{"entity": "researcher", "timestamp": "2026-09-23T22:40:36.540Z", "family": "Melander", "given": "Erik", "initials": "E", "orcid": "0009-0002-9981-3505", "affiliations": ["Department of Pharmacy, Uppsala Drug Optimization and Pharmaceutical Profiling (UDOPP), Uppsala University, Uppsala, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/8526de87b7914d7a9c62170c26fb9e4f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/8526de87b7914d7a9c62170c26fb9e4f"}}, "publications": [{"entity": "publication", "iuid": "915b9ebd53ba4c3bb6699d3532732ad4", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/915b9ebd53ba4c3bb6699d3532732ad4.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/915b9ebd53ba4c3bb6699d3532732ad4"}}, "title": "Population pharmacokinetic modelling of cetirizine concentrations in human breast milk-A contribution from the ConcePTION project.", "authors": [{"family": "Melander", "given": "Erik", "initials": "E", "orcid": "0009-0002-9981-3505", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8526de87b7914d7a9c62170c26fb9e4f.json"}}, {"family": "Nielsen", "given": "Elisabet I", "initials": "EI"}, {"family": "Lindqvist", "given": "Annika", "initials": "A"}, {"family": "Hovd", "given": "Markus", "initials": "M", "orcid": "0000-0002-6077-0934", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/40bec1eda0684e43a25fb3a9552d9f03.json"}}, {"family": "Gandia", "given": "Peggy", "initials": "P"}, {"family": "Panchaud", "given": "Alice", "initials": "A"}, {"family": "Guidi", "given": "Monia", "initials": "M"}, {"family": "Annaert", "given": "Pieter", "initials": "P", "orcid": "0000-0003-3525-7351", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c12682c9664f43bb952a481608467d1c.json"}}, {"family": "Baranczewski", "given": "Pawel", "initials": "P"}, {"family": "Spigset", "given": "Olav", "initials": "O"}, {"family": "Nordeng", "given": "Hedvig", "initials": "H", "orcid": "0000-0001-6361-2918", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e149ec4deccc4c02a3d77948d4a3355d.json"}}], "type": "journal article", "published": "2025-01-00", "journal": {"title": "Basic Clin. Pharmacol. Toxicol.", "issn": "1742-7843", "volume": "136", "issue": "1", "pages": "e14100", "issn-l": "1742-7835"}, "abstract": "Cetirizine is an antihistamine commonly used to treat allergic rhinitis and other allergic conditions. Cetirizine is often prescribed to breastfeeding mothers although there is limited information on infant exposure via breast milk. The aim of this study was to develop a popPK model based on data from a lactation study to predict cetirizine breast milk concentrations and estimate the relative infant dose (RID) in a breastfed infant. A popPK model was developed in NONMEM on data from a human lactation study including 35 women using cetirizine or levocetirizine while breastfeeding. Serial samples of breast milk were collected (n = 205) and the cetirizine concentrations quantified using a validated LC-MS/MS method. A one-compartment model of cetirizine in breast milk was developed and employed to calculate the relative infant dose (RID). Covariates related to the maternal characteristics and breastfeeding patterns were evaluated in the model; only milk sampling pumping duration was found to be a significant covariate, with an increasing pumping duration leading to an increased apparent milk volume of distribution (Vm). The mean RID was 1.99% with the highest RID being 3.36% at Cmax. PopPK modelling could be used to estimate infant exposure to cetirizine via breast milk. The low predicted exposure in infants supports that cetirizine is compatible with breastfeeding.", "doi": "10.1111/bcpt.14100", "pmid": "39497323", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11655701"}], "notes": [], "created": "2026-09-23T12:22:04.142Z", "modified": "2026-09-23T12:22:04.227Z"}, {"entity": "publication", "iuid": "8923e25544c44ed9993b5b5c8954e17f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/8923e25544c44ed9993b5b5c8954e17f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/8923e25544c44ed9993b5b5c8954e17f"}}, "title": "Transfer of cetirizine/levocetirizine into human breast milk and estimation of drug exposure to infants through breastfeeding: A human lactation study from the ConcePTION project.", "authors": [{"family": "Nordeng", "given": "Hedvig", "initials": "H", "orcid": "0000-0001-6361-2918", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e149ec4deccc4c02a3d77948d4a3355d.json"}}, {"family": "Wegler", "given": "Christine", "initials": "C", "orcid": "0000-0002-2810-7518", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fcb45d19c52847f19bd5c0aa296afe10.json"}}, {"family": "Lindqvist", "given": "Annika", "initials": "A", "orcid": "0009-0003-2587-8434", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/89bd045cc7844e508c837da8a2887a22.json"}}, {"family": "Melander", "given": "Erik", "initials": "E", "orcid": "0009-0002-9981-3505", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8526de87b7914d7a9c62170c26fb9e4f.json"}}, {"family": "Magnusson", "given": "Mikaela", "initials": "M", "orcid": "0000-0003-4347-2094", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/eade0faf6b75494d84a4ad63d2799040.json"}}, {"family": "Gandia", "given": "Peggy", "initials": "P", "orcid": "0000-0002-4385-7894", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6b66aba78159426ca9c50d348c962a3d.json"}}, {"family": "Panchaud", "given": "Alice", "initials": "A", "orcid": "0000-0001-6086-2401", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/abd99a5f06aa401a86e0c14de367c914.json"}}, {"family": "Baranczewski", "given": "Pawel", "initials": "P", "orcid": "0000-0001-5772-6791", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/327feae3833d425c9d5936f48627390c.json"}}, {"family": "Spigset", "given": "Olav", "initials": "O", "orcid": "0000-0001-7902-9014", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4029fefdca91491896e055abda57f25d.json"}}], "type": "journal article", "published": "2024-01-00", "journal": {"title": "Basic Clin. Pharmacol. Toxicol.", "issn": "1742-7843", "volume": "134", "issue": "1", "pages": "153-164", "issn-l": "1742-7835"}, "abstract": "Data on drug transfer into human breast milk are sparse. This study aimed to quantify concentrations of cetirizine and levocetirizine in breast milk and to estimate drug exposure to infants. Breastfeeding women at least 8 weeks postpartum and using cetirizine or its pure (R)-enantiomer levocetirizine were eligible to participate. Breast milk samples were collected at six predefined times during a dose interval (0, 2, 4, 8, 12 and 24 h after drug intake) at steady state. Infant drug exposure was estimated by calculating the absolute infant dose (AID) and the weight-adjusted relative infant dose (RID). In total, 32 women were eligible for final inclusion, 31 women using cetirizine and one woman using levocetirizine. Means of the individual maximum and average cetirizine milk concentrations were 41.0 and 16.8 \u03bcg/L, respectively. Maximum concentrations occurred on average 2.4 h after intake, and the mean half-life in milk was 7.0 h. Estimated AID and RID for cetirizine in a day were 2.5 \u03bcg/kg and 1.9%, respectively. The corresponding values for levocetirizine were 1.1 \u03bcg/kg and 1.9%. No severe adverse events were reported. Our findings demonstrate that the transfer of cetirizine and levocetirizine into breast milk is low and compatible with breastfeeding.", "doi": "10.1111/bcpt.13948", "pmid": "37811726", "labels": [], "xrefs": [], "notes": [], "created": "2026-09-23T12:10:11.915Z", "modified": "2026-09-23T12:10:12.195Z"}]}