a8b8d7ba6a0578193b7.json"}}, {"family": "Kieler", "given": "Helle", "initials": "H", "orcid": "0000-0001-9338-7133", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/831da95a6b2f4a9b9e29aed574219101.json"}}, {"family": "Ekbom", "given": "Anders", "initials": "A", "orcid": "0000-0001-6674-5003", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3e61ab107fe347aebb2c7bb29e3fb795.json"}}, {"family": "Gissler", "given": "Mika", "initials": "M", "orcid": "0000-0001-8254-7525", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8d4fbc591a0547beaaf224856e96949f.json"}}, {"family": "Hellgren", "given": "Karin", "initials": "K", "orcid": "0000-0001-7149-0973", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d7f3861a3f14424785315e5d4d3e330e.json"}}, {"family": "Lahesmaa-Korpinen", "given": "Anna-Maria", "initials": "AM", "orcid": "0000-0003-1062-2893", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6530a707032341d09ae43c794c54e84a.json"}}, {"family": "Pedersen", "given": "Lars", "initials": "L", "orcid": "0000-0002-9341-3888", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fa1b528444da46a89a923e3e3eb87280.json"}}, {"family": "Schmitt-Egenolf", "given": "Marcus", "initials": "M", "orcid": "0000-0002-3858-8474", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8656f121cd504cddaf2cd658fbeed9d8.json"}}, {"family": "S\u00f8rensen", "given": "Henrik T", "initials": "HT", "orcid": "0000-0003-4299-7040", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/66671606c59445cb967124edb7827eda.json"}}, {"family": "Granath", "given": "Fredrik", "initials": "F"}], "type": "journal article", "published": "2020-03-00", "journal": {"title": "Pharmacoepidemiol Drug Saf", "issn": "1099-1557", "volume": "29", "issue": "3", "pages": "316-327", "issn-l": null}, "abstract": "To study the risk of preterm birth, caesarean section, and small for gestational age after anti-tumor necrosis factor agent treatment (anti-TNF) in pregnancy.\n\nPopulation-based study including women with inflammatory bowel disease, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, and psoriasis, and their infants born 2006 to 2013 from the national health registers in Denmark, Finland, and Sweden. Women treated with anti-TNF were compared with women with nonbiologic systemic treatment. Adalimumab, etanercept, and infliximab were compared pairwise. Continuation of treatment in early pregnancy was compared with discontinuation. Odds ratios with 95% confidence intervals were calculated in logistic regression models adjusted for country and maternal characteristics.\n\nAmong 1 633 909 births, 1027 infants were to women treated with anti-TNF and 9399 to women with nonbiologic systemic treatment. Compared with non-biologic systemic treatment, women with anti-TNF treatment had a higher risk of preterm birth, odds ratio 1.61 (1.29-2.02) and caesarean section, 1.57 (1.35-1.82). The odds ratio for small for gestational age was 1.36 (0.96-1.92). In pairwise comparisons, infliximab was associated with a higher risk of severely small for gestational age for inflammatory joint and skin diseases but not for inflammatory bowel disease. Discontinuation of anti-TNF had opposite effects on preterm birth for inflammatory bowel disease and inflammatory joint and skin diseases.\n\nAnti-TNF agents were associated with increased risks of preterm birth, caesarean section, and small for gestational age. However, the diverse findings across disease groups may indicate an association related to the underlying disease activity, rather than to agent-specific effects.", "doi": "10.1002/pds.4930", "pmid": "32020767", "labels": [], "xrefs": [], "notes": [], "created": "2026-09-23T08:32:34.342Z", "modified": "2026-09-23T08:32:34.950Z"}]}